{"ymdb_id":"YMDB01575","created_at":"2011-08-31T03:24:25.000Z","updated_at":"2016-09-08T18:36:51.000Z","name":"1-Methyladenosine","cas":null,"state":"Solid","melting_point":null,"description":"1-Methyladenosine (m1A) is a modified nucleoside derived from adenosine and found in RNA. RNA modifications are present in many different types of cellular RNAs and a large number of enzymes and pathways that catalyze post-transcriptional RNA modifications are known. RNA modifications can play regulatory roles in cells, especially in response to stress conditions. 1-Methyladenosine is obtained in nature by post-transcriptional methylation of adenosine by methyl-1-adenosine transferase5 and it has a special role in t-RNA folding. [PMID: 21615108]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":"16020","hmdb_id":"HMDB03331","kegg_id":"C02494","pubchem_id":"27476","cs_id":"4573813","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2R,3R,4S,5R)-2-(6-amino-1-methyl-2,9-dihydro-1H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol","traditional_iupac":"1-methyl-adenosine","logp":"-2.3629964963333334","pka":"13.934517815367773","alogps_solubility":"7.42e+00 g/l","alogps_logp":"-2.21","alogps_logs":"-1.58","acceptor_count":"9","donor_count":"4","rotatable_bond_count":"2","polar_surface_area":"127.14000000000001","refractivity":"78.27800000000002","polarizability":"28.084089503341733","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"1.722863428948461","pka_strongest_acidic":"12.555019455927592","bioavailability":"1","number_of_rings":"3","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":19889834,"citation":"Boer, V. M., Crutchfield, C. A., Bradley, P. H., Botstein, D., Rabinowitz, J. D. (2010). \"Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations.\" Mol Biol Cell 21:198-211."}],"proteins":[]}