{"ymdb_id":"YMDB00998","created_at":"2011-06-14T19:34:30.000Z","updated_at":"2016-09-08T18:36:08.000Z","name":"D-Tryptophan","cas":"153-94-6","state":"Solid","melting_point":"230 oC","description":"Tryptophan (abbreviated as Trp or W) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. D-isomers are used as carbon, nitrogen, and energy source. D-Tryptophan is occasionally found in naturally produced peptides (for example, the marine venom peptide contryphan). Tryptophan is the precursor of serotonin.","experimental_water_solubility":"13.4 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-1.06 [HANSCH,C ET AL. (1995)]","location":null,"synthesis_reference":null,"chebi_id":"16296","hmdb_id":"HMDB13609","kegg_id":"C00525","pubchem_id":"9060","cs_id":"8707","foodb_id":null,"wikipedia_link":"Tryptophan","biocyc_id":"D-TRYPTOPHAN","iupac":"(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid","traditional_iupac":"D-tryptophan","logp":"-1.0854569138833579","pka":"16.1565885064574","alogps_solubility":"1.36e+00 g/l","alogps_logp":"-1.10","alogps_logs":"-2.18","acceptor_count":"3","donor_count":"3","rotatable_bond_count":"3","polar_surface_area":"79.11000000000001","refractivity":"56.20280000000002","polarizability":"21.167931614481088","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.396082567807317","pka_strongest_acidic":"2.5439286383469866","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(+)-tryptophan","(2R)-2-amino-3-(1H-indol-3-yl)propanoate","(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid","(R)-(+)-2-Amino-3-(3-indolyl)propionic acid","(R)-2-Amino-3-(3-indolyl)propionic acid","(r)-tryptophan","D-(+)-tryptophan","D-alpha-Amino-3-indolepropionic acid","D-Tryptophan","D-tryptophane","D-trytophane","delta-(+)-tryptophan","delta-alpha-Amino-3-indolepropionic acid","delta-tryptophane","delta-trytophane","DL-tryptophan","DTR","H-d-TRP-oh","H-delta-TRP-oh","Tryptophan","Tryptophan, D-"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":15375647,"citation":"Yow, G. Y., Uo, T., Yoshimura, T., Esaki, N. (2004). \"D-amino acid N-acetyltransferase of Saccharomyces cerevisiae: a close homologue of histone acetyltransferase Hpa2p acting exclusively on free D-amino acids.\" Arch Microbiol 182:396-403."}],"proteins":[{"created_at":"2011-05-26T23:37:41.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"N-acetyltransferase HPA3","uniprot_id":"P39979","uniprot_name":"HPA3_YEAST","enzyme":true,"transporter":false,"gene_name":"HPA3","num_residues":179,"molecular_weight":"20698.5","theoretical_pi":"7.84","general_function":"Involved in N-acetyltransferase activity","specific_function":"N-acetyltransferase whose physiological acetyl acceptor substrate is still unknown. In vitro, histone acetylation is very weak","reactions":[{"id":2617,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U18795","genbank_protein_id":"603252","gene_card_id":"HPA3","chromosome_location":"chromosome 5","locus":"YEL066W","synonyms":[],"enzyme_classes":["2.3.1.-","2.3.1.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" acetyltransferase activity"},{"category":"Function","description":" N-acetyltransferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Acetyltransf_1","identifier":"PF00583"}],"pathways":[],"gene_sequence":"ATGAAAAAGACCCCAGACCCATCTCCACCTTTTGCAAGCACGAAGAACGTAGGCATGTCAAACGAAGAACCGGAAAAAATGGTTAACGATCGAATTGTGGTGAAGGCCATCGAGCCAAAAGATGAGGAAGCCTGGAACAAACTGTGGAAGGAGTATCAGGGTTTCCAAAAAACGGTTATGCCTCCGGAAGTAGCCACCACTACCTTCGCAAGGTTTATAGACCCTACGGTCAAACTATGGGGTGCTCTAGCCTTTGACACCGAGACCGGCGATGCAATTGGCTTTGCACACTACCTGAACCATTTGACGTCGTGGCATGTCGAAGAAGTTGTCTACATGAATGACTTATATGTCACTGAACGCGCAAGAGTCAAAGGCGTAGGTAGAAAGCTCATAGAATTTGTATACAGCCGTGCCGATGAGCTCGGTACGCCTGCAGTGTACTGGGTTACAGACCATTACAATCACCGCGCACAGTTGCTGTACACCAAAGTGGCTTACAAGACAGATAAGGTTCTTTACAAGAGAAACGGATACTGA","protein_sequence":"MKKTPDPSPPFASTKNVGMSNEEPEKMVNDRIVVKAIEPKDEEAWNKLWKEYQGFQKTVMPPEVATTTFARFIDPTVKLWGALAFDTETGDAIGFAHYLNHLTSWHVEEVVYMNDLYVTERARVKGVGRKLIEFVYSRADELGTPAVYWVTDHYNHRAQLLYTKVAYKTDKVLYKRNGY"}]}