{"ymdb_id":"YMDB16236","created_at":"2016-09-12T18:26:41.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"Mannosyl-(N-acetylglucosaminyl)2-diphosphodolichol","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(2S,3R,4R,5S,6R)-3-acetamido-5-{[(2S,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-{[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}[({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid","traditional_iupac":"[(2S,3R,4R,5S,6R)-3-acetamido-5-{[(2S,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-{[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy(hydroxy)phosphoryl}oxy)phosphinic acid","logp":"19.28894755166667","pka":"3.171781737140521","alogps_solubility":"8.77e-04 g/l","alogps_logp":"7.82","alogps_logs":"-6.32","acceptor_count":"19","donor_count":"12","rotatable_bond_count":"62","polar_surface_area":"368.48","refractivity":"524.6419","polarizability":"218.0194551991465","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.52536536954484","pka_strongest_acidic":"1.7444953207900582","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-27T03:21:53.000Z","updated_at":"2011-07-22T17:54:18.000Z","name":"Chitobiosyldiphosphodolichol beta-mannosyltransferase","uniprot_id":"P16661","uniprot_name":"ALG1_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG1","num_residues":449,"molecular_weight":"51928.5","theoretical_pi":"9.07","general_function":"Involved in biosynthetic process","specific_function":"Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER","reactions":[{"id":1345,"direction":"\u003c\u003e","locations":"endoplasmic reticulum membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2721,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass type II membrane protein (Potential)","altext":"GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.","export":false,"pw_reaction_id":null,"source":null},{"id":14871,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007062","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"8-34","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass type II membrane protein (Potential)","genbank_gene_id":"J05416","genbank_protein_id":"171050","gene_card_id":"ALG1","chromosome_location":"chromosome 2","locus":"YBR110W","synonyms":["Asparagine-linked glycosylation protein 1","Beta-1,4-mannosyltransferase","GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase","GDP-mannose-dolichol diphosphochitobiose mannosyltransferase"],"enzyme_classes":["2.4.1.142"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Glycos_transf_1","identifier":"PF00534"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGTTTTTGGAAATTCCTCGGTGGTTACTTGCCTTAATAATATTATACCTTTCCATACCGTTAGTGGTTTATTATGTTATACCCTACTTGTTTTATGGCAACAAGTCGACCAAAAAAAGGATCATCATATTTGTGCTGGGTGATGTAGGACACTCTCCAAGGATATGCTATCACGCTATAAGTTTCAGTAAGTTAGGTTGGCAAGTCGAGCTATGCGGTTATGTGGAGGACACTCTACCCAAAATTATTTCCAGTGATCCAAATATCACCGTCCATCATATGTCAAACTTGAAAAGAAAGGGAGGCGGAACATCAGTTATATTTATGGTAAAGAAGGTGCTTTTTCAAGTTTTAAGTATTTTCAAATTACTTTGGGAATTGAGAGGAAGCGATTACATACTAGTTCAAAATCCACCGAGCATACCCATTCTTCCGATTGCTGTGCTATACAAGTTGACCGGTTGTAAACTAATTATTGATTGGCACAATCTAGCATATTCGATATTGCAACTAAAATTTAAAGGAAACTTTTACCATCCTTTAGTGTTGATATCTTACATGGTAGAGATGATATTCAGCAAATTTGCTGATTATAACTTGACTGTTACTGAAGCAATGAGGAAATATTTAATTCAAAGCTTTCACTTGAATCCAAAGAGATGTGCTGTTCTCTACGACCGCCCGGCTTCCCAATTTCAACCTTTGGCAGGTGACATTTCTCGTCAAAAAGCCCTAACTACCAAAGCCTTTATAAAGAATTATATTCGCGATGATTTTGATACAGAAAAAGGCGATAAAATTATTGTGACTTCAACATCATTCACCCCTGATGAAGATATTGGTATTTTATTAGGTGCCCTAAAGATTTACGAAAACTCTTATGTCAAATTTGATTCAAGTTTGCCTAAGATCTTGTGTTTTATAACGGGTAAAGGACCACTAAAGGAGAAATATATGAAGCAAGTAGAAGAATATGACTGGAAGCGCTGTCAAATCGAATTTGTGTGGTTGTCAGCAGAGGATTACCCAAAGTTATTACAATTATGCGATTACGGAGTTTCCCTGCATACTTCAAGTTCAGGGTTGGACCTGCCAATGAAAATTTTAGATATGTTTGGCTCAGGTCTTCCTGTTATTGCAATGAACTATCCAGTGCTTGACGAATTAGTACAACACAATGTAAATGGGTTAAAATTTGTTGATAGAAGGGAGCTTCATGAATCTCTGATTTTTGCTATGAAAGATGCTGATTTATACCAAAAATTGAAGAAAAATGTAACGCAGGAAGCTGAGAACAGATGGCAATCAAATTGGGAACGAACAATGAGAGATTTGAAGCTAATTCATTGA","protein_sequence":"MFLEIPRWLLALIILYLSIPLVVYYVIPYLFYGNKSTKKRIIIFVLGDVGHSPRICYHAISFSKLGWQVELCGYVEDTLPKIISSDPNITVHHMSNLKRKGGGTSVIFMVKKVLFQVLSIFKLLWELRGSDYILVQNPPSIPILPIAVLYKLTGCKLIIDWHNLAYSILQLKFKGNFYHPLVLISYMVEMIFSKFADYNLTVTEAMRKYLIQSFHLNPKRCAVLYDRPASQFQPLAGDISRQKALTTKAFIKNYIRDDFDTEKGDKIIVTSTSFTPDEDIGILLGALKIYENSYVKFDSSLPKILCFITGKGPLKEKYMKQVEEYDWKRCQIEFVWLSAEDYPKLLQLCDYGVSLHTSSSGLDLPMKILDMFGSGLPVIAMNYPVLDELVQHNVNGLKFVDRRELHESLIFAMKDADLYQKLKKNVTQEAENRWQSNWERTMRDLKLIH"},{"created_at":"2011-05-27T17:53:30.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Alpha-1,3-mannosyltransferase ALG2","uniprot_id":"P43636","uniprot_name":"ALG2_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG2","num_residues":503,"molecular_weight":"58046.5","theoretical_pi":"6.2","general_function":"Cell wall/membrane/envelope biogenesis","specific_function":"Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate","reactions":[{"id":14872,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007063","source":"Smpdb"},{"id":14873,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007064","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"64-84;112-132;443-463","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z72587","genbank_protein_id":"1322572","gene_card_id":"ALG2","chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 2","GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase"],"enzyme_classes":["2.4.1.-","2.4.1.132"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Glycos_transf_1","identifier":"PF00534"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGATTGAAAAGGATAAAAGAACGATTGCTTTTATTCATCCAGACCTAGGTATTGGGGGCGCTGAAAGGTTAGTCGTCGATGCAGCATTAGGTCTACAGCAACAAGGACATAGTGTAATCATCTATACTAGTCACTGTGATAAATCACATTGTTTCGAAGAAGTTAAAAACGGCCAATTAAAAGTCGAAGTTTATGGTGATTTTTTACCGACAAACTTTTTGGGTCGTTTTTTTATTGTTTTCGCAACAATTAGACAGCTTTATTTAGTTATTCAATTGATCCTACAGAAAAAAGTGAATGCGTACCAATTAATTATCATTGATCAACTGTCTACATGTATTCCGCTTCTGCATATCTTTAGTTCTGCCACTTTGATGTTTTATTGTCATTTCCCCGACCAATTATTGGCTCAAAGAGCTGGGCTATTGAAGAAAATATACAGACTACCATTTGACTTAATAGAACAGTTTTCCGTGAGTGCTGCCGATACTGTTGTGGTAAATTCAAATTTCACTAAGAATACGTTCCACCAAACGTTCAAGTATTTATCCAATGATCCAGACGTCATTTATCCATGCGTGGATTTATCAACAATCGAAATTGAAGATATTGACAAGAAATTTTTCAAAACAGTGTTTAACGAAGGCGATAGATTTTACCTAAGTATAAATCGTTTTGAGAAAAAAAAGGATGTTGCGCTGGCTATAAAGGCTTTTGCGTTATCTGAAGATCAAATCAATGACAACGTTAAGTTAGTTATTTGCGGTGGTTATGACGAGAGGGTTGCAGAAAATGTGGAGTACTTGAAGGAACTACAGTCTCTGGCCGATGAATACGAATTATCCCATACAACCATATACTACCAAGAAATAAAGCGCGTCTCCGATTTAGAGTCATTCAAAACCAATAATAGTAAAATTATATTTTTAACTTCCATTTCATCATCTCTGAAAGAATTACTGCTCGAAAGAACCGAAATGTTATTGTATACACCAGCATATGAGCACTTTGGTATTGTTCCTTTAGAAGCCATGAAATTAGGTAAGCCTGTACTAGCAGTAAACAATGGAGGTCCTTTGGAGACTATCAAATCTTACGTTGCTGGTGAAAATGAAAGTTCTGCCACTGGGTGGCTAAAACCTGCCGTCCCTATTCAATGGGCTACTGCAATTGATGAAAGCAGAAAGATCTTGCAGAACGGTTCTGTGAACTTTGAGAGGAATGGCCCGCTAAGAGTCAAGAAATACTTTTCTAGGGAAGCAATGACTCAGTCATTTGAAGAAAACGTCGAGAAAGTCATATGGAAAGAAAAAAAGTATTATCCTTGGGAAATATTCGGTATTTCATTCTCTAATTTTATTTTGCATATGGCATTTATAAAAATTCTACCCAATAATCCATGGCCCTTCCTATTTATGGCCACTTTTATGGTATTATATTTTAAGAACTACTTATGGGGAATTTACTGGGCATTTGTATTCGCTCTCTCCTACCCTTATGAAGAAATATAA","protein_sequence":"MIEKDKRTIAFIHPDLGIGGAERLVVDAALGLQQQGHSVIIYTSHCDKSHCFEEVKNGQLKVEVYGDFLPTNFLGRFFIVFATIRQLYLVIQLILQKKVNAYQLIIIDQLSTCIPLLHIFSSATLMFYCHFPDQLLAQRAGLLKKIYRLPFDLIEQFSVSAADTVVVNSNFTKNTFHQTFKYLSNDPDVIYPCVDLSTIEIEDIDKKFFKTVFNEGDRFYLSINRFEKKKDVALAIKAFALSEDQINDNVKLVICGGYDERVAENVEYLKELQSLADEYELSHTTIYYQEIKRVSDLESFKTNNSKIIFLTSISSSLKELLLERTEMLLYTPAYEHFGIVPLEAMKLGKPVLAVNNGGPLETIKSYVAGENESSATGWLKPAVPIQWATAIDESRKILQNGSVNFERNGPLRVKKYFSREAMTQSFEENVEKVIWKEKKYYPWEIFGISFSNFILHMAFIKILPNNPWPFLFMATFMVLYFKNYLWGIYWAFVFALSYPYEEI"}]}