Ubiquinol-6 (YMDB00915)

General function:

Involved in peptidyl-lysine modification to hypusine

Specific function:

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue

Gene Name:

DYS1

Uniprot ID:

P38791

Molecular weight:

42891.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE1, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxydation

Gene Name:

NDE2

Uniprot ID:

Q07500

Molecular weight:

61658.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE2, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxydation

Gene Name:

NDE1

Uniprot ID:

P40215

Molecular weight:

62773.60156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidation of NADH generated inside the Mitochondrion

Gene Name:

NDI1

Uniprot ID:

P32340

Molecular weight:

57249.30078

Reactions

General function:

Involved in 2 iron, 2 sulfur cluster binding

Specific function:

Subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4

Gene Name:

SDH2

Uniprot ID:

P21801

Molecular weight:

30230.90039

Reactions

General function:

Involved in ubiquinone biosynthetic process

Specific function:

Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides

Gene Name:

COQ4

Uniprot ID:

O13525

Molecular weight:

38626.80078

General function:

Involved in catalytic activity

Specific function:

In the de novo pyrimidine biosynthesic pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate and the reduction of fumarate to succinate. Does not use oxaloacetate and NAD or NADP as electron acceptors

Gene Name:

URA1

Uniprot ID:

P28272

Molecular weight:

34800.60156

Reactions

General function:

Involved in iron ion binding

Specific function:

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain

Gene Name:

CYC1

Uniprot ID:

P00044

Molecular weight:

12181.90039

Reactions

General function:

Involved in iron ion binding

Specific function:

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain

Gene Name:

CYC7

Uniprot ID:

P00045

Molecular weight:

12532.2998

Reactions