Acetolactate synthase small subunit, mitochondrial (P25605)

Identification
NameAcetolactate synthase small subunit, mitochondrial
Synonyms
  • Acetohydroxy-acid synthase small subunit
  • AHAS
  • ALS
Gene NameILV6
Enzyme ClassNot Available
Biological Properties
General FunctionAmino acid transport and metabolism
Specific FunctionStimulates activity of the acetolactate synthase catalytic subunit ILV2 seven- to tenfold and confers sensitivity to inhibition by valine and activation by ATP
Cellular LocationMitochondrion
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
transferase activity
carboxylic acid binding
amino acid binding
transferase activity, transferring aldehyde or ketonic groups
acetolactate synthase activity
binding
catalytic activity
Process
cellular metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular amino acid biosynthetic process
branched chain family amino acid biosynthetic process
metabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>930 bp ATGCTGAGATCGTTATTGCAAAGCGGCCACCGCAGGGTGGTTGCTTCTTCATGTGCTACC ATGGTGCGTTGCAGTTCCTCGTCGACCTCCGCGTTGGCGTACAAGCAGATGCACAGACAC GCAACAAGACCTCCCTTGCCCACACTAGACACTCCTTCCTGGAATGCCAACAGTGCCGTT TCATCCATCATTTACGAAACACCAGCGCCTTCTCGTCAACCAAGAAAACAGCATGTCTTG AACTGTTTGGTGCAAAACGAACCCGGTGTCTTGTCCAGAGTCTCGGGTACGTTAGCTGCC AGAGGCTTTAACATCGATTCGTTGGTCGTGTGCAACACCGAGGTCAAAGACCTAAGTAGA ATGACCATTGTTTTGCAAGGGCAAGATGGCGTAGTCGAACAAGCACGCAGACAAATCGAA GACTTGGTCCCCGTCTACGCCGTCCTAGACTATACCAATTCTGAGATCATCAAAAGAGAG CTAGTGATGGCCAGAATCTCTCTATTGGGTACTGAATACTTCGAAGACCTACTATTGCAC CACCACACTTCCACCAATGCTGGCGCCGCTGACTCCCAAGAATTGGTCGCCGAAATCAGA GAAAAGCAATTCCACCCTGCCAACTTGCCCGCCAGTGAGGTATTAAGGTTGAAGCACGAG CATTTGAACGATATCACCAACTTGACCAACAACTTTGGAGGTCGTGTCGTCGACATCAGC GAAACAAGCTGTATTGTGGAGTTGTCTGCAAAACCCACACGTATCTCTGCCTTCTTGAAG TTGGTCGAGCCATTCGGTGTCCTAGAGTGTGCAAGAAGCGGTATGATGGCATTGCCAAGA ACTCCTTTGAAGACAAGCACCGAGGAAGCTGCCGACGAAGACGAAAAGATCAGCGAAATC GTCGACATTTCCCAACTACCACCTGGTTAG
Protein Properties
Pfam Domain Function
Protein Residues309
Protein Molecular Weight33986.39844
Protein Theoretical pI6.51
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Acetolactate synthase small subunit, mitochondrial MLRSLLQSGHRRVVASSCATMVRCSSSSTSALAYKQMHRHATRPPLPTLDTPSWNANSAV SSIIYETPAPSRQPRKQHVLNCLVQNEPGVLSRVSGTLAARGFNIDSLVVCNTEVKDLSR MTIVLQGQDGVVEQARRQIEDLVPVYAVLDYTNSEIIKRELVMARISLLGTEYFEDLLLH HHTSTNAGAADSQELVAEIREKQFHPANLPASEVLRLKHEHLNDITNLTNNFGGRVVDIS ETSCIVELSAKPTRISAFLKLVEPFGVLECARSGMMALPRTPLKTSTEEAADEDEKISEI VDISQLPPG
References
External Links
ResourceLink
Saccharomyces Genome Database ILV6
Uniprot IDP25605
Uniprot NameILV6_YEAST
GenBank Gene IDX59720
Genebank Protein ID1907135
General Reference
  • Oliver, S. G., van der Aart, Q. J., Agostoni-Carbone, M. L., Aigle, M., Alberghina, L., Alexandraki, D., Antoine, G., Anwar, R., Ballesta, J. P., Benit, P., et, a. l. .. (1992). "The complete DNA sequence of yeast chromosome III." Nature 357:38-46.1574125
  • Bork, P., Ouzounis, C., Sander, C., Scharf, M., Schneider, R., Sonnhammer, E. (1992). "Comprehensive sequence analysis of the 182 predicted open reading frames of yeast chromosome III." Protein Sci 1:1677-1690.1304897
  • Boucherie, H., Dujardin, G., Kermorgant, M., Monribot, C., Slonimski, P., Perrot, M. (1995). "Two-dimensional protein map of Saccharomyces cerevisiae: construction of a gene-protein index." Yeast 11:601-613.7483834
  • Cullin, C., Baudin-Baillieu, A., Guillemet, E., Ozier-Kalogeropoulos, O. (1996). "Functional analysis of YCL09C: evidence for a role as the regulatory subunit of acetolactate synthase." Yeast 12:1511-1518.8972574
  • Pang, S. S., Duggleby, R. G. (1999). "Expression, purification, characterization, and reconstitution of the large and small subunits of yeast acetohydroxyacid synthase." Biochemistry 38:5222-5231.10213630
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956