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PC(18:0/18:0) (YMDB01188)

Identification
YMDB IDYMDB01188
NamePC(18:0/18:0)
SpeciesSaccharomyces cerevisiae
StrainBrewer's yeast
DescriptionPC(18:0/18:0) is a phosphatidylchloline (PC). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, phosphatidylcholines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PC(18:0/18:0), in particular, consists of two octadecanoyl chains at positions C-1 and C-2. In E. coli, PCs can be found in the integral component of the cell outer membrane. They are hydrolyzed by Phospholipases to a 2-acylglycerophosphocholine and a carboxylate.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
  • 1,2-Diacyl-sn-glycero-3-phosphocholine
  • 1,2-distearoyl-rac-glycero-3-phosphocholine
  • 3-O-sn-Phosphatidyl-L-serine
  • 3-sn-Phosphatidylcholine
  • Choline phosphatide
  • GPCho(18:0/18:0)
  • GPCho(36:0)
  • Lecithin
  • Lecithins
  • O3-Phosphatidyl-L-serine
  • PC(18:0/18:0)
  • PC(36:0)
  • Phosphatidyl-L-serine
  • phosphatidyl-L-serines
  • Phosphatidyl-N-trimethylethanolamine
  • Phosphatidylcholine
  • Phosphatidylcholine(18:0/18:0)
  • Phosphatidylcholine(36:0)
  • 1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine
  • 1,2-Distearoyl-sn-3-phosphacholine
  • Distearoyl phosphatidylcholine
  • GPC(18:0/18:0)
  • PC (18:0)2
  • PC 18:0/18:0
  • 1,2-Distearoyl-sn-glycero-3-phosphocholine
  • 1,2-Distearoyllecithin, (S)-isomer
  • 1,2-Distearoyllecithin, (+-)-isomer
  • Distearoylglycerophosphocholine
  • 1,2-Distearoyllecithin
  • Distearoylphosphatidylcholine
  • 1,2-Distearoyllecithin, (R)-isomer
  • 1,2-Distearoylphosphatidylcholine
  • 1,2-Dioctadecanoyl-rac-glycero-3-phosphocholine
  • 4-Hydroxy-N,N,N-trimethyl-10-oxo-7-((1-oxooctadecyl)oxy)-3,5,9-trioxa-4-phosphahepta cosan-1-aminium hydroxide, inner salt, 4-oxide
CAS number8002-43-5
WeightAverage: 790.1452
Monoisotopic: 789.624755309
InChI KeyNRJAVPSFFCBXDT-HUESYALOSA-N
InChIInChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1
IUPAC Name(2-{[(2R)-2,3-bis(octadecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium
Traditional IUPAC Name(2-{[(2R)-2,3-bis(octadecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium
Chemical FormulaC44H88NO8P
SMILES[H][C@@](COC(=O)CCCCCCCCCCCCCCCCC)(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
Chemical Taxonomy
Description belongs to the class of organic compounds known as phosphatidylcholines. These are glycerophosphocholines in which the two free -OH are attached to one fatty acid each through an ester linkage.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphocholines
Direct ParentPhosphatidylcholines
Alternative Parents
Substituents
  • Diacylglycero-3-phosphocholine
  • Phosphocholine
  • Fatty acid ester
  • Dialkyl phosphate
  • Dicarboxylic acid or derivatives
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Fatty acyl
  • Quaternary ammonium salt
  • Tetraalkylammonium salt
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic nitrogen compound
  • Carbonyl group
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxide
  • Organopnictogen compound
  • Amine
  • Organic salt
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
StateSolid
Charge0
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
Water Solubility2.2e-05 g/LALOGPS
logP5.92ALOGPS
logP9.89ChemAxon
logS-7.6ALOGPS
pKa (Strongest Acidic)1.86ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area111.19 ŲChemAxon
Rotatable Bond Count44ChemAxon
Refractivity234.27 m³·mol⁻¹ChemAxon
Polarizability99.02 ųChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular LocationsNot Available
Organoleptic PropertiesNot Available
SMPDB Pathways
Glycerophospholipid metabolismPW002493 ThumbThumb?image type=greyscaleThumb?image type=simple
Lysolipid incorporation into ER PC(18:0/18:0)PW002787 ThumbThumb?image type=greyscaleThumb?image type=simple
Lysolipid incorporation into Mitochondria PC(18:0/18:0)PW002795 ThumbThumb?image type=greyscaleThumb?image type=simple
Phosphatidylcholine biosynthesis PC(18:0/18:0)PW002960 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Arachidonic acid metabolismec00590 Map00590
Glycerophospholipid metabolismec00564 Map00564
Linoleic acid metabolismec00591 Map00591
alpha-Linolenic acid metabolismec00592 Map00592
SMPDB Reactions
Citicoline + DG(18:0/18:0/0:0) → Cytidine monophosphate + hydron + PC(18:0/18:0)
PC(18:0/0:0) → PC(18:0/18:0)
PE-NMe2(18:0/18:0) + S-Adenosyl-L-methionine → S-Adenosylhomocysteine + hydron + PC(18:0/18:0)
KEGG ReactionsNot Available
Concentrations
Intracellular Concentrations
Intracellular ConcentrationSubstrateGrowth ConditionsStrainCitation
22250 ± 2525 umol/L SD media with 2% raffinose24 oCBY4741PMID: 19174513
24500 ± 3150 umol/L SD media with 2% raffinose37 oCBY4741PMID: 19174513
Conversion Details Here
Extracellular ConcentrationsNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 31V, negativesplash10-0089-0000000590-0aad18afe34a7c3e4d4cJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 39V, negativesplash10-00e9-0000000950-0e01653ba450f4cf2474JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 45V, negativesplash10-00e9-0030000910-5f5f6ea7c69c11446a37JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 52V, negativesplash10-0089-0090000600-450dc346ec045426f41aJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 58V, negativesplash10-001i-0090000200-ac0ebb03ecad4a755352JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 64V, negativesplash10-001i-0090000000-0cda3c7a3fd1efdab660JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 78V, negativesplash10-001i-0090000000-8039839adbbb06bce8ccJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 97V, negativesplash10-001i-0090000000-32180842465e1f0ca062JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 118V, negativesplash10-001i-0090000000-add4cfd543c3c7500150JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 143V, negativesplash10-001i-1090000000-731977fa0efe340b2c9bJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 170V, negativesplash10-003r-6090000000-10e012ff7fe106b8a5f0JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 210V, negativesplash10-004i-9000000000-003f91760dbf6d21ebe7JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - n/a 55V, negativesplash10-00di-0000000900-ed2638f28be0dc446783JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 22V, positivesplash10-0006-0000000900-08c46febfbe4ee762593JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 34V, positivesplash10-000x-0600000900-f13e1162895079b39581JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 48V, positivesplash10-001i-0900000000-095cbcd6f3947470459dJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 74V, positivesplash10-001i-0900000000-b0b68022ed94da51246cJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 99V, positivesplash10-001i-2900000000-552209425d26c02a0476JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 124V, positivesplash10-008i-6900000000-b39bf3dd8da792e30123JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 161V, positivesplash10-0079-9600000000-6622c8393c18efd1dd28JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 198V, positivesplash10-007a-9400000000-a1be01e41d76c34ddef8JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 236V, positivesplash10-0072-9200000000-df8e8bf2dc44c5e36e28JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0006-0000000900-ddeff1f077816b130f0bJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000x-0600000900-cbf5b5700da15bd27fafJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-1900021300-9f90c5ee485e939b0d38JSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
References
References:
  • Ejsing, C. S., Sampaio, J. L., Surendranath, V., Duchoslav, E., Ekroos, K., Klemm, R. W., Simons, K., Shevchenko, A. (2009). "Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry." Proc Natl Acad Sci U S A 106:2136-2141.19174513
Synthesis Reference:Not Available
External Links:
ResourceLink
CHEBI ID18303
HMDB IDHMDB08036
Pubchem Compound ID6323481
Kegg IDC00157
ChemSpider ID85004
FOODB IDFDB025227
WikipediaLecithin
BioCyc IDPHOSPHATIDYLCHOLINE

Enzymes

Protein Details
1. Cholinephosphotransferase 1
General function:
Involved in phosphotransferase activity, for other substituted phosphate groups
Specific function:
Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. The multiple transmembrane domains and lumenal hydrophilic domains of the cholinephosphotransferase might participate in the transport process
Gene Name:
CPT1
Uniprot ID:
P17898
Molecular weight:
44829.0
Reactions
CDP-choline + 1,2-diacylglycerol → CMP + a phosphatidylcholine.
Protein Details
2. Methylene-fatty-acyl-phospholipid synthase
General function:
Involved in N-methyltransferase activity
Specific function:
S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid
Gene Name:
OPI3
Uniprot ID:
P05375
Molecular weight:
23150.09961
Reactions
S-adenosyl-L-methionine + phospholipid olefinic fatty acid → S-adenosyl-L-homocysteine + phospholipid methylene fatty acid.