{"ymdb_id":"YMDB00963","created_at":"2011-06-03T16:00:12.000Z","updated_at":"2016-09-08T18:36:05.000Z","name":"N-Tetracosanoylphytosphingosine","cas":null,"state":null,"melting_point":null,"description":"N-Tetracosanoylphytosphingosine is a phytoceramide compound having a tetracosanoyl group attached to the nitrogen atom. [ChEBI]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"endoplasmic reticulum","synthesis_reference":null,"chebi_id":"52979","hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]tetracosanamide","traditional_iupac":"N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]tetracosanamide","logp":"13.553015053333334","pka":"14.4413560488785","alogps_solubility":"4.38e-05 g/l","alogps_logp":"9.88","alogps_logs":"-7.18","acceptor_count":"4","donor_count":"4","rotatable_bond_count":"39","polar_surface_area":"89.79","refractivity":"202.9826","polarizability":"91.74061558502274","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"0.02944992997796647","pka_strongest_acidic":"13.262014760738879","bioavailability":"0","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["cer2_24","ceramide-2 (phytosphingosine:N-C24:0)"],"pathways":[{"name":"Biosynthesis of unsaturated fatty acids (tetracosanoyl-CoA)","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10900202,"citation":"Mao, C., Xu, R., Bielawska, A., Szulc, Z. M., Obeid, L. M. (2000). \"Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide.\" J Biol Chem 275:31369-31378."},{"pubmed_id":9872981,"citation":"Jiang, J. C., Kirchman, P. A., Zagulski, M., Hunt, J., Jazwinski, S. M. (1998). \"Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.\" Genome Res 8:1259-1272."}],"proteins":[{"created_at":"2011-05-24T21:19:36.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Alkaline ceramidase YDC1","uniprot_id":"Q02896","uniprot_name":"YDC1_YEAST","enzyme":true,"transporter":false,"gene_name":"YDC1","num_residues":317,"molecular_weight":"37230.5","theoretical_pi":"7.17","general_function":"Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides","specific_function":"Catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"43-60;67-89;99-121;134-156;160-182;203-225;240-262","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein","genbank_gene_id":"AF214455","genbank_protein_id":"10764171","gene_card_id":"YDC1","chromosome_location":"chromosome 16","locus":"YPL087W","synonyms":[],"enzyme_classes":["3.5.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" membrane lipid metabolic process"},{"category":"Process","description":" sphingolipid metabolic process"},{"category":"Process","description":" sphingoid metabolic process"},{"category":"Process","description":" ceramide metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"aPHC","identifier":"PF05875"}],"pathways":[],"gene_sequence":"ATGCTGTTCAGCTGGCCTTATCCAGAAGCCCCGATTGAAGGTTATTGGGGCAAGCCAACTTCTCTGATTGATTGGTGCGAGGAGAATTATGTCGTATCCCCCTATATTGCAGAATGGTCAAATACTATTACCAATAGTATATTCTTAATGACCGCCTTCTATTCTACATATAGCGCTTGGCGTAATAAGTTAGAAACAAGGTATATATTGATAGGAATGGGGTTCTCGCTGGTTGGTATTGGTTCGTGGTTATTTCATATGACTTTACAGTATCGTTATCAATTGCTAGACGAACTACCAATGCTGTATGCGACCATCATCCCATCGTGGAGTATTTTTGCAGAAACTCAAGAAATCTTGATTAAGGATGAGAAGAAAAGGAAGGAAAGCTCATTTAGAATCCAAATGGTCATTTCTTTTATCATGTGTGGTATAGTCACCATTTTAACCTGGATTTACGTTGTCGTCCAAAAGCCAGCAATTTTCCAAGTCCTTTATGGTATATTGACGCTTCTAGTTGTGGTTCTTTCTGGCTGGCTGACCTACTATCACGTTCATGATTCATTTGCAAAGAAAAATCTTTTTATTACTATGGTTATGGGCATGATTCCTTTTGTCATTGGGTTCATTTGCTGGCAACTAGATATTCACCTGTGTTCTTTTTGGATCTATATCCGGAGAACATATTTGGCCCTGCCATTAGGTGTTCTATTGGAACTGCATGCTTGGTGGCATCTTTTGACCGGTACTGGTGTCTATATCTTCGTCGTGTATTTGCAATATTTGAGAATATTAACCCATGGAAATCCAAATGACTTCTTATTTATATGGAGGTGGGGATTTTTCCCTGAGCTGGTAAGAAAGGGCTTACCGATTGGTACTTCTTATTCACTGGAGTATCTGGGGCCAATTGTAAATACACAGGTAGATGATGAAACAAAAAAGAATAACTAA","protein_sequence":"MLFSWPYPEAPIEGYWGKPTSLIDWCEENYVVSPYIAEWSNTITNSIFLMTAFYSTYSAWRNKLETRYILIGMGFSLVGIGSWLFHMTLQYRYQLLDELPMLYATIIPSWSIFAETQEILIKDEKKRKESSFRIQMVISFIMCGIVTILTWIYVVVQKPAIFQVLYGILTLLVVVLSGWLTYYHVHDSFAKKNLFITMVMGMIPFVIGFICWQLDIHLCSFWIYIRRTYLALPLGVLLELHAWWHLLTGTGVYIFVVYLQYLRILTHGNPNDFLFIWRWGFFPELVRKGLPIGTSYSLEYLGPIVNTQVDDETKKNN"},{"created_at":"2011-05-24T21:46:35.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAG1","uniprot_id":"P38703","uniprot_name":"LAG1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAG1","num_residues":411,"molecular_weight":"48454.10156","theoretical_pi":"9.17","general_function":"Involved in protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;177-197;212-232;252-272;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY558514","genbank_protein_id":"45270918","gene_card_id":"LAG1","chromosome_location":"chromosome 8","locus":"YHL003C","synonyms":["Longevity assurance factor 1","Longevity assurance gene 1 protein","Longevity assurance protein 1"],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGACATCAGCTACGGACAAATCTATCGATAGGTTAGTTGTTAATGCAAAAACAAGAAGACGAAACTCTTCCGTGGGTAAAATTGATTTAGGTGATACAGTTCCTGGCTTTGCAGCCATGCCTGAAAGTGCTGCCTCTAAAAATGAGGCCAAAAAAAGGATGAAAGCCTTGACTGGTGACTCTAAAAAGGATAGTGACCTACTGTGGAAGGTTTGGTTTTCATATAGAGAAATGAATTACCGTCATAGTTGGTTGACACCATTCTTCATACTTGTATGCGTGTATAGCGCGTACTTTTTATCTGGGAATAGAACAGAATCAAACCCGCTGCACATGTTCGTAGCCATATCATATCAAGTTGATGGCACAGACTCATATGCAAAAGGTATCAAAGATTTGAGTTTTGTGTTTTTCTACATGATTTTCTTCACATTTTTACGTGAGTTTTTGATGGATGTTGTAATTCGACCATTCACGGTATACCTAAATGTTACTTCCGAGCATCGTCAAAAGCGTATGCTAGAACAAATGTATGCCATATTTTATTGCGGAGTTTCAGGGCCCTTTGGTCTTTATATTATGTACCATAGTGATTTGTGGTTGTTCAAGACAAAACCAATGTACAGAACATATCCTGTTATAACCAATCCGTTCTTGTTTAAGATATTTTACTTGGGTCAAGCGGCATTTTGGGCGCAACAGGCTTGTGTTCTTGTTCTACAATTAGAAAAGCCAAGAAAGGATTACAAGGAATTGGTTTTTCATCACATTGTGACATTATTATTAATTTGGTCATCATATGTTTTCCATTTTACCAAAATGGGATTGGCTATCTATATTACTATGGATGTGTCAGATTTTTTCCTTTCTTTGTCTAAGACATTAAACTATCTGAATTCTGTATTTACTCCCTTTGTGTTCGGCTTGTTCGTGTTCTTTTGGATCTATCTGCGCCATGTCGTGAATATCAGAATATTATGGTCAGTCTTAACAGAATTCCGTCATGAAGGTAATTATGTGTTGAATTTTGCCACACAACAATACAAATGTTGGATTTCGTTGCCAATTGTATTTGTACTAATTGCTGCGTTACAATTAGTTAACCTGTATTGGCTGTTTTTAATTCTTAGAATCTTGTACAGATTGATATGGCAAGGTATCCAAAAGGACGAAAGAAGTGACAGTGATTCTGATGAGAGCGCTGAAAATGAAGAATCTAAGGAAAAGTGTGAATAA","protein_sequence":"MTSATDKSIDRLVVNAKTRRRNSSVGKIDLGDTVPGFAAMPESAASKNEAKKRMKALTGDSKKDSDLLWKVWFSYREMNYRHSWLTPFFILVCVYSAYFLSGNRTESNPLHMFVAISYQVDGTDSYAKGIKDLSFVFFYMIFFTFLREFLMDVVIRPFTVYLNVTSEHRQKRMLEQMYAIFYCGVSGPFGLYIMYHSDLWLFKTKPMYRTYPVITNPFLFKIFYLGQAAFWAQQACVLVLQLEKPRKDYKELVFHHIVTLLLIWSSYVFHFTKMGLAIYITMDVSDFFLSLSKTLNYLNSVFTPFVFGLFVFFWIYLRHVVNIRILWSVLTEFRHEGNYVLNFATQQYKCWISLPIVFVLIAALQLVNLYWLFLILRILYRLIWQGIQKDERSDSDSDESAENEESKEKCE"},{"created_at":"2011-05-26T16:06:16.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Alkaline ceramidase YPC1","uniprot_id":"P38298","uniprot_name":"YPC1_YEAST","enzyme":true,"transporter":false,"gene_name":"YPC1","num_residues":316,"molecular_weight":"36419.39844","theoretical_pi":"8.41","general_function":"Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides","specific_function":"Hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Has also reverse hydrolysis activity, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide","reactions":[{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"69-89;94-114;136-156;161-181;196-216;229-249","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein","genbank_gene_id":"AF191745","genbank_protein_id":"7248652","gene_card_id":"YPC1","chromosome_location":"chromosome 2","locus":"YBR183W","synonyms":[],"enzyme_classes":["3.5.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" membrane lipid metabolic process"},{"category":"Process","description":" sphingolipid metabolic process"},{"category":"Process","description":" sphingoid metabolic process"},{"category":"Process","description":" ceramide metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"aPHC","identifier":"PF05875"}],"pathways":[],"gene_sequence":"ATGGGAATATTTCGTTGGAACTATCCAGAGAGTTCTGTCCCCGGCGTTTGGGGAGAAACAACTTCCACTATTGACTGGTGTGAGGAGAACTATGTCGTTTCTCCCTATATTGCCGAGTGGTCAAACACTTTAACTAACAGCGTATTCATACTGTCAGCGATTTACACAACTTACTCTGCTTACAAGAATAAATTAGAAAAAAGGTTTTTACTTATTGGCTTCGGGTACGGTTTGGTCGGAGTAGGATCATGGCTATTTCATATGACACTGAAGTATAGATTCCAACTATTGGATGAACTTCCAATGATATACGCCATGTGCATTCCGACATGGAGTTTAGTATGCGAGGCCAAAGAGGCATTACTTAACGGAGATAATCACAAGAAGGTTCCTCTATTTGAACAGATATTCATCGGCGTAATTATCGGCCTGGCCGTTACAACAGCAAGCATACTCTACGTTATTTACAAAAATGTCGATATCCATCAAATTTTGTTTGGCGTACAGATTGTAGTTGTGGCTGCTACTGCAGGAAGTTTGACGTACAGATACGTCCATGATCCACTTGCCAAAAGAAATCTCAAGGCTTCAATGGCGCTCGGCGCAATTTTGTTCTTATCTGGCTACATTTCGTGGCTACTTGATATACACTATTGTTCGTTCTGGGTGCACGTTAGAAGAAGTATTTTGGCTTTACCACTTGGTGTACTGCTTGAACCACACGGATGGTGGCATATATTAACTGGTATGGGGATTTATTTCTACATTGTTTCTTTGGAACATTTAAGGGTCATTACGCTCAACGTCAGCTGCAATTACCAGTTCATCTGGAGATGGAAAGTCTTCCCTGAACTGATATGGAAAGGGCGCAAACCCTCAACAAGATATTCACTTGAACTATTTGGCCCATACGTAGAAGATCAATCAATTGAAGTTAAAAAGGAGAAGTAA","protein_sequence":"MGIFRWNYPESSVPGVWGETTSTIDWCEENYVVSPYIAEWSNTLTNSVFILSAIYTTYSAYKNKLEKRFLLIGFGYGLVGVGSWLFHMTLKYRFQLLDELPMIYAMCIPTWSLVCEAKEALLNGDNHKKVPLFEQIFIGVIIGLAVTTASILYVIYKNVDIHQILFGVQIVVVAATAGSLTYRYVHDPLAKRNLKASMALGAILFLSGYISWLLDIHYCSFWVHVRRSILALPLGVLLEPHGWWHILTGMGIYFYIVSLEHLRVITLNVSCNYQFIWRWKVFPELIWKGRKPSTRYSLELFGPYVEDQSIEVKKEK"},{"created_at":"2011-05-26T16:11:34.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAC1","uniprot_id":"P28496","uniprot_name":"LAC1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAC1","num_residues":418,"molecular_weight":"48991.60156","theoretical_pi":"9.81","general_function":"Involved in identical protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;173-193;222-242;260-280;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z28008","genbank_protein_id":"485983","gene_card_id":"LAC1","chromosome_location":"chromosome 11","locus":"YKL008C","synonyms":[],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGTCGACAATAAAGCCAAGCCCTTCAAACAACAATTTGAAAGTGAGGTCAAGACCAAGACGCAAGTCTTCCATAGGTAAGATCGACCTCGGGGACACTGTACCTAGTTTAGGTACTATGTTCGAGACAAAAGAATCTAAAACGGCTGCTAAAAGGCGTATGCAGAGATTATCTGAAGCCACCAAAAATGATAGCGACCTGGTCAAGAAAATCTGGTTTTCATTCCGAGAGATAAGTTACCGTCATGCCTGGATAGCTCCCTTGATGATTTTAATCGCGGTATATAGTGCCTATTTCACTTCTGGTAACACTACAAAGACAAATGTGTTACATAGATTTGTCGCTGTGTCATACCAAATAGGTGATACCAACGCATATGGTAAAGGTATTAACGATTTGTGCTTTGTATTTTACTATATGATTTTTTTCACATTCTTACGTGAATTCCTAATGGATGTTGTCATTAGACCGTTCGCTATTAGGTTACACGTCACTTCTAAGCACAGAATAAAAAGAATCATGGAACAAATGTACGCTATTTTCTACACCGGTGTTTCCGGTCCTTTCGGGATATATTGTATGTACCATTCGGATTTATGGTTTTTCAACACAAAGGCAATGTACAGAACATATCCAGATTTCACTAATCCCTTCTTATTCAAGGTATTCTATTTGGGTCAAGCTGCATTTTGGGCTCAACAAGCCTGCATTCTTGTATTGCAACTAGAAAAGCCAAGAAAAGATCATAACGAGTTGACTTTCCATCATATTGTTACTTTACTATTGATTTGGTCTTCCTACGTATTTCATTTCACTAAAATGGGACTGCCAATCTATATCACAATGGATGTTTCTGATTTTCTTTTGTCATTCTCCAAAACTCTAAATTATTTGGACTCTGGATTGGCTTTTTTTTCTTTTGCTATCTTTGTTGTTGCGTGGATTTATTTGCGTCATTACATAAATTTAAAGATCCTATGGTCCGTTTTAACGCAATTTCGCACGGAAGGTAACTATGTCTTGAATTTTGCCACTCAGCAATATAAATGTTGGATTTCCTTACCAATTGTCTTTGTATTGATAGGCGCTTTGCAATTAGTGAATCTTTATTGGCTGTTCCTTATTTTTAGAGTTCTTTACAGGATTCTATGGAGAGGTATTCTCAAGGATGACAGAAGTGATAGTGAATCAGACGAAGAAAGTGATGAAAGTTCCACTACTCCAACTGACAGTACTCCAACGAAAAAGGATATTTGA","protein_sequence":"MSTIKPSPSNNNLKVRSRPRRKSSIGKIDLGDTVPSLGTMFETKESKTAAKRRMQRLSEATKNDSDLVKKIWFSFREISYRHAWIAPLMILIAVYSAYFTSGNTTKTNVLHRFVAVSYQIGDTNAYGKGINDLCFVFYYMIFFTFLREFLMDVVIRPFAIRLHVTSKHRIKRIMEQMYAIFYTGVSGPFGIYCMYHSDLWFFNTKAMYRTYPDFTNPFLFKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIYITMDVSDFLLSFSKTLNYLDSGLAFFSFAIFVVAWIYLRHYINLKILWSVLTQFRTEGNYVLNFATQQYKCWISLPIVFVLIGALQLVNLYWLFLIFRVLYRILWRGILKDDRSDSESDEESDESSTTPTDSTPTKKDI"},{"created_at":"2011-05-27T06:06:25.000Z","updated_at":"2011-07-22T17:54:24.000Z","name":"Sphingolipid C4-hydroxylase SUR2","uniprot_id":"P38992","uniprot_name":"SUR2_YEAST","enzyme":true,"transporter":false,"gene_name":"SUR2","num_residues":349,"molecular_weight":"40734.0","theoretical_pi":"8.73","general_function":"Involved in iron ion binding","specific_function":"Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin","reactions":[{"id":1370,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1372,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1896,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":3889,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006408","source":"Smpdb"},{"id":14345,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006856","source":"Smpdb"},{"id":14389,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006900","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"9-29;50-70;99-119;148-168;209-229","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"U07171","genbank_protein_id":"458718","gene_card_id":"SUR2","chromosome_location":"chromosome 4","locus":"YDR297W","synonyms":["Syringomycin response protein 2"],"enzyme_classes":["1.-.-.-"],"go_classes":[{"category":"Component","description":" endoplasmic reticulum"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"}],"pfams":[{"name":"FA_hydroxylase","identifier":"PF04116"}],"pathways":[{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"},{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGAACGTAACATCGAATGCAACTGCAGCCGGTTCCTTTCCACTAGCATTTGGTCTCAAGACCTCATTTGGGTTTATGCACTATGCCAAGGCCCCTGCCATTAATTTACGCCCCAAGGAATCCTTGCTGCCGGAAATGAGTGATGGTGTGCTGGCCTTGGTTGCGCCGGTTGTTGCCTACTGGGCGTTGTCTGGTATATTCCATGTAATAGACACTTTCCATCTGGCTGAGAAGTACAGAATTCATCCGAGCGAAGAGGTTGCCAAGAGGAACAAGGCGTCGAGAATGCATGTTTTCCTTGAAGTGATTCTACAACATATCATACAGACCATTGTTGGCCTTATCTTTATGCACTTCGAGCCGATCTACATGACTGGGTTTGAAGAAAATGCCATGTGGAAGCTTCGTGCAGACCTTCCTCGGATTATTCCAGATGCCGCTATTTATTACGGCTATATGTACGGAATGTCCGCTTTGAAGATCTTTGCAGGCTTTTTATTCGTTGATACATGGCAATACTTTTTGCATAGATTGATGCATATGAATAAGACCTTATACAAATGGTTCCACTCTGTTCATCATGAACTATACGTGCCATATGCTTACGGTGCTCTTTTCAACAATCCTGTTGAGGGCTTCTTGTTAGATACTTTGGGAACCGGTATTGCCATGACGTTAACTCATTTGACTCACAGAGAGCAAATCATTCTTTTTACCTTTGCCACCATGAAGACTGTCGATGACCACTGTGGGTATGCTTTGCCACTTGACCCATTCCAATGGCTTTTCCCTAATAACGCTGTCTATCACGATATCCACCACCAGCAATTTGGTATCAAGACGAACTTTGCTCAACCATTTTTCACTTTCTGGGACAATTTGTTCCAAACTAACTTTAAAGGGTTTGAAGAATATCAAAAGAAGCAAAGACGTGTCACCATCGACAAGTACAAAGAGTTTTTGCAAGAGAGAGAATTGGAAAAGAAGGAGAAACTCAAAAACTTCAAAGCTATGAATGCTGCTGAAAATGAAGTAAAGAAAGAGAAATAA","protein_sequence":"MNVTSNATAAGSFPLAFGLKTSFGFMHYAKAPAINLRPKESLLPEMSDGVLALVAPVVAYWALSGIFHVIDTFHLAEKYRIHPSEEVAKRNKASRMHVFLEVILQHIIQTIVGLIFMHFEPIYMTGFEENAMWKLRADLPRIIPDAAIYYGYMYGMSALKIFAGFLFVDTWQYFLHRLMHMNKTLYKWFHSVHHELYVPYAYGALFNNPVEGFLLDTLGTGIAMTLTHLTHREQIILFTFATMKTVDDHCGYALPLDPFQWLFPNNAVYHDIHHQQFGIKTNFAQPFFTFWDNLFQTNFKGFEEYQKKQRRVTIDKYKEFLQERELEKKEKLKNFKAMNAAENEVKKEK"},{"created_at":"2011-05-27T07:58:49.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Ceramide very long chain fatty acid hydroxylase SCS7","uniprot_id":"Q03529","uniprot_name":"SCS7_YEAST","enzyme":true,"transporter":false,"gene_name":"SCS7","num_residues":384,"molecular_weight":"44881.10156","theoretical_pi":"6.55","general_function":"Involved in heme binding","specific_function":"Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. 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synthase subunit LIP1","uniprot_id":"A6ZN14","uniprot_name":"LIP1","enzyme":false,"transporter":false,"gene_name":"LIP1","num_residues":null,"molecular_weight":"17206.535","theoretical_pi":null,"general_function":"lipid metabolic process","specific_function":"Component of the ceramide synthase complex required for synthesis of ceramides.","reactions":[{"id":3893,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006411","source":"Smpdb"},{"id":3894,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006414","source":"Smpdb"},{"id":3895,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006426","source":"Smpdb"},{"id":3896,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006514","source":"Smpdb"},{"id":3897,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006515","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"21-40","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"lipid metabolic 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