oxygen (YMDB00900)

General function:

Involved in D-arabinono-1,4-lactone oxidase activity

Specific function:

Can oxidize L-gulono-1,4-lactone as well as D-arabinono- 1,4-lactone and L-galactono-1,4-lactone

Gene Name:

ALO1

Uniprot ID:

P54783

Molecular weight:

59493.19922

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol

Gene Name:

ERG11

Uniprot ID:

P10614

Molecular weight:

60719.80078

Reactions

General function:

Involved in pyridoxamine-phosphate oxidase activity

Specific function:

Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

Gene Name:

PDX3

Uniprot ID:

P38075

Molecular weight:

26908.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance

Gene Name:

FMS1

Uniprot ID:

P50264

Molecular weight:

57805.10156

Reactions

General function:

Involved in acyl-CoA dehydrogenase activity

Specific function:

Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)

Gene Name:

POX1

Uniprot ID:

P13711

Molecular weight:

84041.39844

Reactions

General function:

Involved in fatty acid elongase activity

Specific function:

May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0)

Gene Name:

ELO1

Uniprot ID:

P39540

Molecular weight:

36233.60156

Reactions

General function:

Involved in acyl carrier activity

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Gene Name:

ACP1

Uniprot ID:

P32463

Molecular weight:

13942.5

General function:

Involved in oxygen-dependent protoporphyrinogen oxidase activity

Specific function:

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX

Gene Name:

HEM14

Uniprot ID:

P40012

Molecular weight:

59702.39844

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

Gene Name:

HEM13

Uniprot ID:

P11353

Molecular weight:

37711.30078

Reactions

General function:

Involved in electron carrier activity

Specific function:

Could be a fumarate reductase

Gene Name:

OSM1

Uniprot ID:

P21375

Molecular weight:

55064.80078

Reactions

General function:

Involved in monooxygenase activity

Specific function:

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid

Gene Name:

BNA4

Uniprot ID:

P38169

Molecular weight:

52428.89844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals

Gene Name:

MCR1

Uniprot ID:

P36060

Molecular weight:

34137.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Acts as a alpha-ketoglutarate-dependent dioxygenase active on sulfonates. Although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate

Gene Name:

JLP1

Uniprot ID:

Q12358

Molecular weight:

46982.30078

Reactions

General function:

Involved in heme binding

Specific function:

Required for biosynthesis of nicotinic acid

Gene Name:

BNA2

Uniprot ID:

P47125

Molecular weight:

50774.80078

Reactions

General function:

Involved in protein complex assembly

Specific function:

Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase

Gene Name:

COX15

Uniprot ID:

P40086

Molecular weight:

54657.89844

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway

Gene Name:

ERG1

Uniprot ID:

P32476

Molecular weight:

55125.39844

Reactions

General function:

Involved in ubiquinone biosynthetic process

Specific function:

Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides

Gene Name:

COQ4

Uniprot ID:

O13525

Molecular weight:

38626.80078

General function:

Involved in iron ion binding

Specific function:

Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol

Gene Name:

ERG25

Uniprot ID:

P53045

Molecular weight:

36478.89844

Reactions

General function:

Involved in ferroxidase activity

Specific function:

Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain

Gene Name:

YFH1

Uniprot ID:

Q07540

Molecular weight:

19490.0

Reactions

General function:

Involved in 3-hydroxyanthranilate 3,4-dioxygenase activity

Specific function:

Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate

Gene Name:

BNA1

Uniprot ID:

P47096

Molecular weight:

20234.90039

Reactions

General function:

Involved in iron ion binding

Specific function:

Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin

Gene Name:

SUR2

Uniprot ID:

P38992

Molecular weight:

40734.0

Reactions

General function:

Involved in metal ion binding

Specific function:

Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Gene Name:

SOD1

Uniprot ID:

P00445

Molecular weight:

15854.59961

Reactions

General function:

Involved in superoxide dismutase activity

Specific function:

Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Gene Name:

SOD2

Uniprot ID:

P00447

Molecular weight:

25774.09961

Reactions

General function:

Involved in catalytic activity

Specific function:

In the de novo pyrimidine biosynthesic pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate and the reduction of fumarate to succinate. Does not use oxaloacetate and NAD or NADP as electron acceptors

Gene Name:

URA1

Uniprot ID:

P28272

Molecular weight:

34800.60156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5

Gene Name:

NCP1

Uniprot ID:

P16603

Molecular weight:

76771.10156

Reactions

General function:

Involved in iron ion binding

Specific function:

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain

Gene Name:

CYC1

Uniprot ID:

P00044

Molecular weight:

12181.90039

Reactions

General function:

Involved in iron ion binding

Specific function:

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain

Gene Name:

CYC7

Uniprot ID:

P00045

Molecular weight:

12532.2998

Reactions

General function:

Involved in stearoyl-CoA 9-desaturase activity

Specific function:

Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates (Probable)

Gene Name:

OLE1

Uniprot ID:

P21147

Molecular weight:

58402.60156

Reactions

General function:

Involved in heme binding

Specific function:

Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3

Gene Name:

SCS7

Uniprot ID:

Q03529

Molecular weight:

44881.10156

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis

Gene Name:

ERG3

Uniprot ID:

P32353

Molecular weight:

42729.89844

Reactions

General function:

Involved in catalase activity

Specific function:

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

Gene Name:

CTT1

Uniprot ID:

P06115

Molecular weight:

64583.0

Reactions

General function:

Involved in catalase activity

Specific function:

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

Gene Name:

CTA1

Uniprot ID:

P15202

Molecular weight:

58555.19922

Reactions

General function:

Involved in thiol oxidase activity

Specific function:

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1

Gene Name:

ERV2

Uniprot ID:

Q12284

Molecular weight:

22141.30078

Reactions

General function:

Involved in thiol oxidase activity

Specific function:

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS). Forms a redox cycle with MIA40 that involves a disulfide relay system. Important for maintaining the cysteine residues in MIA40 in an oxidized state. Reduced ERV1 is reoxidized by cytochrome c. Required for the maturation of cytoplasmic, but not of mitochondrial Fe/S proteins

Gene Name:

ERV1

Uniprot ID:

P27882

Molecular weight:

21639.30078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes. Plays a role in bud morphology

Gene Name:

CBR1

Uniprot ID:

P38626

Molecular weight:

31493.59961

Reactions