{"ymdb_id":"YMDB00902","created_at":"2011-05-29T19:03:05.000Z","updated_at":"2016-09-08T18:36:02.000Z","name":"ubiquinol","cas":"56275-39-9","state":"Solid","melting_point":"45.6 oC ","description":"Ubiquinol is a lipid-soluble benzoquinol that is found in all cellular systems. Ubiquinol is the fully reduced form of ubiquinone. The redox functions of ubiquinol in cellular energy production and antioxidant protection are based on the ability to exchange two electrons in a redox cycle between ubiquinol (reduced) and the ubiquinone (oxidized) form.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":"17976","hmdb_id":"HMDB01060","kegg_id":"C00390","pubchem_id":"1154","cs_id":"17216048","foodb_id":null,"wikipedia_link":"Ubiquinol","biocyc_id":"UBIQUINOL-8","iupac":"2,3-dimethoxy-5-methyl-6-[(2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl]benzene-1,4-diol","traditional_iupac":"ubiquinol-8","logp":"14.910760955","pka":"12.153761006645082","alogps_solubility":"2.73e-04 g/l","alogps_logp":"9.35","alogps_logs":"-6.43","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"25","polar_surface_area":"58.92","refractivity":"238.84840000000014","polarizability":"94.27937653403029","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-4.664919089384427","pka_strongest_acidic":"10.266548299637904","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["coenzymes QH2","CoQH2","QH(2)","QH2","reduced ubiquinone","Ubiquinol","ubiquinol-8","ubiquinol(8)","ubiquinols"],"pathways":[{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":19747168,"citation":"Swida-Barteczka, A., Woyda-Ploszczyca, A., Sluse, F. E., Jarmuszkiewicz, W. (2009). \"Uncoupling protein 1 inhibition by purine nucleotides is under the control of the endogenous ubiquinone redox state.\" Biochem J 424:297-306."},{"pubmed_id":8639607,"citation":"Schultz, J. R., Ellerby, L. M., Gralla, E. B., Valentine, J. S., Clarke, C. F. (1996). \"Autoxidation of ubiquinol-6 is independent of superoxide dismutase.\" Biochemistry 35:6595-6603."}],"proteins":[{"created_at":"2011-05-26T18:04:17.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial","uniprot_id":"Q00711","uniprot_name":"DHSA_YEAST","enzyme":true,"transporter":false,"gene_name":"SDH1","num_residues":640,"molecular_weight":"70228.79688","theoretical_pi":"7.53","general_function":"Involved in electron carrier activity","specific_function":"Catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"M86746","genbank_protein_id":"172557","gene_card_id":"SDH1","chromosome_location":"chromosome 11","locus":"YKL148C","synonyms":["Flavoprotein subunit of complex II","FP"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" generation of precursor metabolites and energy"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" electron transport chain"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"},{"name":"Succ_DH_flav_C","identifier":"PF02910"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGCTATCGCTAAAAAAATCAGCGCTCTCCAAGTTGACTTTGCTCAGAAACACAAGAACATTTACATCGTCAGCTTTGGTGCGCCAAACGCAGGGCTCTGTAAACGGTTCCGCGTCCAGATCTGCAGACGGGAAGTACCACATAATAGATCACGAGTATGACTGTGTGGTAATCGGTGCCGGTGGTGCCGGCCTTAGAGCGGCCTTTGGTCTTGCCGAGGCGGGCTACAAGACTGCTTGTATATCCAAGCTTTTCCCCACCAGATCCCACACTGTTGCTGCTCAGGGTGGTATCAATGCCGCTCTGGGAAATATGCACAAGGATAACTGGAAATGGCATATGTACGATACTGTGAAAGGATCTGATTGGCTAGGTGACCAGGACTCCATCCATTACATGACCAGGGAAGCGCCCAAATCGATCATTGAACTGGAACACTATGGTGTTCCTTTTTCAAGAACTGAAAACGGTAAGATCTACCAAAGAGCCTTTGGTGGTCAGACCAAGGAGTACGGTAAGGGTGCTCAGGCCTATAGAACATGCGCTGTCGCAGACAGGACAGGACATGCTCTTTTACACACGCTTTATGGCCAAGCTTTAAGACATGACACACATTTCTTTATTGAGTACTTTGCCCTCGATCTGTTGACCCATAATGGCGAGGTCGTTGGTGTCATCGCTTATAATCAGGAAGACGGTACCATCCACAGATTCAGAGCACACAAGACCATTATTGCCACTGGTGGCTATGGTAGAGCATACTTCTCTTGTACCTCTGCTCACACATGTACGGGTGACGGTAATGCCATGGTTTCGCGTGCTGGTTTCCCCTTGCAAGATTTAGAGTTTGTTCAATTCCATCCTTCAGGTATATATGGGTCTGGTTGCTTAATCACTGAAGGTGCTCGTGGTGAAGGTGGTTTTTTGGTTAATTCTGAAGGTGAAAGATTCATGGAACGTTACGCTCCTACGGCCAAGGATCTAGCTTGTAGAGATGTCGTTTCCAGAGCAATCACCATGGAGATCAGAGAAGGCAGAGGTGTTGGTAAGAAAAAGGACCACATGTACTTACAATTGAGCCATCTACCTCCGGAAGTTCTAAAGGAAAGATTGCCAGGTATCTCTGAAACAGCAGCCATTTTTGCTGGTGTAGACGTCACTAAGGAACCTATTCCCATTATTCCTACCGTCCACTATAACATGGGTGGTATTCCCACGAAGTGGAATGGTGAGGCATTAACCATTGATGAAGAAACTGGCGAAGACAAGGTTATTCCCGGTTTAATGGCTTGTGGTGAAGCCGCTTGTGTTTCTGTCCATGGTGCCAATAGATTAGGTGCCAATTCCTTGTTGGATCTTGTTGTCTTTGGTCGTGCTGTTGCCCATACGGTTGCTGACACTTTACAGCCTGGGTTGCCACACAAACCACTACCTTCTGATTTGGGTAAAGAATCCATCGCAAACTTGGATAAACTAAGAAATGCTAATGGTTCAAGATCTACGGCAGAAATTAGAATGAATATGAAACAAACTATGCAAAAGGATGTTTCCGTCTTTAGAACACAATCATCTTTAGATGAAGGTGTTCGGAACATTACTGCAGTAGAGAAGACCTTTGATGATGTGAAGACGACCGATAGATCAATGATCTGGAATTCTGACTTGGTTGAAACTCTGGAGCTACAGAACTTATTAACCTGTGCCTCCCAAACAGCTGTTTCCGCTGCTAATAGAAAGGAATCCCGTGGTGCTCATGCAAGAGAGGATTATCCAAATAGAGATGACGAACATTGGATGAAGCATACATTATCCTGGCAAAAGGACGTCGCTGCCCCAGTGACTTTGAAATACAGAAGGGTTATCGATCACACTTTGGACGAAAAGGAATGTCCTTCCGTACCTCCAACTGTAAGAGCCTACTAA","protein_sequence":"MLSLKKSALSKLTLLRNTRTFTSSALVRQTQGSVNGSASRSADGKYHIIDHEYDCVVIGAGGAGLRAAFGLAEAGYKTACISKLFPTRSHTVAAQGGINAALGNMHKDNWKWHMYDTVKGSDWLGDQDSIHYMTREAPKSIIELEHYGVPFSRTENGKIYQRAFGGQTKEYGKGAQAYRTCAVADRTGHALLHTLYGQALRHDTHFFIEYFALDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTIIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLQDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPTAKDLACRDVVSRAITMEIREGRGVGKKKDHMYLQLSHLPPEVLKERLPGISETAAIFAGVDVTKEPIPIIPTVHYNMGGIPTKWNGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVAHTVADTLQPGLPHKPLPSDLGKESIANLDKLRNANGSRSTAEIRMNMKQTMQKDVSVFRTQSSLDEGVRNITAVEKTFDDVKTTDRSMIWNSDLVETLELQNLLTCASQTAVSAANRKESRGAHAREDYPNRDDEHWMKHTLSWQKDVAAPVTLKYRRVIDHTLDEKECPSVPPTVRAY"},{"created_at":"2011-05-26T18:04:53.000Z","updated_at":"2011-05-26T18:04:53.000Z","name":"Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial","uniprot_id":"P47052","uniprot_name":"DHSX_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":634,"molecular_weight":"69382.0","theoretical_pi":"7.4","general_function":"Involved in electron carrier activity","specific_function":"Probable minor catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Probably forms a catalytic dimer with SDH2. Electrons flow from succinate to the FAD bound to the catalytic subunit, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"Z49320","genbank_protein_id":"1008175","gene_card_id":null,"chromosome_location":null,"locus":"YJL045W","synonyms":["Flavoprotein subunit of complex II","FP","SDH1b"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" generation of precursor metabolites and energy"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" electron transport chain"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"},{"name":"Succ_DH_flav_C","identifier":"PF02910"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGTTATCTTTGAAAAAAGGAATAACAAAATCATACATCTTGCAAAGAACTTTCACTTCTTCCTCTGTTGTTCGTCAAATTGGGGAAGTGAAATCTGAATCGAAACCGCCGGCCAAATATCATATTATCGACCATGAATATGATTGTGTGGTGGTAGGCGCTGGCGGTGCAGGTTTAAGAGCAGCTTTCGGTTTGGCTGAAGCTGGATACAAGACTGCTTGTTTATCCAAGTTGTTTCCAACAAGGTCACATACTGTGGCTGCTCAGGGTGGAATTAATGCTGCGCTGGGAAATATGCATCCAGATGATTGGAAATCGCACATGTACGACACTGTCAAGGGTTCTGACTGGCTCGGAGACCAAGATGCAATCCATTACATGACAAGAGAAGCACCTAAGTCTGTCATTGAACTAGAACATTACGGTATGCCCTTTTCGAGGACTGAAGATGGAAGGATTTACCAGAGAGCATTTGGGGGACAATCCAAAGATTTTGGTAAAGGTGGACAGGCCTATAGGACTTGTGCGGTGGCAGATAGAACAGGTCACGCAATGCTTCATACATTGTATGGACAAGCGCTGAAAAATAATACACACTTCTTTATTGAATACTTTGCAATGGATTTGTTGACCCATAATGGCGAGGTTGTGGGTGTCATTGCCTATAATCAGGAGGACGGTACAATTCACAGATTCAGAGCACATAAGACCGTCATCGCGACAGGCGGATACGGTAGAGCTTACTTCTCTTGCACTTCTGCTCACACTTGTACAGGTGACGGTAATGCTATGGTTTCTCGCGCTGGATTTCCACTAGAGGATTTAGAATTTGTTCAATTTCATCCGTCAGGAATTTATGGGTCTGGCTGCCTAATCACTGAAGGTGCCCGTGGTGAGGGTGGATTTTTATTGAATTCTGAAGGAGAAAGGTTTATGGAACGCTATGCTCCTACTGCCAAGGACTTGGCAAGCAGGGATGTTGTTTCCAGAGCAATCACCATGGAAATCAGGGCTGGCAGAGGTGTCGGGAAAAACAAGGATCATATCCTTTTACAATTAAGCCATCTACCACCTGAGGTACTAAAGGAAAGGCTACCGGGAATATCTGAAACAGCTGCTGTCTTTGCGGGTGTCGATGTCACCCAGGAGCCAATTCCTGTCTTGCCAACTGTCCATTATAATATGGGAGGCATTCCCACAAAATGGACTGGTGAAGCATTGACCATTGACGAGGAAACTGGAGAGGATAAGGTCATCCCAGGATTGATGGCGTGTGGTGAAGCTGCTTGCGTATCGGTTCATGGAGCGAACAGATTAGGCGCTAACTCACTACTGGATTTAGTCGTTTTCGGTCGCGCCGTTGCAAATACCATTGCTGACACATTACAGCCTGGCTTGCCTCATAAGCCATTGGCTTCAAACATCGGGCACGAGTCAATTGCTAATTTGGATAAAGTAAGAAATGCTCGCGGCTCACTGAAAACCTCTCAAATCAGGTTGAACATGCAAAGGACAATGCAAAAAGATGTTTCTGTTTTCAGGACGCAAGACACTCTAGATGAAGGTGTTAGAAATATTACTGAAGTGGACAAGACATTTGAGGATGTGCACGTTTCTGATAAGTCAATGATCTGGAATTCTGATCTCGTAGAAACTCTGGAATTGCAAAATTTACTTACTTGTGCCACACAAACGGCTGTTTCTGCTTCCAAAAGAAAGGAGTCTCGTGGTGCTCATGCGAGAGAGGACTATGCAAAAAGAGATGATGTGAATTGGAGAAAGCACACATTATCATGGCAAAAGGGGACATCAACACCTGTAAAAATCAAGTACAGGAATGTAATCGCACATACTTTAGATGAGAATGAATGCGCCCCAGTCCCTCCAGCTGTCAGATCCTATTAA","protein_sequence":"MLSLKKGITKSYILQRTFTSSSVVRQIGEVKSESKPPAKYHIIDHEYDCVVVGAGGAGLRAAFGLAEAGYKTACLSKLFPTRSHTVAAQGGINAALGNMHPDDWKSHMYDTVKGSDWLGDQDAIHYMTREAPKSVIELEHYGMPFSRTEDGRIYQRAFGGQSKDFGKGGQAYRTCAVADRTGHAMLHTLYGQALKNNTHFFIEYFAMDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTVIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLEDLEFVQFHPSGIYGSGCLITEGARGEGGFLLNSEGERFMERYAPTAKDLASRDVVSRAITMEIRAGRGVGKNKDHILLQLSHLPPEVLKERLPGISETAAVFAGVDVTQEPIPVLPTVHYNMGGIPTKWTGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVANTIADTLQPGLPHKPLASNIGHESIANLDKVRNARGSLKTSQIRLNMQRTMQKDVSVFRTQDTLDEGVRNITEVDKTFEDVHVSDKSMIWNSDLVETLELQNLLTCATQTAVSASKRKESRGAHAREDYAKRDDVNWRKHTLSWQKGTSTPVKIKYRNVIAHTLDENECAPVPPAVRSY"},{"created_at":"2011-05-26T18:06:41.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial","uniprot_id":"P21801","uniprot_name":"DHSB_YEAST","enzyme":true,"transporter":false,"gene_name":"SDH2","num_residues":266,"molecular_weight":"30230.90039","theoretical_pi":"8.97","general_function":"Involved in 2 iron, 2 sulfur cluster binding","specific_function":"Subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null},{"id":3707,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003287","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"AY558189","genbank_protein_id":"45270268","gene_card_id":"SDH2","chromosome_location":"chromosome 12","locus":"YLL041C","synonyms":["Iron-sulfur subunit of complex II","Ip"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"}],"pfams":[{"name":"Fer2","identifier":"PF00111"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTGAACGTGCTATTGAGAAGGAAGGCCTTTTGTTTGGTGACGAAGAAGGGTATGGCTACTGCCACAACAGCTGCAGCTACGCATACCCCCAGATTGAAAACTTTTAAAGTTTACAGATGGAATCCAGACGAGCCAAGTGCTAAACCTCATTTACAGTCATATCAAGTGGATCTGAATGACTGTGGGCCCATGGTACTTGATGCGCTGTTAAAGATCAAAGACGAACAGGATTCTACCCTAACTTTTAGAAGATCATGTAGAGAAGGTATCTGCGGTTCATGTGCCATGAACATTGGCGGTAGAAACACGCTAGCTTGTATATGTAAGATCGACCAGAACGAATCCAAACAACTCAAGATCTATCCATTACCCCACATGTTTATTGTCAAAGATTTGGTACCTGATTTAACTAACTTCTACCAACAATACAAATCTATCCAACCTTACTTACAGAGATCATCGTTTCCAAAGGATGGAACGGAAGTGCTACAAAGTATTGAAGATCGTAAGAAACTGGATGGTCTTTACGAATGTATTCTGTGTGCATGCTGCTCTACTTCATGTCCATCGTACTGGTGGAACCAAGAACAGTATTTGGGCCCTGCCGTGCTAATGCAAGCCTACCGTTGGCTAATTGACTCTAGAGACCAAGCTACAAAGACAAGAAAGGCCATGCTAAACAACTCCATGTCATTGTACAGATGTCACACCATCATGAACTGTACTAGAACTTGTCCAAAGGGCTTGAATCCTGGTTTGGCTATTGCTGAAATTAAGAAATCTTTGGCATTTGCCTAG","protein_sequence":"MLNVLLRRKAFCLVTKKGMATATTAAATHTPRLKTFKVYRWNPDEPSAKPHLQSYQVDLNDCGPMVLDALLKIKDEQDSTLTFRRSCREGICGSCAMNIGGRNTLACICKIDQNESKQLKIYPLPHMFIVKDLVPDLTNFYQQYKSIQPYLQRSSFPKDGTEVLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEQYLGPAVLMQAYRWLIDSRDQATKTRKAMLNNSMSLYRCHTIMNCTRTCPKGLNPGLAIAEIKKSLAFA"},{"created_at":"2011-05-27T11:13:30.000Z","updated_at":"2011-05-27T15:01:33.000Z","name":"Cytochrome b-c1 complex subunit Rieske, mitochondrial","uniprot_id":"P08067","uniprot_name":"UCRI_YEAST","enzyme":true,"transporter":false,"gene_name":"RIP1","num_residues":215,"molecular_weight":"23364.69922","theoretical_pi":"8.21","general_function":"Involved in oxidoreductase activity","specific_function":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c","reactions":[{"id":2828,"direction":"\u003e","locations":"Mitochondrion","altext":"QH(2) + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H(+).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1P84","cellular_location":"Mitochondrion","genbank_gene_id":"AY558341","genbank_protein_id":"45270572","gene_card_id":"RIP1","chromosome_location":"chromosome 5","locus":"YEL024W","synonyms":["Complex III subunit 5","Rieske iron-sulfur protein","RISP","Ubiquinol-cytochrome c reductase iron-sulfur subunit"],"enzyme_classes":["1.10.2.2"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" monovalent inorganic cation transmembrane transporter activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrogen ion transmembrane transporter activity"},{"category":"Function","description":" 2 iron, 2 sulfur cluster binding"},{"category":"Function","description":" ubiquinol-cytochrome-c reductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on diphenols and related substances as donors"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" ion transmembrane transporter activity"},{"category":"Function","description":" cation transmembrane transporter activity"},{"category":"Function","description":" inorganic cation transmembrane transporter activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Rieske","identifier":"PF00355"},{"name":"UCR_TM","identifier":"PF02921"}],"pathways":[{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGTTAGGAATAAGATCATCTGTCAAGACCTGCTTCAAGCCAATGTCTTTAACTTCCAAAAGACTGATTTCTCAATCTTTGCTGGCTAGCAAATCCACGTACAGGACCCCAAATTTTGATGACGTTTTAAAGGAAAATAACGATGCTGATAAAGGCCGTTCTTATGCTTACTTTATGGTCGGTGCTATGGGTCTTTTGTCATCTGCAGGTGCCAAATCAACCGTAGAAACCTTTATTTCATCTATGACCGCTACTGCCGATGTTTTGGCTATGGCTAAAGTTGAAGTTAATTTAGCGGCTATCCCATTGGGTAAAAACGTGGTTGTCAAATGGCAAGGTAAGCCTGTGTTCATTAGACACAGAACTCCTCATGAAATTCAGGAAGCCAACAGTGTGGATATGTCCGCTTTGAAGGACCCACAGACCGATGCTGACAGAGTCAAAGACCCTCAATGGTTAATTATGCTGGGTATTTGTACTCACTTAGGTTGTGTTCCAATTGGTGAAGCCGGTGATTTTGGTGGTTGGTTCTGTCCTTGCCATGGTTCACATTATGATATTTCCGGTAGAATCAGAAAGGGACCTGCCCCCTTAAACTTAGAAATTCCTGCTTATGAATTCGATGGTGATAAGGTCATTGTTGGTTAG","protein_sequence":"MLGIRSSVKTCFKPMSLTSKRLISQSLLASKSTYRTPNFDDVLKENNDADKGRSYAYFMVGAMGLLSSAGAKSTVETFISSMTATADVLAMAKVEVNLAAIPLGKNVVVKWQGKPVFIRHRTPHEIQEANSVDMSALKDPQTDADRVKDPQWLIMLGICTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPAYEFDGDKVIVG"}]}