{"ymdb_id":"YMDB00905","created_at":"2011-05-29T19:03:21.000Z","updated_at":"2016-09-08T18:36:03.000Z","name":"8-Amino-7-oxononanoic acid","cas":"4707-58-8","state":null,"melting_point":null,"description":"8-Amino-7-oxononanoic acid (7-keto-8-aminopelargonate) is used as a substrate in biotin biosynthesis. Biotin is a water soluble, heterocyclic cofactor for a small number of enzymes that facilitate the transfer of CO2 during carboxylation, decarboxylation, and transcarboxylation reactions involved in fatty acid and carbohydrate metabolism. [Biocyc PWY0-1507]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cell Envelope;Cytoplasm;Endoplasmic Reticulum;Extracellular;Lipid Particle;Mitochondrion","synthesis_reference":null,"chebi_id":"15830","hmdb_id":null,"kegg_id":"C01092","pubchem_id":"173","cs_id":"168","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":null,"traditional_iupac":null,"logp":null,"pka":null,"alogps_solubility":"9.50e+02 g/l","alogps_logp":"-1.53","alogps_logs":"1.18","acceptor_count":null,"donor_count":null,"rotatable_bond_count":null,"polar_surface_area":null,"refractivity":null,"polarizability":null,"formal_charge":"0","physiological_charge":null,"pka_strongest_basic":null,"pka_strongest_acidic":null,"bioavailability":null,"number_of_rings":null,"rule_of_five":"0","ghose_filter":"0","veber_rule":null,"mddr_like_rule":null,"synonyms":["8-Amino-7-oxononanoate","8-Amino-7-oxononanoic acid"],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"},{"name":"Biotin Biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10333520,"citation":"Phalip, V., Kuhn, I., Lemoine, Y., Jeltsch, J. M. (1999). \"Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake.\" Gene 232:43-51."}],"proteins":[{"created_at":"2011-05-26T19:26:29.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase","uniprot_id":"P50277","uniprot_name":"BIOA_YEAST","enzyme":true,"transporter":false,"gene_name":"BIO3","num_residues":480,"molecular_weight":"53708.39844","theoretical_pi":"6.41","general_function":"Involved in transaminase activity","specific_function":"Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor","reactions":[{"id":1274,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2566,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate.","export":false,"pw_reaction_id":null,"source":null},{"id":3754,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006278","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AB200248","genbank_protein_id":"67772574","gene_card_id":"BIO3","chromosome_location":"chromosome 14","locus":"YNR058W","synonyms":["7,8-diamino-pelargonic acid aminotransferase","DAPA AT","DAPA aminotransferase","Diaminopelargonic acid synthase"],"enzyme_classes":["2.6.1.62"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" adenosylmethionine-8-amino-7-oxononanoate transaminase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" biotin metabolic process"},{"category":"Process","description":" biotin biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"},{"name":"Biotin Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTCCCAAGAAATTTCATATACACCAGATGTCGCGGAACTGCTAGACTTTGATAAAAAACATATTTGGCATCCTTATACGTCATTGAGTTCACCATTGAACGTTTATCCGGTAAAGAGTGCTCACGGATGCAAGCTGGTGTTGGATACCGACTCACCAGTGGACGTCGAGGTGATCGACGCCATGTCGTCGTGGTGGTGTGTTATTCACGGGTACAATAATCCAGAATTAAATGAGGCCCTTACCAAGCAGATGTTAAAGTTTTCTCACGTCCTTCTTGGTGGATTCACCCATAAAGGAGCTGTGAATCTAGTCCAAAAACTTTTAAAAGTGATTGATGAACCCTCTTTGCAGTACTGTTTCCTCGCAGATTCTGGCTCAGTAGCAGTGGAAGTAGCTTTGAAGATGGCTTTACAATCAAACATGTCAGGGGAAGCTACTAAAAATAGAACAAAATTTTTGACAATCAAGAACGGGTATCATGGTGATACATTTGGCGCTATGAGTGTTTGTGATCCTGAGAATTCTATGCATCATATCTACAACGATCGACTCAGTGAGAACATCTTCGCCCAAGCTCCCTCTATTGTCGATGGTCTTCCAACCAGCCAGAACGGTTTCGAGGACCATTGGAATGCAGAAGAAGTTACCGATCTCAAGAAGCAATTTGAATTGCATAGTGATGAGATCTGTGCTGTGATTTTGGAGCCTATCTTACAGGGTGCAGGAGGTTTGCGACCATACCATCCACAGTTCCTAATTGAAGTTCAGAAACTATGTAACCAATACGACGTTTTATTCATCATGGACGAGATTGCTACGGGATTTGGTAGAACAGGTGAGATTTTCGCATTCAAGCACTGTCAAAAATACCAGGACCAACGTGGCATCAGTCCTTCCGATCAGATCAAAGTTGTTCCTGACATATTGTGCGTTGGGAAGGGCTTAACCAGTGGATATATGACTATGAGTGCAGTGGTAGTCAACGACAAAGTTGCTTCCAGAATCTCTTCTCCAAATAGCCCTACTGGTGGCTGCTTCATGCATGGCCCCACCTTCATGGGCAATGCCCTGGCATGCAGTGTGGCAGAAAAGTCTATGGATATACTACTGCGTGGCGAGTGGAGAAAACAAGTGTCTGCAATTGAAGACCAAATTTATAGAGAACTATACCAGTACATCAAGAACCCAGATAATGGGCTCATTGGAACTGTTGTTAAGCGTGTGTCAGTTATTGGAGCTGTAGGTATCGTAGAGCTATACAAGAAGACAGATCCCGAGTGGTTCCAGAAAAAGTTTATATCCAAGGGAGTACATATCCGACCTTTCAACTGCCTGTGTTACATTATGCCACCATATGTGATCACGACAGAGGAATTGACGAAGGTTAATCAAGTCTTGATTGAAGTATTACATGAGTGGAAATCCCACATAAACCAATGA","protein_sequence":"MSQEISYTPDVAELLDFDKKHIWHPYTSLSSPLNVYPVKSAHGCKLVLDTDSPVDVEVIDAMSSWWCVIHGYNNPELNEALTKQMLKFSHVLLGGFTHKGAVNLVQKLLKVIDEPSLQYCFLADSGSVAVEVALKMALQSNMSGEATKNRTKFLTIKNGYHGDTFGAMSVCDPENSMHHIYNDRLSENIFAQAPSIVDGLPTSQNGFEDHWNAEEVTDLKKQFELHSDKICAVILEPILQGAGGLRPYHPQFLIEVQKLCNQYDVLFIMDEIATGFGRTGEIFAFKHCQKYQDQHGISPSDQIKVVPDILCVGKGLTSGYMTMSAVVVNDKVASRISSPNSPTGGCFMHGPTFMGNALACSVAEKSMDILLRGEWRKQVSAIENQIYRELYQYIKNPDNGLIGTVVKRVSVIGAVGIVELYKKTDPEWFQKKFISKGVHIRPFNCLCYIMPPYVITTEELTKVNQVLIEVLHEWKSHINQ"},{"created_at":"2011-05-27T07:45:52.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"7-keto 8-aminopelargonic acid transporter","uniprot_id":"P53744","uniprot_name":"BIO5_YEAST","enzyme":false,"transporter":true,"gene_name":"BIO5","num_residues":561,"molecular_weight":"62427.5","theoretical_pi":"7.33","general_function":"Involved in amino acid transmembrane transporter activity","specific_function":"Transport into the cell of 7-keto 8-aminopelargonic acid","reactions":[],"signal_regions":"None","transmembrane_regions":"50-70;78-98;161-181;205-225;231-251;282-302;322-342;370-390;440-460;462-482;508-528;541-560","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"U90440","genbank_protein_id":"1899253","gene_card_id":"BIO5","chromosome_location":"chromosome 14","locus":"YNR056C","synonyms":["KAPA transporter"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[],"pathways":[{"name":"Biotin Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGAACAGAGTAGGGGCAGTGTTCCTATTTGTATATGAAAGAAATTTTTTTTTGTCTATTGTTCCAGATCGTCACAGGACGGAAATAAGAATGTCTAGTTCAGAAAGGTCAGAAGTCAAGTTTGACAAGCACTTTAATTGGTGGTCCCTATTAGGTATCGCGTTCTCATTAAGTTGCTCATGGGTCGGTATCTCAGCGTCGATGGCCGTTGGTATTGCCAGTGGAGGGCCACTGCTTATCATCTATGGGTTGATAATTGCTGCTTTTTTCAGTCTCATGTGTGGTATATCTCTGGGAGATTTTGCTGCTATCCTGCCAAACAGCAGCGGTGGTTCATTTTGGGTTCTTAAAATGTTGGAACAAGAATCAGTCACTTTGAAAACCCCTGAGTACGAGGACCCTTCTGACGATGATGAAGAAGTGTTCCTCGAGAATTATTGTCAAACTTTCAACGTGGAAGTTTCTTCTAAATTTCAAAAGGTTTCTTCCATGGTTGTAGGGTTGCTGAACTATTTCGGTGCCATTTTTACTACCGCAAGTATCTGCTCATCTTTGTCAATGAGCTGTATCGGTATTCATAAGTTGTTGCATCCGGACTACGAGTTAAAGCACTGGCATGTTTTTGTGGGTTACGAGTGTATCAATGCCGTTTTGACACTTTTCAACATTTATTCAACTCCGTTGCCCTATATCTCTCAGTTTGGGCTCTATACGTCTCTATTGTCTTTCGCCATGACTTTCATTATTTGTATTGTTTCAAGATCTGACAACACCGTAGACCCATGGCCCAAAGCTTCTAATATATTTGGGAGCTTTGATAATCAAACAGGCTGGAATTCGTCTGGAATGGCGTTTGTTGTCGGTTTGGTCAATCCGATCTGGGCATTTGTTGGCATTGACTCTGCTACGCACATGATTGATGAAGTGGGTTATAGTAAGTCACGTTTCTTAGTTCCCAAAGTTATTATCACTACCATCATTGTGGGCTTTGTAACTAGTTTTATTTATTGCGTTGGTTTGTTTTTCTGCATCACTGACCAAACGGCAGTCGTTGAGTCTATTTTACCTATCGTAGAAATATTTTACCAGGCCACTGGTAATAGGAATCTCAGTGTCTTCCTGCAATGTATGTGTATCACAACAGGTTTTGTTTCAGGCATTGCAAGTGGAACCTGGCAAAGTCGAATCCTCCAATCATTCGGGAAAAGTTACGCACCATTTTATAAAGAGGGTTCCTTGGGAAACAAATCCTTGAAGAAGCTAGCAGTGTTGACACCTGGGTTTAAGTCTCCATTATATGCCCATTTTTTGTCACAAATATGTGTAACGATAATTGGCTGTATATTTATGGGATCTAGTACCGCTTTCAACGCAATTATCACTGCATGCATCACCCTGTTACTAATGTCGTACGCAGTTCCTTCTTTTATATTCCTGTTCGTTATTAAAAAGGAAAAATTCATTCATAGAATCGAGAGTGACGTAAATTGTGTCAGCAGGCCTAACCGTCGTCGTATGTCTATGATTCCTCATATTATATGTATTCTATGGACCTTGTTCTGCCTGGTATTTTTATCTTTCCCATATACACTACCGGTTACTGCAGGAAACATGAATTACACCTCAGTAGTGTATGCAGTAGTTTTCTGCATTATCAGCATCGTTGTTTTCCCTACATGCATCTAA","protein_sequence":"MNRVGAVFLFVYERNFFLSIVPDRHRTEIRMSSSERSEVKFDKHFNWWSLLGIAFSLSCSWVGISASMAVGIASGGPLLIIYGLIIAAFFSLMCGISLGDFAAILPNSSGGSFWVLKMLEQESVTLKTPEYEDPSDDDEEVFLENYCQTFNVEVSSKFQKVSSMVVGLLNYFGAIFTTASICSSLSMSCIGIHKLLHPDYELKHWHVFVGYECINAVLTLFNIYSTPLPYISQFGLYTSLLSFAMTFIICIVSRSDNTVDPWPKASNIFGSFDNQTGWNSSGMAFVVGLVNPIWAFVGIDSATHMIDEVGYSKSRFLVPKVIITTIIVGFVTSFIYCVGLFFCITDQTAVVESILPIVEIFYQATGNRNLSVFLQCMCITTGFVSGIASGTWQSRILQSFGKSYAPFYKEGSLGNKSLKKLAVLTPGFKSPLYAHFLSQICVTIIGCIFMGSSTAFNAIITACITLLLMSYAVPSFIFLFVIKKEKFIHRIESDVNCVSRPNRRRMSMIPHIICILWTLFCLVFLSFPYTLPVTAGNMNYTSVVYAVVFCIISIVVFPTCI"}]}