{"ymdb_id":"YMDB00953","created_at":"2011-05-30T05:25:42.000Z","updated_at":"2016-09-08T18:36:05.000Z","name":"2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol","cas":null,"state":"Solid","melting_point":"","description":"2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol is an ubiquinone derivative that is an intermediate in ubiquinone-6 biosynthesis.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":"HMDB12146","kegg_id":null,"pubchem_id":"25203764","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":"2-HEXAPRENYL-3-METHYL-5-HYDROXY-6-METHOX","iupac":"5-[(2Z,6E,10E,14E,18Z)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methoxy-6-methylbenzene-1,2,4-triol","traditional_iupac":"5-[(2Z,6E,10E,14E,18Z)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methoxy-6-methylbenzene-1,2,4-triol","logp":"11.445438349000002","pka":"11.512154695235251","alogps_solubility":"6.45e-04 g/l","alogps_logp":"8.32","alogps_logs":"-5.95","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"18","polar_surface_area":"69.92","refractivity":"186.7609000000001","polarizability":"72.48513220004254","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-4.781071451386308","pka_strongest_acidic":"9.959557571533354","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Demethyl-ubiquinol-6"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."}],"proteins":[{"created_at":"2011-05-26T16:35:40.000Z","updated_at":"2011-05-29T05:06:18.000Z","name":"Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial","uniprot_id":"P27680","uniprot_name":"COQ3_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ3","num_residues":312,"molecular_weight":"36330.60156","theoretical_pi":"6.98","general_function":"Involved in methyltransferase activity","specific_function":"Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway","reactions":[{"id":2429,"direction":"\u003e","locations":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","altext":"S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate.","export":false,"pw_reaction_id":null,"source":null},{"id":2430,"direction":"\u003e","locations":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","altext":"S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.","export":false,"pw_reaction_id":null,"source":null},{"id":2431,"direction":"\u003e","locations":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","altext":"S-adenosyl-L-methionine + 2-hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol = S-adenosyl-L-homocysteine + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"M73270","genbank_protein_id":"171392","gene_card_id":"COQ3","chromosome_location":"chromosome 15","locus":"YOL096C","synonyms":["3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase","DHHB methyltransferase","DHHB-MT","DHHB-MTase","Dihydroxyhexaprenylbenzoate methyltransferase"],"enzyme_classes":["2.1.1.114","2.1.1.64"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" C-methyltransferase activity"},{"category":"Function","description":" quinone cofactor methyltransferase activity"},{"category":"Function","description":" 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" oxidoreduction coenzyme metabolic process"},{"category":"Process","description":" ubiquinone metabolic process"},{"category":"Process","description":" ubiquinone biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"Methyltransf_11","identifier":"PF08241"}],"pathways":[{"name":"Ubiquinone and other terpenoid-quinone biosynthesis","kegg_map_id":"00130"}],"gene_sequence":"ATGGGATTCATAATGTTGTTAAGATCTAGATTTTTGAAGGTTATTCATGTGAGGAAACAATTGAGCGCCTGTTCAAGATTTGCAATTCAAACACAAACGAGATGTAAGAGCACAGATGCTTCTGAAGATGAAGTGAAGCATTTCCAGGAGCTAGCCCCTACTTGGTGGGATACAGACGGATCACAAAGAATTCTACACAAAATGAATCTAACTAGGTTAGATTTTGTGCAGAGGACTGTGAGGAACCAGGTTAAAATTCAGAATCCTGAAATATTTGTCCCTGGATTTAATTACAAGGAGTTTCTACCAGAATACGTCTGCGACAATATTCAGCGGGAAATGCAGGAAAGCATAGAGACTAATCTAGATAAGAGGCCAGAAGTGAGCGTCTTGGATGTTGGATGCGGTGGTGGCATTTTGAGTGAATCGCTCGCGAGACTAAAATGGGTGAAGAATGTTCAAGGGATCGATCTGACTCGCGATTGTATCATGGTAGCAAAAGAGCATGCCAAGAAAGACCCCATGCTGGAGGGAAAGATAAATTATGAGTGCAAGGCTCTGGAGGATGTTACTGGACAATTTGATATTATCACCTGTATGGAAATGCTAGAGCACGTGGATATGCCTAGTGAAATTTTAAGGCATTGTTGGTCGAGGTTAAATCCCGAAAAAGGTATACTCTTTTTAAGTACTATAAACAGAGATCTCATCTCATGGTTTACTACAATTTTTATGGGTGAAAACGTCTTGAAGATCGTCCCAAAGGGTACTCATCATTTGAGCAAATACATAAACTCAAAGGAAATCCTTGCCTGGTTCAATGACAACTACAGTGGCCAATTTCGCTTGTTGGATCTCAAGGGGACCATGTACCTCCCATATCAAGGGTGGGTTGAGCACGATTGTTCCGATGTCGGTAATTATTTTATGGCTATTCAGAGACTGAATTGA","protein_sequence":"MLLRSRFLKVIHVRKQLSACSRFAIQTQTRCKSTDASEDEVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVRNQVKIQNPEIFVPGFNYKEFLPEYVCDNIQREMQESIETNLDKRPEVSVLDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKKDPMLEGKINYECKALEDVTGQFDIITCMEMLEHVDMPSEILRHCWSRLNPEKGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHHLSKYINSKEILAWFNDNYSGQFRLLDLKGTMYLPYQGWVEHDCSDVGNYFMAIQRLN"}]}