{"ymdb_id":"YMDB16232","created_at":"2016-09-12T18:26:18.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"(N-Acetylglucosaminyl)2-diphosphodolichol","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(2S,3R,4R,5S,6R)-3-acetamido-5-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}[({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid","traditional_iupac":"[(2S,3R,4R,5S,6R)-3-acetamido-5-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy(hydroxy)phosphoryl}oxy)phosphinic acid","logp":"21.05978319733334","pka":"3.1717817375107944","alogps_solubility":"5.01e-04 g/l","alogps_logp":"8.40","alogps_logs":"-6.52","acceptor_count":"14","donor_count":"9","rotatable_bond_count":"59","polar_surface_area":"289.33","refractivity":"492.22859999999986","polarizability":"203.06692308115407","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-2.9813431279973566","pka_strongest_acidic":"1.7444953208041847","bioavailability":"0","number_of_rings":"2","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-26T16:40:26.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"UDP-N-acetylglucosamine transferase subunit ALG13","uniprot_id":"P53178","uniprot_name":"ALG13_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG13","num_residues":202,"molecular_weight":"22660.90039","theoretical_pi":"5.66","general_function":"Involved in transferase activity, transferring hexosyl groups","specific_function":"Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway","reactions":[{"id":2437,"direction":"\u003e","locations":"Endoplasmic reticulum","altext":"UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol.","export":false,"pw_reaction_id":null,"source":null},{"id":14870,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007061","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Endoplasmic reticulum","genbank_gene_id":"Z72569","genbank_protein_id":"1322537","gene_card_id":"ALG13","chromosome_location":"chromosome 7","locus":"YGL047W","synonyms":["Asparagine-linked glycosylation protein 13"],"enzyme_classes":["2.4.1.141"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" carbohydrate binding"},{"category":"Process","description":" lipid glycosylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" lipid modification"}],"pfams":[{"name":"Glyco_tran_28_C","identifier":"PF04101"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGGTATTATTGAAGAAAAGGCTCTTTTTGTTACGTGTGGGGCAACGGTGCCATTTCCAAAGCTCGTCTCATGTGTGCTAAGCGACGAATTCTGCCAAGAATTGATTCAATATGGATTCGTACGTCTAATCATTCAGTTTGGGAGAAACTACAGTTCTGAATTTGAGCATTTAGTGCAAGAACGCGGGGGCCAAAGAGAAAGCCAAAAAATTCCAATTGACCAGTTTGGCTGTGGCGACACCGCAAGACAGTATGTCCTGATGAACGGGAAATTAAAGGTGATCGGGTTTGACTTTTCGACCAAGATGCAAAGTATTATACGTGATTATTCAGATTTGGTCATATCACACGCTGGAACGGGCTCTATACTAGATTCTCTACGGTTGAATAAACCGTTGATAGTTTGCGTAAACGATTCTTTGATGGATAACCACCAGCAGCAGATAGCAGACAAGTTTGTAGAGTTGGGCTACGTATGGTCTTGTGCACCCACTGAAACAGGTTTGATAGCTGGTTTACGTGCATCTCAAACAGAGAAACTCAAACCATTCCCAGTTTCTCATAACCCGTCATTTGAGCGATTGCTAGTTGAAACTATATACAGCTAG","protein_sequence":"MGIIEEKALFVTCGATVPFPKLVSCVLSDEFCQELIQYGFVRLIIQFGRNYSSEFEHLVQERGGQRESQKIPIDQFGCGDTARQYVLMNGKLKVIGFDFSTKMQSIIRDYSDLVISHAGTGSILDSLRLNKPLIVCVNDSLMDNHQQQIADKFVELGYVWSCAPTETGLIAGLRASQTEKLKPFPVSHNPSFERLLVETIYS"},{"created_at":"2011-05-27T03:21:53.000Z","updated_at":"2011-07-22T17:54:18.000Z","name":"Chitobiosyldiphosphodolichol beta-mannosyltransferase","uniprot_id":"P16661","uniprot_name":"ALG1_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG1","num_residues":449,"molecular_weight":"51928.5","theoretical_pi":"9.07","general_function":"Involved in biosynthetic process","specific_function":"Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER","reactions":[{"id":1345,"direction":"\u003c\u003e","locations":"endoplasmic reticulum membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2721,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass type II membrane protein (Potential)","altext":"GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.","export":false,"pw_reaction_id":null,"source":null},{"id":14871,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007062","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"8-34","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass type II membrane protein (Potential)","genbank_gene_id":"J05416","genbank_protein_id":"171050","gene_card_id":"ALG1","chromosome_location":"chromosome 2","locus":"YBR110W","synonyms":["Asparagine-linked glycosylation protein 1","Beta-1,4-mannosyltransferase","GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase","GDP-mannose-dolichol diphosphochitobiose mannosyltransferase"],"enzyme_classes":["2.4.1.142"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Glycos_transf_1","identifier":"PF00534"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGTTTTTGGAAATTCCTCGGTGGTTACTTGCCTTAATAATATTATACCTTTCCATACCGTTAGTGGTTTATTATGTTATACCCTACTTGTTTTATGGCAACAAGTCGACCAAAAAAAGGATCATCATATTTGTGCTGGGTGATGTAGGACACTCTCCAAGGATATGCTATCACGCTATAAGTTTCAGTAAGTTAGGTTGGCAAGTCGAGCTATGCGGTTATGTGGAGGACACTCTACCCAAAATTATTTCCAGTGATCCAAATATCACCGTCCATCATATGTCAAACTTGAAAAGAAAGGGAGGCGGAACATCAGTTATATTTATGGTAAAGAAGGTGCTTTTTCAAGTTTTAAGTATTTTCAAATTACTTTGGGAATTGAGAGGAAGCGATTACATACTAGTTCAAAATCCACCGAGCATACCCATTCTTCCGATTGCTGTGCTATACAAGTTGACCGGTTGTAAACTAATTATTGATTGGCACAATCTAGCATATTCGATATTGCAACTAAAATTTAAAGGAAACTTTTACCATCCTTTAGTGTTGATATCTTACATGGTAGAGATGATATTCAGCAAATTTGCTGATTATAACTTGACTGTTACTGAAGCAATGAGGAAATATTTAATTCAAAGCTTTCACTTGAATCCAAAGAGATGTGCTGTTCTCTACGACCGCCCGGCTTCCCAATTTCAACCTTTGGCAGGTGACATTTCTCGTCAAAAAGCCCTAACTACCAAAGCCTTTATAAAGAATTATATTCGCGATGATTTTGATACAGAAAAAGGCGATAAAATTATTGTGACTTCAACATCATTCACCCCTGATGAAGATATTGGTATTTTATTAGGTGCCCTAAAGATTTACGAAAACTCTTATGTCAAATTTGATTCAAGTTTGCCTAAGATCTTGTGTTTTATAACGGGTAAAGGACCACTAAAGGAGAAATATATGAAGCAAGTAGAAGAATATGACTGGAAGCGCTGTCAAATCGAATTTGTGTGGTTGTCAGCAGAGGATTACCCAAAGTTATTACAATTATGCGATTACGGAGTTTCCCTGCATACTTCAAGTTCAGGGTTGGACCTGCCAATGAAAATTTTAGATATGTTTGGCTCAGGTCTTCCTGTTATTGCAATGAACTATCCAGTGCTTGACGAATTAGTACAACACAATGTAAATGGGTTAAAATTTGTTGATAGAAGGGAGCTTCATGAATCTCTGATTTTTGCTATGAAAGATGCTGATTTATACCAAAAATTGAAGAAAAATGTAACGCAGGAAGCTGAGAACAGATGGCAATCAAATTGGGAACGAACAATGAGAGATTTGAAGCTAATTCATTGA","protein_sequence":"MFLEIPRWLLALIILYLSIPLVVYYVIPYLFYGNKSTKKRIIIFVLGDVGHSPRICYHAISFSKLGWQVELCGYVEDTLPKIISSDPNITVHHMSNLKRKGGGTSVIFMVKKVLFQVLSIFKLLWELRGSDYILVQNPPSIPILPIAVLYKLTGCKLIIDWHNLAYSILQLKFKGNFYHPLVLISYMVEMIFSKFADYNLTVTEAMRKYLIQSFHLNPKRCAVLYDRPASQFQPLAGDISRQKALTTKAFIKNYIRDDFDTEKGDKIIVTSTSFTPDEDIGILLGALKIYENSYVKFDSSLPKILCFITGKGPLKEKYMKQVEEYDWKRCQIEFVWLSAEDYPKLLQLCDYGVSLHTSSSGLDLPMKILDMFGSGLPVIAMNYPVLDELVQHNVNGLKFVDRRELHESLIFAMKDADLYQKLKKNVTQEAENRWQSNWERTMRDLKLIH"},{"created_at":"2016-09-09T22:45:16.000Z","updated_at":"2016-09-09T22:45:16.000Z","name":"UDP-N-acetylglucosamine transferase subunit ALG14","uniprot_id":"P38242","uniprot_name":"ALG14","enzyme":false,"transporter":false,"gene_name":"ALG14","num_residues":237,"molecular_weight":"27034.92","theoretical_pi":null,"general_function":"dolichol-linked oligosaccharide biosynthetic process","specific_function":"Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.","reactions":[{"id":14870,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007061","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"8-28","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 14"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"nuclear membrane"},{"category":"Function","description":"integral component of endoplasmic reticulum membrane"},{"category":"Function","description":"intrinsic component of endoplasmic reticulum membrane"},{"category":"Function","description":"nuclear outer membrane-endoplasmic reticulum membrane network"},{"category":"Function","description":"UDP-N-acetylglucosamine transferase complex"},{"category":"Function","description":"protein anchor"},{"category":"Function","description":"dolichol-linked oligosaccharide biosynthetic process"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAAAACGGCCTACTTGGCGTCATTGGTGCTCATCGTATCGACAGCATATGTTATTAGGTTGATAGCGATTCTGCCTTTTTTCCACACTCAAGCAGGTACAGAAAAGGATACGAAAGATGGAGTTAACCTACTGAAAATACGAAAATCGTCAAAGAAACCGCTCAAGATTTTTGTATTCTTAGGATCGGGAGGTCATACTGGTGAAATGATCCGTCTTCTAGAAAATTACCAGGATCTTTTACTGGGTAAGTCGATTGTGTACTTGGGTTATTCTGATGAGGCTTCCAGGCAAAGATTCGCCCACTTTATAAAAAAATTTGGTCATTGCAAAGTAAAATACTATGAATTCATGAAAGCTAGGGAAGTTAAAGCGACTCTCCTACAAAGTGTAAAGACCATCATTGGAACGTTGGTACAATCTTTTGTGCACGTGGTTAGAATCAGATTTGCTATGTGTGGTTCCCCTCATCTGTTTTTATTGAATGGGCCTGGAACATGCTGTATAATATCCTTTTGGTTGAAAATTATGGAACTTCTTTTGCCCCTGTTGGGTTCCTCCCATATAGTTTATGTAGAATCGCTGGCAAGGATTAATACTCCTAGTCTGACCGGAAAAATATTATATTGGGTAGTGGATGAATTCATTGTCCAGTGGCAAGAATTGAGGGACAATTATTTACCAAGATCCAAGTGGTTCGGCATCCTTGTTTAA","protein_sequence":"MKTAYLASLVLIVSTAYVIRLIAILPFFHTQAGTEKDTKDGVNLLKIRKSSKKPLKIFVFLGSGGHTGEMIRLLENYQDLLLGKSIVYLGYSDEASRQRFAHFIKKFGHCKVKYYEFMKAREVKATLLQSVKTIIGTLVQSFVHVVRIRFAMCGSPHLFLLNGPGTCCIISFWLKIMELLLPLLGSSHIVYVESLARINTPSLTGKILYWVVDEFIVQWQELRDNYLPRSKWFGILV"}]}