{"ymdb_id":"YMDB16188","created_at":"2016-09-12T18:21:28.000Z","updated_at":"2016-10-17T22:34:42.000Z","name":"Dihydroceramide","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]formamide","traditional_iupac":"N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]formamide","logp":"4.542742140333335","pka":"14.634932904558912","alogps_solubility":"4.65e-03 g/l","alogps_logp":"4.68","alogps_logs":"-4.85","acceptor_count":"3","donor_count":"3","rotatable_bond_count":"17","polar_surface_area":"69.56","refractivity":"95.88269999999997","polarizability":"42.49344088572215","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-0.40960863392873204","pka_strongest_acidic":"14.113115052553052","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-24T21:46:35.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAG1","uniprot_id":"P38703","uniprot_name":"LAG1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAG1","num_residues":411,"molecular_weight":"48454.10156","theoretical_pi":"9.17","general_function":"Involved in protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;177-197;212-232;252-272;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY558514","genbank_protein_id":"45270918","gene_card_id":"LAG1","chromosome_location":"chromosome 8","locus":"YHL003C","synonyms":["Longevity assurance factor 1","Longevity assurance gene 1 protein","Longevity assurance protein 1"],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGACATCAGCTACGGACAAATCTATCGATAGGTTAGTTGTTAATGCAAAAACAAGAAGACGAAACTCTTCCGTGGGTAAAATTGATTTAGGTGATACAGTTCCTGGCTTTGCAGCCATGCCTGAAAGTGCTGCCTCTAAAAATGAGGCCAAAAAAAGGATGAAAGCCTTGACTGGTGACTCTAAAAAGGATAGTGACCTACTGTGGAAGGTTTGGTTTTCATATAGAGAAATGAATTACCGTCATAGTTGGTTGACACCATTCTTCATACTTGTATGCGTGTATAGCGCGTACTTTTTATCTGGGAATAGAACAGAATCAAACCCGCTGCACATGTTCGTAGCCATATCATATCAAGTTGATGGCACAGACTCATATGCAAAAGGTATCAAAGATTTGAGTTTTGTGTTTTTCTACATGATTTTCTTCACATTTTTACGTGAGTTTTTGATGGATGTTGTAATTCGACCATTCACGGTATACCTAAATGTTACTTCCGAGCATCGTCAAAAGCGTATGCTAGAACAAATGTATGCCATATTTTATTGCGGAGTTTCAGGGCCCTTTGGTCTTTATATTATGTACCATAGTGATTTGTGGTTGTTCAAGACAAAACCAATGTACAGAACATATCCTGTTATAACCAATCCGTTCTTGTTTAAGATATTTTACTTGGGTCAAGCGGCATTTTGGGCGCAACAGGCTTGTGTTCTTGTTCTACAATTAGAAAAGCCAAGAAAGGATTACAAGGAATTGGTTTTTCATCACATTGTGACATTATTATTAATTTGGTCATCATATGTTTTCCATTTTACCAAAATGGGATTGGCTATCTATATTACTATGGATGTGTCAGATTTTTTCCTTTCTTTGTCTAAGACATTAAACTATCTGAATTCTGTATTTACTCCCTTTGTGTTCGGCTTGTTCGTGTTCTTTTGGATCTATCTGCGCCATGTCGTGAATATCAGAATATTATGGTCAGTCTTAACAGAATTCCGTCATGAAGGTAATTATGTGTTGAATTTTGCCACACAACAATACAAATGTTGGATTTCGTTGCCAATTGTATTTGTACTAATTGCTGCGTTACAATTAGTTAACCTGTATTGGCTGTTTTTAATTCTTAGAATCTTGTACAGATTGATATGGCAAGGTATCCAAAAGGACGAAAGAAGTGACAGTGATTCTGATGAGAGCGCTGAAAATGAAGAATCTAAGGAAAAGTGTGAATAA","protein_sequence":"MTSATDKSIDRLVVNAKTRRRNSSVGKIDLGDTVPGFAAMPESAASKNEAKKRMKALTGDSKKDSDLLWKVWFSYREMNYRHSWLTPFFILVCVYSAYFLSGNRTESNPLHMFVAISYQVDGTDSYAKGIKDLSFVFFYMIFFTFLREFLMDVVIRPFTVYLNVTSEHRQKRMLEQMYAIFYCGVSGPFGLYIMYHSDLWLFKTKPMYRTYPVITNPFLFKIFYLGQAAFWAQQACVLVLQLEKPRKDYKELVFHHIVTLLLIWSSYVFHFTKMGLAIYITMDVSDFFLSLSKTLNYLNSVFTPFVFGLFVFFWIYLRHVVNIRILWSVLTEFRHEGNYVLNFATQQYKCWISLPIVFVLIAALQLVNLYWLFLILRILYRLIWQGIQKDERSDSDSDESAENEESKEKCE"},{"created_at":"2011-05-26T16:11:34.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAC1","uniprot_id":"P28496","uniprot_name":"LAC1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAC1","num_residues":418,"molecular_weight":"48991.60156","theoretical_pi":"9.81","general_function":"Involved in identical protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;173-193;222-242;260-280;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z28008","genbank_protein_id":"485983","gene_card_id":"LAC1","chromosome_location":"chromosome 11","locus":"YKL008C","synonyms":[],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGTCGACAATAAAGCCAAGCCCTTCAAACAACAATTTGAAAGTGAGGTCAAGACCAAGACGCAAGTCTTCCATAGGTAAGATCGACCTCGGGGACACTGTACCTAGTTTAGGTACTATGTTCGAGACAAAAGAATCTAAAACGGCTGCTAAAAGGCGTATGCAGAGATTATCTGAAGCCACCAAAAATGATAGCGACCTGGTCAAGAAAATCTGGTTTTCATTCCGAGAGATAAGTTACCGTCATGCCTGGATAGCTCCCTTGATGATTTTAATCGCGGTATATAGTGCCTATTTCACTTCTGGTAACACTACAAAGACAAATGTGTTACATAGATTTGTCGCTGTGTCATACCAAATAGGTGATACCAACGCATATGGTAAAGGTATTAACGATTTGTGCTTTGTATTTTACTATATGATTTTTTTCACATTCTTACGTGAATTCCTAATGGATGTTGTCATTAGACCGTTCGCTATTAGGTTACACGTCACTTCTAAGCACAGAATAAAAAGAATCATGGAACAAATGTACGCTATTTTCTACACCGGTGTTTCCGGTCCTTTCGGGATATATTGTATGTACCATTCGGATTTATGGTTTTTCAACACAAAGGCAATGTACAGAACATATCCAGATTTCACTAATCCCTTCTTATTCAAGGTATTCTATTTGGGTCAAGCTGCATTTTGGGCTCAACAAGCCTGCATTCTTGTATTGCAACTAGAAAAGCCAAGAAAAGATCATAACGAGTTGACTTTCCATCATATTGTTACTTTACTATTGATTTGGTCTTCCTACGTATTTCATTTCACTAAAATGGGACTGCCAATCTATATCACAATGGATGTTTCTGATTTTCTTTTGTCATTCTCCAAAACTCTAAATTATTTGGACTCTGGATTGGCTTTTTTTTCTTTTGCTATCTTTGTTGTTGCGTGGATTTATTTGCGTCATTACATAAATTTAAAGATCCTATGGTCCGTTTTAACGCAATTTCGCACGGAAGGTAACTATGTCTTGAATTTTGCCACTCAGCAATATAAATGTTGGATTTCCTTACCAATTGTCTTTGTATTGATAGGCGCTTTGCAATTAGTGAATCTTTATTGGCTGTTCCTTATTTTTAGAGTTCTTTACAGGATTCTATGGAGAGGTATTCTCAAGGATGACAGAAGTGATAGTGAATCAGACGAAGAAAGTGATGAAAGTTCCACTACTCCAACTGACAGTACTCCAACGAAAAAGGATATTTGA","protein_sequence":"MSTIKPSPSNNNLKVRSRPRRKSSIGKIDLGDTVPSLGTMFETKESKTAAKRRMQRLSEATKNDSDLVKKIWFSFREISYRHAWIAPLMILIAVYSAYFTSGNTTKTNVLHRFVAVSYQIGDTNAYGKGINDLCFVFYYMIFFTFLREFLMDVVIRPFAIRLHVTSKHRIKRIMEQMYAIFYTGVSGPFGIYCMYHSDLWFFNTKAMYRTYPDFTNPFLFKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIYITMDVSDFLLSFSKTLNYLDSGLAFFSFAIFVVAWIYLRHYINLKILWSVLTQFRTEGNYVLNFATQQYKCWISLPIVFVLIGALQLVNLYWLFLIFRVLYRILWRGILKDDRSDSESDEESDESSTTPTDSTPTKKDI"}]}