{"ymdb_id":"YMDB00986","created_at":"2011-06-14T19:23:37.000Z","updated_at":"2016-09-08T18:36:07.000Z","name":"7-Methylguanine","cas":"578-76-7","state":"Solid","melting_point":"370 oC","description":"7-Methylguanine (also referred to as 7-methylguanylate cap, abbreviated m7G) is a methylated guanine nucleotide found at the 5' end of an mRNA: this structure is called 5' cap. The process of 5' capping is vital to creating mature mRNA, which is then able to undergo translation. Capping ensures the mRNA's stability while it undergoes translation in the process of protein synthesis, and is a highly regulated process that occurs in the cell nucleus.\n","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":"Adams, Benjamin L.  De-D-ribosylation of 7-alkylpurine D-ribonucleosides by a reduction-displacement procedure.  Conversion of 7-methylguanosine into 7-methylguanine.    Nucleic Acid Chem.  (1978),  2  615-17. ","chebi_id":"28664","hmdb_id":"HMDB00897","kegg_id":"C02242","pubchem_id":"11361","cs_id":"10883","foodb_id":null,"wikipedia_link":"5'_cap","biocyc_id":null,"iupac":"2-amino-7-methyl-6,7-dihydro-3H-purin-6-one","traditional_iupac":"2-amino-7-methylhypoxanthine","logp":"-0.3656628686666665","pka":null,"alogps_solubility":"6.12e+00 g/l","alogps_logp":"-0.62","alogps_logs":"-1.43","acceptor_count":"5","donor_count":"2","rotatable_bond_count":"0","polar_surface_area":"85.3","refractivity":"43.797799999999995","polarizability":"15.410738215147513","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"2.066735324909107","pka_strongest_acidic":"9.351073076855275","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-amino-1,7-dihydro-7-methyl-6H-purin-6-one","2-amino-1,7-dihydroxy-7-methyl-6H-purine-6-one","2-Amino-6-hydroxy-7-methylpurine","2-Amino-7-methyl-1,7-dihydro-6H-purin-6-one","2-amino-7-methyl-7H-purin-6-ol","2-Amino-7-methylhypoxanthine","6H-Purin-6-one, 2-amino-1, 7-dihydro-7-methyl-","6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-","7-methyl-Guanine","7-methylguanine","Guanine, 7-methyl-","N-Methylguanine","N(7)-methylguanine","N7-Methylguanine"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":10440863,"citation":"Wyatt, M. D., Allan, J. M., Lau, A. Y., Ellenberger, T. E., Samson, L. D. (1999). \"3-methyladenine DNA glycosylases: structure, function, and biological importance.\" Bioessays 21:668-676."}],"proteins":[{"created_at":"2011-06-14T19:23:36.000Z","updated_at":"2011-06-14T19:23:36.000Z","name":"DNA-3-methyladenine glycosylase","uniprot_id":"P22134","uniprot_name":"MAG_YEAST","enzyme":true,"transporter":false,"gene_name":"MAG1","num_residues":296,"molecular_weight":"34332.5","theoretical_pi":"8.26","general_function":"Involved in alkylbase DNA N-glycosylase activity","specific_function":"Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"AY692938","genbank_protein_id":"51013327","gene_card_id":"MAG1","chromosome_location":"chromosome 5","locus":"YER142C","synonyms":["3-methyladenine DNA glycosidase","3MEA DNA glycosylase"],"enzyme_classes":["3.2.2.21"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on glycosyl bonds"},{"category":"Function","description":" nucleic acid binding"},{"category":"Function","description":" hydrolase activity, hydrolyzing N-glycosyl compounds"},{"category":"Function","description":" DNA binding"},{"category":"Function","description":" DNA N-glycosylase activity"},{"category":"Function","description":" alkylbase DNA N-glycosylase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" DNA metabolic process"},{"category":"Process","description":" DNA repair"},{"category":"Process","description":" base-excision repair"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"}],"pfams":[{"name":"HhH-GPD","identifier":"PF00730"}],"pathways":[],"gene_sequence":"ATGAAACTAAAAAGGGAGTATGATGAGTTAATAAAAGCAGACGCTGTTAAGGAAATAGCAAAAGAATTAGGGTCTCGACCTCTAGAGGTTGCTCTTCCTGAGAAATATATTGCTAGACATGAAGAAAAGTTCAATATGGCTTGCGAACACATTTTAGAGAAAGATCCATCACTTTTTCCCATACTTAAGAATAATGAATTTACGTTGTACTTGAAGGAGACTCAAGTCCCTAATACACTCGAAGATTATTTTATTAGGCTTGCAAGCACAATTTTGTCTCAACAGATCAGTGGCCAAGCAGCTGAAAGCATCAAGGCAAGGGTTGTCAGTCTTTATGGCGGTGCATTTCCTGATTACAAAATCCTTTTCGAAGACTTCAAAGACCCAGCAAAATGTGCAGAAATCGCAAAATGTGGATTGAGTAAAAGGAAAATGATATATCTAGAGTCTCTTGCTGTCTATTTTACTGAAAAATATAAGGATATCGAAAAGCTCTTCGGTCAAAAAGATAATGATGAGGAAGTGATTGAAAGTTTAGTTACGAATGTAAAAGGTATAGGCCCATGGAGTGCCAAAATGTTCTTGATCTCCGGATTGAAAAGAATGGATGTATTTGCTCCTGAAGATCTAGGTATTGCTAGGGGTTTTTCAAAATACCTTTCAGATAAGCCAGAATTGGAAAAAGAATTAATGCGTGAAAGAAAAGTAGTTAAAAAGAGTAAGATTAAGCATAAGAAATACAACTGGAAAATATATGACGACGACATAATGGAAAAATGCTCTGAAACATTTTCTCCGTATAGGTCTGTGTTTATGTTCATACTTTGGAGGCTCGCGAGCACAAATACAGATGCCATGATGAAGGCAGAAGAAAATTTCGTGAAATCCTAA","protein_sequence":"MKLKREYDELIKADAVKEIAKELGSRPLEVALPEKYIARHEEKFNMACEHILEKDPSLFPILKNNEFTLYLKETQVPNTLEDYFIRLASTILSQQISGQAAESIKARVVSLYGGAFPDYKILFEDFKDPAKCAEIAKCGLSKRKMIYLESLAVYFTEKYKDIEKLFGQKDNDEEVIESLVTNVKGIGPWSAKMFLISGLKRMDVFAPEDLGIARGFSKYLSDKPELEKELMRERKVVKKSKIKHKKYNWKIYDDDIMEKCSETFSPYRSVFMFILWRLASTNTDAMMKAEENFVKS"}]}