{"ymdb_id":"YMDB16336","created_at":"2016-09-12T18:37:48.000Z","updated_at":"2016-10-17T22:34:45.000Z","name":"N-acetyl-α-D-glucosaminyl-diphosphodolichol","cas":null,"state":null,"melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"N-[(3R,4R,5S,6R)-2-[({[(3S,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34Z,38Z,42Z,46Z,50Z,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl phosphonato]oxy}(hydroxy)phosphoryl)oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]ethanecarboximidate","traditional_iupac":"N-[(3R,4R,5S,6R)-2-({[(3S,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34Z,38Z,42Z,46Z,50Z,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl phosphonato]oxy(hydroxy)phosphoryl}oxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]ethanecarboximidate","logp":"23.39036554101567","pka":"3.1954631706139582","alogps_solubility":"5.54e-04 g/l","alogps_logp":"8.67","alogps_logs":"-6.44","acceptor_count":"10","donor_count":"4","rotatable_bond_count":"55","polar_surface_area":"210.45999999999995","refractivity":"458.6643000000001","polarizability":"168.6976851236062","formal_charge":"-2","physiological_charge":"-2","pka_strongest_basic":"1.2003327643376476","pka_strongest_acidic":"1.890187124633036","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-24T19:20:17.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase","uniprot_id":"P07286","uniprot_name":"GPT_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG7","num_residues":448,"molecular_weight":"50367.39844","theoretical_pi":"8.51","general_function":"Involved in phospho-N-acetylmuramoyl-pentapeptide-transferase activity","specific_function":"Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides","reactions":[{"id":2247,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.","export":false,"pw_reaction_id":null,"source":null},{"id":14869,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007060","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"24-44;72-92;129-149;157-177;202-222;231-251;256-276;283-303;309-329;387-407;419-439","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Y00126","genbank_protein_id":"4685","gene_card_id":"ALG7","chromosome_location":"chromosome 2","locus":"YBR243C","synonyms":["GlcNAc-1-P transferase","G1PT","GPT","N-acetylglucosamine-1-phosphate transferase","Tunicamycin resistance protein 1"],"enzyme_classes":["2.7.8.15"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, for other substituted phosphate groups"},{"category":"Function","description":" phospho-N-acetylmuramoyl-pentapeptide-transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Glycos_transf_4","identifier":"PF00953"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGTTGCGACTTTTTTCACTGGCACTTATCACATGCTTAATCTACTATTCCAAAAATCAGGGCCCATCTGCTCTTGTTGCGGCCGTGGGATTTGGTATAGCAGGCTATTTAGCTACAGATATGTTGATTCCACGTGTGGGCAAATCCTTCATCAAAATAGGCCTATTCGGTAAGGACTTGAGTAAACCTGGCCGTCCGGTGCTTCCAGAAACAATAGGTGCTATCCCTGCTGCAGTTTATTTATTTGTAATGTTCATTTACATTCCCTTCATTTTCTACAAGTATATGGTCATAACCACTTCAGGTGGGGGCCATCGCGATGTCTCAGTGGTTGAAGATAACGGTATGAATTCTAATATTTTTCCTCATGATAAACTATCTGAATATTTGAGCGCTATCCTATGCTTGGAAAGTACGGTCCTCTTGGGTATCGCTGATGATTTATTTGATTTACGTTGGAGACATAAGTTTTTCTTGCCTGCCATTGCAGCCATCCCACTGCTAATGGTTTATTATGTGGATTTTGGAGTTACGCATGTACTTATTCCCGGATTCATGGAACGCTGGTTGAAAAAGACTAGTGTTGATTTGGGGCTGTGGTATTATGTTTATATGGCATCGATGGCAATTTTTTGCCCCAACTCCATCAACATCCTGGCAGGTGTTAATGGTTTAGAGGTTGGCCAATGTATAGTGTTGGCCATCTTAGCGCTATTGAACGATTTGCTGTACTTCTCGATGGGGCCATTAGCCACAAGAGACTCCCATAGGTTTTCCGCTGTTTTGATTATCCCATTTTTGGGTGTATCCTTGGCGCTATGGAAATGGAATCGTTGGCCCGCCACAGTGTTTGTGGGAGATACATATTGTTATTTCGCTGGAATGGTATTCGCAGTCGTTGGTATACTGGGTCATTTTTCAAAGACGATGCTTTTGCTATTCATTCCTCAAATCGTTAATTTTATTTATTCATGTCCTCAGCTATTCAAATTGGTCCCCTGCCCGAGACATAGGTTACCTAAATTTAATGAAAAAGACGGTTTAATGTATCCATCAAGAGCAAACTTAAAAGAAGAACCGCCAAAGAGCATTTTTAAACCGATCTTGAAGTTACTATACTGTCTCCATTTGATTGACCTGGAATTTGATGAAAATAATGAGATTATTAGCACCTCTAATATGACGTTAATAAACTTGACATTAGTATGGTTTGGCCCTATGAGGGAAGACAAATTGTGCAATACAATCTTGAAGTTGCAATTCTGCATTGGAATTTTGGCTTTACTTGGAAGACACGCTATAGGCGCTATCATCTTTGGCCACGACAACCTATGGACAGTACGTTGA","protein_sequence":"MLRLFSLALITCLIYYSKNQGPSALVAAVGFGIAGYLATDMLIPRVGKSFIKIGLFGKDLSKPGRPVLPETIGAIPAAVYLFVMFIYIPFIFYKYMVITTSGGGHRDVSVVEDNGMNSNIFPHDKLSEYLSAILCLESTVLLGIADDLFDLRWRHKFFLPAIAAIPLLMVYYVDFGVTHVLIPGFMERWLKKTSVDLGLWYYVYMASMAIFCPNSINILAGVNGLEVGQCIVLAILALLNDLLYFSMGPLATRDSHRFSAVLIIPFLGVSLALWKWNRWPATVFVGDTYCYFAGMVFAVVGILGHFSKTMLLLFIPQIVNFIYSCPQLFKLVPCPRHRLPKFNEKDGLMYPSRANLKEEPPKSIFKPILKLLYCLHLIDLEFDENNEIISTSNMTLINLTLVWFGPMREDKLCNTILKLQFCIGILALLGRHAIGAIIFGHDNLWTVR"},{"created_at":"2011-05-26T16:40:26.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"UDP-N-acetylglucosamine transferase subunit ALG13","uniprot_id":"P53178","uniprot_name":"ALG13_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG13","num_residues":202,"molecular_weight":"22660.90039","theoretical_pi":"5.66","general_function":"Involved in transferase activity, transferring hexosyl groups","specific_function":"Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway","reactions":[{"id":2437,"direction":"\u003e","locations":"Endoplasmic reticulum","altext":"UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol.","export":false,"pw_reaction_id":null,"source":null},{"id":14870,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007061","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Endoplasmic reticulum","genbank_gene_id":"Z72569","genbank_protein_id":"1322537","gene_card_id":"ALG13","chromosome_location":"chromosome 7","locus":"YGL047W","synonyms":["Asparagine-linked glycosylation protein 13"],"enzyme_classes":["2.4.1.141"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" carbohydrate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" lipid modification"},{"category":"Process","description":" lipid glycosylation"}],"pfams":[{"name":"Glyco_tran_28_C","identifier":"PF04101"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGGTATTATTGAAGAAAAGGCTCTTTTTGTTACGTGTGGGGCAACGGTGCCATTTCCAAAGCTCGTCTCATGTGTGCTAAGCGACGAATTCTGCCAAGAATTGATTCAATATGGATTCGTACGTCTAATCATTCAGTTTGGGAGAAACTACAGTTCTGAATTTGAGCATTTAGTGCAAGAACGCGGGGGCCAAAGAGAAAGCCAAAAAATTCCAATTGACCAGTTTGGCTGTGGCGACACCGCAAGACAGTATGTCCTGATGAACGGGAAATTAAAGGTGATCGGGTTTGACTTTTCGACCAAGATGCAAAGTATTATACGTGATTATTCAGATTTGGTCATATCACACGCTGGAACGGGCTCTATACTAGATTCTCTACGGTTGAATAAACCGTTGATAGTTTGCGTAAACGATTCTTTGATGGATAACCACCAGCAGCAGATAGCAGACAAGTTTGTAGAGTTGGGCTACGTATGGTCTTGTGCACCCACTGAAACAGGTTTGATAGCTGGTTTACGTGCATCTCAAACAGAGAAACTCAAACCATTCCCAGTTTCTCATAACCCGTCATTTGAGCGATTGCTAGTTGAAACTATATACAGCTAG","protein_sequence":"MGIIEEKALFVTCGATVPFPKLVSCVLSDEFCQELIQYGFVRLIIQFGRNYSSEFEHLVQERGGQRESQKIPIDQFGCGDTARQYVLMNGKLKVIGFDFSTKMQSIIRDYSDLVISHAGTGSILDSLRLNKPLIVCVNDSLMDNHQQQIADKFVELGYVWSCAPTETGLIAGLRASQTEKLKPFPVSHNPSFERLLVETIYS"},{"created_at":"2016-09-09T22:45:16.000Z","updated_at":"2016-09-09T22:45:16.000Z","name":"UDP-N-acetylglucosamine transferase subunit ALG14","uniprot_id":"P38242","uniprot_name":"ALG14","enzyme":false,"transporter":false,"gene_name":"ALG14","num_residues":237,"molecular_weight":"27034.92","theoretical_pi":null,"general_function":"dolichol-linked oligosaccharide biosynthetic process","specific_function":"Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.","reactions":[{"id":14870,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007061","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"8-28","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 14"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"nuclear membrane"},{"category":"Function","description":"integral component of endoplasmic reticulum membrane"},{"category":"Function","description":"intrinsic component of endoplasmic reticulum membrane"},{"category":"Function","description":"nuclear outer membrane-endoplasmic reticulum membrane network"},{"category":"Function","description":"UDP-N-acetylglucosamine transferase complex"},{"category":"Function","description":"protein anchor"},{"category":"Function","description":"dolichol-linked oligosaccharide biosynthetic process"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAAAACGGCCTACTTGGCGTCATTGGTGCTCATCGTATCGACAGCATATGTTATTAGGTTGATAGCGATTCTGCCTTTTTTCCACACTCAAGCAGGTACAGAAAAGGATACGAAAGATGGAGTTAACCTACTGAAAATACGAAAATCGTCAAAGAAACCGCTCAAGATTTTTGTATTCTTAGGATCGGGAGGTCATACTGGTGAAATGATCCGTCTTCTAGAAAATTACCAGGATCTTTTACTGGGTAAGTCGATTGTGTACTTGGGTTATTCTGATGAGGCTTCCAGGCAAAGATTCGCCCACTTTATAAAAAAATTTGGTCATTGCAAAGTAAAATACTATGAATTCATGAAAGCTAGGGAAGTTAAAGCGACTCTCCTACAAAGTGTAAAGACCATCATTGGAACGTTGGTACAATCTTTTGTGCACGTGGTTAGAATCAGATTTGCTATGTGTGGTTCCCCTCATCTGTTTTTATTGAATGGGCCTGGAACATGCTGTATAATATCCTTTTGGTTGAAAATTATGGAACTTCTTTTGCCCCTGTTGGGTTCCTCCCATATAGTTTATGTAGAATCGCTGGCAAGGATTAATACTCCTAGTCTGACCGGAAAAATATTATATTGGGTAGTGGATGAATTCATTGTCCAGTGGCAAGAATTGAGGGACAATTATTTACCAAGATCCAAGTGGTTCGGCATCCTTGTTTAA","protein_sequence":"MKTAYLASLVLIVSTAYVIRLIAILPFFHTQAGTEKDTKDGVNLLKIRKSSKKPLKIFVFLGSGGHTGEMIRLLENYQDLLLGKSIVYLGYSDEASRQRFAHFIKKFGHCKVKYYEFMKAREVKATLLQSVKTIIGTLVQSFVHVVRIRFAMCGSPHLFLLNGPGTCCIISFWLKIMELLLPLLGSSHIVYVESLARINTPSLTGKILYWVVDEFIVQWQELRDNYLPRSKWFGILV"}]}