{"ymdb_id":"YMDB01807","created_at":"2011-08-31T03:47:27.000Z","updated_at":"2016-09-08T18:37:09.000Z","name":"Xanthurenic acid","cas":"59-00-7","state":"Solid","melting_point":"289 oC","description":"Xanthurenic acid is known as a product of the normal metabolism of amino acid L-tryptophan in mammals. In many eukaryotes, tryptophan is used for the synthesis of the enzymatic cofactor NAD+. Xanthurenic acid has been identified has a metabolite in tryptophan to nicacin in S. uvarum. [PWY-6309] [PMID: 1919812]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":"HMDB00881","kegg_id":"C02470","pubchem_id":"5699","cs_id":"5497","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"4,8-dihydroxyquinoline-2-carboxylic acid","traditional_iupac":"xanthurenic acid","logp":"-0.16662861726590097","pka":"9.066086911279461","alogps_solubility":"1.63e+00 g/l","alogps_logp":"2.01","alogps_logs":"-2.10","acceptor_count":"5","donor_count":"3","rotatable_bond_count":"1","polar_surface_area":"90.65","refractivity":"50.8253","polarizability":"19.064003634931545","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"5.753313640791366","pka_strongest_acidic":"1.1352227807412834","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["8-Hydroxykynurenic acid","Gametocyte activating factor (gaf)","Xanthurenate"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":19889834,"citation":"Boer, V. M., Crutchfield, C. A., Bradley, P. H., Botstein, D., Rabinowitz, J. D. (2010). \"Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations.\" Mol Biol Cell 21:198-211."}],"proteins":[]}