Serine/threonine-protein kinase STE11 (P23561)

Identification
NameSerine/threonine-protein kinase STE11
SynonymsNot Available
Gene NameSTE11
Enzyme ClassNot Available
Biological Properties
General Functionsignal transduction involved in filamentous growth
Specific FunctionSerine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KSS1 kinases.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarityPW002516 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity 1469654356PW002970 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: starvation test 1PW003483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
osmosensory signaling pathway via Sho1 osmosensor
ATP binding
pheromone-dependent signal transduction involved in conjugation with cellular fusion
cytoplasm
invasive growth in response to glucose limitation
MAPK cascade involved in cell wall organization or biogenesis
protein phosphorylation
pseudohyphal growth
regulation of transposition, RNA-mediated
signal transduction involved in filamentous growth
cellular response to heat
identical protein binding
MAP kinase kinase kinase activity
SAM domain binding
activation of MAPKK activity
MAPK cascade involved in osmosensory signaling pathway
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2154 bp ATGGAACAGACACAAACAGCAGAGGGCACTGACTTACTAATTGGTGACGAAAAGACCAAC GATTTACCTTTTGTGCAGTTATTTCTGGAGGAAATAGGATGCACTCAATACCTGGATAGC TTTATTCAGTGCAACCTTGTCACAGAAGAAGAAATTAAGTATCTCGACAAGGATATCCTC ATTGCTTTGGGTGTAAACAAAATAGGAGACAGACTCAAAATTTTAAGGAAGTCAAAATCG TTCCAGAGAGATAAACGGATTGAACAGGTGAATAGATTGAAAAACCTGATGGAAAAAGTA AGCTCTCTATCCACTGCTACGCTATCGATGAATTCAGAATTGATTCCTGAAAAGCACTGT GTTATATTTATCTTAAACGATGGTTCCGCTAAGAAAGTTAATGTAAATGGTTGCTTTAAT GCAGATTCTATTAAGAAAAGGCTAATCAGAAGATTGCCACATGAATTATTAGCCACAAAC TCCAATGGAGAAGTAACTAAAATGGTCCAAGATTATGATGTGTTTGTCTTAGATTATACC AAGAACGTACTGCATTTGCTATATGACGTGGAATTAGTCACTATTTGCCACGCAAATGAT CGTGTTGAGAAAAATAGGCTAATTTTTGTTTCCAAAGACCAAACACCAAGTGATAAAGCT ATATCCACATCCAAAAAACTATATCTAAGAACGTTGAGTGCATTGAGCCAGGTTGGGCCA TCCTCGTCAAATTTGTTGGCACAGAACAAGGGGATTTCGCATAACAATGCTGAAGGGAAA CTCCGGATCGACAACACAGAAAAGGACAGAATTAGACAGATTTTTAATCAGAGGCCTCCT AGCGAATTTATTTCTACCAATTTGGCCGGATATTTTCCTCATACAGACATGAAGCGGTTG CAAAAGACGATGAGAGAGTCATTTCGCCATTCAGCAAGGCTAAGCATTGCTCAAAGAAGA CCTTTAAGTGCAGAATCAAATAATATCGGTGACATACTATTGAAACACTCAAACGCTGTT GATATGGCCCTATTACAAGGATTAGATCAGACAAGATTAAGCAGTAAACTTGACACAACT AAAATTCCGAAGCTTGCCCATAAAAGGCCAGAAGATAATGATGCCATATCTAACCAGTTA GAACTATTAAGTGTAGAGTCTGGTGAAGAAGAAGATCACGATTTCTTTGGGGAGGACAGT GACATTGTTTCATTACCGACGAAAATTGCCACGCCCAAGAATTGGTTAAAAGGTGCTTGC ATTGGATCAGGCAGTTTTGGGAGTGTTTACTTGGGCATGAATGCTCACACTGGTGAACTA ATGGCAGTAAAGCAAGTGGAGATAAAAAATAATAACATTGGTGTTCCCACAGACAACAAT AAACAAGCCAATTCTGATGAGAATAATGAGCAGGAGGAACAACAAGAGAAAATAGAAGAT GTTGGGGCGGTAAGTCATCCAAAAACCAATCAAAATATTCACAGAAAGATGGTTGATGCT TTACAGCATGAAATGAATTTATTGAAGGAGTTACATCATGAGAACATTGTTACTTATTAT GGTGCTTCTCAAGAAGGCGGAAATTTAAATATTTTTCTTGAATACGTTCCTGGGGGTTCG GTTTCCTCCATGCTGAATAATTACGGTCCATTTGAGGAATCACTGATTACTAATTTCACT AGGCAAATACTGATTGGGGTTGCGTATTTGCATAAGAAGAACATTATTCACAGAGATATC AAGGGTGCAAATATTTTGATTGATATCAAAGGTTGCGTAAAAATTACTGATTTTGGTATT TCAAAAAAATTATCACCTTTGAATAAAAAACAAAATAAGAGAGCTTCTTTGCAAGGTTCC GTATTCTGGATGTCACCAGAGGTGGTCAAACAGACCGCTACTACTGCTAAAGCGGATATA TGGTCTACAGGATGTGTTGTCATTGAAATGTTTACCGGTAAGCATCCTTTCCCAGATTTT TCTCAAATGCAAGCGATCTTCAAAATAGGCACAAACACGACCCCCGAGATACCTTCCTGG GCTACGTCAGAAGGAAAGAATTTCTTAAGAAAGGCATTTGAGTTGGATTATCAATACAGG CCTAGTGCCCTTGAATTGCTGCAGCATCCATGGCTGGATGCACACATAATTTGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues717
Protein Molecular Weight80720.24
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Serine/threonine-protein kinase STE11 MEQTQTAEGTDLLIGDEKTNDLPFVQLFLEEIGCTQYLDSFIQCNLVTEEEIKYLDKDIL IALGVNKIGDRLKILRKSKSFQRDKRIEQVNRLKNLMEKVSSLSTATLSMNSELIPEKHC VIFILNDGSAKKVNVNGCFNADSIKKRLIRRLPHELLATNSNGEVTKMVQDYDVFVLDYT KNVLHLLYDVELVTICHANDRVEKNRLIFVSKDQTPSDKAISTSKKLYLRTLSALSQVGP SSSNLLAQNKGISHNNAEGKLRIDNTEKDRIRQIFNQRPPSEFISTNLAGYFPHTDMKRL QKTMRESFRHSARLSIAQRRPLSAESNNIGDILLKHSNAVDMALLQGLDQTRLSSKLDTT KIPKLAHKRPEDNDAISNQLELLSVESGEEEDHDFFGEDSDIVSLPTKIATPKNWLKGAC IGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIED VGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGS VSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGI SKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDF SQMQAIFKIGTNTTPEIPSWATSEGKNFLRKAFELDYQYRPSALELLQHPWLDAHII
References
External Links
ResourceLink
Saccharomyces Genome Database STE11
Uniprot IDP23561
Uniprot NameSTE11
PDB ID
1OW5
General ReferenceNot Available