{"ymdb_id":"YMDB00991","created_at":"2011-06-14T19:33:50.000Z","updated_at":"2016-09-08T18:36:07.000Z","name":"N-acetyl-D-methionine","cas":"1509-92-8","state":null,"melting_point":null,"description":"N-Acetyl-D-methionine is an N-acetyl aminoacid. It is a detoxified version of D-methionine. D-Amino acids inhibit the growth of S. cerevisiae. D-amino acid-N-acetyltransferase detoxifies D-amino acids by the addition of an acetyl group. [PMID: 16362288]","experimental_water_solubility":"307 mg/mL at 25 oC [BEILSTEIN]","experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":"","hmdb_id":"","kegg_id":"","pubchem_id":"6991987","cs_id":"5360153","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2R)-2-acetamido-4-(methylsulfanyl)butanoic acid","traditional_iupac":"D-methionine, N-acetyl-","logp":"-0.10843633333333366","pka":"15.74609503889521","alogps_solubility":"6.84e+00 g/l","alogps_logp":"-0.15","alogps_logs":"-1.45","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"5","polar_surface_area":"66.4","refractivity":"47.02980000000001","polarizability":"19.446019728848825","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-1.1661318801485798","pka_strongest_acidic":"4.023634209549613","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2R)-2-acetamido-4-(Methylsulfanyl)butanoate","(2R)-2-acetamido-4-(Methylsulfanyl)butanoic acid","(2R)-2-acetamido-4-(Methylsulphanyl)butanoate","(2R)-2-acetamido-4-(Methylsulphanyl)butanoic acid","(2R)-N-Acetylmethionine","(R)-N-Acetylmethionine"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":15375647,"citation":"Yow, G. Y., Uo, T., Yoshimura, T., Esaki, N. (2004). \"D-amino acid N-acetyltransferase of Saccharomyces cerevisiae: a close homologue of histone acetyltransferase Hpa2p acting exclusively on free D-amino acids.\" Arch Microbiol 182:396-403."},{"pubmed_id":16362288,"citation":"Yow, G. Y., Uo, T., Yoshimura, T., Esaki, N. (2006). \"Physiological role of D-amino acid-N-acetyltransferase of Saccharomyces cerevisiae: detoxification of D-amino acids.\" Arch Microbiol 185:39-46."}],"proteins":[{"created_at":"2011-05-26T23:37:41.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"N-acetyltransferase HPA3","uniprot_id":"P39979","uniprot_name":"HPA3_YEAST","enzyme":true,"transporter":false,"gene_name":"HPA3","num_residues":179,"molecular_weight":"20698.5","theoretical_pi":"7.84","general_function":"Involved in N-acetyltransferase activity","specific_function":"N-acetyltransferase whose physiological acetyl acceptor substrate is still unknown. In vitro, histone acetylation is very weak","reactions":[{"id":2617,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U18795","genbank_protein_id":"603252","gene_card_id":"HPA3","chromosome_location":"chromosome 5","locus":"YEL066W","synonyms":[],"enzyme_classes":["2.3.1.-","2.3.1.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" acetyltransferase activity"},{"category":"Function","description":" N-acetyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Acetyltransf_1","identifier":"PF00583"}],"pathways":[],"gene_sequence":"ATGAAAAAGACCCCAGACCCATCTCCACCTTTTGCAAGCACGAAGAACGTAGGCATGTCAAACGAAGAACCGGAAAAAATGGTTAACGATCGAATTGTGGTGAAGGCCATCGAGCCAAAAGATGAGGAAGCCTGGAACAAACTGTGGAAGGAGTATCAGGGTTTCCAAAAAACGGTTATGCCTCCGGAAGTAGCCACCACTACCTTCGCAAGGTTTATAGACCCTACGGTCAAACTATGGGGTGCTCTAGCCTTTGACACCGAGACCGGCGATGCAATTGGCTTTGCACACTACCTGAACCATTTGACGTCGTGGCATGTCGAAGAAGTTGTCTACATGAATGACTTATATGTCACTGAACGCGCAAGAGTCAAAGGCGTAGGTAGAAAGCTCATAGAATTTGTATACAGCCGTGCCGATGAGCTCGGTACGCCTGCAGTGTACTGGGTTACAGACCATTACAATCACCGCGCACAGTTGCTGTACACCAAAGTGGCTTACAAGACAGATAAGGTTCTTTACAAGAGAAACGGATACTGA","protein_sequence":"MKKTPDPSPPFASTKNVGMSNEEPEKMVNDRIVVKAIEPKDEEAWNKLWKEYQGFQKTVMPPEVATTTFARFIDPTVKLWGALAFDTETGDAIGFAHYLNHLTSWHVEEVVYMNDLYVTERARVKGVGRKLIEFVYSRADELGTPAVYWVTDHYNHRAQLLYTKVAYKTDKVLYKRNGY"}]}