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phosphate (YMDB00907)
| Identification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| YMDB ID | YMDB00907 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Name | phosphate | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strain | Baker's yeast | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | Phosphate, also known as phosphoric acid or [po(OH)3], belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion. Phosphate exists in all living species, ranging from bacteria to plants to humans. Based on a literature review a significant number of articles have been published on Phosphate. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Structure |  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms |
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| CAS number | 14265-44-2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Weight | Average: 94.9714 Monoisotopic: 94.95342 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI Key | NBIIXXVUZAFLBC-UHFFFAOYSA-K | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI | InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IUPAC Name | phosphoric acid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Traditional IUPAC Name | phosphoric acid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Formula | O4P | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMILES | [O-]P([O-])([O-])=O | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kingdom | Inorganic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Super Class | Homogeneous non-metal compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Class | Non-metal oxoanionic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sub Class | Non-metal phosphates | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Direct Parent | Non-metal phosphates | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Alternative Parents | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Substituents |
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| Molecular Framework | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Descriptors |
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| Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| State | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Charge | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Melting point | 42.35 °C | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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| Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Locations |
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| Organoleptic Properties | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMPDB Pathways |
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| KEGG Pathways |
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| SMPDB Reactions |
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| KEGG Reactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Intracellular Concentrations |
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| Extracellular Concentrations | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra |
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| References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| References: |
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| Synthesis Reference: | Cremer, Josef; Hartmann, Fridolin; Rodis, Franz; Hinz, Arnulf. Preparation of alkali or alkaline earth phosphates with simultaneous recovery of volatile mineral acids. Ger. (1966), 2 pp. CODEN: GWXXAW DE 1227435 19661027 CAN 66:12584 AN 196 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Links: |
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Enzymes
- General function:
- Involved in catalytic activity
- Specific function:
- Non-essential protein which is required for efficient N- glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate
- Gene Name:
- CAX4
- Uniprot ID:
- P53223
- Molecular weight:
- 27648.80078
Reactions
| Dolichyl diphosphate + H(2)O → dolichyl phosphate + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate
- Gene Name:
- ADE6
- Uniprot ID:
- P38972
- Molecular weight:
- 148904.0
Reactions
| ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O → ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. |
- General function:
- Involved in catalytic activity
- Specific function:
- 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
- Gene Name:
- CPA1
- Uniprot ID:
- P07258
- Molecular weight:
- 45361.19922
Reactions
| 2 ATP + L-glutamine + HCO(3)(-) + H(2)O → 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. |
- General function:
- Involved in carboxyl- or carbamoyltransferase activity
- Specific function:
- This protein is a "fusion" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase)
- Gene Name:
- URA2
- Uniprot ID:
- P07259
- Molecular weight:
- 245124.0
Reactions
| 2 ATP + L-glutamine + HCO(3)(-) + H(2)O → 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. |
| Carbamoyl phosphate + L-aspartate → phosphate + N-carbamoyl-L-aspartate. |
- General function:
- Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
- Specific function:
- Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln). Required for HMG2-induced ER-remodeling
- Gene Name:
- HER2
- Uniprot ID:
- Q03557
- Molecular weight:
- 50918.0
Reactions
| ATP + L-glutamyl-tRNA(Gln) + L-glutamine → ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. |
- General function:
- Involved in ATP binding
- Specific function:
- 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
- Gene Name:
- CPA2
- Uniprot ID:
- P03965
- Molecular weight:
- 123914.0
Reactions
| 2 ATP + L-glutamine + HCO(3)(-) + H(2)O → 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. |
- General function:
- Involved in CTP synthase activity
- Specific function:
- Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
- Gene Name:
- URA7
- Uniprot ID:
- P28274
- Molecular weight:
- 64709.80078
Reactions
| ATP + UTP + NH(3) → ADP + phosphate + CTP. |
- General function:
- Involved in glutamate-ammonia ligase activity
- Specific function:
- ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine
- Gene Name:
- GLN1
- Uniprot ID:
- P32288
- Molecular weight:
- 41705.60156
Reactions
| ATP + L-glutamate + NH(3) → ADP + phosphate + L-glutamine. |
- General function:
- Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
- Specific function:
- Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)
- Gene Name:
- PET112
- Uniprot ID:
- P33893
- Molecular weight:
- 61842.19922
Reactions
| ATP + L-glutamyl-tRNA(Gln) + L-glutamine → ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. |
- General function:
- Involved in CTP synthase activity
- Specific function:
- Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis
- Gene Name:
- URA8
- Uniprot ID:
- P38627
- Molecular weight:
- 63055.69922
Reactions
| ATP + UTP + NH(3) → ADP + phosphate + CTP. |
- General function:
- Involved in ATP binding
- Specific function:
- Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)
- Gene Name:
- Not Available
- Uniprot ID:
- P53260
- Molecular weight:
- 20786.80078
Reactions
| ATP + L-glutamyl-tRNA(Gln) + L-glutamine → ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. |
- General function:
- Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
- Specific function:
- Hydrolysis of urea to ammonia and CO(2)
- Gene Name:
- DUR1
- Uniprot ID:
- P32528
- Molecular weight:
- 201830.0
Reactions
| ATP + urea + HCO(3)(-) → ADP + phosphate + urea-1-carboxylate. |
| Urea-1-carboxylate + H(2)O → 2 CO(2) + 2 NH(3). |
- General function:
- Involved in ATP adenylyltransferase activity
- Specific function:
- Ap4A phosphorylase catabolizes Ap4N nucleotides (where N is A,C,G or U). Additionally this enzyme catalyzes the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulfate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP
- Gene Name:
- APA1
- Uniprot ID:
- P16550
- Molecular weight:
- 36492.19922
Reactions
| ADP + ATP → phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate. |
| ADP + sulfate → phosphate + adenylyl sulfate. |
| Adenylylsulfate + ATP → P(1),P(4)-bis(5'-adenosyl)tetraphosphate + sulfate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process
- Gene Name:
- TPS2
- Uniprot ID:
- P31688
- Molecular weight:
- 102976.0
Reactions
| Trehalose 6-phosphate + H(2)O → trehalose + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- This is predominantly if not solely a fructose-2,6- bisphosphatase
- Gene Name:
- FBP26
- Uniprot ID:
- P32604
- Molecular weight:
- 52594.5
Reactions
| Beta-D-fructose 2,6-bisphosphate + H(2)O → D-fructose 6-phosphate + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Synthesis and degradation of fructose 2,6-bisphosphate
- Gene Name:
- Not Available
- Uniprot ID:
- Q06137
- Molecular weight:
- 58385.19922
Reactions
| Beta-D-fructose 2,6-bisphosphate + H(2)O → D-fructose 6-phosphate + phosphate. |
| ATP + D-fructose 6-phosphate → ADP + beta-D-fructose 2,6-bisphosphate. |
- General function:
- Involved in adenylosuccinate synthase activity
- Specific function:
- Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
- Gene Name:
- ADE12
- Uniprot ID:
- P80210
- Molecular weight:
- 48279.10156
Reactions
| GTP + IMP + L-aspartate → GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. |
- General function:
- Involved in hydrolase activity
- Specific function:
- May eliminate potentially toxic dinucleoside polyphosphates during sporulation. Most active against diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A). Can also hydrolyze diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A), adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate)
- Gene Name:
- DDP1
- Uniprot ID:
- Q99321
- Molecular weight:
- 21572.30078
Reactions
| Diphospho-myo-inositol polyphosphate + H(2)O → myo-inositol polyphosphate + phosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
- Gene Name:
- GSH2
- Uniprot ID:
- Q08220
- Molecular weight:
- 55814.69922
Reactions
| ATP + gamma-L-glutamyl-L-cysteine + glycine → ADP + phosphate + glutathione. |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide
- Gene Name:
- ADE5
- Uniprot ID:
- P07244
- Molecular weight:
- 86067.39844
Reactions
| ATP + 5-phospho-D-ribosylamine + glycine → ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. |
| ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine → ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. |
- General function:
- Involved in catalytic activity
- Specific function:
- Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)
- Gene Name:
- UTR4
- Uniprot ID:
- P32626
- Molecular weight:
- 25187.19922
Reactions
| 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O → 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. |
| 2-Phosphoglycolate + H2O → glycolate + phosphate |
- General function:
- Involved in phosphatase activity
- Specific function:
- Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing
- Gene Name:
- POA1
- Uniprot ID:
- P38218
- Molecular weight:
- 19937.59961
Reactions
| ADP-ribose 1''-phosphate + H(2)O → ADP-ribose + phosphate. |
- General function:
- Involved in phosphatase activity
- Specific function:
- Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing
- Gene Name:
- Not Available
- Uniprot ID:
- Q04299
- Molecular weight:
- 32067.0
Reactions
| ADP-ribose 1''-phosphate + H(2)O → ADP-ribose + phosphate. |
- General function:
- Involved in 3-dehydroquinate dehydratase activity
- Specific function:
- The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis
- Gene Name:
- ARO1
- Uniprot ID:
- P08566
- Molecular weight:
- 174754.0
Reactions
| 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate → 3-dehydroquinate + phosphate. |
| 3-dehydroquinate → 3-dehydroshikimate + H(2)O. |
| Shikimate + NADP(+) → 3-dehydroshikimate + NADPH. |
| ATP + shikimate → ADP + shikimate 3-phosphate. |
| Phosphoenolpyruvate + 3-phosphoshikimate → phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
- Gene Name:
- ARO4
- Uniprot ID:
- P32449
- Molecular weight:
- 39748.80078
Reactions
| Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O → 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
- Gene Name:
- ARO3
- Uniprot ID:
- P14843
- Molecular weight:
- 41069.5
Reactions
| Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O → 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. |
- General function:
- Involved in purine-nucleoside phosphorylase activity
- Specific function:
- Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules
- Gene Name:
- PNP1
- Uniprot ID:
- Q05788
- Molecular weight:
- 33754.60156
Reactions
| Purine nucleoside + phosphate → purine + alpha-D-ribose 1-phosphate. |
- General function:
- Involved in aspartate-semialdehyde dehydrogenase activity
- Specific function:
- This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp
- Gene Name:
- HOM2
- Uniprot ID:
- P13663
- Molecular weight:
- 39543.30078
Reactions
| L-aspartate 4-semialdehyde + phosphate + NADP(+) → L-4-aspartyl phosphate + NADPH. |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
- Gene Name:
- LSC1
- Uniprot ID:
- P53598
- Molecular weight:
- 35032.19922
Reactions
| ATP + succinate + CoA → ADP + phosphate + succinyl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
- Gene Name:
- LSC2
- Uniprot ID:
- P53312
- Molecular weight:
- 46900.30078
Reactions
| ATP + succinate + CoA → ADP + phosphate + succinyl-CoA. |
- General function:
- Involved in glutamate-cysteine ligase activity
- Specific function:
- ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
- Gene Name:
- GSH1
- Uniprot ID:
- P32477
- Molecular weight:
- 78252.89844
Reactions
| ATP + L-glutamate + L-cysteine → ADP + phosphate + gamma-L-glutamyl-L-cysteine. |
- General function:
- Involved in acetylglutamate kinase activity
- Specific function:
- N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH
- Gene Name:
- ARG5
- Uniprot ID:
- Q01217
- Molecular weight:
- 94868.39844
Reactions
| N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate → N-acetyl-5-glutamyl phosphate + NADPH. |
| ATP + N-acetyl-L-glutamate → ADP + N-acetyl-L-glutamate 5-phosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis
- Gene Name:
- YND1
- Uniprot ID:
- P40009
- Molecular weight:
- 71851.20313
Reactions
| ATP + 2 H(2)O → AMP + 2 phosphate. |
- General function:
- Involved in carboxyl- or carbamoyltransferase activity
- Specific function:
- Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
- Gene Name:
- ARG3
- Uniprot ID:
- P05150
- Molecular weight:
- 37844.80078
Reactions
| Carbamoyl phosphate + L-ornithine → phosphate + L-citrulline. |
- General function:
- Involved in phosphoribosylaminoimidazole carboxylase activity
- Specific function:
- 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)
- Gene Name:
- ADE2
- Uniprot ID:
- P21264
- Molecular weight:
- 62338.69922
Reactions
| 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate → 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2). |
- General function:
- Involved in catalytic activity
- Specific function:
- Glycerol 3-phosphate + H(2)O = glycerol + phosphate
- Gene Name:
- HOR2
- Uniprot ID:
- P40106
- Molecular weight:
- 27813.5
Reactions
| Glycerol 3-phosphate + H(2)O → glycerol + phosphate. |
| glycerol 1-phosphate + H2O → glycerol + phosphate |
- General function:
- Involved in catalytic activity
- Specific function:
- Glycerol 3-phosphate + H(2)O = glycerol + phosphate
- Gene Name:
- RHR2
- Uniprot ID:
- P41277
- Molecular weight:
- 27946.59961
Reactions
| Glycerol 3-phosphate + H(2)O → glycerol + phosphate. |
| glycerol 1-phosphate + H2O → glycerol + phosphate |
- General function:
- Involved in magnesium ion binding
- Specific function:
- ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin
- Gene Name:
- BIO4
- Uniprot ID:
- P53630
- Molecular weight:
- 26256.69922
Reactions
| ATP + 7,8-diaminononanoate + CO(2) → ADP + phosphate + dethiobiotin. |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate
- Gene Name:
- ADE1
- Uniprot ID:
- P27616
- Molecular weight:
- 34603.10156
Reactions
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate → ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. |
- General function:
- Involved in phosphoric ester hydrolase activity
- Specific function:
- D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate
- Gene Name:
- FBP1
- Uniprot ID:
- P09201
- Molecular weight:
- 38262.19922
Reactions
| D-fructose 1,6-bisphosphate + H(2)O → D-fructose 6-phosphate + phosphate. |
- General function:
- Involved in tetrahydrofolylpolyglutamate synthase activity
- Specific function:
- Conversion of folates to polyglutamate derivatives
- Gene Name:
- FOL3
- Uniprot ID:
- Q12676
- Molecular weight:
- 47850.80078
Reactions
| ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate → ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). |
- General function:
- Involved in formate-tetrahydrofolate ligase activity
- Specific function:
- 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH
- Gene Name:
- MIS1
- Uniprot ID:
- P09440
- Molecular weight:
- 106216.0
Reactions
| 5,10-methylenetetrahydrofolate + NADP(+) → 5,10-methenyltetrahydrofolate + NADPH. |
| 5,10-methenyltetrahydrofolate + H(2)O → 10-formyltetrahydrofolate. |
| ATP + formate + tetrahydrofolate → ADP + phosphate + 10-formyltetrahydrofolate. |
- General function:
- Involved in formate-tetrahydrofolate ligase activity
- Specific function:
- 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH
- Gene Name:
- ADE3
- Uniprot ID:
- P07245
- Molecular weight:
- 102204.0
Reactions
| 5,10-methylenetetrahydrofolate + NADP(+) → 5,10-methenyltetrahydrofolate + NADPH. |
| 5,10-methenyltetrahydrofolate + H(2)O → 10-formyltetrahydrofolate. |
| ATP + formate + tetrahydrofolate → ADP + phosphate + 10-formyltetrahydrofolate. |
- General function:
- Involved in acid phosphatase activity
- Specific function:
- A phosphate monoester + H(2)O = an alcohol + phosphate
- Gene Name:
- PHO11
- Uniprot ID:
- P35842
- Molecular weight:
- 52757.39844
Reactions
| A phosphate monoester + H(2)O → an alcohol + phosphate. |
- General function:
- Involved in acid phosphatase activity
- Specific function:
- Partially mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and NPP2
- Gene Name:
- PHO5
- Uniprot ID:
- P00635
- Molecular weight:
- 52858.10156
Reactions
| A phosphate monoester + H(2)O → an alcohol + phosphate. |
- General function:
- Involved in 3'(2'),5'-bisphosphate nucleotidase activity
- Specific function:
- Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance. Confers resistance to lithium
- Gene Name:
- HAL2
- Uniprot ID:
- P32179
- Molecular weight:
- 39148.89844
Reactions
| Adenosine 3',5'-bisphosphate + H(2)O → adenosine 5'-phosphate + phosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Not Available
- Gene Name:
- Not Available
- Uniprot ID:
- P28273
- Molecular weight:
- 140426.0
Reactions
| ATP + 5-oxo-L-proline + 2 H(2)O → ADP + phosphate + L-glutamate. |
- General function:
- Involved in methionine adenosyltransferase activity
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP
- Gene Name:
- SAM1
- Uniprot ID:
- P10659
- Molecular weight:
- 41818.0
Reactions
| ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine. |
- General function:
- Involved in acetyl-CoA carboxylase activity
- Specific function:
- Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions:biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase
- Gene Name:
- HFA1
- Uniprot ID:
- P32874
- Molecular weight:
- 259161.0
Reactions
| ATP + acetyl-CoA + HCO(3)(-) → ADP + phosphate + malonyl-CoA. |
| ATP + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein]. |
- General function:
- Involved in catalytic activity
- Specific function:
- Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
- Gene Name:
- PYC1
- Uniprot ID:
- P11154
- Molecular weight:
- 130098.0
Reactions
| ATP + pyruvate + HCO(3)(-) → ADP + phosphate + oxaloacetate. |
- General function:
- Involved in ATP binding
- Specific function:
- PI-SceI is an endonuclease that can cleave at a site present in a VMA1 allele that lacks the derived endonuclease segment of the open reading frame; cleavage at this site only occurs during meiosis and initiates "homing", a genetic event that converts a VMA1 allele lacking VDE into one that contains it
- Gene Name:
- TFP1
- Uniprot ID:
- P17255
- Molecular weight:
- 118636.0
Reactions
| ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out). |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2)
- Gene Name:
- MVD1
- Uniprot ID:
- P32377
- Molecular weight:
- 44115.5
Reactions
| ATP + (R)-5-diphosphomevalonate → ADP + phosphate + isopentenyl diphosphate + CO(2). |
- General function:
- Involved in acetyl-CoA carboxylase activity
- Specific function:
- Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase
- Gene Name:
- FAS3
- Uniprot ID:
- Q00955
- Molecular weight:
- 250351.0
Reactions
| ATP + acetyl-CoA + HCO(3)(-) → ADP + phosphate + malonyl-CoA. |
| ATP + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein]. |
- General function:
- Involved in binding
- Specific function:
- Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. STT4 functions in PKC1 protein kinase pathway
- Gene Name:
- STT4
- Uniprot ID:
- P37297
- Molecular weight:
- 214605.0
Reactions
| ATP + 1-phosphatidyl-1D-myo-inositol → ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses
- Gene Name:
- PMA1
- Uniprot ID:
- P05030
- Molecular weight:
- 99618.39844
Reactions
| ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out). |
- General function:
- Involved in DNA binding
- Specific function:
- Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxin TSA1. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and as thioltransferase
- Gene Name:
- SRX1
- Uniprot ID:
- P36077
- Molecular weight:
- 13853.90039
Reactions
| Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH → peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R. |
- General function:
- Involved in ATP adenylyltransferase activity
- Specific function:
- Sustains the catabolism of Np-4-N' nucleotides, rather than their synthesis
- Gene Name:
- APA2
- Uniprot ID:
- P22108
- Molecular weight:
- 36840.5
Reactions
| ADP + ATP → phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- A phosphate monoester + H(2)O = an alcohol + phosphate
- Gene Name:
- PHO8
- Uniprot ID:
- P11491
- Molecular weight:
- 63003.60156
Reactions
| A phosphate monoester + H(2)O → an alcohol + phosphate. |
| (2E,6E)-farnesyl diphosphate + H(2)O → (2E,6E)-farnesol + diphosphate. |
| beta-D-fructose 2,6-bisphosphate + H2O → beta-D-fructofuranose 2-phosphate + phosphate |
- General function:
- Involved in tetrahydrofolylpolyglutamate synthase activity
- Specific function:
- Conversion of folates to polyglutamate derivatives
- Gene Name:
- RMA1
- Uniprot ID:
- P36001
- Molecular weight:
- 48142.89844
Reactions
| ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate → ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). |
- General function:
- Involved in nucleotide binding
- Specific function:
- The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses
- Gene Name:
- PMA2
- Uniprot ID:
- P19657
- Molecular weight:
- 102171.0
Reactions
| ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out). |
- General function:
- Involved in ATP binding
- Specific function:
- Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits
- Gene Name:
- ATP2
- Uniprot ID:
- P00830
- Molecular weight:
- 54793.30078
Reactions
| ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out). |
- General function:
- Involved in catalytic activity
- Specific function:
- Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
- Gene Name:
- PYC2
- Uniprot ID:
- P32327
- Molecular weight:
- 130166.0
Reactions
| ATP + pyruvate + HCO(3)(-) → ADP + phosphate + oxaloacetate. |
- General function:
- Involved in ATP binding
- Specific function:
- Utilizes 5-formyltetrahydrofolate (folinic acid) as substrate in an alternative way of folate biosynthesis
- Gene Name:
- FAU1
- Uniprot ID:
- P40099
- Molecular weight:
- 24058.5
Reactions
| ATP + 5-formyltetrahydrofolate → ADP + phosphate + 5,10-methenyltetrahydrofolate. |
- General function:
- Involved in phosphatidylinositol phosphate kinase activity
- Specific function:
- Catalyzes the phosphorylation of phosphatidylinositol-4- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol-4,5-biphosphate. Acts downstream of STT4, but in a pathway that does not involve PKC1. May be involved in the organization of the actin cytoskeleton
- Gene Name:
- MSS4
- Uniprot ID:
- P38994
- Molecular weight:
- 89319.60156
Reactions
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate → ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
- General function:
- Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
- Specific function:
- D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
- Gene Name:
- TDH1
- Uniprot ID:
- P00360
- Molecular weight:
- 35749.60156
Reactions
| D-glyceraldehyde 3-phosphate + phosphate + NAD(+) → 3-phospho-D-glyceroyl phosphate + NADH. |
- General function:
- Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
- Specific function:
- D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
- Gene Name:
- TDH2
- Uniprot ID:
- P00358
- Molecular weight:
- 35846.60156
Reactions
| D-glyceraldehyde 3-phosphate + phosphate + NAD(+) → 3-phospho-D-glyceroyl phosphate + NADH. |
- General function:
- Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
- Specific function:
- D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
- Gene Name:
- TDH3
- Uniprot ID:
- P00359
- Molecular weight:
- 35746.39844
Reactions
| D-glyceraldehyde 3-phosphate + phosphate + NAD(+) → 3-phospho-D-glyceroyl phosphate + NADH. |
- General function:
- Involved in catalytic activity
- Specific function:
- O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate
- Gene Name:
- SER2
- Uniprot ID:
- P42941
- Molecular weight:
- 34207.0
Reactions
| O-phospho-L(or D)-serine + H(2)O → L(or D)-serine + phosphate. |
- General function:
- Involved in histidinol-phosphatase activity
- Specific function:
- L-histidinol phosphate + H(2)O = L-histidinol + phosphate
- Gene Name:
- HIS2
- Uniprot ID:
- P38635
- Molecular weight:
- 38581.5
Reactions
| L-histidinol phosphate + H(2)O → L-histidinol + phosphate. |
- General function:
- Involved in protein tyrosine/serine/threonine phosphatase activity
- Specific function:
- May act as a phosphoinositide 3-phosphatase by regulating PtdIns(3,4,5)P3 levels
- Gene Name:
- TEP1
- Uniprot ID:
- P53916
- Molecular weight:
- 50151.5
Reactions
| Phosphatidylinositol 3,4,5-trisphosphate + H(2)O → phosphatidylinositol 4,5-bisphosphate + phosphate. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate
- Gene Name:
- PRO2
- Uniprot ID:
- P54885
- Molecular weight:
- 49740.0
Reactions
| L-glutamate 5-semialdehyde + phosphate + NADP(+) → L-glutamyl 5-phosphate + NADPH. |
- General function:
- Involved in chorismate synthase activity
- Specific function:
- 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
- Gene Name:
- ARO2
- Uniprot ID:
- P28777
- Molecular weight:
- 40838.0
Reactions
| 5-O-(1-carboxyvinyl)-3-phosphoshikimate → chorismate + phosphate. |
- General function:
- Involved in inositol or phosphatidylinositol phosphatase activity
- Specific function:
- Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling
- Gene Name:
- INM2
- Uniprot ID:
- Q05533
- Molecular weight:
- 32092.40039
Reactions
| Myo-inositol phosphate + H(2)O → myo-inositol + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Seems to be implicated in the regulation of the expression of the ADH2 gene
- Gene Name:
- MEU1
- Uniprot ID:
- Q07938
- Molecular weight:
- 37856.30078
Reactions
| S-methyl-5'-thioadenosine + phosphate → adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate |
- General function:
- Involved in nicotinate phosphoribosyltransferase activity
- Specific function:
- Essential for growth under anaerobic conditions
- Gene Name:
- NPT1
- Uniprot ID:
- P39683
- Molecular weight:
- 49018.19922
Reactions
| Nicotinate D-ribonucleotide + diphosphate → nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. Can function independently of the complex
- Gene Name:
- TPS1
- Uniprot ID:
- Q00764
- Molecular weight:
- 56147.5
Reactions
| UDP-glucose + D-glucose 6-phosphate → UDP + alpha,alpha-trehalose 6-phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
- Gene Name:
- THR4
- Uniprot ID:
- P16120
- Molecular weight:
- 57473.69922
Reactions
| O-phospho-L-homoserine + H(2)O → L-threonine + phosphate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Involved in energy production. Its activity is stimulated by uncouplers of ATP synthesis
- Gene Name:
- PPA2
- Uniprot ID:
- P28239
- Molecular weight:
- 35572.39844
Reactions
| Diphosphate + H(2)O → 2 phosphate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Diphosphate + H(2)O = 2 phosphate
- Gene Name:
- IPP1
- Uniprot ID:
- P00817
- Molecular weight:
- 32299.30078
Reactions
| Diphosphate + H(2)O → 2 phosphate. |
- General function:
- Involved in acid phosphatase activity
- Specific function:
- A phosphate monoester + H(2)O = an alcohol + phosphate
- Gene Name:
- PHO3
- Uniprot ID:
- P24031
- Molecular weight:
- 52776.10156
Reactions
| A phosphate monoester + H(2)O → an alcohol + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- PHO13 is dispensable for vegetative growth and sporulation
- Gene Name:
- PHO13
- Uniprot ID:
- P19881
- Molecular weight:
- 34624.30078
Reactions
| 4-nitrophenyl phosphate + H(2)O → 4-nitrophenol + phosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol
- Gene Name:
- GDA1
- Uniprot ID:
- P32621
- Molecular weight:
- 56821.0
Reactions
| GDP + H(2)O → GMP + phosphate. |
- General function:
- Involved in phosphorylase activity
- Specific function:
- Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
- Gene Name:
- GPH1
- Uniprot ID:
- P06738
- Molecular weight:
- 103274.0
Reactions
| (1,4-alpha-D-glucosyl)(n) + phosphate → (1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate. |
- General function:
- Involved in inositol or phosphatidylinositol phosphatase activity
- Specific function:
- Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN
- Gene Name:
- INP53
- Uniprot ID:
- Q12271
- Molecular weight:
- 124576.0
Reactions
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
| D-myo-inositol 1,4,5-trisphosphate + H2O → D-myo-inositol 1,4-bisphosphate + phosphate |
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O → D-myo-inositol 1,3,4-trisphosphate + phosphate |
- General function:
- Involved in inositol or phosphatidylinositol phosphatase activity
- Specific function:
- Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Specifically functions within the early endocytic pathway and actin organization
- Gene Name:
- INP52
- Uniprot ID:
- P50942
- Molecular weight:
- 133330.0
Reactions
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
| D-myo-inositol 1,4,5-trisphosphate + H2O → D-myo-inositol 1,4-bisphosphate + phosphate |
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O → D-myo-inositol 1,3,4-trisphosphate + phosphate |
- General function:
- Involved in catalytic activity
- Specific function:
- Active on 2-DOG-6P, also very active on fructose-1P
- Gene Name:
- DOG1
- Uniprot ID:
- P38774
- Molecular weight:
- 27099.59961
Reactions
| 2-deoxy-D-glucose 6-phosphate + H(2)O → 2-deoxy-D-glucose + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Active on 2-DOG-6P, not very active on fructose-1p
- Gene Name:
- DOG2
- Uniprot ID:
- P38773
- Molecular weight:
- 27164.80078
Reactions
| 2-deoxy-D-glucose 6-phosphate + H(2)O → 2-deoxy-D-glucose + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex
- Gene Name:
- TPS3
- Uniprot ID:
- P38426
- Molecular weight:
- 118834.0
Reactions
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
- Gene Name:
- Not Available
- Uniprot ID:
- Q12040
- Molecular weight:
- 26176.5
Reactions
| 2-phospho-D-glycerate → 3-phospho-D-glycerate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Could be non-functional
- Gene Name:
- GPM2
- Uniprot ID:
- Q12008
- Molecular weight:
- 36072.80078
Reactions
| 2-phospho-D-glycerate → 3-phospho-D-glycerate. |
- General function:
- Involved in inositol or phosphatidylinositol phosphatase activity
- Specific function:
- Regulates the phosphatidylinositol (4,5)-diphosphate levels on the cytoplasmic surface of the endoplasmic reticulum and thereby regulates secretion
- Gene Name:
- INP54
- Uniprot ID:
- Q08227
- Molecular weight:
- 43798.69922
Reactions
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
- General function:
- Involved in phosphoric ester hydrolase activity
- Specific function:
- The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Major enzyme required for hyperosmotic shock- induced turnover of PtdIns(3,5)P2 and requires VAC14 for this function. In vivo, mediates turnover of PtdIns(3,5)P2 at the vacuole membrane necessary for vacuolar size control. In vitro, catalyzes the removal of phosphate from the fifth hydroxyl of the myo-inositol ring of phosphatidylinositol-3,5-bisphosphate
- Gene Name:
- FIG4
- Uniprot ID:
- P42837
- Molecular weight:
- 101745.0
Reactions
| 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
- General function:
- Involved in inositol or phosphatidylinositol phosphatase activity
- Specific function:
- Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth
- Gene Name:
- INP51
- Uniprot ID:
- P40559
- Molecular weight:
- 108429.0
Reactions
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the dephosphorylation of diacylglycerol phosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with DPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is PA > DGPP > LPA
- Gene Name:
- LPP1
- Uniprot ID:
- Q04396
- Molecular weight:
- 31585.90039
Reactions
| A 1,2-diacylglycerol 3-phosphate + H(2)O → a 1,2-diacyl-sn-glycerol + phosphate. |
| Diacylglycerol pyrophosphate + H(2)O → phosphatidate + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the dephosphorylation of diacylglycerol phosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with LPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is DGPP > LPA > PA
- Gene Name:
- DPP1
- Uniprot ID:
- Q05521
- Molecular weight:
- 33513.60156
Reactions
| A 1,2-diacylglycerol 3-phosphate + H(2)O → a 1,2-diacyl-sn-glycerol + phosphate. |
| Diacylglycerol pyrophosphate + H(2)O → phosphatidate + phosphate. |
- General function:
- Involved in phosphatidylglycerophosphatase activity
- Specific function:
- Phosphatidylglycerophosphatase involved in the biosynthesis of cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes and which has important functions for cellular energy metabolism, mitochondrial dynamics and the initiation of apoptotic pathways. Required for the stability of respiratory chain supercomplexes and for growth at elevated temperature, in presence of ethidium bromide or in absence of prohibitins
- Gene Name:
- GEP4
- Uniprot ID:
- P38812
- Molecular weight:
- 20944.90039
Reactions
| Phosphatidylglycerophosphate + H(2)O → phosphatidylglycerol + phosphate. |
- General function:
- Involved in protein tyrosine phosphatase activity
- Specific function:
- Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates
- Gene Name:
- LTP1
- Uniprot ID:
- P40347
- Molecular weight:
- 18675.09961
Reactions
| Protein tyrosine phosphate + H(2)O → protein tyrosine + phosphate. |
| A phosphate monoester + H(2)O → an alcohol + phosphate. |
- General function:
- Involved in endopolyphosphatase activity
- Specific function:
- Catalyzes the hydrolysis of inorganic polyphosphate (poly P) chains of many hundreds of phosphate residues into shorter lengths. The limited digestion products are 1 and 3 P(i) residues
- Gene Name:
- PPN1
- Uniprot ID:
- Q04119
- Molecular weight:
- 78343.70313
Reactions
| Polyphosphate + n H(2)O → (n+1) oligophosphate. |
| (Polyphosphate)(n) + H(2)O → (polyphosphate)(n-1) + phosphate. |
- General function:
- Involved in acid phosphatase activity
- Specific function:
- A phosphate monoester + H(2)O = an alcohol + phosphate
- Gene Name:
- DIA3
- Uniprot ID:
- P52290
- Molecular weight:
- 53075.89844
Reactions
| A phosphate monoester + H(2)O → an alcohol + phosphate. |
- General function:
- Involved in acid phosphatase activity
- Specific function:
- A phosphate monoester + H(2)O = an alcohol + phosphate
- Gene Name:
- PHO12
- Uniprot ID:
- P38693
- Molecular weight:
- 52699.30078
Reactions
| A phosphate monoester + H(2)O → an alcohol + phosphate. |
- General function:
- Involved in pyrophosphatase activity
- Specific function:
- Degradation of inorganic polyphosphates
- Gene Name:
- PPX1
- Uniprot ID:
- P38698
- Molecular weight:
- 45051.0
Reactions
| (Polyphosphate)(n) + H(2)O → (polyphosphate)(n-1) + phosphate. |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Conversion of folates to polyglutamate derivatives
- Gene Name:
- MET7
- Uniprot ID:
- Q08645
- Molecular weight:
- 62150.89844
Reactions
| ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate → ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP
- Gene Name:
- SAM2
- Uniprot ID:
- P19358
- Molecular weight:
- 42255.5
Reactions
| ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine. |
- General function:
- Involved in catalytic activity
- Specific function:
- Not Available
- Gene Name:
- Not Available
- Uniprot ID:
- Q12486
- Molecular weight:
- 24839.80078
Reactions
| 2-Phosphoglycolate + H2O → glycolate + phosphate |
- General function:
- Involved in catalytic activity
- Specific function:
- Not Available
- Gene Name:
- Not Available
- Uniprot ID:
- Q04223
- Molecular weight:
- 35278.10156
Reactions
| 2-Phosphoglycolate + H2O → glycolate + phosphate |
- General function:
- Involved in inositol or phosphatidylinositol phosphatase activity
- Specific function:
- Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides
- Gene Name:
- INM1
- Uniprot ID:
- P38710
- Molecular weight:
- 32823.0
Reactions
| Myo-inositol phosphate + H(2)O → myo-inositol + phosphate. |
- General function:
- tRNA wobble uridine modification
- Specific function:
- Involved in the dephosphorylation of the large subunit of RNA polymerase II. Is required in late G1 for normal G1 cyclin expression, bud initiation and expression of certain genes that are periodically expressed during late G1. Associates with the SAP proteins in a cell cycle-dependent manner.
- Gene Name:
- SIT4
- Uniprot ID:
- P20604
- Molecular weight:
- 35537.32
Reactions
- General function:
- vacuole fusion, non-autophagic
- Specific function:
- Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. Required for de novo lipid synthesis and formation of lipid droplets. Controles transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope. Involved in plasmid maintenance, in respiration and in cell proliferation.
- Gene Name:
- PAH1
- Uniprot ID:
- P32567
- Molecular weight:
- 95029.985
Reactions
- General function:
- translational initiation
- Specific function:
- Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4 (PubMed:10198052, PubMed:10329624, PubMed:10604478, PubMed:10995454, PubMed:11741537, PubMed:15620355, PubMed:7606777, PubMed:8741837, PubMed:9539725, PubMed:9843498). In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase (S6K) YPK3, activating YPK3 kinase activity and promoting phosphorylation of ribosomal protein S6 (PubMed:25767889). Phosphorylates kinase SCH9 at 6 amino acids in the C-terminus, activating SCH9 kinase activity to properly regulate ribosome biogenesis, translation initiation, and entry into stationary phase (PubMed:17560372).
- Gene Name:
- TOR1
- Uniprot ID:
- P35169
- Molecular weight:
- 281136.755
Reactions
- General function:
- ribosome biogenesis
- Specific function:
- Sedoheptulose 1,7-bisphosphatase involved in riboneogenesis. Dephosphorylates sedoheptulose 1,7-bisphosphate (SBP), which is converted via the non-oxidative pentose phosphate pathway to ribose-5-phosphate. Has a fructose 1,6-bisphosphatase activity in vitro, but this is probably not biologically relevant, since deletion does not affect fructose 1,6-biphosphate (FBP) levels.
- Gene Name:
- SHB17
- Uniprot ID:
- P36136
- Molecular weight:
- 31021.71
Reactions
Transporters
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3
- Gene Name:
- ENA1
- Uniprot ID:
- P13587
- Molecular weight:
- 120356.0
Reactions
| ATP + H(2)O + Na(+)(In) → ADP + phosphate + Na(+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithium ions to allow salt tolerance
- Gene Name:
- ENA5
- Uniprot ID:
- Q12691
- Molecular weight:
- 120295.0
Reactions
| ATP + H(2)O + Na(+)(In) → ADP + phosphate + Na(+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithiums ions to allow salt tolerance
- Gene Name:
- ENA2
- Uniprot ID:
- Q01896
- Molecular weight:
- 120316.0
Reactions
| ATP + H(2)O + Na(+)(In) → ADP + phosphate + Na(+)(Out). |
- General function:
- Involved in ATP binding
- Specific function:
- STE6 is required in yeast MATA cells for production of A-factor pheromone. STE6 is involved in the transport of the farnesyl-derivation of the A-factor pheromone
- Gene Name:
- STE6
- Uniprot ID:
- P12866
- Molecular weight:
- 144764.0
Reactions
| ATP + H(2)O + alpha-factor(In) → ADP + phosphate + alpha-factor(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles
- Gene Name:
- CCC2
- Uniprot ID:
- P38995
- Molecular weight:
- 109828.0
Reactions
| ATP + H(2)O + Cu(2+)(In) → ADP + phosphate + Cu(2+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway
- Gene Name:
- PMR1
- Uniprot ID:
- P13586
- Molecular weight:
- 104570.0
Reactions
| ATP + H(2)O + Ca(2+)(Cis) → ADP + phosphate + Ca(2+)(Trans). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + H(2)O = ADP + phosphate
- Gene Name:
- SPF1
- Uniprot ID:
- P39986
- Molecular weight:
- 135267.0
Reactions
| ATP + H(2)O → ADP + phosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium
- Gene Name:
- PMC1
- Uniprot ID:
- P38929
- Molecular weight:
- 130860.0
Reactions
| ATP + H(2)O + Ca(2+)(Cis) → ADP + phosphate + Ca(2+)(Trans). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential)
- Gene Name:
- DNF3
- Uniprot ID:
- Q12674
- Molecular weight:
- 188318.0
Reactions
| ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles
- Gene Name:
- DNF2
- Uniprot ID:
- Q12675
- Molecular weight:
- 182617.0
Reactions
| ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly
- Gene Name:
- DRS2
- Uniprot ID:
- P39524
- Molecular weight:
- 153843.0
Reactions
| ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential)
- Gene Name:
- DNF1
- Uniprot ID:
- P32660
- Molecular weight:
- 177796.0
Reactions
| ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Probably involved in copper transport and in the regulation of cellular copper level
- Gene Name:
- PCA1
- Uniprot ID:
- P38360
- Molecular weight:
- 131838.0
Reactions
| ATP + H(2)O + Cu(2+)(In) → ADP + phosphate + Cu(2+)(Out). |
| ATP + H2O + Cd2+/in → ADP + phosphate + Cd2+/out |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes
- Gene Name:
- NEO1
- Uniprot ID:
- P40527
- Molecular weight:
- 130217.0
Reactions
| ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + H(2)O = ADP + phosphate
- Gene Name:
- Not Available
- Uniprot ID:
- Q12697
- Molecular weight:
- 166748.0
Reactions
| ATP + H(2)O → ADP + phosphate. |