{"ymdb_id":"YMDB00941","created_at":"2011-05-30T04:50:10.000Z","updated_at":"2016-09-12T20:56:49.000Z","name":"dolichyl phosphate","cas":"12698-55-4","state":"Solid","melting_point":null,"description":"Dolichol phosphate is an isoprenoid compound (90-100 carbons total) made from dolichol by phosphorylation catalyzed by a kinase that uses CTP as the energy and phosphate source. Dolichol phosphate performs important functions in synthesis of N-linked glycoproteins.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"endoplasmic reticulum;cytoplasm","synthesis_reference":null,"chebi_id":"16214","hmdb_id":null,"kegg_id":"C00110","pubchem_id":"24892715","cs_id":null,"foodb_id":null,"wikipedia_link":"dolichyl_phosphate","biocyc_id":null,"iupac":"{[(6E,10E,14E,18E,22Z,26E,30E,34E,38E,42E,46E,50E,54E,58Z,62E,66E,70E,74E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75,79-icosamethyloctaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70,74,78-nonadecaen-1-yl]oxy}phosphonic acid","traditional_iupac":"[(6E,10E,14E,18E,22Z,26E,30E,34E,38E,42E,46E,50E,54E,58Z,62E,66E,70E,74E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75,79-icosamethyloctaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70,74,78-nonadecaen-1-yl]oxyphosphonic acid","logp":"32.503346236","pka":"6.823239539177949","alogps_solubility":"4.12e-04 g/l","alogps_logp":"9.64","alogps_logs":"-6.55","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"61","polar_surface_area":"66.75999999999999","refractivity":"489.80579999999946","polarizability":"193.63328437053298","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":null,"pka_strongest_acidic":"1.8000172005152635","bioavailability":"0","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["dolichol monophosphate","Dolichol phosphate","Dolicholmonophosphate","Dolichyl monophosphate","Dolichyl phosphate"],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":12213788,"citation":"Fernandez, F., Shridas, P., Jiang, S., Aebi, M., Waechter, C. J. (2002). \"Expression and characterization of a human cDNA that complements the temperature-sensitive defect in dolichol kinase activity in the yeast sec59-1 mutant: the enzymatic phosphorylation of dolichol and diacylglycerol are catalyzed by separate CTP-mediated kinase activities in Saccharomyces cerevisiae.\" Glycobiology 12:555-562."},{"pubmed_id":17397129,"citation":"Orlowski, J., Machula, K., Janik, A., Zdebska, E., Palamarczyk, G. (2007). \"Dissecting the role of dolichol in cell wall assembly in the yeast mutants impaired in early glycosylation reactions.\" Yeast 24:239-252."}],"proteins":[{"created_at":"2011-05-24T19:18:45.000Z","updated_at":"2011-07-22T17:54:39.000Z","name":"Dolichol kinase","uniprot_id":"P20048","uniprot_name":"SEC59_YEAST","enzyme":true,"transporter":false,"gene_name":"SEC59","num_residues":519,"molecular_weight":"58905.39844","theoretical_pi":"9.22","general_function":"Involved in transferase activity, transferring phosphorus-containing groups","specific_function":"Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. It is required for spore germination. Has an essential role in cellular metabolism","reactions":[{"id":1471,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2244,"direction":"\u003e","locations":"Endoplasmic reticulum membrane (Probable)","altext":"CTP + dolichol = CDP + dolichyl phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14868,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007056","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"48-68;89-109;119-139;152-172;182-203;224-244;254-274;295-315;327-347;350-370;395-415;418-438;450-470;473-493","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane (Probable)","genbank_gene_id":"AY692829","genbank_protein_id":"51013109","gene_card_id":"SEC59","chromosome_location":"chromosome 13","locus":"YMR013C","synonyms":[],"enzyme_classes":["2.7.1.108"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"CTP_transf_1","identifier":"PF01148"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGTCGCTATAATACCTCATGCTTCCTTTACCACAATTAAACTAACCCAGAAAACTGAGGGAAGCCAAATGCCAACTGAGGAGATCTGCAAAATCAATATGAGGACTCGTAAATTTGATGTGGGCGGGAATTCTCGAGATTTTGAGTGCTTTTATTCGAATTTTGTTCAAACTGTTATATTGTTGGGCACTTTTTTTTACTGTGTTGAAAGGCTTCAGCCGTGGTCCATTGTTACCGCTGATATATCTTATAAACAAATCTTTGTAAATGTCTTTGTGGTGTGTTTGATAATGGTTGGTCTGATATTCACAAAATATTGGCAACATGGTTACAAAAGCCTACCCAAGTTCGATACCATTTACAGTTTATATTTACCGTTTATGGTTTCGTTGTTGTTCGATACATCATCTACGGTGATAAATACTATTTTGATCCTTTCGGTATTAAATTCATATAGATGGCGAACTCAGTTGGTAGTGATCATTTTACAGCTCTGCCTCATATTTTTTAATTTTGAGGCTGGTGACAGGTTAAAGAATATTATTAGCATAGTAATAAATTCTTTACTGTCGTTAATTTTGAAGTATATTGGGCAATTGAAAAGTTTAGATAATATCGACTCTAATCTTTTTAGTATCCTATTAACCAATATTCTGTACGTTTCAGAGGCTGGCACAGTACATTTTAGAATTTTGAAGGGCATTATCCTTGCTCTCACAACAATAATTTCAATTAACTATGTGCTCAAAAAGGTAATGCACTTTAAACCGTTTATGCTGTCAATATCCTTTGCCATCGGGCTTCCACTTTTTGCCAATACCTTCATTCATTTAGAAGACGGTGAAAATCCGCTACTTTGGCTGGTAAAATATATCTTAGAGTCTACTATTCGTCAAAAGATTTTGTTTGCTTGGTCTTCAATTCTTATACTGTCCATACCAAGTATATTGATCGAGAAGGACAGTCTATCGTTGAACACCTCCCGAAAATTGTGGCATTTCATCATTTTCTTACTCATAATACCGTCATTCCAAATGGATTCAAACTTTGTGAAAATTGCATTGTCCGGAACAATACCAGTCTTCTTATCAATTGAGTACATAAGATTTCAAAACCTACCGCCGTTAGGATCTGCTATTGAATTACAACTAAGAAGGTTTGCTGATGATAGGGACCACAGCGGGCCATTGATCATATCATACCTTTATTTACTCTTCGGAATATCAACACCTTTATTAATGAATAACTCTCCAATGGGTCTAATAGGATTGGGAATTGGTGATTCCTTAGCATCTATTATTGGTAAAAGGTATGGCCGCATTCGTTGGAAAGGTACACAAAAAACTTTAGAGGGAACTCTTGCGTTTATAGTAACGAGTTTTATCGTTTGTTTGGTATTGTTACGTTTTGATAAAGCTGCAATTTTTAACCACCTAACTACTTTACAATTGCTTACCCTTTGTACACTGAGTGGAGTGCTAGAAGGTAATAGTGTGCTTAATGACAATATTTTGATACCTGCATTTATGATGATTTGTGAAAAATTAATTACTCTTTGA","protein_sequence":"MVAIIPHASFTTIKLTQKTEGSQMPTEEICKINMRTRKFDVGGNSRDFECFYSNFVQTVILLGTFFYCVERLQPWSIVTADISYKQIFVNVFVVCLIMVGLIFTKYWQHGYKSLPKFDTIYSLYLPFMVSLLFDTSSTVINTILILSVLNSYRWRTQLVVIILQLCLIFFNFEAGDRLKNIISIVINSLLSLILKYIGQLKSLDNIDSNLFSILLTNILYVSEAGTVHFRILKGIILALTTIISINYVLKKVMHFKPFMLSISFAIGLPLFANTFIHLEDGENPLLWLVKYILESTIRQKILFAWSSILILSIPSILIEKDSLSLNTSRKLWHFIIFLLIIPSFQMDSNFVKIALSGTIPVFLSIEYIRFQNLPPLGSAIELQLRRFADDRDHSGPLIISYLYLLFGISTPLLMNNSPMGLIGLGIGDSLASIIGKRYGRIRWKGTQKTLEGTLAFIVTSFIVCLVLLRFDKAAIFNHLTTLQLLTLCTLSGVLEGNSVLNDNILIPAFMMICEKLITL"},{"created_at":"2011-05-24T19:19:09.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Dolichyldiphosphatase","uniprot_id":"P53223","uniprot_name":"CAX4_YEAST","enzyme":true,"transporter":false,"gene_name":"CAX4","num_residues":239,"molecular_weight":"27648.80078","theoretical_pi":"8.65","general_function":"Involved in catalytic activity","specific_function":"Non-essential protein which is required for efficient N- glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate","reactions":[{"id":2245,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Dolichyl diphosphate + H(2)O = dolichyl phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"35-55;132-152;165-185","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY557771","genbank_protein_id":"45269433","gene_card_id":"CAX4","chromosome_location":"chromosome 7","locus":"YGR036C","synonyms":["Dolichyl pyrophosphate phosphatase"],"enzyme_classes":["3.6.1.43"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PAP2","identifier":"PF01569"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAATAGTACCGCCGCTGCAATAAATCCAAATCCAAATGTTATACCATTCGATGACACATACATTCTCTATGATTCGCATGACTTTCTATCATTCCTTAGTGCATATTTCTCGCTGATGCCCATCCTAGTGCTAGCTTTTTATTTGTCGTGGTTTATCATCACAAGAGAGTTAGAAGCCTGCATTGTAGCCTTTGGCCAATTGATGAACGAAATATTCAATAACGTGATCAAGAATATAATAAAACAGCCACGCCCCGTATCGTTCGGTGCGTCGTTCCAAAATGACACTATAAGATCCGGTTACGGGATGCCCAGTGCACACTCCCAATTCATGGGGTTTTGTTTTACCTATAACTCTCTGAAGATATACACTTCCTGGAAGAATCTAAACTTCTTAGAAAAATGCATTTTTTCTGGTGCATTGGCTTTATTATCGTTTTGCGTTTGCTTTTCCAGAGTTTACTTGCACTACCACAATTTAGATCAAGTAATCGTGGGATTCAGCGTGGGGGCACTGACTGGATCACTTTATTTTTTTATAGTTGGCATCATAAGAGAGCTTGGTTTAATCAATTGGTTTTTAAAACTACGTATTGTCAGATTATTTTACATGACAGATTCTTACAATCTGGCGCCTTTGACATTGAAAGAGAATTACGAGGCGTATTGGAAAAGAATAAATCAGCGATCTTTCAATGATAAATCCAAAAGGGATTAG","protein_sequence":"MNSTAAAINPNPNVIPFDDTYILYDSHDFLSFLSAYFSLMPILVLAFYLSWFIITRELEACIVAFGQLMNEIFNNVIKNIIKQPRPVSFGASFQNDTIRSGYGMPSAHSQFMGFCFTYNSLKIYTSWKNLNFLEKCIFSGALALLSFCVCFSRVYLHYHNLDQVIVGFSVGALTGSLYFFIVGIIRELGLINWFLKLRIVRLFYMTDSYNLAPLTLKENYEAYWKRINQRSFNDKSKRD"},{"created_at":"2011-05-24T19:19:45.000Z","updated_at":"2011-07-22T17:54:39.000Z","name":"Dolichol-phosphate mannosyltransferase","uniprot_id":"P14020","uniprot_name":"DPM1_YEAST","enzyme":true,"transporter":false,"gene_name":"DPM1","num_residues":267,"molecular_weight":"30362.0","theoretical_pi":"8.06","general_function":"Cell wall/membrane/envelope biogenesis","specific_function":"Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins","reactions":[{"id":1472,"direction":"\u003e","locations":"endoplasmic reticulum membrane;endoplasmic reticulum;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2246,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass type IV membrane protein","altext":"GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14875,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007066","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"239-259","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass type IV membrane protein","genbank_gene_id":"J04184","genbank_protein_id":"171418","gene_card_id":"DPM1","chromosome_location":"chromosome 16","locus":"YPR183W","synonyms":["Dolichol-phosphate mannose synthase","DPM synthase","Dolichyl-phosphate beta-D-mannosyltransferase","Mannose-P-dolichol synthase","MPD synthase"],"enzyme_classes":["2.4.1.83"],"go_classes":[],"pfams":[{"name":"Glycos_transf_2","identifier":"PF00535"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAGCATCGAATACTCTGTTATCGTTCCCGCTTACCATGAAAAGCTGAACATCAAACCCTTAACAACCAGATTGTTTGCCGGTATGAGCCCTGAAATGGCCAAGAAGACCGAGTTGATCTTTGTCGATGACAACTCACAGGATGGCTCCGTTGAGGAGGTGGACGCCCTAGCTCACCAAGGCTACAACGTCCGCATCATCGTCAGGACAAATGAACGTGGTCTATCCTCCGCCGTGCTTAAGGGTTTCTACGAGGCCAAGGGTCAGTACCTGGTATGCATGGACGCAGACCTACAACACCCTCCAGAGACCGTGCCCAAGTTGTTCGAGTCTTTGCACGATCACGCCTTTACTCTGGGCACCAGATATGCCCCAGGTGTCGGCATTGACAAGGACTGGCCTATGTACAGACGCGTCATTTCCTCCACTGCTAGAATGATGGCCAGACCTTTGACCATCGCCTCCGACCCCATGAGCGGGTTCTTCGGTCTACAAAAGAAGTACCTCGAAAACTGCAACCCTAGGGACATCAACTCGCAAGGTTTCAAGATTGCCCTCGAGCTTCTCGCCAAGCTTCCTCTTCCAAGAGACCCTAGAGTGGCGATCGGCGAAGTGCCATTCACTTTCGGCGTGAGAACGGAAGGTGAATCCAAACTGTCAGGTAAAGTCATTATCCAATACTTGCAACAACTTAAGGAGCTCTACGTCTTCAAGTTTGGCGCCAATAACCTTATCCTTTTCATTACTTTCTGGTCCATTCTGTTCTTCTACGTTTGCTACCAGCTATACCATTTGGTCTTTTAA","protein_sequence":"MSIEYSVIVPAYHEKLNIKPLTTRLFAGMSPEMAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEAKGQYLVCMDADLQHPPETVPKLFESLHDHAFTLGTRYAPGVGIDKDWPMYRRVISSTARMMARPLTIASDPMSGFFGLQKKYLENCNPRDINSQGFKIALELLAKLPLPRDPRVAIGEVPFTFGVRTEGESKLSGKVIIQYLQQLKELYVFKFGANNLILFITFWSILFFYVCYQLYHLVF"},{"created_at":"2011-05-24T19:20:17.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase","uniprot_id":"P07286","uniprot_name":"GPT_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG7","num_residues":448,"molecular_weight":"50367.39844","theoretical_pi":"8.51","general_function":"Involved in phospho-N-acetylmuramoyl-pentapeptide-transferase activity","specific_function":"Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides","reactions":[{"id":2247,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.","export":false,"pw_reaction_id":null,"source":null},{"id":14869,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007060","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"24-44;72-92;129-149;157-177;202-222;231-251;256-276;283-303;309-329;387-407;419-439","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Y00126","genbank_protein_id":"4685","gene_card_id":"ALG7","chromosome_location":"chromosome 2","locus":"YBR243C","synonyms":["GlcNAc-1-P transferase","G1PT","GPT","N-acetylglucosamine-1-phosphate transferase","Tunicamycin resistance protein 1"],"enzyme_classes":["2.7.8.15"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, for other substituted phosphate groups"},{"category":"Function","description":" phospho-N-acetylmuramoyl-pentapeptide-transferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Glycos_transf_4","identifier":"PF00953"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGTTGCGACTTTTTTCACTGGCACTTATCACATGCTTAATCTACTATTCCAAAAATCAGGGCCCATCTGCTCTTGTTGCGGCCGTGGGATTTGGTATAGCAGGCTATTTAGCTACAGATATGTTGATTCCACGTGTGGGCAAATCCTTCATCAAAATAGGCCTATTCGGTAAGGACTTGAGTAAACCTGGCCGTCCGGTGCTTCCAGAAACAATAGGTGCTATCCCTGCTGCAGTTTATTTATTTGTAATGTTCATTTACATTCCCTTCATTTTCTACAAGTATATGGTCATAACCACTTCAGGTGGGGGCCATCGCGATGTCTCAGTGGTTGAAGATAACGGTATGAATTCTAATATTTTTCCTCATGATAAACTATCTGAATATTTGAGCGCTATCCTATGCTTGGAAAGTACGGTCCTCTTGGGTATCGCTGATGATTTATTTGATTTACGTTGGAGACATAAGTTTTTCTTGCCTGCCATTGCAGCCATCCCACTGCTAATGGTTTATTATGTGGATTTTGGAGTTACGCATGTACTTATTCCCGGATTCATGGAACGCTGGTTGAAAAAGACTAGTGTTGATTTGGGGCTGTGGTATTATGTTTATATGGCATCGATGGCAATTTTTTGCCCCAACTCCATCAACATCCTGGCAGGTGTTAATGGTTTAGAGGTTGGCCAATGTATAGTGTTGGCCATCTTAGCGCTATTGAACGATTTGCTGTACTTCTCGATGGGGCCATTAGCCACAAGAGACTCCCATAGGTTTTCCGCTGTTTTGATTATCCCATTTTTGGGTGTATCCTTGGCGCTATGGAAATGGAATCGTTGGCCCGCCACAGTGTTTGTGGGAGATACATATTGTTATTTCGCTGGAATGGTATTCGCAGTCGTTGGTATACTGGGTCATTTTTCAAAGACGATGCTTTTGCTATTCATTCCTCAAATCGTTAATTTTATTTATTCATGTCCTCAGCTATTCAAATTGGTCCCCTGCCCGAGACATAGGTTACCTAAATTTAATGAAAAAGACGGTTTAATGTATCCATCAAGAGCAAACTTAAAAGAAGAACCGCCAAAGAGCATTTTTAAACCGATCTTGAAGTTACTATACTGTCTCCATTTGATTGACCTGGAATTTGATGAAAATAATGAGATTATTAGCACCTCTAATATGACGTTAATAAACTTGACATTAGTATGGTTTGGCCCTATGAGGGAAGACAAATTGTGCAATACAATCTTGAAGTTGCAATTCTGCATTGGAATTTTGGCTTTACTTGGAAGACACGCTATAGGCGCTATCATCTTTGGCCACGACAACCTATGGACAGTACGTTGA","protein_sequence":"MLRLFSLALITCLIYYSKNQGPSALVAAVGFGIAGYLATDMLIPRVGKSFIKIGLFGKDLSKPGRPVLPETIGAIPAAVYLFVMFIYIPFIFYKYMVITTSGGGHRDVSVVEDNGMNSNIFPHDKLSEYLSAILCLESTVLLGIADDLFDLRWRHKFFLPAIAAIPLLMVYYVDFGVTHVLIPGFMERWLKKTSVDLGLWYYVYMASMAIFCPNSINILAGVNGLEVGQCIVLAILALLNDLLYFSMGPLATRDSHRFSAVLIIPFLGVSLALWKWNRWPATVFVGDTYCYFAGMVFAVVGILGHFSKTMLLLFIPQIVNFIYSCPQLFKLVPCPRHRLPKFNEKDGLMYPSRANLKEEPPKSIFKPILKLLYCLHLIDLEFDENNEIISTSNMTLINLTLVWFGPMREDKLCNTILKLQFCIGILALLGRHAIGAIIFGHDNLWTVR"},{"created_at":"2011-05-27T09:08:43.000Z","updated_at":"2011-05-27T15:01:30.000Z","name":"GPI mannosyltransferase 2","uniprot_id":"P38211","uniprot_name":"GPI18_YEAST","enzyme":true,"transporter":false,"gene_name":"GPI18","num_residues":433,"molecular_weight":"50772.19922","theoretical_pi":"9.81","general_function":"Involved in transferase activity, transferring hexosyl groups","specific_function":"Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly","reactions":[{"id":1613,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"2-22;110-130;151-168;170-182;198-220;222-236;244-264;319-339;351-371;410-430","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z35873","genbank_protein_id":"536192","gene_card_id":"GPI18","chromosome_location":"chromosome 2","locus":"YBR004C","synonyms":["GPI mannosyltransferase II","GPI-MT-II","Glycosylphosphatidylinositol-anchor biosynthesis protein 18"],"enzyme_classes":["2.4.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" endoplasmic reticulum membrane"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" protein amino acid lipidation"},{"category":"Process","description":" GPI anchor biosynthetic process"}],"pfams":[],"pathways":[],"gene_sequence":"ATGATTGTGGGGTTGACACTTTATTTTGTATTATTCCGTTCAATACAGTATTTACTGGTTTTTTTGACTCCAATTAGGCAGTTTGATACATCAACATCACTTTTATTAAACGAATTATGTTCTTCTCCCTCTGAAATCAACAGTTATTGGAACAAGTATTTTTGGAATAAGCTACTATCATGGGACAGTGTTTTTTTTATCAAGAACATAACTTCCAAAAACGGAAAACCTCAATTTGAGCATGAATACGCGTTTTCTCAGTTGTGGACTTTTTTCGTTAGGCTGTTTATTAAAAGTAATAACGATAGCATCTACCATGCCTTAAGGGTTGGAGTTGCAATAGAAAATGTTTTATTTTACTTGTCAGGTATTGTTTTATATTTTCTAACAAAAAAAATTTTCAGCCAAAATATAAGGCAATCACAGTTTGCTAGAACTATCGCTAAAAAAACATCTCTGTTGTTTTTCTTAACGAGTGCCGCTGGATTTTTAACAAGCATATATTCTGAACCATTATCTTTTTTTTTTGCATTTGTTGGTATTTGGAGTCGTGAATGCACCATTTCCGTGCCCGTATTGGGTCAATTCGATATTTCGTGGAGATATTGGTTTCCTTACTCCTTTATCAGCATGGCTTGCTTTACCTTAGCATCCTTGAATCGTTCAAACTGTGTTTTGTTAGGGATTTACTTTATTTTTGACCTTATTGAACTAACAAAGAACAGGAAGTTTGTAAAAGCAATATGTTTCCCACTATTATCAGGATCATTAATGTTTTCTGCTCTACTATATCAACAATATTACCTACCATATAAGACATTTTGTCCTCAAAGGGGTGAATGGTGTAAATCTCAATTGTTTTCAAGCATTTTTATCACGAAAACTTCTTTATATTCCTACATTCAGAGTCATTATTGGGGAGTTGGGTTATTGAAATACTGGACCCCAAACAACATCCCAAACTTTTTGTTTGCTGTCCCAAATATTATTATTTTAATCTATTCCTCCATATATTTCAGCAAAATTTATCCCTCCTATAACTTGAAGGCTCTCGTATGGATCACCAGAGCACTGGTCGTCATAGTATGCTTTTTTGCCCATGTCCAAATTCTGAATCGTATAGCCTCCTTTTTACCCTTGCACCTTTGGTATTTGGCTGATAGATTGGTTAAAACTTCTGATCCAAAAAAAATGGAAAATCCGAAAGGTGACGATAAGATAGTCAAGTTTTACATATACTGGTTGGCATTCTGGATACCTTTACAGACTATCCTATTTGCAGCTTTTTTACCACCAGCCTGA","protein_sequence":"MIVGLTLYFVLFRSIQYLLVFLTPIRQFDTSTSLLLNELCSSPSEINSYWNKYFWNKLLSWDSVFFIKNITSKNGKPQFEHEYAFSQLWTFFVRLFIKSNNDSIYHALRVGVAIENVLFYLSGIVLYFLTKKIFSQNIRQSQFARTIAKKTSLLFFLTSAAGFLTSIYSEPLSFFFAFVGIWSRECTISVPVLGQFDISWRYWFPYSFISMACFTLASLNRSNCVLLGIYFIFDLIELTKNRKFVKAICFPLLSGSLMFSALLYQQYYLPYKTFCPQRGEWCKSQLFSSIFITKTSLYSYIQSHYWGVGLLKYWTPNNIPNFLFAVPNIIILIYSSIYFSKIYPSYNLKALVWITRALVVIVCFFAHVQILNRIASFLPLHLWYLADRLVKTSDPKKMENPKGDDKIVKFYIYWLAFWIPLQTILFAAFLPPA"},{"created_at":"2011-05-29T03:49:02.000Z","updated_at":"2011-05-29T05:06:53.000Z","name":"GPI mannosyltransferase 1","uniprot_id":"P47088","uniprot_name":"GPI14_YEAST","enzyme":true,"transporter":false,"gene_name":"GPI14","num_residues":403,"molecular_weight":"47165.89844","theoretical_pi":"9.33","general_function":"Involved in transferase activity, transferring hexosyl groups","specific_function":"Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity","reactions":[],"signal_regions":"None","transmembrane_regions":"5-25;79-99;111-131;133-149;161-181;194-214;267-287;311-331;335-355;362-382","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"GPI14","chromosome_location":"chromosome 10","locus":"YJR013W","synonyms":["GPI mannosyltransferase I","GPI-MT-I","Glycosylphosphatidylinositol-anchor biosynthesis protein 14"],"enzyme_classes":["2.4.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" endoplasmic reticulum membrane"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" protein amino acid lipidation"},{"category":"Process","description":" GPI anchor biosynthetic process"}],"pfams":[{"name":"Mannosyl_trans","identifier":"PF05007"}],"pathways":[],"gene_sequence":"ATGACTGGCGAAGAATGGGGCTTGACTGTACTGTCATTCTTGGTAAGAGTCGGATTTTTTCTTTTTGGCATTTACCAGGACGCTAATTTCAAAGTGAGGTACACTGATATCGACTATTTTGTGTTTCATGATGCTGCTAAATATGTATACGAAGGCAAATCACCTTATGCAAGGGATACATATCGTTACACACCGCTACTAAGTTGGCTGCTAGTGCCTAATCATTATTTTGGATGGTTTCATTTGGGGAAGGTCATATTTGTTATTTTCGATTTGGTTACTGGGCTCATTATAATGAAGCTTTTGAACCAGGCCATCTCCAGAAAAAGAGCTTTAATATTGGAAAGCATTTGGCTATTGAATCCGATGGTTATCACCATCAGTACAAGGGGAAACGCTGAAAGCGTGCTTTGCTGTTTGATCATGTTCACGCTTTTTTTTCTACAAAAGAGTAGATACACCCTAGCTGGAATCTTATATGGTCTTTCTATCCATTTCAAAATATATCCAATCATATATTGTATCCCAATAGCAATTTTTATATACTACAATAAAAGAAACCAGGGTCCACGAACACAACTTACATCGCTACTCAATATCGGTTTGAGTACTCTAACAACTTTGCTTGGATGTGGTTGGGCAATGTACAAGATATACGGATACGAGTTTCTGGATCAGGCATACTTGTACCACTTATACAGAACGGATCACAGACACAATTTTTCAGTGTGGAACATGCTATTGTATTTAGATTCTGCAAATAAGGAAAATGGTGAGTCCAATCTCTCAAGGTACGCATTTGTGCCTCAATTGCTGCTTGTTTTAGTAACTGGATGTCTTGAATGGTGGAATCCCACATTCGATAACCTATTGAGGGTTTTATTTGTGCAGACGTTCGCATTTGTGACATATAATAAAGTGTGCACATCGCAATATTTTGTTTGGTACCTGATCTTTCTACCATTTTACCTCTCAAGAACGCACATTGGTTGGAAGAAGGGGCTTTTAATGGCCACGCTTTGGGTAGGAACGCAGGGAATTTGGTTAAGCCAAGGTTACTATTTGGAATTCGAAGGCAAGAATGTATTCTATCCTGGACTATTTATTGCAAGCGTGTTATTTTTCGTCACCAATGTGTGGCTACTGGGTCAATTTATTACTGATATTAAGATACCGACGCAACCCACAGTTTCCAACAAAAAGAACAACTGA","protein_sequence":"MTGEEWGLTVLSFLVRVGFFLFGIYQDANFKVRYTDIDYFVFHDAAKYVYEGKSPYARDTYRYTPLLSWLLVPNHYFGWFHLGKVIFVIFDLVTGLIIMKLLNQAISRKRALILESIWLLNPMVITISTRGNAESVLCCLIMFTLFFLQKSRYTLAGILYGLSIHFKIYPIIYCIPIAIFIYYNKRNQGPRTQLTSLLNIGLSTLTTLLGCGWAMYKIYGYEFLDQAYLYHLYRTDHRHNFSVWNMLLYLDSANKENGESNLSRYAFVPQLLLVLVTGCLEWWNPTFDNLLRVLFVQTFAFVTYNKVCTSQYFVWYLIFLPFYLSRTHIGWKKGLLMATLWVGTQGIWLSQGYYLEFEGKNVFYPGLFIASVLFFVTNVWLLGQFITDIKIPTQPTVSNKKNN"}]}