Mitogen-activated protein kinase FUS3 (P16892)

Identification
NameMitogen-activated protein kinase FUS3
Synonyms
  • MAP kinase FUS3
Gene NameFUS3
Enzyme ClassNot Available
Biological Properties
General Functionprotein phosphorylation
Specific FunctionTogether with closely related KSS1, FUS3 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively. Phosphorylated FUS3 activates the mating but suppresses the filamentation pathway, whereas activated KSS1 activates both pathways. Pheromone-activated FUS3 functions by inhibiting the binding of the transcriptional activator STE12 to filamentation specific genes while inducing its binding to and activity at mating specific genes. Non-activated FUS3 has a repressive effect on STE12 transcriptional activity. KSS1 can partially compensate for the lack of FUS3 but mating efficiency is reduced and the filamentation program is partially activated upon pheromone signaling. FUS3 phosphorylates STE7, STE5, FAR1, DIG1, DIG2 and STE12.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
cytoplasm
cell division
mating projection tip
invasive growth in response to glucose limitation
protein phosphorylation
periplasmic space
MAP kinase activity
identical protein binding
cell cycle arrest
mitotic nuclear division
negative regulation of MAPK cascade
negative regulation of transposition, RNA-mediated
positive regulation of protein export from nucleus
ATP binding
protein autophosphorylation
pheromone-dependent signal transduction involved in conjugation with cellular fusion
nucleus
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1062 bp ATGCCAAAGAGAATTGTATACAATATATCCAGTGACTTCCAGTTGAAGTCGTTACTGGGA GAGGGTGCATACGGTGTGGTATGTTCTGCAACGCATAAGCCCACGGGAGAAATCGTGGCA ATAAAAAAGATCGAACCATTCGATAAGCCTTTGTTCGCATTACGTACGCTGCGTGAAATA AAGATCCTGAAGCACTTCAAGCACGAAAATATCATAACAATCTTCAACATTCAACGCCCT GACTCGTTCGAAAACTTCAATGAGGTCTACATAATTCAAGAGCTAATGCAGACAGATTTA CACCGTGTAATCTCCACCCAGATGCTGAGTGACGATCATATACAATATTTTATATACCAA ACCTTGAGAGCAGTGAAAGTGCTGCATGGTTCGAACGTCATCCATCGTGATTTAAAGCCC TCCAACCTTCTCATAAACTCCAACTGTGACTTGAAAGTATGTGATTTCGGTTTAGCAAGA ATCATTGACGAGTCAGCCGCGGACAATTCAGAGCCCACAGGTCAGCAAAGCGGCATGACC GAGTATGTGGCCACACGTTGGTACAGGGCGCCAGAGGTGATGTTAACCTCTGCCAAATAC TCAAGGGCCATGGACGTGTGGTCCTGCGGATGTATTCTCGCTGAACTTTTCTTAAGACGG CCAATCTTCCCTGGCAGAGATTATCGCCATCAACTACTACTGATATTCGGTATCATCGGT ACACCTCACTCAGATAATGATTTGCGGTGTATAGAGTCACCCAGGGCTAGAGAGTACATA AAGTCGCTTCCCATGTACCCTGCCGCGCCACTGGAGAAGATGTTCCCTCGAGTCAACCCG AAAGGCATAGATCTTTTACAGCGTATGCTTGTTTTTGACCCTGCGAAGAGGATTACTGCT AAGGAGGCACTGGAGCATCCGTATTTGCAAACATACCACGATCCAAACGACGAACCTGAA GGCGAACCCATCCCACCCAGCTTCTTCGAGTTTGATCACTACAAGGAGGCACTAACGACG AAAGACCTCAAGAAACTCATTTGGAACGAAATATTTAGTTAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues353
Protein Molecular Weight40771.63
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Mitogen-activated protein kinase FUS3 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS
References
External Links
ResourceLink
Saccharomyces Genome Database FUS3
Uniprot IDP16892
Uniprot NameFUS3
PDB ID
2B9F
General ReferenceNot Available