{"ymdb_id":"YMDB00913","created_at":"2011-05-29T19:04:25.000Z","updated_at":"2016-09-08T18:36:03.000Z","name":"D-Cysteine","cas":"921-01-7","state":"Solid","melting_point":"220 oC","description":"Cysteine (abbreviated as Cys or C) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. D-isomers are used as carbon, nitrogen, and energy source. Cysteine is unique among the twenty common amino acids because it contains a thiol group.","experimental_water_solubility":"277 mg/mL at 25 oC [BEILSTEIN]","experimental_logp_hydrophobicity":"-2.49 [HANSCH,C ET AL. (1995)]","location":null,"synthesis_reference":null,"chebi_id":"16375","hmdb_id":"HMDB03417","kegg_id":"C00793","pubchem_id":"92851","cs_id":"83819","foodb_id":null,"wikipedia_link":"Carbon_dioxide","biocyc_id":"D-CYSTEINE","iupac":"(2S)-2-amino-3-sulfanylpropanoic acid","traditional_iupac":"L cysteine","logp":"-2.7921332976482773","pka":"10.171891903949282","alogps_solubility":"2.31e+01 g/l","alogps_logp":"-2.57","alogps_logs":"-0.72","acceptor_count":"3","donor_count":"3","rotatable_bond_count":"2","polar_surface_area":"63.31999999999999","refractivity":"28.2236","polarizability":"11.401989924934824","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.053809511128133","pka_strongest_acidic":"2.345995198078135","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["D-Amino-3-mercaptopropionate","D-Amino-3-mercaptopropionic acid"],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18305111,"citation":"Abe, T., Hashimoto, Y., Hosaka, H., Tomita-Yokotani, K., Kobayashi, M. (2008). \"Discovery of amide (peptide) bond synthetic activity in Acyl-CoA synthetase.\" J Biol Chem 283:11312-11321."}],"proteins":[{"created_at":"2011-05-26T23:37:41.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"N-acetyltransferase HPA3","uniprot_id":"P39979","uniprot_name":"HPA3_YEAST","enzyme":true,"transporter":false,"gene_name":"HPA3","num_residues":179,"molecular_weight":"20698.5","theoretical_pi":"7.84","general_function":"Involved in N-acetyltransferase activity","specific_function":"N-acetyltransferase whose physiological acetyl acceptor substrate is still unknown. In vitro, histone acetylation is very weak","reactions":[{"id":2617,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U18795","genbank_protein_id":"603252","gene_card_id":"HPA3","chromosome_location":"chromosome 5","locus":"YEL066W","synonyms":[],"enzyme_classes":["2.3.1.-","2.3.1.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" acetyltransferase activity"},{"category":"Function","description":" N-acetyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Acetyltransf_1","identifier":"PF00583"}],"pathways":[],"gene_sequence":"ATGAAAAAGACCCCAGACCCATCTCCACCTTTTGCAAGCACGAAGAACGTAGGCATGTCAAACGAAGAACCGGAAAAAATGGTTAACGATCGAATTGTGGTGAAGGCCATCGAGCCAAAAGATGAGGAAGCCTGGAACAAACTGTGGAAGGAGTATCAGGGTTTCCAAAAAACGGTTATGCCTCCGGAAGTAGCCACCACTACCTTCGCAAGGTTTATAGACCCTACGGTCAAACTATGGGGTGCTCTAGCCTTTGACACCGAGACCGGCGATGCAATTGGCTTTGCACACTACCTGAACCATTTGACGTCGTGGCATGTCGAAGAAGTTGTCTACATGAATGACTTATATGTCACTGAACGCGCAAGAGTCAAAGGCGTAGGTAGAAAGCTCATAGAATTTGTATACAGCCGTGCCGATGAGCTCGGTACGCCTGCAGTGTACTGGGTTACAGACCATTACAATCACCGCGCACAGTTGCTGTACACCAAAGTGGCTTACAAGACAGATAAGGTTCTTTACAAGAGAAACGGATACTGA","protein_sequence":"MKKTPDPSPPFASTKNVGMSNEEPEKMVNDRIVVKAIEPKDEEAWNKLWKEYQGFQKTVMPPEVATTTFARFIDPTVKLWGALAFDTETGDAIGFAHYLNHLTSWHVEEVVYMNDLYVTERARVKGVGRKLIEFVYSRADELGTPAVYWVTDHYNHRAQLLYTKVAYKTDKVLYKRNGY"}]}