{"ymdb_id":"YMDB16227","created_at":"2016-09-12T18:25:25.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"(Mannosyl)5-(N-acetylglucosaminyl)2-diphosphodolichol","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(2S,3R,4R,5S,6R)-5-{[(2S,3R,4R,5S,6R)-5-{[(2S,3S,4S,5R,6R)-4-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,5-dihydroxy-6-({[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}[({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid","traditional_iupac":"[(2S,3R,4R,5S,6R)-5-{[(2S,3R,4R,5S,6R)-5-{[(2S,3S,4S,5R,6R)-4-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,5-dihydroxy-6-({[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy(hydroxy)phosphoryl}oxy)phosphinic acid","logp":"12.205604969000005","pka":"3.1717817365825316","alogps_solubility":"9.69e-03 g/l","alogps_logp":"5.43","alogps_logs":"-5.41","acceptor_count":"39","donor_count":"24","rotatable_bond_count":"74","polar_surface_area":"685.0800000000004","refractivity":"654.2951000000004","polarizability":"278.65621429327905","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.68551332115012","pka_strongest_acidic":"1.7444953207682339","bioavailability":"0","number_of_rings":"7","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-27T09:09:38.000Z","updated_at":"2011-07-22T17:54:10.000Z","name":"Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase","uniprot_id":"P38179","uniprot_name":"ALG3_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG3","num_residues":458,"molecular_weight":"52860.39844","theoretical_pi":"9.09","general_function":"Involved in transferase activity, transferring hexosyl groups","specific_function":"Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol. Sensitive to H.mrakii HM-1 killer toxin","reactions":[{"id":1317,"direction":"\u003c\u003e","locations":"endoplasmic reticulum membrane;endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14876,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007067","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"42-62;96-116;138-158;172-192;217-237;243-263;303-323;346-366;382-402;416-436","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"X79489","genbank_protein_id":"496697","gene_card_id":"ALG3","chromosome_location":"chromosome 2","locus":"YBL082C","synonyms":["Asparagine-linked glycosylation protein 3","Dol-P-Man-dependent alpha(1-3)-mannosyltransferase","Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase","HM-1 killer toxin resistance protein"],"enzyme_classes":["2.4.1.130"],"go_classes":[{"category":"Component","description":" endoplasmic reticulum"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ALG3","identifier":"PF05208"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGAAGGTGAACAGTCTCCGCAAGGTGAAAAGTCTCTGCAAAGGAAGCAATTTGTCAGACCTCCGCTGGATCTGTGGCAGGATCTCAAGGACGGTGTGCGCTACGTGATCTTCGATTGTAGGGCCAATCTTATCGTTATGCCCCTTTTGATTTTGTTCGAAAGCATGCTGTGCAAGATTATCATTAAGAAGGTAGCTTACACAGAGATCGATTACAAGGCGTACATGGAGCAGATCGAGATGATTCAGCTCGATGGCATGCTGGACTACTCTCAGGTGAGTGGTGGAACGGGCCCGCTGGTGTATCCAGCAGGCCACGTCTTGATCTACAAGATGATGTACTGGCTAACAGAGGGAATGGACCACGTTGAGCGCGGGCAAGTGTTTTTCAGATACTTGTATCTCCTTACACTGGCGTTACAAATGGCGTGTTACTACCTTTTACATCTACCACCGTGGTGTGTGGTCTTGGCGTGCCTCTCTAAAAGATTGCACTCTATTTACGTGCTACGGTTATTCAATGATTGCTTCACTACTTTGTTTATGGTCGTCACGGTTTTGGGGGCTATCGTGGCCAGCAGGTGCCATCAGCGCCCCAAATTAAAGAAGTCCCTTGCGCTGGTGATCTCCGCAACATACAGTATGGCTGTGAGCATTAAGATGAATGCGCTGTTGTATTTCCCTGCAATGATGATTTCTCTATTCATCCTTAATGACGCGAACGTAATCCTTACTTTGTTGGATCTCGTTGCGATGATTGCATGGCAAGTCGCAGTTGCAGTGCCCTTCCTGCGCAGCTTTCCGCAACAGTACCTGCATTGCGCTTTTAATTTCGGCAGGAAGTTTATGTACCAATGGAGTATCAATTGGCAAATGATGGATGAAGAGGCTTTCAATGATAAGAGGTTCCACTTGGCCCTTTTAATCAGCCACCTGATAGCGCTCACCACACTGTTCGTCACAAGATACCCTCGCATCCTGCCCGATTTATGGTCTTCCCTGTGCCATCCGCTGAGGAAAAATGCAGTGCTCAATGCCAATCCCGCCAAGACTATTCCATTCGTTCTAATCGCATCCAACTTCATCGGCGTCCTATTTTCAAGGTCCCTCCACTACCAGTTTCTATCCTGGTATCACTGGACTTTGCCTATACTGATCTTTTGGTCGGGAATGCCCTTCTTCGTTGGTCCCATTTGGTACGTCTTGCACGAGTGGTGCTGGAATTCCTATCCACCAAACTCACAAGCAAGCACGCTATTGTTGGCATTGAATACTGTTCTGTTGCTTCTATTGGCCTTGACGCAGCTATCTGGTTCGGTCGCCCTCGCCAAAAGCCATCTTCGTACCACCAGCTCTATGGAAAAAAAGCTCAACTGA","protein_sequence":"MEGEQSPQGEKSLQRKQFVRPPLDLWQDLKDGVRYVIFDCRANLIVMPLLILFESMLCKIIIKKVAYTEIDYKAYMEQIEMIQLDGMLDYSQVSGGTGPLVYPAGHVLIYKMMYWLTEGMDHVERGQVFFRYLYLLTLALQMACYYLLHLPPWCVVLACLSKRLHSIYVLRLFNDCFTTLFMVVTVLGAIVASRCHQRPKLKKSLALVISATYSMAVSIKMNALLYFPAMMISLFILNDANVILTLLDLVAMIAWQVAVAVPFLRSFPQQYLHCAFNFGRKFMYQWSINWQMMDEEAFNDKRFHLALLISHLIALTTLFVTRYPRILPDLWSSLCHPLRKNAVLNANPAKTIPFVLIASNFIGVLFSRSLHYQFLSWYHWTLPILIFWSGMPFFVGPIWYVLHEWCWNSYPPNSQASTLLLALNTVLLLLLALTQLSGSVALAKSHLRTTSSMEKKLN"},{"created_at":"2016-09-09T22:48:23.000Z","updated_at":"2016-09-09T22:48:24.000Z","name":"GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase","uniprot_id":"P53954","uniprot_name":"ALG11","enzyme":true,"transporter":false,"gene_name":"ALG11","num_residues":548,"molecular_weight":"63142.705","theoretical_pi":null,"general_function":"protein glycosylation","specific_function":"Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum.","reactions":[{"id":14874,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007065","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"21-41","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Alpha-1,2-mannosyltransferase ALG11","Asparagine-linked glycosylation protein 11","Glycolipid 2-alpha-mannosyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"dolichol-linked oligosaccharide biosynthetic process"},{"category":"Function","description":"oligosaccharide-lipid intermediate biosynthetic process"},{"category":"Function","description":"protein glycosylation"},{"category":"Function","description":"alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":"GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGGCAGTGCTTGGACAAACTACAATTTTGAAGAGGTTAAGTCTCATTTTGGGTTCAAAAAATATGTTGTATCATCTTTAGTACTAGTGTATGGACTAATTAAGGTTCTCACGTGGATCTTCCGTCAATGGGTGTATTCCAGCTTGAATCCGTTCTCCAAAAAATCTTCATTACTGAACAGAGCAGTTGCCTCCTGTGGTGAGAAGAATGTGAAAGTTTTTGGTTTTTTTCATCCGTATTGTAATGCTGGTGGTGGTGGGGAAAAAGTGCTCTGGAAAGCTGTAGATATCACTTTGAGAAAAGATGCTAAGAACGTTATTGTCATTTATTCAGGGGATTTTGTGAATGGAGAGAATGTTACTCCGGAGAATATTCTAAATAATGTGAAAGCGAAGTTCGATTACGACTTGGATTCGGATAGAATATTTTTCATTTCATTGAAGCTAAGATACTTGGTGGATTCTTCAACATGGAAGCATTTCACGTTGATTGGACAAGCAATTGGATCAATGATTCTCGCATTTGAATCCATTATTCAGTGTCCACCTGATATATGGATTGATACAATGGGGTACCCTTTCAGCTATCCTATTATTGCTAGGTTTTTGAGGAGAATTCCTATCGTCACATATACGCATTATCCGATAATGTCAAAAGACATGTTAAATAAGCTGTTCAAAATGCCCAAGAAGGGTATCAAAGTTTACGGTAAAATATTATACTGGAAAGTTTTTATGTTAATTTATCAATCCATTGGTTCTAAAATTGATATTGTAATCACAAACTCAACATGGACAAATAACCACATAAAGCAAATTTGGCAATCCAATACGTGTAAAATTATATATCCTCCATGCTCTACTGAGAAATTAGTAGATTGGAAGCAAAAGTTTGGTACTGCAAAGGGTGAGAGATTAAATCAAGCAATTGTGTTGGCACAATTTCGTCCTGAGAAACGTCATAAGTTAATCATTGAGTCCTTTGCAACTTTCTTGAAAAATTTACCGGATTCTGTATCGCCAATTAAATTGATAATGGCGGGGTCCACTAGATCCAAGCAAGATGAAAATTATGTTAAAAGTTTACAAGACTGGTCAGAAAATGTATTAAAAATTCCTAAACATTTGATATCATTCGAAAAAAATCTGCCCTTCGATAAGATTGAAATATTACTAAACAAATCTACTTTCGGTGTTAATGCCATGTGGAATGAGCACTTTGGAATTGCAGTTGTAGAGTATATGGCTTCCGGTTTGATCCCCATAGTTCATGCCTCGGCGGGCCCATTGTTAGATATAGTTACTCCATGGGATGCCAACGGGAATATCGGAAAAGCTCCACCACAATGGGAGTTACAAAAGAAATATTTTGCAAAACTCGAAGATGATGGTGAAACTACTGGATTTTTCTTTAAAGAGCCGAGTGATCCTGATTATAACACAACCAAAGATCCTCTGAGATACCCTAATTTGTCCGACCTTTTCTTACAAATTACGAAACTGGACTATGACTGCCTAAGGGTGATGGGCGCAAGAAACCAGCAGTATTCATTGTATAAATTCTCTGATTTGAAGTTTGATAAAGATTGGGAAAACTTTGTACTGAATCCTATTTGTAAATTATTAGAAGAGGAGGAAAGGGGCTGA","protein_sequence":"MGSAWTNYNFEEVKSHFGFKKYVVSSLVLVYGLIKVLTWIFRQWVYSSLNPFSKKSSLLNRAVASCGEKNVKVFGFFHPYCNAGGGGEKVLWKAVDITLRKDAKNVIVIYSGDFVNGENVTPENILNNVKAKFDYDLDSDRIFFISLKLRYLVDSSTWKHFTLIGQAIGSMILAFESIIQCPPDIWIDTMGYPFSYPIIARFLRRIPIVTYTHYPIMSKDMLNKLFKMPKKGIKVYGKILYWKVFMLIYQSIGSKIDIVITNSTWTNNHIKQIWQSNTCKIIYPPCSTEKLVDWKQKFGTAKGERLNQAIVLAQFRPEKRHKLIIESFATFLKNLPDSVSPIKLIMAGSTRSKQDENYVKSLQDWSENVLKIPKHLISFEKNLPFDKIEILLNKSTFGVNAMWNEHFGIAVVEYMASGLIPIVHASAGPLLDIVTPWDANGNIGKAPPQWELQKKYFAKLEDDGETTGFFFKEPSDPDYNTTKDPLRYPNLSDLFLQITKLDYDCLRVMGARNQQYSLYKFSDLKFDKDWENFVLNPICKLLEEEERG"}]}