5'-nucleotidase (P21589)

Identification
Name5'-nucleotidase
Synonyms
  • 5'-NT
  • Ecto-5'-nucleotidase
Gene NameNT5E
Enzyme ClassNot Available
Biological Properties
General Functionresponse to aluminum ion
Specific FunctionHydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.
Cellular LocationNot Available
SMPDB Pathways
Glycolysis IPW002386 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
nucleotide binding
positive regulation of lipid biosynthetic process
cytoplasm
purine nucleotide biosynthetic process
anchored component of membrane
purine nucleotide catabolic process
plasma membrane
pyrimidine nucleoside catabolic process
membrane
response to aluminum ion
cell surface
extracellular exosome
synaptic membrane
5'-nucleotidase activity
ferrous iron binding
adenosine biosynthetic process
AMP catabolic process
brain development
DNA metabolic process
leukocyte cell-cell adhesion
negative regulation of inflammatory response
Gene Properties
Chromosome Location6
Locus6q14-q21
Gene Sequence>3936 bp ACTCCTCCTCTCTGCCCCTCAGCTCGCTCATCTTTCTTCCCGCCCCCTCTCTTTTCCTTC TTTGGTTCTTTGAAGTGATGAGCTAGCGCAACCACAAACCATACATTCCTTTTGTAGAAA AACCCGTGCCTCGAATGAGGCGAGACTCAGAGAGGACCCAGGCGCGGGGCGGACCCCTCC AATTCCTTCCTCGCGCCCCCGAAAGAGCGGCGCACCAGCAGCCGAACTGCCGGCGCCCAG GCTCCCTGGTCCGGCCGGGATGCGGCCGGTACCCGCTCCCCGCCGGGAACAACCTCTCCA CTCTTCCTGCAGGGAGCTGGTGCCAGCCGACAGCCGCGCCAGGGCCGCTCCGGGTACCAG GGTCGGATCGGGTGACGTCGCGAACTTGCGCCTGGCCGCCAAGCCGGCCTCCAGGCTGAA GAAGGACCCGCCCCGGCCTTGACCCGGGCCCCGCCCCTCCAGCCGGGGCACCGAGCCCCG GCCCTAGCTGCTCGCCCCTACTCGCCGGCACTCGCCCGGCTCGCCCGCTTTCGCACCCAG TTCACGCGCCACAGCTATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGC CCTGGGCGCGGTGCTGTGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAA CGACGTGCACAGCCGGCTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAG CCGCTGCATGGGTGGCGTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGA ACCCAACGTGCTGCTGCTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGT GTACAAGGGCGCCGAGGTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACT GGGAAATCATGAATTTGATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGC CAAATTTCCAATTCTGAGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATC AGGACTTTATTTGCCATATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGG ATACACTTCCAAAGAAACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGA TGAAATCACTGCATTACAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAAT TATTGCACTGGGACATTCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGG TGTGGACGTCGTGGTGGGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTC CAAAGAGGTGCCTGCTGGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGT TCCTGTAGTCCAGGCCTATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGA TGAAAGAGGAAACGTCATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCC TGAAGATCCAAGCATAAAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTC TACCCAGGAATTAGGGAAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTT TAGAGAATGCAACATGGGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACA CACGGATGAAATGTTCTGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCG GTCGCCCATTGATGAACGCAACAATGGAATCCATGTGGTGTATGATCTTTCCCGAAAACC TGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGAGTGCCCAGTTATGA CCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTCCTGGCCAATGGTGG AGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCTGGTGACCAAGATAT CAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCAGCAGTTGAAGGTCG GATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTAATATTTCTTTCACT TTGGGCAGTGATCTTTGTTTTATACCAATAGCCAAAAATTCTCCTTGCCTTTAATGTGTG AAACTGCATTTTTTCAAGTGAGATTCAAATCTGCCTTTTAGGACCTGGCTTTGTGACAGC AAAAACCATCTTTACAGGCTCCTAGAAGCTGAAGGTTAGAGCATTATAAAATGAAGAGAC AGACATGATTACTCAGGGTCAGCAACCTAGTGAGTTAGAAAAAAAATTAACATAGGGCCC TATAAGGAGAAAGCCAACTATGTTAAGTTTACGTGTCCAAATTTTAATGAAATTTTACTA ACAATTTTAAACCATATTTTTCTTCTTCATATCCATTTCTAATCCATCAAACAGCTTATG TTTACATAAAATTTTATCATTCACAAGGAAGTTTTAAGCACACTGTCTCATTTGATATCC ACAACTTATTTTTGGTAGGAAAGAGAGATGTTTTTCCCACCTGTCAGATGAAAAAACTGA AGCTCAAAAAGGGTTGACTTGACCATACAGCTAATGCTGACAGATCCAAGACCTAGACCT AGGTCTTTTGAACTCAAGTCCAGCATTCTCAACTATATCAAGTTACTGTTCAGAATACTT AATATCTCCTCTCTTCATAATTATCAATAGCCCCAAGCTCATGGATGACAAATCTCTGCT TTATTTCTTGTCTCTATTTTTTCACTTTATAGCTCCTGTTATAATAGCAAGTTTAATGGT ATAAACACAGGATACCATCCTCTCTTGCAACACCCATGTGCCTTTGATGAGTCAGGTAGC AAGCTGTAGTAGATAATGAGAAAGGCCAGAGGCTGCAAAAGACAGTCAAAGGACACGAGA GAAAGGAAGGGGAAGAACAGGACTCCAGGACTGTTTTATATTATAGAAAAGCAAGAGCTA AAGAGCATTTACACATGTTAAACAGATACTTGTTAAGCATAGTGCCTGACACACGGCATT AGCTGTTATTTTATGAGATTCCATCAGCTCTGCCTCTGTCCTCTTTCTTCTAACATGAAG GTATCATGAGAAGAGAACCTTCTAACATAAGCTGTAATTCTAAACCTGCACTTGTCCCTC TCCAGCAAGAGGCTAGCACTGAATTCATTCTACTCATACTACACACCCAGTTATGGAATG TCCAGAGTTCTCGAAGAAAATAAATGACTTTAGGAAGAGGTATACATTTTTTAAGTCGCT CTGCCTCCAAATCTGAACAGTCACTGTAAATCATTCTTAAGCCCAGATATGAGAACTTCT GCTGGAAAGTGGGACCCTCTGAGTGGGTGGTCAGAAAATACCCATGCTGATGAAATGACC TATGCCCAAAGAACAAATACTTAACGTGGGAGTGGAACCACATGAGCCTGCTCAGCTCTG CATAAGTAATTCAAGAAATGGGAGGCTTCACCTTAAAAACAGTGTGCAAATGGCAGCTAG AGGTTTTGATAGGAAGTATGTTTGTTTCTTAGTGTTTACAAATATTAAGTACTCTTGATA CAAAATATACTTTTAAACTTCATAACCTTTTTATAAAAGTTGTTGCAGCAAAATAATAGC CTCGGTTCTATGCATATATGGATTAGCTATAAAAAATGTCAATAAGATTGTACAAGGAAA ATTAGAGAAAGTCACATTTAGGGTTTATTTTTTACACTTGGCCAGTAAAATAGGGTAAAT CCTATTAGAATTTTTTAAAGAACTTTTTTTAAGTTTCCTAAATCTGTGTGTGTATTGTGA AGTGGTATAAGAAATGACTTTGAACCACTTTGCAATTGTAGATTCCCAACAATAAAATTG AAGATAAGCTCTTTGGTCAAAAAAAAAAAAAAAAAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues524
Protein Molecular Weight63367.255
Protein Theoretical pINot Available
PDB Fileshow
Signalling Regions
  • 1-26
Transmembrane RegionsNot Available
Protein Sequence>5'-nucleotidase MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
References
External Links
ResourceLink
Saccharomyces Genome Database NT5E
Uniprot IDP21589
Uniprot NameNT5E
PDB ID
4H1S
General ReferenceNot Available