MAP kinase kinase PBS2 (P08018)

Identification
NameMAP kinase kinase PBS2
Synonyms
  • Polymyxin B resistance protein 2
  • Suppressor of fluoride sensitivity 4
Gene NamePBS2
Enzyme ClassNot Available
Biological Properties
General Functionresponse to antibiotic
Specific FunctionKinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Seems to phosphorylate HOG1 on a tyrosine residue.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarityPW002516 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity 1469654356PW002970 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
MAPK import into nucleus involved in osmosensory signaling pathway
ATP binding
mitotic cell cycle
cellular bud neck
N-terminal peptidyl-methionine acetylation
cytoplasm
osmosensory signaling pathway
cellular bud tip
response to antibiotic
MAP kinase kinase activity
receptor signaling protein serine/threonine kinase activity
protein phosphorylation
NatB complex
MAP-kinase scaffold activity
peptide alpha-N-acetyltransferase activity
protein tyrosine kinase activity
actin filament organization
activation of MAPK activity involved in osmosensory signaling pathway
cellular response to heat
hyperosmotic response
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2007 bp ATGGAAGACAAGTTTGCTAACCTCAGTCTCCATGAGAAAACTGGTAAGTCATCTATCCAA TTAAACGAGCAAACAGGCTCAGATAATGGCTCTGCTGTCAAGAGAACATCTTCGACGTCC TCGCACTACAATAACATCAACGCTGACCTTCATGCTCGTGTAAAAGCTTTTCAAGAACAA CGTGCATTGAAAAGGTCTGCCAGCGTGGGCAGTAATCAAAGCGAGCAAGACAAAGGCAGT TCACAATCACCTAAACATATTCAGCAGATTGTTAATAAGCCATTGCCGCCTCTTCCCGTA GCAGGAAGTTCTAAGGTTTCACAAAGAATGAGTAGCCAAGTCGTGCAAGCGTCCTCCAAG AGCACTCTTAAGAACGTTCTGGACAATCAAGAAACACAAAACATTACCGACGTAAATATT AACATCGATACAACCAAAATTACCGCCACAACAATTGGTGTAAATACTGGCCTACCTGCT ACTGACATTACGCCGTCAGTTTCTAATACTGCATCAGCAACACATAAGGCGCAATTGCTG AATCCTAACAGAAGGGCACCAAGAAGGCCGCTTTCTACCCAGCACCCTACAAGACCAAAT GTTGCCCCGCATAAGGCCCCTGCTATAATCAACACACCAAAACAAAGTTTAAGTGCCCGT CGAGGGCTCAAATTACCACCAGGAGGAATGTCATTAAAAATGCCCACTAAAACAGCTCAA CAGCCGCAGCAGTTTGCCCCAAGCCCTTCAAACAAAAAACATATAGAAACCTTATCAAAC AGCAAAGTTGTTGAAGGGAAAAGATCGAATCCGGGTTCTTTGATAAATGGTGTGCAAAGC ACATCCACCTCATCAAGTACCGAAGGCCCACATGACACTGTAGGCACTACACCCAGAACT GGAAACAGCAACAACTCTTCAAATTCTGGTAGTAGTGGTGGTGGTGGTCTTTTCGCAAAT TTCTCGAAATACGTGGATATCAAATCCGGCTCTTTGAATTTTGCAGGCAAACTATCGCTA TCCTCTAAAGGAATAGATTTCAGCAATGGTTCTAGTTCGAGAATTACATTGGACGAACTA GAATTTTTGGATGAACTGGGTCATGGTAACTATGGTAACGTCTCAAAGGTACTGCATAAG CCCACAAATGTTATTATGGCGACGAAGGAAGTCCGTTTGGAGCTAGATGAGGCTAAATTT AGACAAATTTTAATGGAACTAGAAGTTTTGCATAAATGCAATTCTCCCTATATTGTGGAT TTTTATGGTGCATTCTTTATTGAGGGCGCCGTCTACATGTGTATGGAATACATGGATGGT GGTTCCTTGGATAAAATATACGACGAATCATCTGAAATCGGCGGCATTGATGAACCTCAG CTAGCGTTTATTGCCAATGCTGTCATTCATGGACTAAAAGAACTCAAAGAGCAGCATAAT ATCATACACAGAGATGTCAAACCAACAAATATTTTATGTTCAGCCAACCAAGGCACCGTA AAGCTGTGCGATTTCGGTGTTTCTGGTAATTTGGTGGCATCTTTAGCGAAGACTAATATT GGTTGTCAGTCATACATGGCACCTGAACGAATCAAATCGTTGAATCCAGATAGAGCCACC TATACCGTACAGTCAGACATCTGGTCTTTAGGTTTAAGCATTCTGGAAATGGCACTAGGT AGATATCCGTATCCACCAGAAACATACGACAACATTTTCTCTCAATTGAGCGCTATTGTT GATGGGCCGCCACCGAGATTACCTTCAGATAAATTCAGTTCTGACGCACAAGATTTTGTT TCTTTATGTCTACAAAAGATTCCGGAAAGAAGACCTACATACGCAGCTTTAACAGAGCAT CCTTGGTTAGTAAAATACAGAAACCAGGATGTCCACATGAGTGAGTATATCACTGAACGA TTAGAAAGGCGCAACAAAATCTTACGGGAACGTGGTGAGAATGGTTTATCTAAAAATGTA CCGGCATTACATATGGGTGGTTTATAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues668
Protein Molecular Weight72719.245
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>MAP kinase kinase PBS2 MEDKFANLSLHEKTGKSSIQLNEQTGSDNGSAVKRTSSTSSHYNNINADLHARVKAFQEQ RALKRSASVGSNQSEQDKGSSQSPKHIQQIVNKPLPPLPVAGSSKVSQRMSSQVVQASSK STLKNVLDNQETQNITDVNINIDTTKITATTIGVNTGLPATDITPSVSNTASATHKAQLL NPNRRAPRRPLSTQHPTRPNVAPHKAPAIINTPKQSLSARRGLKLPPGGMSLKMPTKTAQ QPQQFAPSPSNKKHIETLSNSKVVEGKRSNPGSLINGVQSTSTSSSTEGPHDTVGTTPRT GNSNNSSNSGSSGGGGLFANFSKYVDIKSGSLNFAGKLSLSSKGIDFSNGSSSRITLDEL EFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCNSPYIVD FYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEPQLAFIANAVIHGLKELKEQHN IIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKTNIGCQSYMAPERIKSLNPDRAT YTVQSDIWSLGLSILEMALGRYPYPPETYDNIFSQLSAIVDGPPPRLPSDKFSSDAQDFV SLCLQKIPERRPTYAALTEHPWLVKYRNQDVHMSEYITERLERRNKILRERGENGLSKNV PALHMGGL
References
External Links
ResourceLink
Saccharomyces Genome Database PBS2
Uniprot IDP08018
Uniprot NamePBS2
PDB ID
2VKN
General ReferenceNot Available