{"ymdb_id":"YMDB00981","created_at":"2011-06-14T17:59:31.000Z","updated_at":"2016-09-08T18:36:07.000Z","name":"Nitrate","cas":"14797-55-8","state":"Solid","melting_point":null,"description":"The nitrate ion (NO3-) is the conjugate base of nitric acid. Nitrates should not be confused with nitrites, the salts of nitrous acid. Nitrate ions can be toxic.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":"17632","hmdb_id":"HMDB02878","kegg_id":"C00244","pubchem_id":"943","cs_id":"918","foodb_id":null,"wikipedia_link":"Nitrate","biocyc_id":"CPD-144","iupac":"nitrate","traditional_iupac":"nitrate","logp":"0.8368003898615884","pka":null,"alogps_solubility":null,"alogps_logp":null,"alogps_logs":null,"acceptor_count":"3","donor_count":"0","rotatable_bond_count":"0","polar_surface_area":"66.2","refractivity":"8.347100000000001","polarizability":"3.275441232355817","formal_charge":"-1","physiological_charge":"-1","pka_strongest_basic":"-9.93762264919614","pka_strongest_acidic":null,"bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Econazole Nitrate","Femstat 3","Ganite","Gynazole-1","Isordil","Isosorbide Dinitrate","Nitrate","Nitrate ion","Nitric acid","Sorbitrate","trioxidonitrate","trioxonitrate"],"pathways":[{"name":"Nitrogen metabolism","kegg_map_id":"00910"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":19850002,"citation":"Mowat, C. G., Gazur, B., Campbell, L. P., Chapman, S. K. (2010). \"Flavin-containing heme enzymes.\" Arch Biochem Biophys 493:37-52."}],"proteins":[{"created_at":"2011-06-14T17:59:30.000Z","updated_at":"2011-06-14T17:59:30.000Z","name":"Flavohemoprotein","uniprot_id":"P39676","uniprot_name":"FHP_YEAST","enzyme":true,"transporter":false,"gene_name":"YHB1","num_residues":399,"molecular_weight":"44646.0","theoretical_pi":"6.24","general_function":"Involved in oxidoreductase activity","specific_function":"In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity","reactions":[{"id":2850,"direction":"\u003e","locations":"Cytoplasm","altext":"2 NO + 2 O(2) + NAD(P)H = 2 NO(3)(-) + NAD(P)(+).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692964","genbank_protein_id":"51013379","gene_card_id":"YHB1","chromosome_location":"chromosome 7","locus":"YGR234W","synonyms":["Flavohemoglobin","Hemoglobin-like protein","Nitric oxide dioxygenase","NO oxygenase","NOD"],"enzyme_classes":["1.14.12.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" oxygen binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" gas transport"},{"category":"Process","description":" oxygen transport"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FAD_binding_6","identifier":"PF00970"},{"name":"NAD_binding_1","identifier":"PF00175"},{"name":"Globin","identifier":"PF00042"}],"pathways":[],"gene_sequence":"ATGCTAGCCGAAAAAACCCGTTCCATAATCAAAGCAACCGTTCCTGTTTTGGAACAGCAGGGCACTGTCATCACGCGTACATTCTACAAAAATATGCTTACTGAACACACCGAATTACTTAATATTTTTAACAGAACTAATCAAAAGGTTGGCGCACAACCAAATGCCTTGGCCACTACTGTTTTGGCAGCGGCTAAGAACATTGACGATTTGTCTGTGCTTATGGACCATGTCAAGCAAATTGGCCACAAGCATCGTGCCTTGCAAATTAAACCTGAGCATTATCCAATCGTTGGTGAGTACTTGTTAAAAGCAATCAAGGAAGTTTTAGGCGATGCTGCGACTCCAGAGATAATTAATGCATGGGGCGAGGCTTACCAAGCAATTGCTGACATCTTCATCACTGTTGAAAAAAAAATGTACGAAGAAGCTTTATGGCCAGGTTGGAAACCATTTGACATTACTGCCAAAGAGTACGTTGCTTCAGATATTGTTGAATTTACTGTTAAGCCAAAGTTCGGTTCTGGTATTGAATTGGAAAGCTTGCCAATCACTCCAGGTCAGTATATTACGGTAAACACTCACCCAATTAGACAGGAAAACCAATACGACGCTTTAAGACACTACTCTCTTTGTTCTGCTTCAACTAAAAATGGTTTACGATTTGCAGTAAAGATGGAAGCTGCCAGAGAAAATTTTCCTGCAGGATTAGTCTCTGAATATTTACACAAGGACGCTAAAGTTGGTGATGAAATTAAGCTTAGTGCTCCGGCTGGTGATTTCGCAATAAATAAAGAGTTGATACACCAAAACGAAGTTCCATTGGTGTTACTATCGTCTGGTGTTGGTGTTACACCACTTTTAGCTATGTTAGAAGAACAAGTCAAATGCAACCCAAATAGGCCAATTTACTGGATTCAATCTTCCTATGATGAAAAGACTCAAGCATTCAAAAAACATGTAGATGAACTATTAGCTGAATGTGCGAATGTCGACAAAATAATTGTTCATACTGATACTGAACCACTGATTAATGCTGCATTCTTGAAGGAAAAGTCACCTGCGCATGCCGATGTCTACACTTGCGGCTCTTTAGCTTTTATGCAAGCTATGATTGGTCATCTAAAAGAACTAGAGCATCGTGATGATATGATTCACTATGAACCATTTGGTCCAAAGATGTCAACCGTGCAAGTTTAG","protein_sequence":"MLAEKTRSIIKATVPVLEQQGTVITRTFYKNMLTEHTELLNIFNRTNQKVGAQPNALATTVLAAAKNIDDLSVLMDHVKQIGHKHRALQIKPEHYPIVGEYLLKAIKEVLGDAATPEIINAWGEAYQAIADIFITVEKKMYEEALWPGWKPFDITAKEYVASDIVEFTVKPKFGSGIELESLPITPGQYITVNTHPIRQENQYDALRHYSLCSASTKNGLRFAVKMEAARENFPAGLVSEYLHKDAKVGDEIKLSAPAGDFAINKELIHQNEVPLVLLSSGVGVTPLLAMLEEQVKCNPNRPIYWIQSSYDEKTQAFKKHVDELLAECANVDKIIVHTDTEPLINAAFLKEKSPAHADVYTCGSLAFMQAMIGHLKELEHRDDMIHYEPFGPKMSTVQV"}]}