{"ymdb_id":"YMDB00927","created_at":"2011-05-30T03:39:53.000Z","updated_at":"2016-09-08T18:36:04.000Z","name":"Dolichyl diphosphate","cas":"37247-98-6","state":"Solid","melting_point":null,"description":"Dolichyl diphosphate is involved in dolichyl-diphosphooligosaccharide biosynthesis (N-linked glycosylation) pathway. N-linked glycosylation is an important process found in eukaryotes and archaea, and very rarely in bacteria. During this process certain oligosaccharides are attached to an asparagine residue in the polypeptide chain of the target protein. [Biocyc MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":"","location":null,"synthesis_reference":null,"chebi_id":"15750","hmdb_id":"HMDB01513","kegg_id":"C00621","pubchem_id":"391","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":"CPD-224","iupac":"{[hydroxy({[(6E,10E,14E,18E,22Z,26E,30E,34E,38E,42E,46E,50E,54E,58Z,62E,66E,70E,74E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75,79-icosamethyloctaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70,74,78-nonadecaen-1-yl]oxy})phosphoryl]oxy}phosphonic acid","traditional_iupac":"{hydroxy[(6E,10E,14E,18E,22Z,26E,30E,34E,38E,42E,46E,50E,54E,58Z,62E,66E,70E,74E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75,79-icosamethyloctaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70,74,78-nonadecaen-1-yl]oxyphosphoryl}oxyphosphonic acid","logp":"32.081547756999996","pka":"3.2011995186537656","alogps_solubility":"4.16e-04 g/l","alogps_logp":"9.68","alogps_logs":"-6.57","acceptor_count":"5","donor_count":"3","rotatable_bond_count":"63","polar_surface_area":"113.28999999999999","refractivity":"500.6786999999994","polarizability":"198.08035592479752","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":null,"pka_strongest_acidic":"1.7793143319379459","bioavailability":"0","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Dolichyl diphosphate","Dolichyl diphosphic acid"],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"},{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":11504728,"citation":"Fernandez, F., Rush, J. S., Toke, D. A., Han, G. S., Quinn, J. E., Carman, G. M., Choi, J. Y., Voelker, D. R., Aebi, M., Waechter, C. J. (2001). \"The CWH8 gene encodes a dolichyl pyrophosphate phosphatase with a luminally oriented active site in the endoplasmic reticulum of Saccharomyces cerevisiae.\" J Biol Chem 276:41455-41464."}],"proteins":[{"created_at":"2011-05-24T19:19:09.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Dolichyldiphosphatase","uniprot_id":"P53223","uniprot_name":"CAX4_YEAST","enzyme":true,"transporter":false,"gene_name":"CAX4","num_residues":239,"molecular_weight":"27648.80078","theoretical_pi":"8.65","general_function":"Involved in catalytic activity","specific_function":"Non-essential protein which is required for efficient N- glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate","reactions":[{"id":2245,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Dolichyl diphosphate + H(2)O = dolichyl phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"35-55;132-152;165-185","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY557771","genbank_protein_id":"45269433","gene_card_id":"CAX4","chromosome_location":"chromosome 7","locus":"YGR036C","synonyms":["Dolichyl pyrophosphate phosphatase"],"enzyme_classes":["3.6.1.43"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"PAP2","identifier":"PF01569"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAATAGTACCGCCGCTGCAATAAATCCAAATCCAAATGTTATACCATTCGATGACACATACATTCTCTATGATTCGCATGACTTTCTATCATTCCTTAGTGCATATTTCTCGCTGATGCCCATCCTAGTGCTAGCTTTTTATTTGTCGTGGTTTATCATCACAAGAGAGTTAGAAGCCTGCATTGTAGCCTTTGGCCAATTGATGAACGAAATATTCAATAACGTGATCAAGAATATAATAAAACAGCCACGCCCCGTATCGTTCGGTGCGTCGTTCCAAAATGACACTATAAGATCCGGTTACGGGATGCCCAGTGCACACTCCCAATTCATGGGGTTTTGTTTTACCTATAACTCTCTGAAGATATACACTTCCTGGAAGAATCTAAACTTCTTAGAAAAATGCATTTTTTCTGGTGCATTGGCTTTATTATCGTTTTGCGTTTGCTTTTCCAGAGTTTACTTGCACTACCACAATTTAGATCAAGTAATCGTGGGATTCAGCGTGGGGGCACTGACTGGATCACTTTATTTTTTTATAGTTGGCATCATAAGAGAGCTTGGTTTAATCAATTGGTTTTTAAAACTACGTATTGTCAGATTATTTTACATGACAGATTCTTACAATCTGGCGCCTTTGACATTGAAAGAGAATTACGAGGCGTATTGGAAAAGAATAAATCAGCGATCTTTCAATGATAAATCCAAAAGGGATTAG","protein_sequence":"MNSTAAAINPNPNVIPFDDTYILYDSHDFLSFLSAYFSLMPILVLAFYLSWFIITRELEACIVAFGQLMNEIFNNVIKNIIKQPRPVSFGASFQNDTIRSGYGMPSAHSQFMGFCFTYNSLKIYTSWKNLNFLEKCIFSGALALLSFCVCFSRVYLHYHNLDQVIVGFSVGALTGSLYFFIVGIIRELGLINWFLKLRIVRLFYMTDSYNLAPLTLKENYEAYWKRINQRSFNDKSKRD"}]}