{"ymdb_id":"YMDB00982","created_at":"2011-06-14T17:59:34.000Z","updated_at":"2016-09-08T18:36:07.000Z","name":"no","cas":"10102-43-9","state":"Gas","melting_point":"-163.6 oC","description":"Nitric oxide (NO) is a biologically active molecule with multiple cellular molecular targets. It may act as a hormone, neurotransmitter, paracrine messenger, mediator, cytoprotective and cytotoxic molecule. It influences the activity of transcription factors, modulates upstream signaling cascades, mRNA stability and translation, and processes the primary gene products.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":null,"synthesis_reference":"Morabito, Paul; Heicklen, Julian. Disproportionation to combination ratios of alkoxy radicals with nitric oxide. Journal of Physical Chemistry (1985), 89(13), 2914-16.","chebi_id":"16480","hmdb_id":"HMDB03378","kegg_id":"C00533","pubchem_id":"945","cs_id":"127983","foodb_id":null,"wikipedia_link":"Nitric_oxide","biocyc_id":"NITRIC-OXIDE","iupac":"nitroso","traditional_iupac":"nitric oxide","logp":"-0.3514","pka":null,"alogps_solubility":null,"alogps_logp":null,"alogps_logs":null,"acceptor_count":"2","donor_count":"0","rotatable_bond_count":"0","polar_surface_area":"34.14","refractivity":"2.8858","polarizability":"1.6908497027346385","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-2.9121689657156256","pka_strongest_acidic":null,"bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"1","mddr_like_rule":"0","synonyms":["Mononitrogen monoxide","Nitric oxide","Nitrogen monoxide","Nitrogen oxide","nitrogen protoxide","Nitrosyl hydride","Nitrosyl radical","Nitroxide radical","Nitroxyl"],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":15598505,"citation":"Gardner, P. R. (2005). \"Nitric oxide dioxygenase function and mechanism of flavohemoglobin, hemoglobin, myoglobin and their associated reductases.\" J Inorg Biochem 99:247-266."}],"proteins":[{"created_at":"2011-06-14T17:59:30.000Z","updated_at":"2011-06-14T17:59:30.000Z","name":"Flavohemoprotein","uniprot_id":"P39676","uniprot_name":"FHP_YEAST","enzyme":true,"transporter":false,"gene_name":"YHB1","num_residues":399,"molecular_weight":"44646.0","theoretical_pi":"6.24","general_function":"Involved in oxidoreductase activity","specific_function":"In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity","reactions":[{"id":2850,"direction":"\u003e","locations":"Cytoplasm","altext":"2 NO + 2 O(2) + NAD(P)H = 2 NO(3)(-) + NAD(P)(+).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692964","genbank_protein_id":"51013379","gene_card_id":"YHB1","chromosome_location":"chromosome 7","locus":"YGR234W","synonyms":["Flavohemoglobin","Hemoglobin-like protein","Nitric oxide dioxygenase","NO oxygenase","NOD"],"enzyme_classes":["1.14.12.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" oxygen binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" gas transport"},{"category":"Process","description":" oxygen transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FAD_binding_6","identifier":"PF00970"},{"name":"NAD_binding_1","identifier":"PF00175"},{"name":"Globin","identifier":"PF00042"}],"pathways":[],"gene_sequence":"ATGCTAGCCGAAAAAACCCGTTCCATAATCAAAGCAACCGTTCCTGTTTTGGAACAGCAGGGCACTGTCATCACGCGTACATTCTACAAAAATATGCTTACTGAACACACCGAATTACTTAATATTTTTAACAGAACTAATCAAAAGGTTGGCGCACAACCAAATGCCTTGGCCACTACTGTTTTGGCAGCGGCTAAGAACATTGACGATTTGTCTGTGCTTATGGACCATGTCAAGCAAATTGGCCACAAGCATCGTGCCTTGCAAATTAAACCTGAGCATTATCCAATCGTTGGTGAGTACTTGTTAAAAGCAATCAAGGAAGTTTTAGGCGATGCTGCGACTCCAGAGATAATTAATGCATGGGGCGAGGCTTACCAAGCAATTGCTGACATCTTCATCACTGTTGAAAAAAAAATGTACGAAGAAGCTTTATGGCCAGGTTGGAAACCATTTGACATTACTGCCAAAGAGTACGTTGCTTCAGATATTGTTGAATTTACTGTTAAGCCAAAGTTCGGTTCTGGTATTGAATTGGAAAGCTTGCCAATCACTCCAGGTCAGTATATTACGGTAAACACTCACCCAATTAGACAGGAAAACCAATACGACGCTTTAAGACACTACTCTCTTTGTTCTGCTTCAACTAAAAATGGTTTACGATTTGCAGTAAAGATGGAAGCTGCCAGAGAAAATTTTCCTGCAGGATTAGTCTCTGAATATTTACACAAGGACGCTAAAGTTGGTGATGAAATTAAGCTTAGTGCTCCGGCTGGTGATTTCGCAATAAATAAAGAGTTGATACACCAAAACGAAGTTCCATTGGTGTTACTATCGTCTGGTGTTGGTGTTACACCACTTTTAGCTATGTTAGAAGAACAAGTCAAATGCAACCCAAATAGGCCAATTTACTGGATTCAATCTTCCTATGATGAAAAGACTCAAGCATTCAAAAAACATGTAGATGAACTATTAGCTGAATGTGCGAATGTCGACAAAATAATTGTTCATACTGATACTGAACCACTGATTAATGCTGCATTCTTGAAGGAAAAGTCACCTGCGCATGCCGATGTCTACACTTGCGGCTCTTTAGCTTTTATGCAAGCTATGATTGGTCATCTAAAAGAACTAGAGCATCGTGATGATATGATTCACTATGAACCATTTGGTCCAAAGATGTCAACCGTGCAAGTTTAG","protein_sequence":"MLAEKTRSIIKATVPVLEQQGTVITRTFYKNMLTEHTELLNIFNRTNQKVGAQPNALATTVLAAAKNIDDLSVLMDHVKQIGHKHRALQIKPEHYPIVGEYLLKAIKEVLGDAATPEIINAWGEAYQAIADIFITVEKKMYEEALWPGWKPFDITAKEYVASDIVEFTVKPKFGSGIELESLPITPGQYITVNTHPIRQENQYDALRHYSLCSASTKNGLRFAVKMEAARENFPAGLVSEYLHKDAKVGDEIKLSAPAGDFAINKELIHQNEVPLVLLSSGVGVTPLLAMLEEQVKCNPNRPIYWIQSSYDEKTQAFKKHVDELLAECANVDKIIVHTDTEPLINAAFLKEKSPAHADVYTCGSLAFMQAMIGHLKELEHRDDMIHYEPFGPKMSTVQV"}]}