{"ymdb_id":"YMDB16328","created_at":"2016-09-12T18:36:48.000Z","updated_at":"2016-10-17T22:34:45.000Z","name":"2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine","cas":null,"state":null,"melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2-{[(S)-((2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl phosphono)]oxy}ethyl)trimethylazanium","traditional_iupac":"(2-{[(S)-((2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl phosphono)]oxy}ethyl)trimethylazanium","logp":"2.014663483194923","pka":null,"alogps_solubility":"2.25e-04 g/l","alogps_logp":"2.71","alogps_logs":"-6.41","acceptor_count":"4","donor_count":"0","rotatable_bond_count":"26","polar_surface_area":"94.12","refractivity":"151.67059999999995","polarizability":"62.860812259498246","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-4.140951302162491","pka_strongest_acidic":"1.8550607605084153","bioavailability":"0","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"Ether lipid metabolism","kegg_map_id":"00565"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-26T18:07:16.000Z","updated_at":"2011-07-22T17:54:27.000Z","name":"Cholinephosphotransferase 1","uniprot_id":"P17898","uniprot_name":"CPT1_YEAST","enzyme":true,"transporter":false,"gene_name":"CPT1","num_residues":393,"molecular_weight":"44829.0","theoretical_pi":"6.57","general_function":"Involved in phosphotransferase activity, for other substituted phosphate groups","specific_function":"Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. The multiple transmembrane domains and lumenal hydrophilic domains of the cholinephosphotransferase might participate in the transport process","reactions":[{"id":1386,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1387,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2507,"direction":"\u003e","locations":"Microsome membrane; Multi-pass membrane protein; Multi-pass membrane protein. Endoplasmic reticulum membrane","altext":"CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.","export":false,"pw_reaction_id":null,"source":null},{"id":14462,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006981","source":"Smpdb"},{"id":14463,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006984","source":"Smpdb"},{"id":14464,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007002","source":"Smpdb"},{"id":14465,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047264","source":"Smpdb"},{"id":14466,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047316","source":"Smpdb"},{"id":14467,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047322","source":"Smpdb"},{"id":14468,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047327","source":"Smpdb"},{"id":14469,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047333","source":"Smpdb"},{"id":14470,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047339","source":"Smpdb"},{"id":14471,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047344","source":"Smpdb"},{"id":14472,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R047350","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"41-61;173-193;211-231;264-284;286-306;321-341;349-369","pdb_id":null,"cellular_location":"Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"J05203","genbank_protein_id":"171318","gene_card_id":"CPT1","chromosome_location":"chromosome 14","locus":"YNL130C","synonyms":["Diacylglycerol cholinephosphotransferase 1","Sn-1,2-diacylglycerol cholinephosphotransferase","CHOPT"],"enzyme_classes":["2.7.8.2"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, for other substituted phosphate groups"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" phospholipid biosynthetic process"}],"pfams":[{"name":"CDP-OH_P_transf","identifier":"PF01066"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Ether lipid metabolism","kegg_map_id":"00565"},{"name":"Choline metabolism","kegg_map_id":null},{"name":"Lysolipid incorporation into ER","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(10:0/10:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(14:0/14:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:0/16:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null}],"gene_sequence":"ATGGATTCGAAAACAGTATTACTAACTGATTCAGGGGAAACAATGGGATTCTTTATTCCTCAGAGTAGTTTGGGAAACTTGAAGCTTTACAAGTATCAAAGTGATGACCGCTCTTTCCTTTCAAACCATGTATTGAGGCCCTTTTGGAGAAAGTTTGCGACTATTTTTCCACTATGGATGGCACCCAATTTGGTAACATTATTAGGGTTCTGCTTTATTATATTTAATGTGTTAACAACACTTTACTACGACCCGTATTTTGACCAGGAATCGCCACGTTGGACCTATTTCTCCTATGCTATAGGTTTGTTTTTATACCAGACTTTTGATGCTTGCGATGGAATGCATGCACGTCGTACAGGCCAGCAGGGCCCTCTAGGGGAATTGTTTGACCATTGTATTGATTCAATCAACACAACTTTGTCAATGATTCCTGTCTGTTCCATGACAGGTATGGGTTACACATATATGACCATTTTTTCACAATTTGCGATATTGTGCAGCTTTTACTTGAGCACATGGGAAGAGTATCACACCCACAAACTTTATCTAGCTGAATTCTGCGGTCCTGTTGAAGGTATTATTGTTTTGTGTATTTCTTTCATTGCAGTCGGAATTTACGGACCTCAAACCATCTGGCACACTAAAGTAGCGCAATTCTCCTGGCAAGATTTTGTGTTTGATGTTGAAACCGTTCATCTAATGTATGCATTTTGCACAGGAGCATTAATATTTAATATTGTCACAGCTCATACAAACGTCGTGAGGTATTACGAATCCCAATCGACCAAATCTGCAACTCCAAGCAAAACTGCAGAAAATATAAGTAAAGCAGTAAATGGTCTTTTGCCATTCTTTGCATACTTCTCTTCAATTTTTACCTTAGTCTTGATTCAACCATCTTTTATTTCTTTGGCTTTAATTTTATCGATTGGTTTTTCGGTTGCCTTTGTAGTTGGTCGGATGATTATTGCTCATTTAACCATGCAACCATTCCCAATGGTCAATTTCCCATTTTTAATCCCAACTATCCAATTGGTATTGTACGCATTTATGGTTTACGTTTTAGATTACCAAAAAGGAAGCATAGTTTCTGCATTGGTTTGGATGGGACTCGGCTTGACACTTGCTATCCATGGAATGTTCATCAATGATATTATCTATGACATCACTACCTTTCTGGATATTTACGCTTTATCAATTAAACATCCAAAAGAAATTTAG","protein_sequence":"MGFFIPQSSLGNLKLYKYQSDDRSFLSNHVLRPFWRKFATIFPLWMAPNLVTLLGFCFIIFNVLTTLYYDPYFDQESPRWTYFSYAIGLFLYQTFDACDGMHARRTGQQGPLGELFDHCIDSINTTLSMIPVCSMTGMGYTYMTIFSQFAILCSFYLSTWEEYHTHKLYLAEFCGPVEGIIVLCISFIAVGIYGPQTIWHTKVAQFSWQDFVFDVETVHLMYAFCTGALIFNIVTAHTNVVRYYESQSTKSATPSKTAENISKAVNGLLPFFAYFSSIFTLVLIQPSFISLALILSIGFSVAFVVGRMIIAHLTMQPFPMVNFPFLIPTIQLVLYAFMVYVLDYQKGSIVSALVWMGLGLTLAIHGMFINDIIYDITTFLDIYALSIKHPKEI"},{"created_at":"2016-09-09T22:46:02.000Z","updated_at":"2016-09-09T22:46:02.000Z","name":"Nuclear distribution protein PAC1","uniprot_id":"P39946","uniprot_name":"PAC1","enzyme":false,"transporter":false,"gene_name":"PAC1","num_residues":494,"molecular_weight":"56900.345","theoretical_pi":null,"general_function":"positive regulation of microtubule plus-end binding","specific_function":"Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. Following plus end binding, dynein may be offloaded to the cortex by NUM1. Required for viability in the absence of the kinesin-related microtubule-dependent motor protein CIN8.","reactions":[{"id":14473,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006982","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Lissencephaly-1 homolog","nudF homolog","LIS-1"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"nucleus"},{"category":"Function","description":"cell division"},{"category":"Function","description":"identical protein binding"},{"category":"Function","description":"mitotic nuclear division"},{"category":"Function","description":"cytoplasmic microtubule"},{"category":"Function","description":"microtubule associated complex"},{"category":"Function","description":"spindle pole"},{"category":"Function","description":"microtubule plus-end binding"},{"category":"Function","description":"establishment of mitotic spindle orientation"},{"category":"Function","description":"nuclear migration along microtubule"},{"category":"Function","description":"positive regulation of ATP-dependent microtubule motor activity, plus-end-directed"},{"category":"Function","description":"positive regulation of microtubule plus-end binding"}],"pfams":[],"pathways":[{"name":"Ether lipid metabolism","kegg_map_id":"00565"}],"gene_sequence":"ATGACTAACTGGCAGCAACAGCTTCCTTTAACAGATACACAGAAAAATGAACTCGATAAAAGTGTCCTCCGATATTTGAATTGGAATTACAAACAAACTGTACGACATGAGCATGCTCAAGATTACGAAAGTGTTCGACATGCAATTGTAACTCTATCAGGTTTTCTGTTGCAAGAATCAGTGGACCGGCAAGAATTCATCAGTAACAATGACACCAGTAACGAAAGTATGGTAGACATTGATGAATTACTGCTACCGAAGAAGTGGAACTCAATTGTTAGACTACAAAAAAAAATCATTGAATTGGAGCAGAATACAGAGACCCTTGTATCTCAGATTAAAGATTTGAACACTCAAGTGTCAGAACTAGCACAATTCAAACCTACCACCAGTAACGGCACCAGCGCACATAATGTTTTGAAATGGATACCGAGAAATCTACCAAGCTGTTTAATTAATGTTGAATCATCTGTCACTTCCGTCAAACTACATCCCAATTTGCCTATAGTGTTTGTGGCCACAGATCATGGCAAATTATACGCATTTGATTTATTTAACTACACCATCCCTCTGGCATCCTTGCAAAGTCATACCAAGGCAATTACCTCCATGGATGTTTTATTTACCAATTATACGAACTCCAGCAAGAAGAACTATTTGGTGATCGTTACCGCGTCTAAAGATTTGCAGATTCATGTTTTCAAGTGGGTCTCCGAGGAATGCAAGTTCCAACAAATTAGGTCTTTATTGGGCCATGAGCATATTGTCTCTGCGGTAAAAATCTGGCAGAAAAATAATGATGTCCATATAGCGTCCTGTTCCAGAGATCAAACTGTTAAAATTTGGGACTTCCACAATGGTTGGTCGTTGAAAACATTTCAGCCTCATTCCCAATGGGTTCGTTCCATAGACGTTCTAGGCGATTACATCATCTCTGGTTCACATGACACTACATTAAGGTTAACACATTGGCCATCAGGTAATGGTCTTAGTGTTGGCACGGGTCATGAATTTCCCATAGAGAAAGTTAAATTTATTCATTTCATCGAAGACTCTCCGGAGATAAGGTTTAGAACACCATCAACGGATCGATATAAGAATTGGGGGATGCAATATTGTGTCTCAGCGTCAAGAGATAGAACGATAAAAATCTGGGAGATACCTCTACCTACGTTAATGGCCCATAGAGCACCCATACCGAATCCTACAGATTCAAATTTCAGATGTGTTCTTACGTTGAAGGGGCATCTTTCGTGGGTTAGAGATATTAGTATTCGAGGCCAATACTTGTTTTCTTGTGCTGATGATAAATCTGTCAGATGTTGGGATCTGAACACGGGGCAGTGCTTACACGTTTGGGAAAAGTTGCATACAGGATTTGTCAACTGTTTAGACCTGGATGTGGATTTCGATTCTAACGTTACCCCAAGGCAAATGATGGTCACTGGTGGATTGGATTGCAAGTCTAACGTTTTCATGAGATAA","protein_sequence":"MTNWQQQLPLTDTQKNELDKSVLRYLNWNYKQTVRHEHAQDYESVRHAIVTLSGFLLQESVDRQEFISNNDTSNESMVDIDELLLPKKWNSIVRLQKKIIELEQNTETLVSQIKDLNTQVSELAQFKPTTSNGTSAHNVLKWIPRNLPSCLINVESSVTSVKLHPNLPIVFVATDHGKLYAFDLFNYTIPLASLQSHTKAITSMDVLFTNYTNSSKKNYLVIVTASKDLQIHVFKWVSEECKFQQIRSLLGHEHIVSAVKIWQKNNDVHIASCSRDQTVKIWDFHNGWSLKTFQPHSQWVRSIDVLGDYIISGSHDTTLRLTHWPSGNGLSVGTGHEFPIEKVKFIHFIEDSPEIRFRTPSTDRYKNWGMQYCVSASRDRTIKIWEIPLPTLMAHRAPIPNPTDSNFRCVLTLKGHLSWVRDISIRGQYLFSCADDKSVRCWDLNTGQCLHVWEKLHTGFVNCLDLDVDFDSNVTPRQMMVTGGLDCKSNVFMR"}]}