{"ymdb_id":"YMDB01110","created_at":"2011-07-24T19:02:01.000Z","updated_at":"2016-10-18T17:11:46.000Z","name":"Cer 20:0;3/26:0;1","cas":null,"state":null,"melting_point":null,"description":"\u003cp\u003eCer 20:0;3/26:0;1 is a ceramide. Ceramides are composed of a sphingosine and a fatty acid. Ceramides are found in high concentrations within the cell membrane of cells. Caramides are known to promote transport of secretory vesicles from the ER to the Golgi apparatus. Sphingolipids like ceramide play import roles in lipid rafts which in yeast are responsible for delivering and sorting membrane bound proteins. Lipid rafts also play roles in membrane fusion during mating.[PMID: 16730802]\u003c/p\u003e\n\n\u003cp\u003eThere are three major pathways of ceramide generation. The sphingomyelinase pathway uses an enzyme to breakdown IPC, MIPC and M(IP)2C in the cell membrane and release ceramide. The de novo pathway creates ceramide from less complex molecules. Ceramide generation can also occur through breakdown of complex sphingolipids that are ultimately broken down into sphingosine, which is then reused by reacylation to form ceramide. This latter pathway is termed the Salvage pathway.[Wikipedia, PMID: 16730802]\u003c/p\u003e","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(9R)-9-hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxyicosan-2-yl]hexacosanamide","traditional_iupac":"(9R)-9-hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxyicosan-2-yl]hexacosanamide","logp":"13.944571186333338","pka":"14.385631960970802","alogps_solubility":"6.31e-05 g/l","alogps_logp":"9.58","alogps_logs":"-7.07","acceptor_count":"5","donor_count":"5","rotatable_bond_count":"43","polar_surface_area":"110.02","refractivity":"223.0561","polarizability":"100.58337103906975","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"0.050485364092658136","pka_strongest_acidic":"13.209740656153702","bioavailability":"0","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[],"growth_conditions":[{"growth_media":"SD media with 2% raffinose","concentration":"14750.0","concentration_units":"umol/L","error":"11775.0"}],"references":[{"pubmed_id":19174513,"citation":"Ejsing, C. S., Sampaio, J. L., Surendranath, V., Duchoslav, E., Ekroos, K., Klemm, R. W., Simons, K., Shevchenko, A. (2009). \"Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry.\" Proc Natl Acad Sci U S A 106:2136-2141."},{"pubmed_id":18296751,"citation":"Dickson, R. C. (2008). \"Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast.\" J Lipid Res 49:909-921."}],"proteins":[]}