ATP synthase subunit 4, mitochondrial (P05626)

Identification
NameATP synthase subunit 4, mitochondrial
SynonymsNot Available
Gene NameATP4
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in hydrogen ion transmembrane transporter acti
Specific FunctionMitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements
Cellular LocationMitochondrion. Mitochondrion inner membrane
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
cell part
membrane part
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
mitochondrial membrane part
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
Process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
metabolic process
nucleotide metabolic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
ATP biosynthetic process
ATP synthesis coupled proton transport
nitrogen compound metabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>735 bp ATGAGCATGAGTATGGGTGTCCGTGGCCTAGCGTTAAGGTCCGTTTCTAAAACATTATTT AGCCAAGGTGTTCGTTGTCCTTCGATGGTGATTGGAGCCCGTTATATGTCTTCCACTCCA GAAAAACAGACAGATCCAAAAGCAAAGGCTAACTCTATCATCAATGCCATTCCAGGTAAT AATATTTTGACAAAGACGGGGGTTTTGGGGACTTCTGCTGCCGCTGTCATTTATGCCATT TCCAATGAATTGTACGTTATCAACGATGAAAGTATTTTATTGCTGACTTTTTTGGGTTTC ACTGGTTTAGTGGCAAAGTATTTGGCGCCAGCATATAAAGATTTTGCCGATGCAAGAATG AAGAAAGTCTCCGACGTTTTAAATGCCTCGAGAAACAAGCATGTCGAAGCTGTTAAAGAT AGAATCGACTCTGTCTCTCAACTACAAAATGTTGCTGAAACTACAAAGGTTTTGTTTGAT GTTTCCAAGGAAACTGTTGAACTTGAAAGCGAAGCCTTTGAATTGAAACAAAAGGTAGAA TTAGCTCACGAAGCAAAGGCAGTCTTAGATTCGTGGGTTAGATATGAAGCTTCCTTGCGT CAATTGGAACAAAGGCAACTAGCAAAATCTGTCATCTCCAGAGTTCAGTCAGAATTGGGT AATCCAAAATTCCAAGAGAAAGTTTTGCAACAGTCTATATCTGAAATTGAACAATTGCTT TCTAAATTGAAGTAA
Protein Properties
Pfam Domain Function
Protein Residues244
Protein Molecular Weight26924.80078
Protein Theoretical pI9.68
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>ATP synthase subunit 4, mitochondrial MSMSMGVRGLALRSVSKTLFSQGVRCPSMVIGARYMSSTPEKQTDPKAKANSIINAIPGN NILTKTGVLGTSAAAVIYAISNELYVINDESILLLTFLGFTGLVAKYLAPAYKDFADARM KKVSDVLNASRNKHVEAVKDRIDSVSQLQNVAETTKVLFDVSKETVELESEAFELKQKVE LAHEAKAVLDSWVRYEASLRQLEQRQLAKSVISRVQSELGNPKFQEKVLQQSISEIEQLL SKLK
References
External Links
ResourceLink
Saccharomyces Genome Database ATP4
Uniprot IDP05626
Uniprot NameATPF_YEAST
GenBank Gene IDU41849
Genebank Protein ID1147615
General Reference
  • Velours, J., Durrens, P., Aigle, M., Guerin, B. (1988). "ATP4, the structural gene for yeast F0F1 ATPase subunit 4." Eur J Biochem 170:637-642.2892678
  • Velours, J., Arselin, G., Paul, M. F., Galante, M., Durrens, P., Aigle, M., Guerin, B. (1989). "The yeast ATP synthase subunit 4: structure and function." Biochimie 71:903-915.2553130
  • Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
  • Velours, J., Arselin de Chateaubodeau, G., Galante, M., Guerin, B. (1987). "Subunit 4 of ATP synthase (F0F1) from yeast mitochondria. Purification, amino-acid composition and partial N-terminal sequence." Eur J Biochem 164:579-584.2883007
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666