{"ymdb_id":"YMDB16228","created_at":"2016-09-12T18:25:34.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"(Mannosyl)6-(N-acetylglucosaminyl)2-diphosphodolichol","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(2S,3R,4R,5S,6R)-5-{[(2S,3R,4R,5S,6R)-5-{[(2S,3S,4S,5R,6R)-4-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-({[(2S,3S,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}methyl)-3,5-dihydroxyoxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}[({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid","traditional_iupac":"[(2S,3R,4R,5S,6R)-5-{[(2S,3R,4R,5S,6R)-5-{[(2S,3S,4S,5R,6R)-4-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-({[(2S,3S,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}methyl)-3,5-dihydroxyoxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy(hydroxy)phosphoryl}oxy)phosphinic acid","logp":"10.434769323333338","pka":"3.1717817363758014","alogps_solubility":"1.23e-02 g/l","alogps_logp":"4.83","alogps_logs":"-5.33","acceptor_count":"44","donor_count":"27","rotatable_bond_count":"77","polar_surface_area":"764.2300000000005","refractivity":"686.7084000000004","polarizability":"293.25384801755513","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.947694785894586","pka_strongest_acidic":"1.7444953207602185","bioavailability":"0","number_of_rings":"8","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-27T09:09:38.000Z","updated_at":"2011-07-22T17:54:10.000Z","name":"Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase","uniprot_id":"P38179","uniprot_name":"ALG3_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG3","num_residues":458,"molecular_weight":"52860.39844","theoretical_pi":"9.09","general_function":"Involved in transferase activity, transferring hexosyl groups","specific_function":"Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol. Sensitive to H.mrakii HM-1 killer toxin","reactions":[{"id":1317,"direction":"\u003c\u003e","locations":"endoplasmic reticulum membrane;endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14876,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007067","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"42-62;96-116;138-158;172-192;217-237;243-263;303-323;346-366;382-402;416-436","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"X79489","genbank_protein_id":"496697","gene_card_id":"ALG3","chromosome_location":"chromosome 2","locus":"YBL082C","synonyms":["Asparagine-linked glycosylation protein 3","Dol-P-Man-dependent alpha(1-3)-mannosyltransferase","Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase","HM-1 killer toxin resistance protein"],"enzyme_classes":["2.4.1.130"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" endoplasmic reticulum"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ALG3","identifier":"PF05208"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGAAGGTGAACAGTCTCCGCAAGGTGAAAAGTCTCTGCAAAGGAAGCAATTTGTCAGACCTCCGCTGGATCTGTGGCAGGATCTCAAGGACGGTGTGCGCTACGTGATCTTCGATTGTAGGGCCAATCTTATCGTTATGCCCCTTTTGATTTTGTTCGAAAGCATGCTGTGCAAGATTATCATTAAGAAGGTAGCTTACACAGAGATCGATTACAAGGCGTACATGGAGCAGATCGAGATGATTCAGCTCGATGGCATGCTGGACTACTCTCAGGTGAGTGGTGGAACGGGCCCGCTGGTGTATCCAGCAGGCCACGTCTTGATCTACAAGATGATGTACTGGCTAACAGAGGGAATGGACCACGTTGAGCGCGGGCAAGTGTTTTTCAGATACTTGTATCTCCTTACACTGGCGTTACAAATGGCGTGTTACTACCTTTTACATCTACCACCGTGGTGTGTGGTCTTGGCGTGCCTCTCTAAAAGATTGCACTCTATTTACGTGCTACGGTTATTCAATGATTGCTTCACTACTTTGTTTATGGTCGTCACGGTTTTGGGGGCTATCGTGGCCAGCAGGTGCCATCAGCGCCCCAAATTAAAGAAGTCCCTTGCGCTGGTGATCTCCGCAACATACAGTATGGCTGTGAGCATTAAGATGAATGCGCTGTTGTATTTCCCTGCAATGATGATTTCTCTATTCATCCTTAATGACGCGAACGTAATCCTTACTTTGTTGGATCTCGTTGCGATGATTGCATGGCAAGTCGCAGTTGCAGTGCCCTTCCTGCGCAGCTTTCCGCAACAGTACCTGCATTGCGCTTTTAATTTCGGCAGGAAGTTTATGTACCAATGGAGTATCAATTGGCAAATGATGGATGAAGAGGCTTTCAATGATAAGAGGTTCCACTTGGCCCTTTTAATCAGCCACCTGATAGCGCTCACCACACTGTTCGTCACAAGATACCCTCGCATCCTGCCCGATTTATGGTCTTCCCTGTGCCATCCGCTGAGGAAAAATGCAGTGCTCAATGCCAATCCCGCCAAGACTATTCCATTCGTTCTAATCGCATCCAACTTCATCGGCGTCCTATTTTCAAGGTCCCTCCACTACCAGTTTCTATCCTGGTATCACTGGACTTTGCCTATACTGATCTTTTGGTCGGGAATGCCCTTCTTCGTTGGTCCCATTTGGTACGTCTTGCACGAGTGGTGCTGGAATTCCTATCCACCAAACTCACAAGCAAGCACGCTATTGTTGGCATTGAATACTGTTCTGTTGCTTCTATTGGCCTTGACGCAGCTATCTGGTTCGGTCGCCCTCGCCAAAAGCCATCTTCGTACCACCAGCTCTATGGAAAAAAAGCTCAACTGA","protein_sequence":"MEGEQSPQGEKSLQRKQFVRPPLDLWQDLKDGVRYVIFDCRANLIVMPLLILFESMLCKIIIKKVAYTEIDYKAYMEQIEMIQLDGMLDYSQVSGGTGPLVYPAGHVLIYKMMYWLTEGMDHVERGQVFFRYLYLLTLALQMACYYLLHLPPWCVVLACLSKRLHSIYVLRLFNDCFTTLFMVVTVLGAIVASRCHQRPKLKKSLALVISATYSMAVSIKMNALLYFPAMMISLFILNDANVILTLLDLVAMIAWQVAVAVPFLRSFPQQYLHCAFNFGRKFMYQWSINWQMMDEEAFNDKRFHLALLISHLIALTTLFVTRYPRILPDLWSSLCHPLRKNAVLNANPAKTIPFVLIASNFIGVLFSRSLHYQFLSWYHWTLPILIFWSGMPFFVGPIWYVLHEWCWNSYPPNSQASTLLLALNTVLLLLLALTQLSGSVALAKSHLRTTSSMEKKLN"},{"created_at":"2016-09-09T22:48:16.000Z","updated_at":"2016-09-09T22:48:19.000Z","name":"Alpha-1,2-mannosyltransferase ALG9","uniprot_id":"P53868","uniprot_name":"ALG9","enzyme":true,"transporter":false,"gene_name":"ALG9","num_residues":555,"molecular_weight":"63776.03","theoretical_pi":null,"general_function":"protein glycosylation","specific_function":"Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides.","reactions":[{"id":14877,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007068","source":"Smpdb"},{"id":14878,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007070","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"8-28;63-83;87-107;114-134;177-197;214-234;269-289;317-337;350-370","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 9","Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase","Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"endoplasmic reticulum"},{"category":"Function","description":"dolichol-linked oligosaccharide biosynthetic process"},{"category":"Function","description":"protein glycosylation"},{"category":"Function","description":"dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":"dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":"glycolipid mannosyltransferase activity"},{"category":"Function","description":"mannosyltransferase activity"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAATTGCAAGGCGGTAACCATTAGTTTATTACTGTTGTTATTTTTAACAAGAGTATATATTCAGCCGACATTCTCGTTAATTTCAGATTGCGATGAAACTTTTAATTATTGGGAACCATTAAATTTATTGGTACGTGGATTTGGTAAACAAACCTGGGAATATTCACCCGAGTATTCTATTAGATCATGGGCTTTCTTATTACCTTTTTACTGTATTCTTTATCCAGTAAACAAATTTACTGACCTAGAAAGTCATTGGAACTTTTTCATCACAAGAGCATGCTTAGGCTTTTTTAGTTTTATCATGGAATTTAAACTACATCGTGAAATTGCAGGCAGCTTGGCATTGCAAATCGCAAATATTTGGATTATTTTCCAATTGTTTAATCCGGGCTGGTTCCATGCATCTGTGGAATTATTGCCTTCTGCCGTTGCCATGTTGTTGTATGTAGGTGCCACCAGACACTCTCTACGCTATCTGTCCACTGGGTCTACTTCTAACTTTACGAAAAGTTTAGCGTACAATTTCCTGGCTAGTATACTAGGCTGGCCATTTGTTTTAATTTTAAGCTTGCCATTATGTTTACATTACCTTTTCAACCATAGAATTATTTCTACCATCAGAACCGCATTCGACTGCTGTTTGATATTTTCATTGACTGCATTTGCTGTGATTGTCACTGACAGTATATTTTACGGGAAGCTTGCTCCTGTATCATGGAACATCTTATTTTACAATGTCATTAATGCAAGTGAGGAATCTGGCCCAAATATTTTCGGGGTTGAGCCATGGTACTACTATCCACTAAATTTGTTACTGAATTTCCCACTGCCTGTGCTAGTTTTAGCTATTTTGGGAATTTTCCATTTGAGATTATGGCCATTATGGGCATCATTATTCACATGGATTGCCGTTTTCACTCAACAACCTCACAAAGAGGAAAGATTTCTCTATCCAATTTACGGGTTAATAACTTTGAGTGCAAGTATCGCCTTTTACAAAGTGTTGAATCTATTCAATAGAAAGCCGATTCTTAAAAAAGGTATAAAGTTGTCAGTTTTATTAATTGTTGCAGGCCAGGCAATGTCACGGATAGTGGCTTTGGTGAACAATTACACAGCTCCTATAGCCGTCTACGAGCAATTTTCTTCACTAAATCAAGGTGGTGTGAAGGCACCGGTAGTGAATGTATGTACGGGACGTGAATGGTATCACTTCCCAAGTTCTTTCCTGCTGCCAGATAATCATAGGCTAAAATTTGTTAAATCTGGATTTGATGGTCTTCTTCCAGGTGATTTTCCAGAGAGTGGTTCTATTTTCAAAAAGATTAGAACTTTACCTAAGGGAATGAATAACAAGAATATATATGATACCGGTAAAGAGTGGCCGATCACTAGATGTGATTATTTTATTGACATCGTCGCCCCAATAAATTTAACAAAAGACGTTTTCAACCCTCTACATCTGATGGATAACTGGAATAAGCTGGCATGTGCTGCATTCATCGACGGTGAAAATTCTAAGATTTTGGGTAGAGCATTTTACGTACCGGAGCCAATCAACCGAATCATGCAAATAGTTTTACCAAAACAATGGAATCAAGTGTACGGTGTTCGTTACATTGATTACTGTTTGTTTGAAAAACCAACTGAGACTACTAATTGA","protein_sequence":"MNCKAVTISLLLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIRSWAFLLPFYCILYPVNKFTDLESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQIANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGSTSNFTKSLAYNFLASILGWPFVLILSLPLCLHYLFNHRIISTIRTAFDCCLIFSLTAFAVIVTDSIFYGKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIFHLRLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAFYKVLNLFNRKPILKKGIKLSVLLIVAGQAMSRIVALVNNYTAPIAVYEQFSSLNQGGVKAPVVNVCTGREWYHFPSSFLLPDNHRLKFVKSGFDGLLPGDFPESGSIFKKIRTLPKGMNNKNIYDTGKEWPITRCDYFIDIVAPINLTKDVFNPLHLMDNWNKLACAAFIDGENSKILGRAFYVPEPINRIMQIVLPKQWNQVYGVRYIDYCLFEKPTETTN"}]}