{"ymdb_id":"YMDB16115","created_at":"2016-09-12T18:12:29.000Z","updated_at":"2016-10-17T22:34:41.000Z","name":"4,5-Dihydroorotic acid","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"2,6-dioxo-1,3-diazinane-4-carboxylic acid","traditional_iupac":"dihydroorotic acid","logp":"-1.5232681353333333","pka":"11.713668138573995","alogps_solubility":"1.27e+01 g/l","alogps_logp":"-1.70","alogps_logs":"-1.10","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"1","polar_surface_area":"95.50000000000001","refractivity":"31.575400000000002","polarizability":"13.091120354543254","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-8.186843445720307","pka_strongest_acidic":"3.2849203199118633","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-24T20:43:50.000Z","updated_at":"2011-07-22T17:54:37.000Z","name":"Dihydroorotase","uniprot_id":"P20051","uniprot_name":"PYRC_YEAST","enzyme":true,"transporter":false,"gene_name":"URA4","num_residues":364,"molecular_weight":"40313.0","theoretical_pi":"6.51","general_function":"Involved in dihydroorotase activity","specific_function":"(S)-dihydroorotate + H(2)O = N-carbamoyl-L- aspartate","reactions":[{"id":1460,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2337,"direction":"\u003e","locations":"Cytoplasmic","altext":"(S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.","export":false,"pw_reaction_id":null,"source":null},{"id":14250,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006734","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"U20162","genbank_protein_id":"632670","gene_card_id":"URA4","chromosome_location":"chromosome 12","locus":"YLR420W","synonyms":["DHOase"],"enzyme_classes":["3.5.2.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"},{"category":"Function","description":" dihydroorotase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" nucleobase metabolic process"},{"category":"Process","description":" pyrimidine base metabolic process"},{"category":"Process","description":" pyrimidine base biosynthetic process"}],"pfams":[],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGGTACAAGAAATCGATTTAGGTTTGACATGTGATATGCATGTTCATGTAAGAGAGGGTGCGATGTGTGAACTAGTCACCCCCAAGATTAGAGATGGTGGGGTTTCAATTGCTTACATCATGCCAAATTTACAACCTCCAATTACCACACTAGATAGAGTGATTGAATACAAAAAGACACTGCAGAAACTAGCTCCTAAAACTACCTTCTTAATGAGTTTTTATCTTTCAAAAGACTTAACTCCAGATTTAATTCATGAAGCTGCCCAACAACATGCCATTCGTGGAGTAAAGTGTTATCCAGCGGGAGTAACAACAAATTCGGCTGCTGGGGTGGATCCAAATGACTTCAGCGCATTTTACCCAATTTTCAAGGCTATGCAAGAAGAGAACCTGGTATTAAATTTGCATGGGGAAAAACCTTCTGTCCATGATGGAGACAAAGAACCTATTCATGTATTGAATGCAGAGGAAGCCTTTTTGCCAGCCTTGAAAAAATTGCATAATGATTTCCCAAACCTGAAAATAATTCTGGAACACTGCACTAGCGAGTCGGCAATAAAGACAATCGAGGATATAAATAAGAACGTGAAGAAAGCCACTGACGTAAAGGTTGCTGCCACATTAACGGCTCATCACTTATTTTTAACAATTGATGATTGGGCCGGAAATCCGGTAAATTTTTGCAAACCTGTTGCGAAACTTCCAAATGACAAAAAGGCTCTAGTCAAAGCTGCTGTATCAGGGAAACCATATTTTTTCTTTGGATCTGATTCAGCACCTCATCCTGTACAAAATAAGGCCAATTACGAGGGTGTTTGCGCAGGAGTTTACTCACAATCTTTTGCGATCCCTTATATCGCCCAAGTTTTTGAAGAGCAAAATGCCTTGGAGAACTTAAAGGGCTTTGTTTCCGACTTCGGAATTTCCTTTTATGAGGTTAAAGATAGCGAAGTGGCTTCTTCAGATAAGGCAATATTATTCAAAAAAGAACAAGTTATCCCTCAGGTTATCAGCGATGGCAAAGACATAAGCATCATCCCATTTAAAGCAGGTGATAAACTAAGTTGGTCGGTGAGATGGGAACCTCGTTAA","protein_sequence":"MVQEIDLGLTCDMHVHVREGAMCELVTPKIRDGGVSIAYIMPNLQPPITTLDRVIEYKKTLQKLAPKTTFLMSFYLSKDLTPDLIHEAAQQHAIRGVKCYPAGVTTNSAAGVDPNDFSAFYPIFKAMQEENLVLNLHGEKPSVHDGDKEPIHVLNAEEAFLPALKKLHNDFPNLKIILEHCTSESAIKTIEDINKNVKKATDVKVAATLTAHHLFLTIDDWAGNPVNFCKPVAKLPNDKKALVKAAVSGKPYFFFGSDSAPHPVQNKANYEGVCAGVYSQSFAIPYIAQVFEEQNALENLKGFVSDFGISFYEVKDSEVASSDKAILFKKEQVIPQVISDGKDISIIPFKAGDKLSWSVRWEPR"}]}