{"ymdb_id":"YMDB01170","created_at":"2011-07-24T19:09:10.000Z","updated_at":"2016-10-17T22:34:49.000Z","name":"PA(18:1(9Z)/0:0)","cas":"22002-87-5","state":"Solid","melting_point":null,"description":"LPA(18:1(9Z)/0:0) is a lysophosphatidic acid. Lysophosphatidic acid is the simplest possible glycerophospholipid and the biosynthetic precursor of phosphatidic acid.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm;Endoplasmic reticulum;Mitochondrion membrane","synthesis_reference":null,"chebi_id":"52288","hmdb_id":null,"kegg_id":"C00681","pubchem_id":"5311263","cs_id":"4470776","foodb_id":null,"wikipedia_link":"Lysophosphatidic_acid","biocyc_id":null,"iupac":"[(2R)-2-hydroxy-3-[(9Z)-octadec-9-enoyloxy]propoxy]phosphonic acid","traditional_iupac":"1-oleoyl lysophosphatidic acid","logp":"5.485689521666666","pka":"6.531115837556447","alogps_solubility":"1.64e-03 g/l","alogps_logp":"4.69","alogps_logs":"-5.43","acceptor_count":"5","donor_count":"3","rotatable_bond_count":"21","polar_surface_area":"113.29000000000002","refractivity":"115.29899999999998","polarizability":"49.155153434673906","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.4039997949880556","pka_strongest_acidic":"1.505317785248875","bioavailability":"0","number_of_rings":"0","rule_of_five":"0","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["1-Acyl-sn-glycerol 3-phosphate","2-Lysophosphatidate","LPA","Lysophosphatidate"],"pathways":[{"name":"Glycerolipid metabolism","kegg_map_id":"00561"},{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"}],"growth_conditions":[],"references":[{"pubmed_id":19174513,"citation":"Ejsing, C. S., Sampaio, J. L., Surendranath, V., Duchoslav, E., Ekroos, K., Klemm, R. W., Simons, K., Shevchenko, A. (2009). \"Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry.\" Proc Natl Acad Sci U S A 106:2136-2141."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":14642771,"citation":"Oshiro, J., Han, G. S., Carman, G. M. (2003). \"Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae.\" Biochim Biophys Acta 1635:1-9."}],"proteins":[{"created_at":"2011-05-27T08:00:44.000Z","updated_at":"2011-05-27T15:01:29.000Z","name":"Lipid phosphate phosphatase 1","uniprot_id":"Q04396","uniprot_name":"LPP1_YEAST","enzyme":true,"transporter":false,"gene_name":"LPP1","num_residues":274,"molecular_weight":"31585.90039","theoretical_pi":"8.4","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the dephosphorylation of diacylglycerol phosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with DPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is PA \u003e DGPP \u003e LPA","reactions":[{"id":1717,"direction":"\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2817,"direction":"\u003e","locations":"Golgi apparatus membrane; Multi-pass membrane protein;Vacuole membrane","altext":"A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2818,"direction":"\u003e","locations":"Golgi apparatus membrane; Multi-pass membrane protein;Vacuole membrane","altext":"Diacylglycerol pyrophosphate + H(2)O = phosphatidate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"16-33;70-87;118-139;190-203;215-231;238-255","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Multi-pass membrane protein","genbank_gene_id":"AY693191","genbank_protein_id":"51013833","gene_card_id":"LPP1","chromosome_location":"chromosome 4","locus":"YDR503C","synonyms":["Phosphatidate phosphatase"],"enzyme_classes":["3.1.3.-","3.1.3.4"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PAP2","identifier":"PF01569"}],"pathways":[{"name":"Glycerolipid metabolism","kegg_map_id":"00561"},{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Ether lipid metabolism","kegg_map_id":"00565"},{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGATCTCTGTCATGGCGGATGAGAAACATAAGGAGTATTTTAAGCTATACTACTTTCAGTACATGATAATTGGTCTATGTACGATATTATTCCTCTATTCGGAGATATCCCTGGTACCTAGGGGCCAAAACATCGAATTTAGTCTTGATGACCCCAGTATATCAAAACGTTATGTACCTAACGAACTCGTGGGCCCACTAGAATGTTTGATTTTGAGTGTTGGACTGAGTAACATGGTCGTCTTCTGGACCTGCATGTTTGACAAGGACTTACTGAAGAAGAATAGAGTAAAGAGACTAAGAGAGAGGCCGGACGGAATCTCGAACGATTTTCACTTCATGCATACTAGCATTCTATGTCTGATGCTGATTATAAGCATAAATGCTGCCCTAACAGGCGCCTTAAAGTTGATTATAGGAAACTTGAGGCCTGACTTTGTTGATAGATGTATACCTGACCTCCAAAAGATGAGTGATTCAGATTCTTTGGTTTTTGGCTTGGACATTTGCAAGCAGACTAACAAATGGATTCTATACGAAGGCTTAAAAAGCACTCCAAGCGGACATTCAAGTTTCATAGTCAGTACCATGGGCTTTACATATCTTTGGCAAAGGGTTTTCACCACACGCAATACAAGAAGTTGCATTTGGTGCCCTTTATTAGCTCTAGTAGTAATGGTTTCAAGGGTTATCGATCACAGACATCATTGGTACGATGTTGTCTCTGGAGCTGTTCTAGCATTTTTAGTCATTTATTGTTGCTGGAAATGGACATTTACAAACTTGGCGAAAAGAGACATACTTCCTTCACCGGTTAGTGTTTAG","protein_sequence":"MISVMADEKHKEYFKLYYFQYMIIGLCTILFLYSEISLVPRGQNIEFSLDDPSISKRYVPNELVGPLECLILSVGLSNMVVFWTCMFDKDLLKKNRVKRLRERPDGISNDFHFMHTSILCLMLIISINAALTGALKLIIGNLRPDFVDRCIPDLQKMSDSDSLVFGLDICKQTNKWILYEGLKSTPSGHSSFIVSTMGFTYLWQRVFTTRNTRSCIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKWTFTNLAKRDILPSPVSV"},{"created_at":"2011-05-27T08:13:01.000Z","updated_at":"2011-07-22T17:54:36.000Z","name":"Diacylglycerol pyrophosphate phosphatase 1","uniprot_id":"Q05521","uniprot_name":"DPP1_YEAST","enzyme":true,"transporter":false,"gene_name":"DPP1","num_residues":289,"molecular_weight":"33513.60156","theoretical_pi":"6.42","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the dephosphorylation of diacylglycerol phosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with LPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is DGPP \u003e LPA \u003e PA","reactions":[{"id":1451,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2817,"direction":"\u003e","locations":"Golgi apparatus membrane; Multi-pass membrane protein;Vacuole membrane","altext":"A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2818,"direction":"\u003e","locations":"Golgi apparatus membrane; Multi-pass membrane protein;Vacuole membrane","altext":"Diacylglycerol pyrophosphate + H(2)O = phosphatidate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"22-42;66-86;93-113;173-193;194-214;223-243","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"AY557744","genbank_protein_id":"45269379","gene_card_id":"DPP1","chromosome_location":"chromosome 4","locus":"YDR284C","synonyms":["DGPP phosphatase","Phosphatidate phosphatase"],"enzyme_classes":["3.1.3.-","3.1.3.4"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PAP2","identifier":"PF01569"}],"pathways":[{"name":"Glycerolipid metabolism","kegg_map_id":"00561"},{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"},{"name":"Ether lipid metabolism","kegg_map_id":"00565"},{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGAACAGAGTTTCGTTTATTAAAACGCCTTTCAACATAGGGGCGAAATGGAGATTAGAAGATGTCTTTTTGCTCATTATCATGATACTTCTTAACTACCCAGTGTATTACCAACAACCGTTCGAACGTCAGTTTTACATTAACGATCTCACTATATCGCATCCTTATGCGACAACTGAACGTGTAAATAACAACATGTTGTTTGTTTATAGTTTTGTCGTGCCATCTTTAACCATATTGATAATTGGTTCCATTTTGGCCGATAGAAGACACTTGATTTTTATTTTGTACACATCTCTCCTTGGTTTATCACTCGCTTGGTTCAGTACGAGTTTCTTTACAAACTTCATCAAGAATTGGATTGGAAGACTAAGACCAGATTTTCTAGATCGTTGCCAACCTGTTGAAGGCTTGCCATTGGACACTTTATTTACTGCAAAAGATGTGTGTACGACTAAGAATCACGAACGTCTGTTGGATGGGTTTAGGACAACTCCGTCAGGTCATTCAAGTGAAAGCTTTGCAGGACTGGGTTATTTGTACTTCTGGCTATGTGGGCAACTTTTGACTGAATCACCGTTGATGCCTTTATGGAGAAAAATGGTGGCCTTTCTACCACTGTTAGGAGCTGCACTAATTGCTCTATCCAGAACTCAAGATTACAGACATCATTTCGTCGATGTAATTTTAGGGTCTATGTTGGGTTATATAATGGCACACTTTTTCTACAGAAGAATCTTCCCACCCATTGATGATCCTCTTCCGTTCAAACCATTGATGGACGATTCAGATGTCACCCTGGAGGAAGCAGTCACCCATCAGAGGATCCCGGATGAGGAATTACATCCTTTGTCCGATGAAGGTATGTAA","protein_sequence":"MNRVSFIKTPFNIGAKWRLEDVFLLIIMILLNYPVYYQQPFERQFYINDLTISHPYATTERVNNNMLFVYSFVVPSLTILIIGSILADRRHLIFILYTSLLGLSLAWFSTSFFTNFIKNWIGRLRPDFLDRCQPVEGLPLDTLFTAKDVCTTKNHERLLDGFRTTPSGHSSESFAGLGYLYFWLCGQLLTESPLMPLWRKMVAFLPLLGAALIALSRTQDYRHHFVDVILGSMLGYIMAHFFYRRIFPPIDDPLPFKPLMDDSDVTLEEAVTHQRIPDEELHPLSDEGM"}]}