{"ymdb_id":"YMDB00900","created_at":"2011-05-29T19:02:50.000Z","updated_at":"2016-09-08T18:36:02.000Z","name":"oxygen","cas":"7782-44-7","state":"Liquid","melting_point":"-218.4 oC","description":"Oxygen is the third most abundant element in the universe after hydrogen and helium and the most abundant element by mass in the Earth's crust.","experimental_water_solubility":"37.5 mg/mL at 21 oC [VENABLE,CS \u0026 FUWA,T (1922)]","experimental_logp_hydrophobicity":"0.65 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;endoplasmic reticulum;peroxisome;cytoplasm","synthesis_reference":"Wynn, Richard L.  Production of hydrogen and oxygen by thermal disassociation of water.    U.S. Pat. Appl. Publ.  (2007),     26pp.","chebi_id":"15379","hmdb_id":"HMDB01377","kegg_id":"C00007","pubchem_id":"977","cs_id":"952","foodb_id":null,"wikipedia_link":"Oxygen","biocyc_id":"CPD-6641","iupac":"dioxygen","traditional_iupac":"singlet oxygen","logp":"-0.27723172999999995","pka":null,"alogps_solubility":null,"alogps_logp":null,"alogps_logs":null,"acceptor_count":"2","donor_count":"0","rotatable_bond_count":"0","polar_surface_area":"34.14","refractivity":"2.8858","polarizability":"1.528255145499405","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":null,"pka_strongest_acidic":null,"bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"1","mddr_like_rule":"0","synonyms":["dioxygen","dioxygene","Disauerstoff","molecular oxygen","O(2)","O2","Oxygen","Oxygen molecule","Pure oxygen"],"pathways":[{"name":"Riboflavin metabolism","kegg_map_id":"00740"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"},{"name":"Biosynthesis of unsaturated fatty acids (docosanoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (icosanoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (stearoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (tetracosanoyl-CoA)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"NAD metabolism","kegg_map_id":null},{"name":"Porphyrin Metabolism","kegg_map_id":null},{"name":"Sphingolipid metabolism","kegg_map_id":"00600"},{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Ubiquinone Biosynthesis","kegg_map_id":null},{"name":"Vitamin B6","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10508108,"citation":"Lee, B. H., Huh, W. K., Kim, S. T., Lee, J. S., Kang, S. O. (1999). \"Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono-1,4-lactone oxidase in Escherichia coli.\" Appl Environ Microbiol 65:4685-4687."},{"pubmed_id":16963187,"citation":"Lepesheva, G. I., Waterman, M. R. (2007). \"Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms.\" Biochim Biophys Acta 1770:467-477."},{"pubmed_id":10482536,"citation":"Hogan, D. A., Auchtung, T. A., Hausinger, R. P. (1999). \"Cloning and characterization of a sulfonate/alpha-ketoglutarate dioxygenase from Saccharomyces cerevisiae.\" J Bacteriol 181:5876-5879."},{"pubmed_id":15792955,"citation":"Marbois, B., Gin, P., Faull, K. F., Poon, W. W., Lee, P. T., Strahan, J., Shepherd, J. N., Clarke, C. F. (2005). \"Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.\" J Biol Chem 280:20231-20238."},{"pubmed_id":10850979,"citation":"Schneiter, R., Tatzer, V., Gogg, G., Leitner, E., Kohlwein, S. D. (2000). \"Elo1p-dependent carboxy-terminal elongation of C14:1Delta(9) to C16:1Delta(11) fatty acids in Saccharomyces cerevisiae.\" J Bacteriol 182:3655-3660."},{"pubmed_id":12697341,"citation":"Hiltunen, J. K., Mursula, A. M., Rottensteiner, H., Wierenga, R. K., Kastaniotis, A. J., Gurvitz, A. (2003). \"The biochemistry of peroxisomal beta-oxidation in the yeast Saccharomyces cerevisiae.\" FEMS Microbiol Rev 27:35-64."},{"pubmed_id":9837886,"citation":"Geisbrecht, B. V., Zhu, D., Schulz, K., Nau, K., Morrell, J. C., Geraghty, M., Schulz, H., Erdmann, R., Gould, S. J. (1998). \"Molecular characterization of Saccharomyces cerevisiae Delta3, Delta2-enoyl-CoA isomerase.\" J Biol Chem 273:33184-33191."},{"pubmed_id":12062417,"citation":"Panozzo, C., Nawara, M., Suski, C., Kucharczyka, R., Skoneczny, M., Becam, A. M., Rytka, J., Herbert, C. J. (2002). \"Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae.\" FEBS Lett 517:97-102."},{"pubmed_id":10622712,"citation":"Lamb, D. C., Kelly, D. E., Manning, N. J., Kaderbhai, M. A., Kelly, S. L. (1999). \"Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction.\" FEBS Lett 462:283-288."},{"pubmed_id":9539135,"citation":"Kucharczyk, R., Zagulski, M., Rytka, J., Herbert, C. J. (1998). \"The yeast gene YJR025c encodes a 3-hydroxyanthranilic acid dioxygenase and is involved in nicotinic acid biosynthesis.\" FEBS Lett 424:127-130."},{"pubmed_id":15387819,"citation":"Kastaniotis, A. J., Autio, K. J., Sormunen, R. T., Hiltunen, J. K. (2004). \"Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology.\" Mol Microbiol 53:1407-1421."}],"proteins":[{"created_at":"2011-05-24T20:02:15.000Z","updated_at":"2011-07-22T17:54:34.000Z","name":"D-arabinono-1,4-lactone oxidase","uniprot_id":"P54783","uniprot_name":"ALO_YEAST","enzyme":true,"transporter":false,"gene_name":"ALO1","num_residues":526,"molecular_weight":"59493.19922","theoretical_pi":"6.78","general_function":"Involved in D-arabinono-1,4-lactone oxidase activity","specific_function":"Can oxidize L-gulono-1,4-lactone as well as D-arabinono- 1,4-lactone and L-galactono-1,4-lactone","reactions":[{"id":1431,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2293,"direction":"\u003e","locations":"Mitochondrion membrane.","altext":"D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion membrane.","genbank_gene_id":"AB009401","genbank_protein_id":"2696034","gene_card_id":"ALO1","chromosome_location":"chromosome 13","locus":"YML086C","synonyms":["ALO","L-galactono-gamma-lactone oxidase"],"enzyme_classes":["1.1.3.37"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"},{"category":"Function","description":" D-arabinono-1,4-lactone oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"ALO","identifier":"PF04030"},{"name":"FAD_binding_4","identifier":"PF01565"}],"pathways":[],"gene_sequence":"ATGTCTACTATCCCATTTAGAAAGAACTATGTGTTCAAAAACTGGGCCGGAATTTATTCTGCAAAACCAGAACGTTACTTCCAACCAAGTTCAATTGATGAGGTTGTCGAGTTAGTAAAGAGTGCCAGGCTAGCTGAAAAAAGCTTAGTTACTGTTGGTTCGGGCCATTCTCCTAGTAACATGTGCGTTACTGATGAATGGCTTGTTAACTTAGACAGATTGGACAAAGTACAAAAGTTTGTTGAATATCCTGAGTTACATTATGCCGATGTCACAGTTGATGCCGGTATGAGGCTTTACCAATTGAATGAATTTTTGGGTGCGAAAGGTTACTCTATCCAAAATTTAGGCTCTATCTCAGAACAAAGTGTTGCTGGCATAATCTCTACTGGTAGTCATGGTTCCTCACCTTATCACGGTTTGATTTCTTCTCAATACGTAAACTTGACTATTGTTAATGGTAAGGGCGAATTGAAGTTCTTGGATGCCGAAAACGATCCAGAAGTCTTTAAAGCTGCTTTACTTTCAGTTGGAAAAATCGGTATCATTGTCTCTGCTACTATCAGGGTTGTTCCCGGCTTCAATATTAAATCCACTCAAGAAGTGATTACTTTTGAAAACCTTTTGAAGCAATGGGATACCCTATGGACTTCATCTGAATTTATCAGAGTTTGGTGGTACCCTTATACTAGAAAATGTGTTCTATGGAGGGGTAACAAAACTACAGATGCCCAAAATGGTCCAGCCAAGTCATGGTGGGGTACCAAGCTGGGTAGATTTTTCTACGAAACTCTATTATGGATCTCTACCAAAATCTATGCGCCATTAACCCCATTTGTGGAAAAGTTCGTTTTCAACAGGCAATACGGGAAATTGGAGAAGAGCTCTACTGGTGATGTTAATGTTACCGATTCTATCAGCGGATTTAATATGGACTGTTTGTTTTCACAATTTGTTGATGAATGGGGGTGCCCTATGGATAATGGTTTGGAAGTCTTACGTTCATTGGATCATTCTATTGCGCAGGCTGCCATAAACAAAGAATTTTATGTCCACGTGCCTATGGAAGTCCGTTGCTCAAATACTACATTACCTTCTGAACCCTTGGATACTAGCAAGAGAACAAACACCAGTCCCGGTCCCGTTTATGGCAATGTGTGCCGCCCATTCCTGGATAACACACCATCCCATTGCAGATTTGCTCCGTTGGAAAATGTTACCAACAGTCAGTTGACGTTGTACATAAATCCTACCATTTATAGGCCGTTTGGCTGTAATACTCCAATTCATAAATGGTTTACCCTTTTTGAAAATACTATGATGGTAGCGGGAGGTAAGCCACATTGGGCCAAGAACTTCCTAGGCTCAACCACTCTAGCTGCTGGACCAGTGAAAAAGGATACTGATTACGATGACTTTGAAATGAGGGGGATGGCATTGAAGGTTGAAGAATGGTATGGCGAGGATTTGAAAAAGTTCCGGAAAATAAGAAAGGAGCAAGATCCCGATAATGTATTCTTGGCAAACAAACAGTGGGCTATCATAAATGGTATTATAGATCCTAGTGAGTTGTCCGACTAG","protein_sequence":"MSTIPFRKNYVFKNWAGIYSAKPERYFQPSSIDEVVELVKSARLAEKSLVTVGSGHSPSNMCVTDEWLVNLDRLDKVQKFVEYPELHYADVTVDAGMRLYQLNEFLGAKGYSIQNLGSISEQSVAGIISTGSHGSSPYHGLISSQYVNLTIVNGKGELKFLDAENDPEVFKAALLSVGKIGIIVSATIRVVPGFNIKSTQEVITFENLLKQWDTLWTSSEFIRVWWYPYTRKCVLWRGNKTTDAQNGPAKSWWGTKLGRFFYETLLWISTKIYAPLTPFVEKFVFNRQYGKLEKSSTGDVNVTDSISGFNMDCLFSQFVDEWGCPMDNGLEVLRSLDHSIAQAAINKEFYVHVPMEVRCSNTTLPSEPLDTSKRTNTSPGPVYGNVCRPFLDNTPSHCRFAPLENVTNSQLTLYINATIYRPFGCNTPIHKWFTLFENTMMVAGGKPHWAKNFLGSTTLAAGPVKKDTDYDDFEMRGMALKVEEWYGEDLKKFRKIRKEQDPDNVFLANKQWAIINGIIDPSELSD"},{"created_at":"2011-05-24T20:03:33.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Lanosterol 14-alpha demethylase","uniprot_id":"P10614","uniprot_name":"CP51_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG11","num_residues":530,"molecular_weight":"60719.80078","theoretical_pi":"8.95","general_function":"Involved in iron ion binding","specific_function":"Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol","reactions":[{"id":2295,"direction":"\u003e","locations":"Membrane; Single-pass membrane protein","altext":"Obtusifoliol + 3 O(2) + 3 NADPH = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":14387,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006897","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"21-41","pdb_id":null,"cellular_location":"Membrane; Single-pass membrane protein","genbank_gene_id":"M18109","genbank_protein_id":"170946","gene_card_id":"ERG11","chromosome_location":"chromosome 8","locus":"YHR007C","synonyms":["CYPLI","Cytochrome P450 51","Cytochrome P450-14DM","Cytochrome P450-LIA1","Sterol 14-alpha demethylase"],"enzyme_classes":["1.14.13.70"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" monooxygenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"p450","identifier":"PF00067"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGTCTGCTACCAAGTCAATCGTTGGAGAGGCATTGGAATACGTAAACATTGGTTTAAGTCATTTCTTGGCTTTACCATTGGCCCAAAGAATCTCTTTGATCATAATAATTCCTTTCATTTACAATATTGTATGGCAATTACTATATTCTTTGAGAAAGGACCGTCCACCTCTAGTGTTTTACTGGATTCCATGGGTCGGTAGTGCTGTTGTGTACGGTATGAAGCCATACGAGTTTTTCGAAGAATGTCAAAAGAAATACGGTGATATTTTTTCATTCGTTTTGTTAGGAAGAGTCATGACTGTGTATTTAGGACCAAAGGGTCACGAATTTGTCTTCAACGCTAAGTTGGCAGATGTTTCAGCAGAAGCTGCTTACGCTCATTTGACTACTCCAGTTTTCGGTAAAGGTGTTATTTACGATTGTCCAAATTCTAGATTGATGGAGCAAAAGAAGTTTGTTAAGGGTGCTCTAACCAAAGAAGCCTTCAAGAGCTACGTTCCATTGATTGCTGAAGAAGTGTACAAGTACTTCAGAGACTCCAAAAACTTCCGTTTGAATGAAAGAACTACTGGTACTATTGACGTGATGGTTACTCAACCTGAAATGACTATTTTCACCGCTTCAAGATCATTATTGGGTAAGGAAATGAGAGCAAAATTGGATACCGATTTTGCTTACTTGTACAGTGATTTGGATAAGGGTTTCACTCCAATCAACTTCGTCTTCCCTAACTTACCATTGGAACACTATAGAAAGAGAGATCACGCTCAAAAGGCTATCTCCGGTACTTACATGTCTTTGATTAAGGAAAGAAGAAAGAACAACGACATTCAAGACAGAGATTTGATCGATTCCTTGATGAAGAACTCTACCTACAAGGATGGTGTGAAGATGACTGATCAAGAAATCGCTAACTTGTTAATTGGTGTCTTAATGGGTGGTCAACATACTTCTGCTGCCACTTCTGCTTGGATTTTGTTGCACTTGGCTGAAAGACCAGATGTCCAACAAGAATTGTACGAAGAACAAATGCGTGTTTTGGATGGTGGTAAGAAGGAATTGACCTACGATTTATTACAAGAAATGCCATTGTTGAACCAAACTATTAAGGAAACTCTAAGAATGCACCATCCATTGCACTCTTTGTTCCGTAAGGTTATGAAAGATATGCACGTTCCAAACACTTCTTATGTCATCCCAGCAGGTTATCACGTTTTGGTTTCTCCAGGTTACACTCATTTAAGAGACGAATACTTCCCTAATGCTCACCAATTCAACATTCACCGTTGGAACAAAGATTCTGCCTCCTCTTATTCCGTCGGTGAAGAAGTCGATTACGGTTTCGGTGCCATTTCTAAGGGTGTCAGCTCTCCATACTTACCTTTCGGTGGTGGTAGACACAGATGTATCGGTGAACACTTTGCTTACTGTCAGCTAGGTGTTCTAATGTCCATTTTTATCAGAACATTAAAATGGCATTACCCAGAGGGTAAGACCGTTCCACCTCCTGACTTTACATCTATGGTTACTCTTCCAACCGGTCCAGCCAAGATCATCTGGGAAAAGAGAAATCCAGAACAAAAGATCTAA","protein_sequence":"MSATKSIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRNPEQKI"},{"created_at":"2011-05-24T21:00:56.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Pyridoxamine 5'-phosphate oxidase","uniprot_id":"P38075","uniprot_name":"PDX3_YEAST","enzyme":true,"transporter":false,"gene_name":"PDX3","num_residues":228,"molecular_weight":"26908.0","theoretical_pi":"7.67","general_function":"Involved in pyridoxamine-phosphate oxidase activity","specific_function":"Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)","reactions":[{"id":1923,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1924,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1926,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1928,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2356,"direction":"\u003e","locations":null,"altext":"Pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'-phosphate + NH(3) + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2357,"direction":"\u003e","locations":null,"altext":"Pyridoxine 5'-phosphate + O(2) = pyridoxal 5'-phosphate + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1CI0","cellular_location":null,"genbank_gene_id":"AY557712","genbank_protein_id":"45269315","gene_card_id":"PDX3","chromosome_location":"chromosome 2","locus":"YBR035C","synonyms":["PNP/PMP oxidase","PNPOx"],"enzyme_classes":["1.4.3.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH2 group of donors"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor"},{"category":"Function","description":" pyridoxamine-phosphate oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" FMN binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" vitamin B6 metabolic process"},{"category":"Process","description":" pyridoxine metabolic process"},{"category":"Process","description":" pyridoxine biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PNPOx_C","identifier":"PF10590"},{"name":"Pyridox_oxidase","identifier":"PF01243"}],"pathways":[{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"}],"gene_sequence":"ATGACTAAACAAGCTGAGGAGACCCAAAAGCCAATCATATTTGCTCCTGAGACGTATCAATATGATAAATTTACTTTGAATGAAAAACAACTTACTGACGACCCAATCGATCTTTTCACCAAATGGTTCAACGAAGCCAAGGAAGACCCAAGGGAAACGTTGCCAGAAGCAATTACTTTTTCATCCGCGGAACTACCTAGTGGGAGGGTGTCGTCCAGGATTCTTCTTTTTAAGGAGCTCGACCATAGAGGTTTTACTATTTATTCTAACTGGGGAACCTCTAGAAAGGCTCATGATATTGCTACCAACCCGAATGCGGCAATCGTATTCTTTTGGAAGGATCTGCAAAGGCAGGTGAGAGTTGAAGGTATCACAGAGCATGTTAACAGAGAAACTTCTGAAAGATACTTTAAGACGAGACCTCGTGGATCCAAGATCGGTGCATGGGCTTCCCGCCAATCGGATGTTATCAAGAACAGAGAAGAACTAGACGAGTTGACCCAAAAAAACACCGAACGTTTCAAGGATGCTGAAGACATCCCATGTCCAGATTATTGGGGTGGCTTGAGAATCGTTCCACTGGAAATTGAGTTCTGGCAAGGTAGACCCTCGAGATTGCATGATAGATTCGTTTACAGAAGAAAAACAGAAAACGATCCATGGAAAGTCGTTAGACTAGCCCCATGA","protein_sequence":"MTKQAEETQKPIIFAPETYQYDKFTLNEKQLTDDPIDLFTKWFNEAKEDPRETLPEAITFSSAELPSGRVSSRILLFKELDHRGFTIYSNWGTSRKAHDIATNPNAAIVFFWKDLQRQVRVEGITEHVNRETSERYFKTRPRGSKIGAWASRQSDVIKNREELDELTQKNTERFKDAEDIPCPDYWGGLRIVPLEIEFWQGRPSRLHDRFVYRRKTENDPWKVVRLAP"},{"created_at":"2011-05-24T21:12:40.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Polyamine oxidase FMS1","uniprot_id":"P50264","uniprot_name":"FMS1_YEAST","enzyme":true,"transporter":false,"gene_name":"FMS1","num_residues":508,"molecular_weight":"57805.10156","theoretical_pi":"5.38","general_function":"Amino acid transport and metabolism","specific_function":"Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance","reactions":[{"id":1903,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1906,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1907,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2368,"direction":"\u003e","locations":null,"altext":"Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2369,"direction":"\u003e","locations":null,"altext":"Spermidine + O(2) + H(2)O = putrescine + 3-aminopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2370,"direction":"\u003e","locations":null,"altext":"N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2371,"direction":"\u003e","locations":null,"altext":"N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2372,"direction":"\u003e","locations":null,"altext":"N(8)-acetylspermidine + O(2) + H(2)O = 4-acetamidobutanal + trimethylenediamine + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3757,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006281","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1YY5","cellular_location":null,"genbank_gene_id":"X81848","genbank_protein_id":"1143556","gene_card_id":"FMS1","chromosome_location":"chromosome 13","locus":"YMR020W","synonyms":["Fenpropimorph resistance multicopy suppressor 1"],"enzyme_classes":["1.5.3.17"],"go_classes":[],"pfams":[{"name":"Amino_oxidase","identifier":"PF01593"}],"pathways":[{"name":"beta-Alanine 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H(2)O(2)","reactions":[{"id":1249,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1250,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1251,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1252,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1253,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1254,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2392,"direction":"\u003e","locations":"Peroxisome","altext":"Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Peroxisome","genbank_gene_id":"M27515","genbank_protein_id":"172217","gene_card_id":"POX1","chromosome_location":"chromosome 7","locus":"YGL205W","synonyms":["Acyl-CoA oxidase"],"enzyme_classes":["1.3.3.6"],"go_classes":[{"category":"Component","description":" microbody"},{"category":"Component","description":" peroxisome"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase 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cellular metabolic process"},{"category":"Process","description":" fatty acid catabolic process"},{"category":"Process","description":" fatty acid beta-oxidation"}],"pfams":[{"name":"ACOX","identifier":"PF01756"},{"name":"Acyl-CoA_dh_M","identifier":"PF02770"}],"pathways":[{"name":"Fatty acid metabolism","kegg_map_id":"00071"},{"name":"alpha-Linolenic acid metabolism","kegg_map_id":"00592"},{"name":"Biosynthesis of unsaturated fatty 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of fatty acids protein 1","uniprot_id":"P39540","uniprot_name":"ELO1_YEAST","enzyme":true,"transporter":false,"gene_name":"ELO1","num_residues":310,"molecular_weight":"36233.60156","theoretical_pi":"9.69","general_function":"Involved in fatty acid elongase activity","specific_function":"May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0)","reactions":[{"id":1499,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1501,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1503,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2385,"direction":"\u003e","locations":"Membrane; Multi-pass membrane protein (Potential); Multi-pass membrane protein; Multi-pass membrane protein (Probable)","altext":"Acyl-CoA + malonyl-CoA = 3-oxoacyl-CoA + CoA + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3865,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006386","source":"Smpdb"},{"id":3866,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006396","source":"Smpdb"},{"id":3867,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006400","source":"Smpdb"},{"id":3868,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006392","source":"Smpdb"},{"id":3869,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006404","source":"Smpdb"},{"id":3870,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006412","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"64-84;101-121;187-207;235-255;272-292","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"X77688","genbank_protein_id":"547599","gene_card_id":"ELO1","chromosome_location":"chromosome 10","locus":"YJL196C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ELO","identifier":"PF01151"}],"pathways":[{"name":"Biosynthesis of unsaturated fatty 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carrier protein, mitochondrial","uniprot_id":"P32463","uniprot_name":"ACPM_YEAST","enzyme":true,"transporter":false,"gene_name":"ACP1","num_residues":125,"molecular_weight":"13942.5","theoretical_pi":"4.57","general_function":"Involved in acyl carrier activity","specific_function":"Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY558392","genbank_protein_id":"45270674","gene_card_id":"ACP1","chromosome_location":"chromosome 11","locus":"YKL192C","synonyms":["ACP","NADH-ubiquinone oxidoreductase 9.6 kDa subunit"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" phosphopantetheine binding"},{"category":"Function","description":" substrate-specific transporter activity"},{"category":"Function","description":" acyl carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" carboxylic acid binding"},{"category":"Function","description":" amino acid binding"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"PP-binding","identifier":"PF00550"}],"pathways":[],"gene_sequence":"ATGTTTAGATCCGTTTGCCGCATTTCTTCCCGCGTGGCACCTTCTGCGTACCGCACTATAATGGGCCGTTCCGTTATGTCCAACACCATACTCGCACAAAGATTTTATTCTGCAAACTTGAGCAAAGATCAGGTTTCTCAAAGGGTCATTGATGTTATCAAGGCGTTTGATAAGAACTCTCCCAACATTGCCAACAAGCAAATCTCCAGCGATACCCAATTTCACAAGGATTTGGGGTTGGACTCCTTGGACACTGTCGAGCTGCTCGTAGCTATTGAAGAAGAATTTGATATTGAAATCCCTGACAAAGTGGCTGATGAGTTGAGAAGTGTTGGTGAAACGGTCGATTATATCGCTTCCAATCCCGACGCAAACTAA","protein_sequence":"MFRSVCRISSRVAPSAYRTIMGRSVMSNTILAQRFYSANLSKDQVSQRVIDVIKAFDKNSPNIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIASNPDAN"},{"created_at":"2011-05-26T17:41:21.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Protoporphyrinogen oxidase","uniprot_id":"P40012","uniprot_name":"PPOX_YEAST","enzyme":true,"transporter":false,"gene_name":"HEM14","num_residues":539,"molecular_weight":"59702.39844","theoretical_pi":"9.8","general_function":"Involved in oxygen-dependent protoporphyrinogen oxidase activity","specific_function":"Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX","reactions":[{"id":1913,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2479,"direction":"\u003e","locations":"Mitochondrion inner membrane.","altext":"Protoporphyrinogen-IX + 3 O(2) = protoporphyrin-IX + 3 H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":14203,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006644","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane.","genbank_gene_id":"U18778","genbank_protein_id":"603606","gene_card_id":"HEM14","chromosome_location":"chromosome 5","locus":"YER014W","synonyms":["PPO"],"enzyme_classes":["1.3.3.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" oxygen-dependent protoporphyrinogen oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" tetrapyrrole metabolic process"},{"category":"Process","description":" porphyrin metabolic process"},{"category":"Process","description":" porphyrin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[],"pathways":[{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"},{"name":"Porphyrin Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTATTACCATTAACAAAGCTAAAACCGAGAGCAAAAGTTGCTGTTGTAGGGGGTGGCGTTTCTGGACTATGTTTTACTTATTTTTTAAGCAAGTTGAGACCGGATGTTGAAATCACACTGTTCGAATCGCAGAACAGAACTGGGGGTTGGATATATTCTTGTAACACAAGAGATATGAGTGGGAACCCAATTATGTTGGAGAAGGGACCCAGAACATTGAGGGGCGTATCAGACGGGACCGTTCTGATTATGGATACCCTTAAAGACTTGGGCAAGGAAGCAGTTATTCAAAGCATTGATAAAGGTTGCATTGCAGACAAAAAGTTTCTACTAGACCCCAGTGATAAACTCGTGCAGGTTCCTAATTCGATATCTACAACAGTAAAATTTCTGCTGAATCCGTTGGGAAAAGGACTCATCACGGGTATGATGGGAGAATGGTTCAGAAAAAAATCTCCACATCCTGGCCAAGACGAAAGTGTCGAATCCATTTGTGACAGAAGGTTTGGGAATAACTACATATCAAACAATATGATCAGTGCCTTACTAAGAGGTATCTATGGGGATGACGTTTCCCTATTAAGTGCCAAGAGAACGTTTAAGAAAATATACTACAATGAACTAAAGCACGGATCTAACACACAAGCTATGATTGATAATATGCGCGGAAAGTCAAGAAGTAAAAAAACTGAGAACCTGCACCAATCTTTAACTGGCTGCCTTAACGACTACTCAAATGCGTTTGGAAAAGACAGGTCAAAGTTATTAGACTTATCCAACACGCTAAAGAAATATCCCATGTTGGGTCTTGCTGGGGGACTAGAAACGTTTCCCAAGATAGTCAGAAATGCTTTGAACGAATTTAAAAACGTCAAAATAGTTACTGGGAACCCGGTTACGCAAATAATGAAACGCCCTGCTAACGAAACGACAATCGGATTGAAAGCGAAATCTGGCGACCAATACGAAACATTTGACCATTTAAGACTTACGATAACACCTCCCAAAATCGCTAAATTGCTACCGAAGGATCAAAATTCATTATCCAAGTTATTAGATGAGATACAATCAAACACAATAATTTTAGTTAATTATTATTTGCCAAACAAAGATGTAATAGATGCCGATCTACAAGGCTTTGGATACTTGGTTCCCAAATCCAATAAGAATCCAGGGAAATTGCTTGGTGTAATTTTCGATTCTGTTATCGAAAGGAATTTCAAACCACTTTTTGACAAACTCTCCACAAACCCAAACGCCCTCAACAAATATACAAAAGTGACTGCGATGATAGGAGGTTGTATGCTCAATGAACACGGTGTTCCTGTAGTGCCATCCAGGGAGGTAACCATTAATGCAGTCAAAGATGCGCTGAACAACCACCTCGGCATCAGTAACAAGGATCTGGAAGCTGGTCAGTGGGAATTCACTATCGCCGATAGATGTCTGCCAAGATTTCATGTAGGTTATGACGCATGGCAAGAAAGAGCTGAAAGGAAGTTGCAAGAATCTTACGGCCAAACAGTTTCTGTGGGGGGAATGGGATTTTCTAGAAGTCCCGGTGTCCCTGACGTTATTGTAGACGGCTTTAACGACGCCTTACAGCTAAGCAAATAA","protein_sequence":"MLLPLTKLKPRAKVAVVGGGVSGLCFTYFLSKLRPDVEITLFESQNRTGGWIYSCNTRDMSGNPIMLEKGPRTLRGVSDGTVLIMDTLKDLGKEAVIQSIDKGCIADKKFLLDPSDKLVQVPNSISTTVKFLLNPLGKGLITGMMGEWFRKKSPHPGQDESVESICDRRFGNNYISNNMISALLRGIYGDDVSLLSAKRTFKKIYYNELKHGSNTQAMIDNMRGKSRSKKTENLHQSLTGCLNDYSNAFGKDRSKLLDLSNTLKKYPMLGLAGGLETFPKIVRNALNEFKNVKIVTGNPVTQIMKRPANETTIGLKAKSGDQYETFDHLRLTITPPKIAKLLPKDQNSLSKLLDEIQSNTIILVNYYLPNKDVIDADLQGFGYLVPKSNKNPGKLLGVIFDSVIERNFKPLFDKLSTNPNALNKYTKVTAMIGGCMLNEHGVPVVPSREVTINAVKDALNNHLGISNKDLEAGQWEFTIADRCLPRFHVGYDAWQERAERKLQESYGQTVSVGGMGFSRSPGVPDVIVDGFNDALQLSK"},{"created_at":"2011-05-26T17:55:45.000Z","updated_at":"2011-07-22T17:54:31.000Z","name":"Coproporphyrinogen-III oxidase","uniprot_id":"P11353","uniprot_name":"HEM6_YEAST","enzyme":true,"transporter":false,"gene_name":"HEM13","num_residues":328,"molecular_weight":"37711.30078","theoretical_pi":"6.8","general_function":"Involved in coproporphyrinogen oxidase activity","specific_function":"Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III","reactions":[{"id":1414,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2496,"direction":"\u003e","locations":"Cytoplasm","altext":"Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1TLB","cellular_location":"Cytoplasm","genbank_gene_id":"AY557656","genbank_protein_id":"45269205","gene_card_id":"HEM13","chromosome_location":"chromosome 4","locus":"YDR044W","synonyms":["COX","Coprogen oxidase","Coproporphyrinogenase"],"enzyme_classes":["1.3.3.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" coproporphyrinogen oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" tetrapyrrole metabolic process"},{"category":"Process","description":" porphyrin metabolic process"},{"category":"Process","description":" porphyrin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Coprogen_oxidas","identifier":"PF01218"}],"pathways":[{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"}],"gene_sequence":"ATGCCTGCCCCTCAAGATCCAAGGAATCTTCCAATTAGACAACAAATGGAAGCCCTTATCCGTCGCAAACAAGCTGAAATCACGCAAGGTTTGGAATCCATCGATACTGTTAAGTTCCACGCTGATACTTGGACCCGTGGTAACGATGGTGGTGGTGGTACCTCTATGGTTATCCAAGACGGTACAACTTTCGAAAAAGGTGGTGTTAATGTCTCCGTTGTTTATGGTCAATTGAGCCCAGCGGCCGTTTCAGCCATGAAAGCTGATCATAAGAATCTGCGTCTACCAGAAGATCCAAAGACTGGTTTGCCAGTTACCGACGGTGTCAAGTTCTTCGCTTGTGGTTTAAGTATGGTCATTCATCCCGTTAACCCACACGCTCCAACCACGCACTTAAACTACCGTTACTTCGAAACTTGGAACCAAGATGGGACCCCACAAACTTGGTGGTTTGGTGGTGGTGCTGATTTGACACCTTCTTACTTATACGAAGAAGACGGTCAATTATTCCACCAACTGCACAAGGATGCCTTGGACAAGCACGACACTGCTTTGTACCCACGTTTCAAGAAATGGTGTGATGAGTACTTCTACATTACCCACCGTAAGGAAACACGTGGTATTGGTGGTATATTCTTTGACGATTATGATGAACGTGACCCACAAGAAATATTGAAGATGGTTGAAGACTGTTTCGATGCTTTCTTGCCATCCTACTTGACTATCGTCAAGAGAAGAAAAGATATGCCATATACAAAGGAAGAACAACAATGGCAGGCCATTAGACGTGGTAGATACGTTGAATTCAACTTAATCTACGATAGAGGTACCCAATTCGGTTTGAGAACCCCAGGCTCTAGAGTTGAGTCAATTTTGATGAGTTTGCCTGAACATGCTTCATGGTTATACAACCACCACCCTGCTCCTGGTTCCAGAGAAGCTAAATTACTAGAAGTTACCACCAAACCAAGAGAGTGGGTTAAATAA","protein_sequence":"MPAPQDPRNLPIRQQMEALIRRKQAEITQGLESIDTVKFHADTWTRGNDGGGGTSMVIQDGTTFEKGGVNVSVVYGQLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAPTTHLNYRYFETWNQDGTPQTWWFGGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKKWCDEYFYITHRKETRGIGGIFFDDYDERDPQEILKMVEDCFDAFLPSYLTIVKRRKDMPYTKEEQQWQAIRRGRYVEFNLIYDRGTQFGLRTPGSRVESILMSLPEHASWLYNHHPAPGSREAKLLEVTTKPREWVK"},{"created_at":"2011-05-26T17:57:08.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Osmotic growth protein 1","uniprot_id":"P21375","uniprot_name":"OSM1_YEAST","enzyme":true,"transporter":false,"gene_name":"OSM1","num_residues":501,"molecular_weight":"55064.80078","theoretical_pi":"9.51","general_function":"Involved in electron carrier activity","specific_function":"Could be a fumarate reductase","reactions":[{"id":1555,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1556,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":3732,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006258","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm (Probable)","genbank_gene_id":"L26347","genbank_protein_id":"695798","gene_card_id":"OSM1","chromosome_location":"chromosome 10","locus":"YJR051W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" succinate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"}],"pathways":[],"gene_sequence":"ATGATTAGATCTGTGAGAAGGGTTTTCATTTACGTCTCAATATTCGTATTGATAATAGTTTTGAAAAGAACATTAAGTGGCACAGATCAAACGTCAATGAAACAACCAGTGGTGGTCATTGGCTCTGGTTTGGCAGGCTTAACCACAAGTAATCGTCTCATTAGTAAATACAGAATTCCTGTTGTGCTTTTGGATAAGGCGGCTTCTATTGGTGGGAATTCTATAAAGGCTTCTAGTGGTATTAATGGTGCTCACACAGACACTCAACAAAATTTAAAGGTAATGGACACTCCCGAATTGTTTTTGAAAGATACTTTGCATTCGGCTAAAGGCAGAGGGGTTCCATCACTGATGGATAAGTTGACTAAGGAATCCAAGAGTGCTATCAGGTGGTTGCAAACAGAATTCGATTTGAAATTAGACCTCCTTGCGCAATTGGGCGGTCACTCTGTTCCAAGGACCCATAGATCTTCTGGCAAATTACCACCAGGTTTTGAAATCGTGCAAGCGTTATCAAAAAAACTAAAGGATATCTCTTCCAAAGATTCCAATCTCGTGCAGATTATGCTAAACAGTGAAGTAGTGGATATCGAGCTTGATAATCAAGGTCATGTTACTGGTGTAGTATATATGGACGAGAACGGAAACCGTAAAATCATGAAGTCACACCATGTCGTGTTTTGCTCAGGTGGATTTGGTTACTCTAAGGAAATGTTGAAAGAGTACTCACCAAATTTGATTCACTTGCCAACTACTAATGGCAAACAGACTACAGGTGATGGTCAAAAAATCCTTTCAAAGTTGGGTGCCGAATTGATTGATATGGATCAAGTGCAGGTACACCCTACCGGCTTCATTGATCCAAATGACCGTGAAAATAACTGGAAGTTTTTGGCTGCAGAGGCATTGAGGGGTTTAGGCGGCATCTTATTGCATCCCACCACTGGAAGAAGGTTTACAAATGAATTGAGCACCAGAGATACAGTAACCATGGAAATACAGTCTAAATGTCCGAAAAATGATAATAGAGCACTTTTGGTAATGAGCGACAAAGTCTACGAGAACTATACGAATAACATAAACTTTTATATGTCCAAAAACTTAATCAAAAAAGTGTCAATCAACGATCTGATCCGACAATATGACCTACAAACTACAGCTTCTGAACTGGTAACTGAACTGAAGAGCTATTCCGATGTTAATACTAAGGATACGTTTGATAGGCCATTGATTATCAATGCCTTTGATAAAGATATTTCGACTGAATCAACTGTTTATGTTGGGGAAGTTACACCAGTTGTTCATTTCACAATGGGTGGTGTGAAAATTAATGAGAAATCTCAGGTAATTAAGAAAAATTCGGAAAGCGTTCTATCTAATGGGATATTTGCTGCTGGTGAAGTTTCGGGTGGTGTTCATGGAGCCAACAGATTGGGTGGATCTAGTTTGTTAGAGTGTGTTGTCTTTGGAAAGACAGCTGCGGATAACATAGCAAAATTGTACTGA","protein_sequence":"MIRSVRRVFIYVSIFVLIIVLKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY"},{"created_at":"2011-05-26T19:29:31.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Kynurenine 3-monooxygenase","uniprot_id":"P38169","uniprot_name":"KMO_YEAST","enzyme":true,"transporter":false,"gene_name":"BNA4","num_residues":460,"molecular_weight":"52428.89844","theoretical_pi":"8.59","general_function":"Involved in monooxygenase activity","specific_function":"Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid","reactions":[{"id":1684,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2571,"direction":"\u003e","locations":"Mitochondrion","altext":"L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + NADP(+) + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":4187,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006487","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY692951","genbank_protein_id":"51013353","gene_card_id":"BNA4","chromosome_location":"chromosome 2","locus":"YBL098W","synonyms":["Biosynthesis of nicotinic acid protein 4","Kynurenine 3-hydroxylase"],"enzyme_classes":["1.14.13.9"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" monooxygenase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"FAD_binding_3","identifier":"PF01494"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTGAATCAGTGGCCATTATAGGTGCAGGATTAGTAGGCTGCCTTGCAGCTTTGGCATTCTCCAAAGAAGGCTACAATGTCACACTATATGATTTTAGACAAGATCCTCGATTGGACACCACCAAAAATAAAAATTTGAAATCCATTAATTTGGCTATTTCTGCTCGTGGCATTGATGCTCTGAAATCAATAGATCCGGATGCTTGTGAACATATTCTGCAAGATATGATTCCCATGAAAGGCAGGATGATTCATGACTTGAAAGGCAGACAGGAATCACAATTGTATGGCTTGCATGGAGAAGCTATTAATTCTATCAATAGATCTGTATTAAATAATAGCCTTTTGGACGAATTAGAAAAATCTACAACAGAACTGAAGTTCGGTCACAAATTAGTCAAAATCGAATGGACAGATGATAAACAAATCTGTCATTTTGCCATTGGGGAAGATTTGAAAACCCCACATACTGAAAAGTATGATTTTGTCATAGGTTGTGACGGAGCATACTCTGCGACGAGATCGCAAATGCAACGTAAAGTTGAGATGGATTTTTCACAAGAATATATGAATTTACGTTACATTGAACTTTACATCCCGCCTACTGAGGAATTCAAGCCAAACTATGGCGGAAATTTTGCAATAGCTCCTGACCATTTGCACATTTGGCCTCGTCATAAATTCATGTTAATTGCGCTCGCCAACAGTGACGGCTCGTTCACTTCAACCTTTTTCGGTTCTAAAGATCAAATATCAGATCTGATAACTTCCAAGTCACGTGTGAGGGAATTCTTAATCGAGAACTTTCCCGATATTATTAATATTATGGATTTGGACGATGCTGTCAAAAGGTTTATCACTTATCCAAAGGAAAGTCTTGTCTGTGTAAACTGTAAGCCATACGATGTACCAGGCGGAAAGGCCATCCTACTCGGCGACGCTGCCCATGCAATGGTTCCATTTTACGGCCAAGGTATGAATTGCGGATTTGAAGATGTGAGAATTCTTATGGCGCTATTGAAAAAGCATTCAGGAGATCGTTCAAGAGCCTTTACTGAGTACACTCAAACAAGACATAAGGACCTAGTTTCTATTACTGAGCTGGCAAAAAGGAACTATAAAGAAATGTCACATGACGTTACATCCAAGCGGTTTTTATTAAGGAAAAAGCTAGATGCTCTCTTTAGTATTATAATGAAGGATAAGTGGATACCTTTGTATACAATGATATCTTTCAGATCCGATATCTCGTATTCTAGAGCTTTAGAAAGGGCTGGAAAGCAAACACGTATCTTGAAATTCTTAGAATCTCTGACACTCGGTATGTTATCTATTGGCGGTTACAAGCTTTTCAAATTTTTGACAAGAGAACGTTCCTGA","protein_sequence":"MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKNKNLKSINLAISARGIDALKSIDPDACEHILQDMIPMKGRMIHDLKGRQESQLYGLHGEAINSINRSVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKQICHFAIGEDLKTPHTEKYDFVIGCDGAYSATRSQMQRKVEMDFSQEYMNLRYIELYIPPTEEFKPNYGGNFAIAPDHLHIWPRHKFMLIALANSDGSFTSTFFGSKDQISDLITSKSRVREFLIENFPDIINIMDLDDAVKRFITYPKESLVCVNCKPYDVPGGKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHSGDRSRAFTEYTQTRHKDLVSITELAKRNYKEMSHDVTSKRFLLRKKLDALFSIIMKDKWIPLYTMISFRSDISYSRALERAGKQTRILKFLESLTLGMLSIGGYKLFKFLTRERS"},{"created_at":"2011-05-27T01:41:35.000Z","updated_at":"2011-05-27T15:01:15.000Z","name":"NADH-cytochrome b5 reductase 2","uniprot_id":"P36060","uniprot_name":"MCR1_YEAST","enzyme":true,"transporter":false,"gene_name":"MCR1","num_residues":302,"molecular_weight":"34137.69922","theoretical_pi":"9.11","general_function":"Involved in oxidoreductase activity","specific_function":"The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals","reactions":[{"id":2635,"direction":"\u003e","locations":" Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein;Endoplasmic reticulum membrane;NADH-cytochrome b5 reductase p34 form:Mitochondrion outer membrane; Single-pass membrane protein (Potential)","altext":"NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"12-32","pdb_id":null,"cellular_location":"NADH-cytochrome b5 reductase p34 form:Mitochondrion outer membrane; Single-pass membrane protein","genbank_gene_id":"X81474","genbank_protein_id":"1490392","gene_card_id":"MCR1","chromosome_location":"chromosome 11","locus":"YKL150W","synonyms":["Mitochondrial cytochrome b reductase","p34/p32","NADH-cytochrome b5 reductase p34 form","NADH-cytochrome b5 reductase p32 form"],"enzyme_classes":["1.6.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"FAD_binding_6","identifier":"PF00970"},{"name":"NAD_binding_1","identifier":"PF00175"}],"pathways":[{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGTTTTCCAGATTATCCAGATCTCACTCAAAAGCATTACCGATTGCTCTAGGTACAGTTGCTATAGCAGCTGCTACCGCATTCTATTTTGCAAACCGTAACCAACATTCCTTTGTCTTCAATGAATCCAATAAAGTATTCAAGGGTGATGACAAATGGATCGACTTGCCAATATCTAAAATAGAGGAGGAATCCCACGACACCAGAAGGTTTACTTTTAAGCTGCCTACTGAAGACTCAGAAATGGGGTTGGTCCTAGCATCTGCTCTGTTTGCTAAATTTGTCACACCAAAGGGATCCAATGTGGTGAGACCATACACTCCTGTGAGTGATCTTTCCCAGAAGGGTCACTTCCAGCTGGTCGTCAAGCATTATGAAGGTGGTAAAATGACCTCACATTTATTTGGTCTTAAACCAAATGACACCGTTTCTTTCAAGGGTCCTATTATGAAATGGAAGTGGCAACCTAATCAGTTCAAGTCAATCACCTTGTTAGGTGCCGGTACCGGTATCAACCCTCTGTACCAATTAGCTCATCATATAGTTGAAAACCCAAACGACAAGACCAAAGTTAACTTGCTATATGGGAACAAGACTCCTCAGGACATTTTACTAAGGAAGGAACTGGATGCGTTGAAGGAAAAGTATCCTGACAAGTTCAATGTTACTTACTTTGTTGACGACAAGCAAGATGACCAAGACTTTGATGGTGAAATTAGTTTCATCTCCAAAGATTTTATTCAGGAGCATGTTCCAGGTCCAAAGGAAAGCACACATTTGTTTGTCTGCGGTCCCCCACCATTTATGAACGCTTACTCAGGTGAGAAGAAGTCACCTAAGGACCAAGGTGAATTGATCGGTATCTTGAACAATTTGGGCTACTCCAAGGACCAAGTTTTCAAATTTTAA","protein_sequence":"MFSRLSRSHSKALPIALGTVAIAAATAFYFANRNQHSFVFNESNKVFKGDDKWIDLPISKIEEESHDTRRFTFKLPTEDSEMGLVLASALFAKFVTPKGSNVVRPYTPVSDLSQKGHFQLVVKHYEGGKMTSHLFGLKPNDTVSFKGPIMKWKWQPNQFKSITLLGAGTGINPLYQLAHHIVENPNDKTKVNLLYGNKTPQDILLRKELDALKEKYPDKFNVTYFVDDKQDDQDFDGEISFISKDFIQEHVPGPKESTHLFVCGPPPFMNAYSGEKKSPKDQGELIGILNNLGYSKDQVFKF"},{"created_at":"2011-05-27T02:03:15.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"Alpha-ketoglutarate-dependent sulfonate dioxygenase","uniprot_id":"Q12358","uniprot_name":"JLP1_YEAST","enzyme":true,"transporter":false,"gene_name":"JLP1","num_residues":412,"molecular_weight":"46982.30078","theoretical_pi":"6.65","general_function":"Involved in oxidoreductase activity","specific_function":"Acts as a alpha-ketoglutarate-dependent dioxygenase active on sulfonates. Although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate","reactions":[{"id":1994,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14420,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006933","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692737","genbank_protein_id":"51012925","gene_card_id":"JLP1","chromosome_location":"chromosome 12","locus":"YLL057C","synonyms":[],"enzyme_classes":["1.14.11.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"TauD","identifier":"PF02668"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGTCTCCTGCAGCAGCTCAAACAGCAATCCCTCTTCCATCTACCGATTTACCAGTCAAAATCATTACAAATGGGTTGAAAAACCTGAATTATACCTCCAAGCAAGGTTACGGGAATTTTGATACCCATTTTTATGATGGCCAAGATGAGGTCTCTCCATCTGGTTTATTGAAAATCCGTAAATCTTATAGAGAGAAATCGAAGTATCCAGATTATTTGCCTACATGGGATCCTACTGAAAAGTATGGCCCGCTGGAATTTCACGAATACCATGATCCTGCTTTGAGAGCTGACGGTAACTTTTCAAACCTTTTTGCAAAAGAAAACGTTGGTCAACTAAAGGTGAAGAAGATCACCCCGAAATTAGGTCTCGAGATCAATGGGATCCAGCTAACTGATCTTTCTGATGCTGCAAAAGATGAACTCGCTTTGCTTGTCGCCCAAAAGGGAGTAGTTGTCTTTAGAAATCAGAATTTTGCTGACGAGGGACCCGATTATGTGACTGAATACGGAAGACATTTTGGCAAGTTGCACATTCATCAAACTAGTGGCCACCCTCAAAACAATCCTGAGCTGCATATCACTTTCCGAAGACCTGATGCGGAAGAATTTGCAAGAGTTTTTGATGACTCGACATCATCTGGTGGCTGGCACACAGACGTCTCTTACGAGTTACAGCCACCTTCTTATACTTTCTTTAGTGTTGTTGAAGGTCCTGATGGTGGTGGAGATACGTTATTTGCGGATACGATCGAGGCTTTCGACAGGTTGTCGAAGCCTTTGCAAGATTTCTTGAGCACGCTTCATGTCATCCATAGCTCAAAGGAACAGGCAGAGAATTCACAGCGCCAGGGCGGCATAAAAAGAAGAGCACCTGTCACGCATATTCATCCACTGGTCAGAGTTCATCCTGTCTTGAAAAAGAAATGCTTGTATGTCAATCGTGCATTTTCTAGGAAAATAGTCGAATTGAAAAGACAAGAATCTGAATCACTTTTGAATTTCTTGTACAATCTAGTGGAGAGCAGCCATGATTTACAGTTAAGAGCCAAATGGGAACCTCATTCCGTCGTCATTTGGGATAACCGCAGAGTTCAACATTCAGCAGTGATTGATTGGGAAGAACCAATTCACAGACATGCGTTCAGGATTACTCCACAAGCGGAAAGGCCCGTGGAAGATCTAAAGTTTTTGAATGATGAAAATTATTATCCTTCTTCATTAACTTTGGATATTTGA","protein_sequence":"MSPAAAQTAIPLPSTDLPVKIITNGLKNLNYTSKQGYGNFDTHFYDGQDEVSPSGLLKIRKSYREKSKYPDYLPTWDPTEKYGPLEFHEYHDPALRADGNFSNLFAKENVGQLKVKKITPKLGLEINGIQLTDLSDAAKDELALLVAQKGVVVFRNQNFADEGPDYVTEYGRHFGKLHIHQTSGHPQNNPELHITFRRPDAEEFARVFDDSTSSGGWHTDVSYELQPPSYTFFSVVEGPDGGGDTLFADTIEAFDRLSKPLQDFLSTLHVIHSSKEQAENSQRQGGIKRRAPVTHIHPLVRVHPVLKKKCLYVNRAFSRKIVELKRQESESLLNFLYNLVESSHDLQLRAKWEPHSVVIWDNRRVQHSAVIDWEEPIHRHAFRITPQAERPVEDLKFLNDENYYPSSLTLDI"},{"created_at":"2011-05-27T02:16:50.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Indoleamine 2,3-dioxygenase family protein","uniprot_id":"P47125","uniprot_name":"I23O_YEAST","enzyme":true,"transporter":false,"gene_name":"BNA2","num_residues":453,"molecular_weight":"50774.80078","theoretical_pi":"8.11","general_function":"Involved in heme binding","specific_function":"Required for biosynthesis of nicotinic acid","reactions":[{"id":1707,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":4189,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006489","source":"Smpdb"},{"id":4190,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006533","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"L47993","genbank_protein_id":"1019699","gene_card_id":"BNA2","chromosome_location":"chromosome 10","locus":"YJR078W","synonyms":["Biosynthesis of nicotinic acid protein 2"],"enzyme_classes":["1.13.11.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IDO","identifier":"PF01231"}],"pathways":[{"name":"NAD metabolism","kegg_map_id":null},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGAACAACACTTCCATAACCGGACCACAAGTACTACATAGAACAAAAATGAGACCACTACCAGTGCTAGAAAAATACTGTATCTCGCCACATCATGGGTTTTTGGACGACCGGTTACCCTTGACCAGACTGAGCAGCAAGAAATATATGAAATGGGAAGAAATCGTTGCTGACCTGCCCTCTCTTTTGCAAGAGGATAACAAGGTGCGGAGCGTCATCGATGGGCTGGATGTCTTGGACTTGGATGAGACGATCTTGGGCGACGTCAGGGAGCTCAGAAGAGCATATTCCATTTTGGGGTTTATGGCGCACGCTTATATTTGGGCCAGCGGAACTCCCCGGGATGTATTACCGGAGTGTATTGCAAGGCCACTGTTGGAGACAGCACATATTTTGGGTGTGCCACCGTTAGCTACGTACTCCTCGTTGGTGTTATGGAACTTCAAAGTGACCGACGAGTGCAAGAAAACGGAAACCGGGTGTTTGGACTTGGAAAATATTACAACGATAAACACATTTACGGGAACCGTTGACGAAAGTTGGTTTTATCTGGTCAGCGTGCGGTTTGAAAAAATCGGCAGCGCTTGTTTAAACCATGGGTTGCAGATATTGAGAGCCATTAGAAGCGGTGATAAAGGAGACGCTAACGTGATAGACGGGTTGGAGGGCTTGGCTGCAACGATCGAAAGGTTATCGAAAGCCTTGATGGAAATGGAGCTTAAGTGTGAACCCAATGTATTTTATTTCAAGATAAGACCATTTTTGGCCGGGTGGACGAATATGTCGCATATGGGGTTACCACAGGGTGTTAGGTATGGAGCGGAAGGACAGTATCGGATCTTTTCTGGCGGGTCCAATGCGCAAAGCTCGTTGATACAGACACTGGACATCCTTTTGGGTGTGAAACACACTGCGAATGCTGCGCATTCTTCCCAAGGAGACAGCAAGATCAATTATCTGGACGAAATGAAAAAATACATGCCAAGAGAACATCGTGAATTTCTTTACCATTTGGAATCGGTATGTAATATTCGCGAATACGTTTCTCGTAACGCTTCTAACCGTGCATTGCAAGAGGCCTATGGACGTTGCATTTCCATGCTGAAAATATTTAGAGATAACCACATTCAAATTGTTACCAAGTACATTATTTTGCCCTCCAATTCAAAGCAACACGGCTCCAATAAGCCGAACGTACTAAGTCCAATCGAGCCCAATACCAAAGCAAGTGGTTGTTTAGGGCATAAAGTTGCCTCATCTAAGACTATCGGAACCGGTGGTACAAGATTAATGCCCTTCTTAAAGCAGTGCAGGGACGAGACTGTCGCCACTGCGGACATTAAAAATGAAGATAAAAATTGA","protein_sequence":"MNNTSITGPQVLHRTKMRPLPVLEKYCISPHHGFLDDRLPLTRLSSKKYMKWEEIVADLPSLLQEDNKVRSVIDGLDVLDLDETILGDVRELRRAYSILGFMAHAYIWASGTPRDVLPECIARPLLETAHILGVPPLATYSSLVLWNFKVTDECKKTETGCLDLENITTINTFTGTVDESWFYLVSVRFEKIGSACLNHGLQILRAIRSGDKGDANVIDGLEGLAATIERLSKALMEMELKCEPNVFYFKIRPFLAGWTNMSHMGLPQGVRYGAEGQYRIFSGGSNAQSSLIQTLDILLGVKHTANAAHSSQGDSKINYLDEMKKYMPREHREFLYHLESVCNIREYVSRNASNRALQEAYGRCISMLKIFRDNHIQIVTKYIILPSNSKQHGSNKPNVLSPIEPNTKASGCLGHKVASSKTIGTGGTRLMPFLKQCRDETVATADIKNEDKN"},{"created_at":"2011-05-27T02:28:40.000Z","updated_at":"2011-05-29T05:06:36.000Z","name":"Cytochrome c oxidase assembly protein COX15","uniprot_id":"P40086","uniprot_name":"COX15_YEAST","enzyme":true,"transporter":false,"gene_name":"COX15","num_residues":486,"molecular_weight":"54657.89844","theoretical_pi":"10.83","general_function":"Involved in protein complex assembly","specific_function":"Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase","reactions":[],"signal_regions":"None","transmembrane_regions":"86-106;171-191;201-221;244-264;294-314;403-423;425-445","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"L38643","genbank_protein_id":"603947","gene_card_id":"COX15","chromosome_location":"chromosome 5","locus":"YER141W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" macromolecular complex assembly"},{"category":"Process","description":" protein complex assembly"},{"category":"Process","description":" cellular component organization or biogenesis"},{"category":"Process","description":" cellular component organization"},{"category":"Process","description":" cellular component assembly"}],"pfams":[{"name":"COX15-CtaA","identifier":"PF02628"}],"pathways":[],"gene_sequence":"ATGCTTTTCAGAAACATAGAAGTGGGCAGGCAGGCAGCTAAGCTATTAACGAGAACCTCGAGTCGTTTGGCCTGGCAAAGTATTGGGGCCTCAAGGAATATTTCTACCATCAGACAACAAATCAGAAAGACTCAACTATATAATTTTAAGAAAACTGTGAGCATCCGTCCATTTTCTCTCTCCTCCCCTGTTTTTAAACCACATGTTGCTTCAGAATCAAACCCTATAGAATCACGTTTGAAGACCTCGAAGAATGTTGCTTACTGGTTAATAGGTACATCCGGTTTGGTATTTGGTATTGTTGTTCTTGGTGGGTTGACTAGACTAACAGAATCGGGGCTGAGTATTACCGAATGGAAACCTGTCACAGGTACTTTGCCCCCTATGAACCAGAAGGAATGGGAAGAAGAATTTATCAAGTATAAGGAATCACCAGAATTTAAATTGTTGAATTCTCACATTGATTTAGACGAGTTCAAGTTTATATTTTTTATGGAGTGGATTCATAGATTGTGGGGTCGTGCTATCGGCGCTGTTTTTATATTACCTGCAGTTTATTTCGCTGTATCTAAAAAAACTTCAGGCCATGTCAATAAGAGGTTGTTTGGTCTCGCAGGTTTATTAGGATTACAAGGATTTGTTGGTTGGTGGATGGTGAAGTCTGGTCTTGATCAAGAGCAACTAGACGCAAGAAAATCAAAGCCTACCGTTTCTCAATATAGACTTACTACGCATTTGGGTACCGCCTTCTTTTTATACATGGGTATGCTCTGGACTGGTTTGGAAATATTGAGAGAATGTAAATGGATTAAGAACCCTGTTCAAGCCATTAGTCTCTTCAAAAAATTAGATAATCCCGCAATTGGCCCAATGAGAAAGATTTCTTTAGCTTTGTTAGCGGTGTCTTTCCTTACCGCTATGAGTGGCGGTATGGTTGCCGGTTTGGATGCTGGTTGGGTCTATAACACCTGGCCAAAAATGGGTGAACGATGGTTCCCTAGTTCTCGTGAATTAATGGACGAAAACTTCTGTAGAAGAGAGGACAAGAAAGATCTGTGGTGGAGGAATTTGCTAGAAAACCCGGTTACAGTTCAGTTGGTCCATAGGACATGTGCGTACGTTGCGTTTACATCAGTACTAGCTGCTCATATGTACGCTATCAAAAAGAAGGCCGTAATTCCAAGGAACGCGATGACCTCTTTGCATGTTATGATGGGCGTCGTTACTTTACAAGCAACACTTGGTATTTTAACTATATTGTACCTAGTCCCAATATCGTTAGCTTCTATCCATCAAGCTGGTGCTTTGGCGTTGCTAACAAGTTCTTTGGTGTTTGCCTCTCAATTAAGGAAGCCAAGAGCTCCGATGAGAAACGTAATCATTACCTTGCCACATTCAAGCAAAGTAACTAGCGGTAAAATTTTAAGTGAAGCGTCGAAGTTAGCCTCGAAACCATTATAA","protein_sequence":"MLFRNIEVGRQAAKLLTRTSSRLAWQSIGASRNISTIRQQIRKTQLYNFKKTVSIRPFSLSSPVFKPHVASESNPIESRLKTSKNVAYWLIGTSGLVFGIVVLGGLTRLTESGLSITEWKPVTGTLPPMNQKEWEEEFIKYKESPEFKLLNSHIDLDEFKFIFFMEWIHRLWGRAIGAVFILPAVYFAVSKKTSGHVNKRLFGLAGLLGLQGFVGWWMVKSGLDQEQLDARKSKPTVSQYRLTTHLGTAFFLYMGMLWTGLEILRECKWIKNPVQAISLFKKLDNPAIGPMRKISLALLAVSFLTAMSGGMVAGLDAGWVYNTWPKMGERWFPSSRELMDENFCRREDKKDLWWRNLLENPVTVQLVHRTCAYVAFTSVLAAHMYAIKKKAVIPRNAMTSLHVMMGVVTLQATLGILTILYLVPISLASIHQAGALALLTSSLVFASQLRKPRAPMRNVIITLPHSSKVTSGKILSEASKLASKPL"},{"created_at":"2011-05-27T02:31:30.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Squalene monooxygenase","uniprot_id":"P32476","uniprot_name":"ERG1_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG1","num_residues":496,"molecular_weight":"55125.39844","theoretical_pi":"6.44","general_function":"Involved in oxidoreductase activity","specific_function":"Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway","reactions":[{"id":2678,"direction":"\u003e","locations":"Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Squalene + AH(2) + O(2) = (S)-squalene-2,3-epoxide + A + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":14379,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006894","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"17-37;475-495","pdb_id":null,"cellular_location":"Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"M64994","genbank_protein_id":"171471","gene_card_id":"ERG1","chromosome_location":"chromosome 7","locus":"YGR175C","synonyms":["Squalene epoxidase","SE"],"enzyme_classes":["1.14.99.7"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" monooxygenase activity"},{"category":"Function","description":" squalene monooxygenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"SE","identifier":"PF08491"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGTCTGCTGTTAACGTTGCACCTGAATTGATTAATGCCGACAACACAATTACCTACGATGCGATTGTCATCGGTGCTGGTGTTATCGGTCCATGTGTTGCTACTGGTCTAGCAAGAAAGGGTAAGAAAGTTCTTATCGTAGAACGTGACTGGGCTATGCCTGATAGAATTGTTGGTGAATTGATGCAACCAGGTGGTGTTAGAGCATTGAGAAGTCTGGGTATGATTCAATCTATCAACAACATCGAAGCATATCCTGTTACCGGTTATACCGTCTTTTTCAACGGCGAACAAGTTGATATTCCATACCCTTACAAGGCCGATATCCCTAAAGTTGAAAAATTGAAGGACTTGGTCAAAGATGGTAATGACAAGGTCTTGGAAGACAGCACTATTCACATCAAGGATTACGAAGATGATGAAAGAGAAAGGGGTGTTGCTTTTGTTCATGGTAGATTCTTGAACAACTTGAGAAACATTACTGCTCAAGAGCCAAATGTTACTAGAGTGCAAGGTAACTGTATTGAGATATTGAAGGATGAAAAGAATGAGGTTGTTGGTGCCAAGGTTGACATTGATGGCCGTGGCAAGGTGGAATTCAAAGCCCACTTGACATTTATCTGTGACGGTATCTTTTCACGTTTCAGAAAGGAATTGCACCCAGACCATGTTCCAACTGTCGGTTCTTCGTTTGTCGGTATGTCTTTGTTCAATGCTAAGAATCCTGCTCCTATGCACGGTCACGTTATTTTTGGTAGTGATCATATGCCAATCTTGGTTTACCAAATCAGTCCAGAAGAAACAAGAATCCTTTGTGCTTACAACTCTCCAAAGGTCCCAGCTGATATCAAGAGTTGGATGATTAAGGATGTCCAACCTTTCATTCCAAAGAGTCTACGTCCTTCATTTGATGAAGCCGTCAGCCAAGGTAAATTTAGAGCTATGCCAAACTCCTACTTGCCAGCTAGACAAAACGACGTCACTGGTATGTGTGTTATCGGTGACGCTCTAAATATGAGACATCCATTGACTGGTGGTGGTATGACTGTCGGTTTGCATGATGTTGTCTTGTTGATTAAGAAAATAGGTGACCTAGACTTCAGCGACCGTGAAAAGGTTTTGGATGAATTACTAGACTACCATTTCGAAAGAAAGAGTTACGATTCCGTTATTAACGTTTTGTCAGTGGCTTTGTATTCTTTGTTCGCTGCTGACAGCGATAACTTGAAGGCATTACAAAAAGGTTGTTTCAAATATTTCCAAAGAGGTGGCGATTGTGTCAACAAACCCGTTGAATTTCTGTCTGGTGTCTTGCCAAAGCCTTTGCAATTGACCAGGGTTTTCTTCGCTGTCGCTTTTTACACCATTTACTTGAACATGGAAGAACGTGGTTTCTTGGGATTACCAATGGCTTTATTGGAAGGTATTATGATTTTGATCACAGCTATTAGAGTATTCACCCCATTTTTGTTTGGTGAGTTGATTGGTTAA","protein_sequence":"MSAVNVAPELINADNTITYDAIVIGAGVIGPCVATGLARKGKKVLIVERDWAMPDRIVGELMQPGGVRALRSLGMIQSINNIEAYPVTGYTVFFNGEQVDIPYPYKADIPKVEKLKDLVKDGNDKVLEDSTIHIKDYEDDERERGVAFVHGRFLNNLRNITAQEPNVTRVQGNCIEILKDEKNEVVGAKVDIDGRGKVEFKAHLTFICDGIFSRFRKELHPDHVPTVGSSFVGMSLFNAKNPAPMHGHVILGSDHMPILVYQISPEETRILCAYNSPKVPADIKSWMIKDVQPFIPKSLRPSFDEAVSQGKFRAMPNSYLPARQNDVTGMCVIGDALNMRHPLTGGGMTVGLHDVVLLIKKIGDLDFSDREKVLDELLDYHFERKSYDSVINVLSVALYSLFAADSDNLKALQKGCFKYFQRGGDCVNKPVEFLSGVLPKPLQLTRVFFAVAFYTIYLNMEERGFLGLPMALLEGIMILITAIRVFTPFLFGELIG"},{"created_at":"2011-05-27T02:37:10.000Z","updated_at":"2011-05-29T05:06:36.000Z","name":"Ubiquinone biosynthesis protein COQ4, mitochondrial","uniprot_id":"O13525","uniprot_name":"COQ4_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ4","num_residues":335,"molecular_weight":"38626.80078","theoretical_pi":"10.13","general_function":"Involved in ubiquinone biosynthetic process","specific_function":"Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"Z68194","genbank_protein_id":"1204149","gene_card_id":"COQ4","chromosome_location":"chromosome 4","locus":"YDR204W","synonyms":["Coenzyme Q biosynthesis protein 4"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" oxidoreduction coenzyme metabolic process"},{"category":"Process","description":" ubiquinone metabolic process"},{"category":"Process","description":" ubiquinone biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"}],"pfams":[{"name":"Coq4","identifier":"PF05019"}],"pathways":[],"gene_sequence":"ATGTTGAGGTTATCTTTACTGAGATCAACAGCTACTTTGCCAGTGAAATGCCAACGTCGTGGGCTAATATTACCTGCGGCGGCAATGTACACCTTAGGCTCATTAATATTTGGTAAGGAAGCAAGGTTGGCGGATGCCATGGAACGTGGTGAGTTACATAACAAGAACGTTGATTATGCGAAAGAAGCTGAAGAGCGTACCGAGTTACGTATTAGGGCCCTGGCTAATACTCGGCCAATGGAACCTCGGTACAACGGCCATGTTCCCCTTCATCGGTACGAGAAATTGCTGCTGTTTGCAATTTCCGGTTGGAATTCATTTTTCCATCCTGAAGATGGTTATAATATTGTACAATTGGGTGAGGCAACTGCATTGCCGGTCTTCTTGGAGAATTTGAAGCAAACAATGTTAAGTGATTCCTCTGGGAGGCGCATTTTGAAGGAACAACCCAATATCACAACAGAGATTTTGCATATGGACAAACTAGCTAAATTGCCACATAACACGTTTGGGTATGTATATTACCAATGGTTGAAAAGAGAAAACGTTTCTCCGGACACTAGAGCACCTGTCAAATTTATCGACGATCCTATGCATGCATATATCTTTAAGAGGTATAGACAATGCCACGATTTCTATCACGCTATAACCAACATGCCTATTATCATTGAGGGGGAGATCACCATAAAGGCTCTTGAAGGTGCCAACCTGGGCGTCCCAATGGCCATTCTCGGTGGTATCCTTGCACCTTTACGTTTGAAAAAGGTGCAAAGAAAAAGATTATATAATATATATCTCCCTTGGGCTGTCAGAACAGGTTTAAGCTGCAAGCCATTGATCAACGTGTATTGGGAGGAAATGCTGGAGAAGGATGTTACTGCTTTGAGGAAAGAGCTAAAGATAACACTCCCTCCGGATCTAAGGACAATGAGGAAGGAGCGTGCAGCCCTTAGGAAGGAGATTGACGCAAAATACAACTCACAGAAACGAGCCACGACTCCAGCATGA","protein_sequence":"MLRLSLLRSTATLPVKCQRRGLILPAAAMYTLGSLIFGKEARLADAMERGELHNKNVDYAKEAEERTELRIRALANTRPMEPRYNGHVPLHRYEKLLLFAISGWNSFFHPEDGYNIVQLGEATALPVFLENLKQTMLSDSSGRRILKEQPNITTEILHMDKLAKLPHNTFGYVYYQWLKRENVSPDTRAPVKFIDDPMHAYIFKRYRQCHDFYHAITNMPIIIEGEITIKALEGANLGVPMAILGGILAPLRLKKVQRKRLYNIYLPWAVRTGLSCKPLINVYWEEMLEKDVTALRKELKITLPPDLRTMRKERAALRKEIDAKYNSQKRATTPA"},{"created_at":"2011-05-27T03:19:10.000Z","updated_at":"2011-07-22T17:54:21.000Z","name":"C-4 methylsterol oxidase","uniprot_id":"P53045","uniprot_name":"ERG25_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG25","num_residues":309,"molecular_weight":"36478.89844","theoretical_pi":"8.22","general_function":"Involved in iron ion binding","specific_function":"Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol","reactions":[{"id":1356,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1357,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1358,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1359,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2715,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass membrane protein (Probable)","altext":"4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)(+) + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2716,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass membrane protein (Probable)","altext":"4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)(+) + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2717,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass membrane protein (Probable)","altext":"3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)H + O(2) = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)(+) + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":14398,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006913","source":"Smpdb"},{"id":14399,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006914","source":"Smpdb"},{"id":14400,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006915","source":"Smpdb"},{"id":14401,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006916","source":"Smpdb"},{"id":14402,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006919","source":"Smpdb"},{"id":14403,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006920","source":"Smpdb"},{"id":14404,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006921","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"56-76","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass membrane protein (Probable)","genbank_gene_id":"DQ115391","genbank_protein_id":"71064046","gene_card_id":"ERG25","chromosome_location":"chromosome 7","locus":"YGR060W","synonyms":["Methylsterol monooxygenase"],"enzyme_classes":["1.14.13.72"],"go_classes":[{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" endoplasmic reticulum"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"}],"pfams":[{"name":"FA_hydroxylase","identifier":"PF04116"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGTCTGCCGTTTTCAACAACGCTACCCTTTCAGGTCTAGTCCAAGCAAGCACCTACTCACAAACTTTGCAAAATGTCGCCCATTACCAACCTCAATTGAATTTCATGGAAAAATACTGGGCCGCATGGTACAGTTACATGAACAATGATGTTTTGGCCACCGGTCTAATGTTCTTTTTATTGCATGAATTTATGTATTTCTTTAGATGTTTGCCATGGTTCATCATCGACCAAATTCCATACTTTAGAAGATGGAAGTTACAACCAACTAAGATTCCAAGTGCTAAGGAACAACTATACTGTTTGAAATCCGTTCTTCTATCTCATTTCTTGGTCGAGGCCATCCCTATCTGGACCTTCCACCCAATGTGTGAAAAATTAGGTATTACTGTCGAAGTTCCATTCCCATCTTTGAAAACAATGGCTCTAGAAATTGGTCTATTCTTCGTCTTGGAAGATACATGGCATTACTGGGCTCACCGTCTATTCCACTACGGTGTCTTCTACAAGTACATTCACAAGCAACATCACAGATACGCTGCTCCATTCGGTCTTTCTGCTGAATATGCTCATCCTGCTGAGACTTTGTCTTTGGGTTTTGGTACCGTTGGTATGCCAATTCTTTACGTCATGTACACTGGTAAATTACATTTGTTCACTCTATGTGTATGGATCACCCTAAGATTATTCCAAGCTGTTGACTCTCATTCTGGTTATGACTTCCCATGGTCCTTGAACAAGATCATGCCATTCTGGGCTGGCGCTGAACACCACGATTTGCATCATCACTACTTCATTGGTAACTACGCTTCCTCTTTCAGATGGTGGGATTACTGTCTAGACACTGAATCTGGTCCAGAAGCTAAGGCCTCCAGAGAAGAAAGAATGAAGAAGAGAGCTGAAAACAATGCTCAAAAGAAGACTAACTAA","protein_sequence":"MSAVFNNATLSGLVQASTYSQTLQNVAHYQPQLNFMEKYWAAWYSYMNNDVLATGLMFFLLHEFMYFFRCLPWFIIDQIPYFRRWKLQPTKIPSAKEQLYCLKSVLLSHFLVEAIPIWTFHPMCEKLGITVEVPFPSLKTMALEIGLFFVLEDTWHYWAHRLFHYGVFYKYIHKQHHRYAAPFGLSAEYAHPAETLSLGFGTVGMPILYVMYTGKLHLFTLCVWITLRLFQAVDSHSGYDFPWSLNKIMPFWAGAEHHDLHHHYFIGNYASSFRWWDYCLDTESGPEAKASREERMKKRAENNAQKKTN"},{"created_at":"2011-05-27T03:26:33.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Frataxin homolog, mitochondrial","uniprot_id":"Q07540","uniprot_name":"FRDA_YEAST","enzyme":true,"transporter":false,"gene_name":"YFH1","num_residues":174,"molecular_weight":"19490.0","theoretical_pi":"5.63","general_function":"Involved in ferroxidase activity","specific_function":"Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain","reactions":[{"id":2724,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY558160","genbank_protein_id":"45270210","gene_card_id":"YFH1","chromosome_location":"chromosome 4","locus":"YDL120W","synonyms":["Frataxin homolog intermediate form"],"enzyme_classes":["1.16.3.1"],"go_classes":[],"pfams":[{"name":"Frataxin_Cyay","identifier":"PF01491"}],"pathways":[{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"}],"gene_sequence":"ATGATTAAGCGGTCTCTCGCAAGTTTAGTTCGAGTCAGCTCTGTAATGGGCAGAAGATATATGATAGCAGCGGCAGGAGGAGAACGTGCCAGATTTTGTCCAGCTGTAACAAATAAAAAGAATCATACTGTAAATACTTTTCAGAAGAGATTTGTAGAATCCTCGACAGATGGTCAAGTTGTGCCTCAAGAAGTGTTAAACTTACCGCTTGAAAAATACCATGAAGAGGCAGATGACTACCTAGACCATTTACTAGATAGCTTAGAAGAACTGAGTGAGGCTCATCCGGATTGTATACCTGATGTAGAGCTAAGCCATGGCGTAATGACATTGGAAATTCCAGCTTTTGGAACGTATGTAATAAACAAACAGCCTCCAAATAAGCAAATTTGGTTGGCATCACCATTGTCCGGGCCTAACAGATTTGACCTTCTCAATGGGGAGTGGGTTTCGTTAAGAAATGGCACAAAGCTAACAGATATACTTACTGAAGAAGTTGAGAAGGCCATTTCTAAAAGCCAATAA","protein_sequence":"MIKRSLASLVRVSSVMGRRYMIAAAGGERARFCPAVTNKKNHTVNTFQKRFVESSTDGQVVPQEVLNLPLEKYHEEADDYLDHLLDSLEELSEAHPDCIPDVELSHGVMTLEIPAFGTYVINKQPPNKQIWLASPLSGPNRFDLLNGEWVSLRNGTKLTDILTEEVEKAISKSQ"},{"created_at":"2011-05-27T05:33:48.000Z","updated_at":"2011-07-22T17:53:47.000Z","name":"3-hydroxyanthranilate 3,4-dioxygenase","uniprot_id":"P47096","uniprot_name":"3HAO_YEAST","enzyme":true,"transporter":false,"gene_name":"BNA1","num_residues":177,"molecular_weight":"20234.90039","theoretical_pi":"5.59","general_function":"Involved in 3-hydroxyanthranilate 3,4-dioxygenase activity","specific_function":"Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate","reactions":[{"id":1180,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2777,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde.","export":false,"pw_reaction_id":null,"source":null},{"id":4184,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006485","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY558309","genbank_protein_id":"45270508","gene_card_id":"BNA1","chromosome_location":"chromosome 10","locus":"YJR025C","synonyms":["3-hydroxyanthranilate oxygenase","3-HAO","3-hydroxyanthranilic acid dioxygenase","HAD","Biosynthesis of nicotinic acid protein 1"],"enzyme_classes":["1.13.11.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"},{"category":"Function","description":" oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"},{"category":"Function","description":" 3-hydroxyanthranilate 3,4-dioxygenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"3-HAO","identifier":"PF06052"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTTAATACTACACCAATTAATATCGACAAATGGTTGAAGGAGAACGAAGGCCTTTTGAAACCACCGGTGAATAATTATTGCTTACATAAAGGGGGATTCACTGTGATGATTGTCGGTGGGCCTAATGAAAGAACCGGTTATCACATCAATCCAACTCCCGAATGGTTCTATCAAAAAAAAGGATCTATGCTTTTAAAGGTTGTGGATGAGACAGACGCTGAACCAAAGTTCATTGATATCATCATCAATGAAGGCGATTCATATTTATTGCCAGGAAATGTTCCTCACAGTCCTGTTCGGTTTGCTGATACTGTGGGTATTGTTGTGGAACAAGATAGGCCTGGGGGAGAAAACGATAAGATAAGGTGGTACTGTTCTCATTGTCGCCAAGTGGTCCACGAGAGTGAACTGCAAATGTTAGACTTAGGTACCCAAGTGAAAGAAGCCATTTTAGATTTTGAAAATGATGTCGAAAAGAGGACATGTTTCCATTGCAAGACGTTAAACTACGCACGCCCTCAATCTAATTAA","protein_sequence":"MFNTTPINIDKWLKENEGLLKPPVNNYCLHKGGFTVMIVGGPNERTGYHINPTPEWFYQKKGSMLLKVVDETDAEPKFIDIIINEGDSYLLPGNVPHSPVRFADTVGIVVEQDRPGGENDKIRWYCSHCRQVVHESELQMLDLGTQVKEAILDFENDVEKRTCFHCKTLNYARPQSN"},{"created_at":"2011-05-27T06:06:25.000Z","updated_at":"2011-07-22T17:54:24.000Z","name":"Sphingolipid C4-hydroxylase SUR2","uniprot_id":"P38992","uniprot_name":"SUR2_YEAST","enzyme":true,"transporter":false,"gene_name":"SUR2","num_residues":349,"molecular_weight":"40734.0","theoretical_pi":"8.73","general_function":"Involved in iron ion binding","specific_function":"Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin","reactions":[{"id":1370,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1372,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1896,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":3889,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006408","source":"Smpdb"},{"id":14345,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006856","source":"Smpdb"},{"id":14389,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006900","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"9-29;50-70;99-119;148-168;209-229","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"U07171","genbank_protein_id":"458718","gene_card_id":"SUR2","chromosome_location":"chromosome 4","locus":"YDR297W","synonyms":["Syringomycin response protein 2"],"enzyme_classes":["1.-.-.-"],"go_classes":[{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" endoplasmic reticulum"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"}],"pfams":[{"name":"FA_hydroxylase","identifier":"PF04116"}],"pathways":[{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"},{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGAACGTAACATCGAATGCAACTGCAGCCGGTTCCTTTCCACTAGCATTTGGTCTCAAGACCTCATTTGGGTTTATGCACTATGCCAAGGCCCCTGCCATTAATTTACGCCCCAAGGAATCCTTGCTGCCGGAAATGAGTGATGGTGTGCTGGCCTTGGTTGCGCCGGTTGTTGCCTACTGGGCGTTGTCTGGTATATTCCATGTAATAGACACTTTCCATCTGGCTGAGAAGTACAGAATTCATCCGAGCGAAGAGGTTGCCAAGAGGAACAAGGCGTCGAGAATGCATGTTTTCCTTGAAGTGATTCTACAACATATCATACAGACCATTGTTGGCCTTATCTTTATGCACTTCGAGCCGATCTACATGACTGGGTTTGAAGAAAATGCCATGTGGAAGCTTCGTGCAGACCTTCCTCGGATTATTCCAGATGCCGCTATTTATTACGGCTATATGTACGGAATGTCCGCTTTGAAGATCTTTGCAGGCTTTTTATTCGTTGATACATGGCAATACTTTTTGCATAGATTGATGCATATGAATAAGACCTTATACAAATGGTTCCACTCTGTTCATCATGAACTATACGTGCCATATGCTTACGGTGCTCTTTTCAACAATCCTGTTGAGGGCTTCTTGTTAGATACTTTGGGAACCGGTATTGCCATGACGTTAACTCATTTGACTCACAGAGAGCAAATCATTCTTTTTACCTTTGCCACCATGAAGACTGTCGATGACCACTGTGGGTATGCTTTGCCACTTGACCCATTCCAATGGCTTTTCCCTAATAACGCTGTCTATCACGATATCCACCACCAGCAATTTGGTATCAAGACGAACTTTGCTCAACCATTTTTCACTTTCTGGGACAATTTGTTCCAAACTAACTTTAAAGGGTTTGAAGAATATCAAAAGAAGCAAAGACGTGTCACCATCGACAAGTACAAAGAGTTTTTGCAAGAGAGAGAATTGGAAAAGAAGGAGAAACTCAAAAACTTCAAAGCTATGAATGCTGCTGAAAATGAAGTAAAGAAAGAGAAATAA","protein_sequence":"MNVTSNATAAGSFPLAFGLKTSFGFMHYAKAPAINLRPKESLLPEMSDGVLALVAPVVAYWALSGIFHVIDTFHLAEKYRIHPSEEVAKRNKASRMHVFLEVILQHIIQTIVGLIFMHFEPIYMTGFEENAMWKLRADLPRIIPDAAIYYGYMYGMSALKIFAGFLFVDTWQYFLHRLMHMNKTLYKWFHSVHHELYVPYAYGALFNNPVEGFLLDTLGTGIAMTLTHLTHREQIILFTFATMKTVDDHCGYALPLDPFQWLFPNNAVYHDIHHQQFGIKTNFAQPFFTFWDNLFQTNFKGFEEYQKKQRRVTIDKYKEFLQERELEKKEKLKNFKAMNAAENEVKKEK"},{"created_at":"2011-05-27T07:08:16.000Z","updated_at":"2011-05-29T05:06:45.000Z","name":"Superoxide dismutase [Cu-Zn]","uniprot_id":"P00445","uniprot_name":"SODC_YEAST","enzyme":true,"transporter":false,"gene_name":"SOD1","num_residues":154,"molecular_weight":"15854.59961","theoretical_pi":"5.91","general_function":"Involved in metal ion binding","specific_function":"Destroys radicals which are normally produced within the cells and which are toxic to biological systems","reactions":[{"id":2801,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm. Mitochondrion intermembrane space.","altext":"2 superoxide + 2 H(+) = O(2) + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1F1G","cellular_location":"Cytoplasm. Mitochondrion intermembrane space.","genbank_gene_id":"AY558073","genbank_protein_id":"45270036","gene_card_id":"SOD1","chromosome_location":"chromosome 10","locus":"YJR104C","synonyms":[],"enzyme_classes":["1.15.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" oxygen and reactive oxygen species metabolic process"},{"category":"Process","description":" superoxide metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"Sod_Cu","identifier":"PF00080"}],"pathways":[],"gene_sequence":"ATGGTTCAAGCAGTCGCAGTGTTAAAGGGTGATGCCGGTGTCTCTGGTGTTGTCAAGTTCGAACAGGCTTCCGAATCCGAGCCAACCACTGTCTCTTACGAGATCGCTGGTAACAGTCCTAACGCAGAACGTGGGTTCCACATTCATGAGTTTGGAGATGCCACCAATGGTTGTGTCTCTGCTGGTCCTCACTTCAATCCTTTCAAGAAGACACATGGTGCTCCAACTGACGAAGTCAGACATGTCGGTGACATGGGTAACGTAAAGACGGACGAAAATGGTGTGGCCAAGGGCTCCTTCAAGGACTCTTTGATCAAGCTTATCGGTCCTACCTCCGTTGTAGGCAGAAGCGTCGTTATCCACGCCGGCCAAGATGACTTAGGTAAGGGTGACACTGAAGAATCTTTGAAGACTGGTAATGCCGGTCCAAGACCAGCCTGTGGTGTCATTGGTCTAACCAACTAA","protein_sequence":"MVQAVAVLKGDAGVSGVVKFEQASESEPTTVSYEIAGNSPNAERGFHIHEFGDATNGCVSAGPHFNPFKKTHGAPTDEVRHVGDMGNVKTDENGVAKGSFKDSLIKLIGPTSVVGRSVVIHAGQDDLGKGDTEESLKTGNAGPRPACGVIGLTN"},{"created_at":"2011-05-27T07:09:13.000Z","updated_at":"2011-05-29T05:06:45.000Z","name":"Superoxide dismutase [Mn], mitochondrial","uniprot_id":"P00447","uniprot_name":"SODM_YEAST","enzyme":true,"transporter":false,"gene_name":"SOD2","num_residues":233,"molecular_weight":"25774.09961","theoretical_pi":"8.87","general_function":"Involved in superoxide dismutase activity","specific_function":"Destroys radicals which are normally produced within the cells and which are toxic to biological systems","reactions":[{"id":2801,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm. Mitochondrion intermembrane space.","altext":"2 superoxide + 2 H(+) = O(2) + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY557821","genbank_protein_id":"45269533","gene_card_id":"SOD2","chromosome_location":"chromosome 8","locus":"YHR008C","synonyms":[],"enzyme_classes":["1.15.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" superoxide dismutase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" oxygen and reactive oxygen species metabolic process"},{"category":"Process","description":" superoxide metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"Sod_Fe_C","identifier":"PF02777"},{"name":"Sod_Fe_N","identifier":"PF00081"}],"pathways":[],"gene_sequence":"ATGTTCGCGAAAACAGCAGCTGCTAATTTAACCAAGAAGGGTGGTTTGTCATTGCTCTCCACCACAGCAAGGAGAACCAAAGTCACCTTGCCAGACTTGAAGTGGGACTTCGGTGCATTGGAACCTTATATCTCCGGTCAAATCAACGAATTGCATTACACCAAGCACCATCAAACTTATGTGAACGGATTCAACACTGCTGTTGACCAATTCCAAGAACTCTCAGATCTTCTGGCCAAGGAGCCCTCTCCCGCAAACGCAAGAAAAATGATTGCTATCCAACAAAACATCAAGTTCCATGGCGGTGGTTTCACAAACCACTGTCTATTCTGGGAAAACCTGGCTCCAGAGTCGCAGGGCGGTGGTGAACCACCCACCGGCGCTTTGGCAAAGGCAATCGACGAGCAGTTTGGCAGTCTGGACGAGCTGATTAAGTTGACCAACACAAAGCTAGCAGGCGTGCAGGGCTCCGGATGGGCCTTCATTGTGAAAAACCTCTCTAATGGAGGCAAGCTGGACGTTGTTCAAACCTACAACCAGGATACCGTCACAGGCCCACTAGTTCCTCTAGTTGCCATTGACGCCTGGGAACACGCCTACTACTTGCAGTACCAAAACAAGAAAGCCGACTACTTCAAAGCCATTTGGAATGTGGTCAACTGGAAAGAAGCATCCAGAAGATTCGATGCTGGCAAGATCTGA","protein_sequence":"MFAKTAAANLTKKGGLSLLSTTARRTKVTLPDLKWDFGALEPYISGQINELHYTKHHQTYVNGFNTAVDQFQELSDLLAKEPSPANARKMIAIQQNIKFHGGGFTNHCLFWENLAPESQGGGEPPTGALAKAIDEQFGSLDELIKLTNTKLAGVQGSGWAFIVKNLSNGGKLDVVQTYNQDTVTGPLVPLVAIDAWEHAYYLQYQNKKADYFKAIWNVVNWKEASRRFDAGKI"},{"created_at":"2011-05-27T07:14:15.000Z","updated_at":"2011-07-22T17:54:36.000Z","name":"Dihydroorotate dehydrogenase","uniprot_id":"P28272","uniprot_name":"PYRD_YEAST","enzyme":true,"transporter":false,"gene_name":"URA1","num_residues":314,"molecular_weight":"34800.60156","theoretical_pi":"5.85","general_function":"Involved in catalytic activity","specific_function":"In the de novo pyrimidine biosynthesic pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate and the reduction of fumarate to succinate. Does not use oxaloacetate and NAD or NADP as electron acceptors","reactions":[{"id":1453,"direction":"\u003e","locations":"mitochondrion;mitochondrial membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1454,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1554,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2803,"direction":"\u003e","locations":"Cytoplasm","altext":"(S)-dihydroorotate + O(2) = orotate + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2804,"direction":"\u003e","locations":"Cytoplasm","altext":"(S)-dihydroorotate + a quinone = orotate + a quinol","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AJ585637","genbank_protein_id":"45719878","gene_card_id":"URA1","chromosome_location":"chromosome 11","locus":"YKL216W","synonyms":["DHOD","DHODase","DHOdehase","Dihydroorotate oxidase"],"enzyme_classes":["1.3.3.1","1.3.5.2"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" dihydroorotate oxidase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor"},{"category":"Function","description":" dihydroorotate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" pyrimidine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" UMP biosynthetic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" nucleobase metabolic process"},{"category":"Process","description":" pyrimidine base metabolic process"},{"category":"Process","description":" pyrimidine base biosynthetic process"},{"category":"Process","description":" 'de novo' pyrimidine base biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" pyrimidine nucleoside monophosphate biosynthetic process"}],"pfams":[{"name":"DHO_dh","identifier":"PF01180"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGACAGCCAGTTTAACTACCAAGTTCTTGAACAATACCTATGAAAACCCATTTATGAATGCATCCGGTGTTCATTGCATGACTACACAAGAATTAGATGAATTAGCAAACTCTAAAGCTGGCGCATTCATTACAAAGAGTGCTACAACCTTAGAAAGAGAAGGTAACCCTGAACCACGTTACATTTCTGTCCCTCTAGGCAGTATCAACTCCATGGGTTTACCAAACGAAGGTATCGACTACTATTTGTCCTATGTATTAAACCGTCAAAAGAATTATCCTGATGCACCTGCTATTTTCTTCTCAGTTGCTGGTATGAGCATTGATGAAAATTTAAATTTGTTGAGGAAAATCCAAGATAGCGAATTCAACGGTATTACCGAGTTAAACTTGTCTTGTCCTAATGTGCCTGGGAAACCACAAGTTGCTTATGACTTTGACTTGACAAAGGAAACCTTGGAAAAGGTTTTTGCCTTTTTCAAAAAACCTCTTGGTGTCAAGTTGCCTCCTTATTTTGATTTTGCCCATTTTGATATCATGGCAAAAATATTGAACGAGTTCCCATTAGCTTATGTCAACTCTATCAATAGTATAGGAAATGGTCTTTTCATTGATGTGGAGAAGGAGAGTGTAGTAGTGAAGCCAAAGAATGGTTTCGGGGGTATTGGAGGTGAATATGTTAAGCCAACCGCGCTCGCCAATGTTCGTGCATTTTACACTCGTTTGAGACCTGAAATCAAAGTTATCGGTACAGGTGGAATTAAGTCCGGTAAGGATGCATTTGAACATCTTCTATGTGGTGCCTCTATGCTACAGATTGGTACAGAATTACAAAAAGAGGGCGTCAAGATTTTTGAACGTATCGAAAAAGAATTAAAAGACATAATGGAAGCTAAGGGTTATACATCCATAGATCAGTTCCGTGGGAAGTTGAACAGCATTTAA","protein_sequence":"MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI"},{"created_at":"2011-05-27T07:22:30.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"NADPH--cytochrome P450 reductase","uniprot_id":"P16603","uniprot_name":"NCPR_YEAST","enzyme":true,"transporter":false,"gene_name":"NCP1","num_residues":691,"molecular_weight":"76771.10156","theoretical_pi":"4.8","general_function":"Involved in oxidoreductase activity","specific_function":"This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5","reactions":[{"id":2811,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass membrane protein","altext":"NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"8-24","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass membrane protein","genbank_gene_id":"AY693091","genbank_protein_id":"51013633","gene_card_id":"NCP1","chromosome_location":"chromosome 8","locus":"YHR042W","synonyms":["CPR","P450R"],"enzyme_classes":["1.6.2.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" FMN binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"NAD_binding_1","identifier":"PF00175"},{"name":"Flavodoxin_1","identifier":"PF00258"},{"name":"FAD_binding_1","identifier":"PF00667"}],"pathways":[],"gene_sequence":"ATGCCGTTTGGAATAGACAACACCGACTTCACTGTCCTGGCGGGGCTAGTGCTTGCCGTGCTACTGTACGTAAAGAGAAACTCCATCAAGGAACTGCTGATGTCCGATGACGGAGATATCACAGCTGTCAGCTCGGGCAACAGGGACATTGCTCAGGTGGTGACCGAAAACAACAAGAACTACTTGGTGTTGTATGCGTCGCAGACTGGGACTGCCGAGGATTACGCCAAAAAGTTTTCCAAGGAGCTGGTGGCCAAGTTCAACCTAAACGTGATGTGCGCAGATGTTGAGAACTACGACTTTGAGTCGCTAAACGATGTGCCCGTCATAGTCTCGATTTTTATCTCTACATATGGTGAAGGAGACTTCCCCGACGGGGCGGTCAACTTTGAAGACTTTATTTGTAATGCGGAAGCGGGTGCACTATCGAACCTGAGGTATAATATGTTTGGTCTGGGAAATTCTACTTATGAATTCTTTAATGGTGCCGCCAAGAAGGCCGAGAAGCATCTCTCCGCCGCGGGCGCTATCAGACTAGGCAAGCTCGGTGAAGCTGATGATGGTGCAGGAACTACAGACGAAGATTACATGGCCTGGAAGGACTCCATCCTGGAGGTTTTGAAAGACGAACTGCATTTGGACGAACAGGAAGCCAAGTTCACCTCTCAATTCCAGTACACTGTGTTGAACGAAATCACTGACTCCATGTCGCTTGGTGAACCCTCTGCTCACTATTTGCCCTCGCATCAGTTGAACCGCAACGCAGACGGCATCCAATTGGGTCCCTTCGATTTGTCTCAACCGTATATTGCACCCATCGTGAAATCTCGCGAACTGTTCTCTTCCAATGACCGTAATTGCATCCACTCTGAATTTGACTTGTCCGGCTCTAACATCAAGTACTCCACTGGTGACCATCTTGCTGTTTGGCCTTCCAACCCATTGGAAAAGGTCGAACAGTTCTTATCCATATTCAACCTGGACCCTGAAACCATTTTTGACTTGAAGCCCCTGGATCCCACCGTCAAAGTGCCCTTCCCAACGCCAACTACTATTGGCGCTGCTATTAAACACTATTTGGAAATTACAGGACCTGTCTCCAGACAATTGTTTTCATCTTTGATTCAGTTCGCCCCCAACGCTGACGTCAAGGAAAAATTGACTCTGCTTTCGAAAGACAAGGACCAATTCGCCGTCGAGATAACCTCCAAATATTTCAACATCGCAGATGCTCTGAAATATTTGTCTGATGGCGCCAAATGGGACACCGTACCCATGCAATTCTTGGTCGAATCAGTTCCCCAAATGACTCCTCGTTACTACTCTATCTCTTCCTCTTCTCTGTCTGAAAAGCAAACCGTCCATGTCACCTCCATTGTGGAAAACTTTCCTAACCCAGAATTGCCTGATGCTCCTCCAGTTGTTGGTGTTACGACTAACTTGTTAAGAAACATTCAATTGGCTCAAAACAATGTTAACATTGCCGAAACTAACCTACCTGTTCACTACGATTTAAATGGCCCACGTAAACTTTTCGCCAATTACAAATTGCCCGTCCACGTTCGTCGTTCTAACTTCAGATTGCCTTCCAACCCTTCCACCCCAGTTATCATGATCGGTCCAGGTACCGGTGTTGCCCCATTCCGTGGGTTTATCAGAGAGCGTGTCGCGTTCCTCGAATCACAAAAGAAGGGCGGTAACAACGTTTCGCTAGGTAAGCATATACTGTTTTATGGATCCCGTAACACTGATGATTTCTTGTACCAGGACGAATGGCCAGAATACGCCAAAAAATTGGATGGTTCGTTCGAAATGGTCGTGGCCCATTCCAGGTTGCCAAACACCAAAAAAGTCTATGTTCAAGATAAATTAAAGGATTACGAAGACCAAGTATTTGAAATGATTAACAACGGTGCATTTATCTACGTCTGTGGTGATGCAAAGGGTATGGCCAAGGGTGTGTCAACCGCATTGGTTGGCATCTTATCCCGTGGTAAATCCATTACCACTGATGAAGCAACAGAGCTAATCAAGATGCTCAAGACTTCAGGTAGATACCAAGAAGATGTCTGGTAA","protein_sequence":"MPFGIDNTDFTVLAGLVLAVLLYVKRNSIKELLMSDDGDITAVSSGNRDIAQVVTENNKNYLVLYASQTGTAEDYAKKFSKELVAKFNLNVMCADVENYDFESLNDVPVIVSIFISTYGEGDFPDGAVNFEDFICNAEAGALSNLRYNMFGLGNSTYEFFNGAAKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELHLDEQEAKFTSQFQYTVLNEITDSMSLGEPSAHYLPSHQLNRNADGIQLGPFDLSQPYIAPIVKSRELFSSNDRNCIHSEFDLSGSNIKYSTGDHLAVWPSNPLEKVEQFLSIFNLDPETIFDLKPLDPTVKVPFPTPTTIGAAIKHYLEITGPVSRQLFSSLIQFAPNADVKEKLTLLSKDKDQFAVEITSKYFNIADALKYLSDGAKWDTVPMQFLVESVPQMTPRYYSISSSSLSEKQTVHVTSIVENFPNPELPDAPPVVGVTTNLLRNIQLAQNNVNIAETNLPVHYDLNGPRKLFANYKLPVHVRRSNFRLPSNPSTPVIMIGPGTGVAPFRGFIRERVAFLESQKKGGNNVSLGKHILFYGSRNTDDFLYQDEWPEYAKKLDGSFEMVVAHSRLPNTKKVYVQDKLKDYEDQVFEMINNGAFIYVCGDAKGMAKGVSTALVGILSRGKSITTDEATELIKMLKTSGRYQEDVW"},{"created_at":"2011-05-27T07:28:41.000Z","updated_at":"2011-05-29T05:06:46.000Z","name":"Cytochrome c iso-1","uniprot_id":"P00044","uniprot_name":"CYC1_YEAST","enzyme":true,"transporter":false,"gene_name":"CYC1","num_residues":109,"molecular_weight":"12181.90039","theoretical_pi":"9.96","general_function":"Involved in iron ion binding","specific_function":"Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain","reactions":[{"id":14426,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006939","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"2PCC","cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"L26347","genbank_protein_id":"695795","gene_card_id":"CYC1","chromosome_location":"chromosome 10","locus":"YJR048W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Cytochrom_C","identifier":"PF00034"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGACTGAATTCAAGGCCGGTTCTGCTAAGAAAGGTGCTACACTTTTCAAGACTAGATGTCTACAATGCCACACCGTGGAAAAGGGTGGCCCACATAAGGTTGGTCCAAACTTGCATGGTATCTTTGGCAGACACTCTGGTCAAGCTGAAGGGTATTCGTACACAGATGCCAATATCAAGAAAAACGTGTTGTGGGACGAAAATAACATGTCAGAGTACTTGACTAACCCAAAGAAATATATTCCTGGTACCAAGATGGCCTTTGGTGGGTTGAAGAAGGAAAAAGACAGAAACGACTTAATTACCTACTTGAAAAAAGCCTGTGAGTAA","protein_sequence":"MTEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGRHSGQAEGYSYTDANIKKNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLITYLKKACE"},{"created_at":"2011-05-27T07:29:16.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"Cytochrome c iso-2","uniprot_id":"P00045","uniprot_name":"CYC7_YEAST","enzyme":true,"transporter":false,"gene_name":"CYC7","num_residues":113,"molecular_weight":"12532.2998","theoretical_pi":"10.18","general_function":"Involved in iron ion binding","specific_function":"Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain","reactions":[{"id":14426,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006939","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1YEA","cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"AY693032","genbank_protein_id":"51013515","gene_card_id":"CYC7","chromosome_location":"chromosome 5","locus":"YEL039C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Cytochrom_C","identifier":"PF00034"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGGCTAAAGAAAGTACGGGATTCAAACCAGGCTCTGCAAAAAAGGGTGCTACATTGTTTAAAACGAGGTGTCAGCAGTGTCATACAATAGAAGAGGGTGGTCCTAACAAAGTTGGACCTAATTTACATGGTATTTTTGGTAGACATTCAGGTCAGGTAAAGGGTTATTCTTACACAGATGCAAACATCAACAAGAACGTCAAATGGGATGAGGATAGTATGTCCGAGTACTTGACGAACCCAAAGAAATATATTCCTGGTACCAAGATGGCGTTTGCCGGGTTGAAGAAGGAAAAGGACAGAAACGATTTAATTACTTATATGACAAAGGCTGCCAAATAG","protein_sequence":"MAKESTGFKPGSAKKGATLFKTRCQQCHTIEEGGPNKVGPNLHGIFGRHSGQVKGYSYTDANINKNVKWDEDSMSEYLTNPKKYIPGTKMAFAGLKKEKDRNDLITYMTKAAK"},{"created_at":"2011-05-27T07:54:18.000Z","updated_at":"2011-05-27T15:01:29.000Z","name":"Acyl-CoA desaturase 1","uniprot_id":"P21147","uniprot_name":"ACO1_YEAST","enzyme":true,"transporter":false,"gene_name":"OLE1","num_residues":510,"molecular_weight":"58402.60156","theoretical_pi":"9.33","general_function":"Involved in stearoyl-CoA 9-desaturase activity","specific_function":"Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates (Probable)","reactions":[{"id":1825,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1981,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2816,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)","altext":"Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"113-133;139-159;256-276;281-301","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"J05676","genbank_protein_id":"172064","gene_card_id":"OLE1","chromosome_location":"chromosome 7","locus":"YGL055W","synonyms":["Fatty acid desaturase 1","Stearoyl-CoA desaturase 1"],"enzyme_classes":["1.14.19.1"],"go_classes":[{"category":"Component","description":" endoplasmic reticulum"},{"category":"Component","description":" cell part"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" stearoyl-CoA 9-desaturase activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" lipid metabolic process"}],"pfams":[{"name":"Cyt-b5","identifier":"PF00173"},{"name":"FA_desaturase","identifier":"PF00487"}],"pathways":[{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"}],"gene_sequence":"ATGCCAACTTCTGGAACTACTATTGAATTGATTGACGACCAATTTCCAAAGGATGACTCTGCCAGCAGTGGCATTGTCGACGAAGTCGACTTAACGGAAGCTAATATTTTGGCTACTGGTTTGAATAAGAAAGCACCAAGAATTGTCAACGGTTTTGGTTCTTTAATGGGCTCCAAGGAAATGGTTTCCGTGGAATTCGACAAGAAGGGAAACGAAAAGAAGTCCAATTTGGATCGTCTGCTAGAAAAGGACAACCAAGAAAAAGAAGAAGCTAAAACTAAAATTCACATCTCCGAACAACCATGGACTTTGAATAACTGGCACCAACATTTGAACTGGTTGAACATGGTTCTTGTTTGTGGTATGCCAATGATTGGTTGGTACTTCGCTCTCTCTGGTAAAGTACCTTTGCATTTAAACGTTTTCCTTTTCTCCGTTTTCTACTACGCTGTCGGTGGTGTTTCTATTACTGCCGGTTACCATAGATTATGGTCTCACAGATCTTACTCCGCTCACTGGCCATTGAGATTATTCTACGCTATCTTCGGTTGTGCTTCCGTTGAAGGGTCCGCTAAATGGTGGGGCCACTCTCACAGAATTCACCATCGTTACACTGATACCTTGAGAGATCCTTATGACGCTCGTAGAGGTCTATGGTACTCCCACATGGGATGGATGCTTTTGAAGCCAAATCCAAAATACAAGGCTAGAGCTGATATTACCGATATGACTGATGATTGGACCATTAGATTCCAACACAGACACTACATCTTGTTGATGTTATTAACCGCTTTCGTCATTCCAACTCTTATCTGTGGTTACTTTTTCAACGACTATATGGGTGGTTTGATCTATGCCGGTTTTATTCGTGTCTTTGTCATTCAACAAGCTACCTTTTGCATTAACTCCATGGCTCATTACATCGGTACCCAACCATTCGATGACAGAAGAACCCCTCGTGACAACTGGATTACTGCCATTGTTACTTTCGGTGAAGGTTACCATAACTTCCACCACGAATTCCCAACTGATTACAGAAACGCTATTAAGTGGTACCAATACGACCCAACTAAGGTTATCATCTATTTGACTTCTTTAGTTGGTCTAGCATACGACTTGAAGAAATTCTCTCAAAATGCTATTGAAGAAGCCTTGATTCAACAAGAACAAAAGAAGATCAATAAAAAGAAGGCTAAGATTAACTGGGGTCCAGTTTTGACTGATTTGCCAATGTGGGACAAACAAACCTTCTTGGCTAAGTCTAAGGAAAACAAGGGTTTGGTTATCATTTCTGGTATTGTTCACGACGTATCTGGTTATATCTCTGAACATCCAGGTGGTGAAACTTTAATTAAAACTGCATTAGGTAAGGACGCTACCAAGGCTTTCAGTGGTGGTGTCTACCGTCACTCAAATGCCGCTCAAAATGTCTTGGCTGATATGAGAGTGGCTGTTATCAAGGAAAGTAAGAACTCTGCTATTAGAATGGCTAGTAAGAGAGGTGAAATCTACGAAACTGGTAAGTTCTTTTAA","protein_sequence":"MPTSGTTIELIDDQFPKDDSASSGIVDEVDLTEANILATGLNKKAPRIVNGFGSLMGSKEMVSVEFDKKGNEKKSNLDRLLEKDNQEKEEAKTKIHISEQPWTLNNWHQHLNWLNMVLVCGMPMIGWYFALSGKVPLHLNVFLFSVFYYAVGGVSITAGYHRLWSHRSYSAHWPLRLFYAIFGCASVEGSAKWWGHSHRIHHRYTDTLRDPYDARRGLWYSHMGWMLLKPNPKYKARADITDMTDDWTIRFQHRHYILLMLLTAFVIPTLICGYFFNDYMGGLIYAGFIRVFVIQQATFCINSLAHYIGTQPFDDRRTPRDNWITAIVTFGEGYHNFHHEFPTDYRNAIKWYQYDPTKVIIYLTSLVGLAYDLKKFSQNAIEEALIQQEQKKINKKKAKINWGPVLTDLPMWDKQTFLAKSKENKGLVIISGIVHDVSGYISEHPGGETLIKTALGKDATKAFSGGVYRHSNAAQNVLADMRVAVIKESKNSAIRMASKRGEIYETGKFF"},{"created_at":"2011-05-27T07:58:49.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Ceramide 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Hydroxylates the very long chain fatty acid of ceramides at C2 and C3","reactions":[{"id":1371,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1373,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1378,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1379,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"197-217;223-243;298-318;353-373","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY693150","genbank_protein_id":"51013751","gene_card_id":"SCS7","chromosome_location":"chromosome 13","locus":"YMR272C","synonyms":["Ceramide VLCFA hydroxylase SCS7","Suppressor of calcium sensitivity 7"],"enzyme_classes":["1.-.-.-"],"go_classes":[{"category":"Component","description":" endoplasmic reticulum"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Process","description":" sphingolipid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" membrane lipid metabolic process"}],"pfams":[{"name":"Cyt-b5","identifier":"PF00173"},{"name":"FA_hydroxylase","identifier":"PF04116"}],"pathways":[],"gene_sequence":"ATGTCGACTAATACTTCCAAGACTTTGGAACTGTTTTCAAAAAAGACGGTACAAGAACACAATACTGCCAATGACTGCTGGGTCACTTATCAAAACAGAAAGATTTATGACGTGACCAGGTTTTTGAGCGAACACCCTGGTGGTGACGAGTCCATCTTGGACTATGCTGGTAAGGACATTACTGAGATCATGAAAGACTCAGATGTGCATGAACACAGCGACTCCGCGTATGAAATCCTTGAGGACGAATATTTGATTGGTTACTTGGCAACTGACGAAGAGGCAGCGAGATTGTTGACTAACAAGAACCATAAGGTTGAAGTGCAGTTGTCAGCTGACGGTACTGAGTTTGACTCCACTACTTTTGTAAAGGAGTTGCCCGCCGAGGAGAAACTAAGTATTGCTACGGACTACAGTAACGACTACAAAAAGCATAAATTTTTGGATCTGAACCGTCCTTTGCTGATGCAGATTCTGCGTAGTGATTTCAAGAAAGATTTTTACGTTGACCAAATCCATAGACCAAGACATTACGGTAAGGGGTCTGCCCCGCTATTTGGTAATTTCTTGGAACCATTAACTAAAACAGCTTGGTGGGTTGTTCCAGTTGCTTGGTTGCCTGTAGTTGTGTACCACATGGGTGTTGCTTTGAAGAACATGAACCAGCTATTTGCATGTTTCTTGTTCTGTGTCGGTGTCTTTGTTTGGACTTTGATTGAATACGGTCTTCACCGTTTCCTATTTCATTTCGATGATTGGTTACCTGAAAGTAACATCGCATTCGCCACACATTTTCTACTACATGGTTGCCATCATTACTTGCCCATGGACAAGTACCGTTTAGTTATGCCACCTACTCTGTTCGTCATCCTTTGTGCTCCATTTTACAAGTTGGTATTTGCTCTGCTGCCACTTTATTGGGCTTACGCTGGTTTTGCTGGCGGTCTTTTCGGTTATGTCTGTTATGACGAATGTCATTTCTTCTTGCACCACTCTAAATTGCCTCCCTTCATGCGTAAGTTGAAAAAATATCACCTGGAACATCATTATAAAAACTACCAACTGGGATTTGGCGTCACATCCTGGTTTTGGGACGAAGTTTTTGGCACCTACTTAGGCCCCGATGCCCCATTGTCCAAAATGAAATATGAATAA","protein_sequence":"MSTNTSKTLELFSKKTVQEHNTANDCWVTYQNRKIYDVTRFLSEHPGGDESILDYAGKDITEIMKDSDVHEHSDSAYEILEDEYLIGYLATDEEAARLLTNKNHKVEVQLSADGTEFDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYE"},{"created_at":"2011-05-27T08:08:27.000Z","updated_at":"2011-07-22T17:54:21.000Z","name":"C-5 sterol desaturase","uniprot_id":"P32353","uniprot_name":"ERG3_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG3","num_residues":365,"molecular_weight":"42729.89844","theoretical_pi":"7.79","general_function":"Involved in iron ion binding","specific_function":"Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis","reactions":[{"id":1360,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14412,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006926","source":"Smpdb"},{"id":14413,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007266","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"93-113;141-161;243-263","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"AY692996","genbank_protein_id":"51013443","gene_card_id":"ERG3","chromosome_location":"chromosome 12","locus":"YLR056W","synonyms":["Ergosterol Delta(5,6) desaturase","Sterol-C5-desaturase"],"enzyme_classes":["1.3.3.-"],"go_classes":[{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" endoplasmic reticulum"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"}],"pfams":[{"name":"FA_hydroxylase","identifier":"PF04116"}],"pathways":[{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null},{"name":"Steroid biosynthesis","kegg_map_id":"00100"}],"gene_sequence":"ATGGATTTGGTCTTAGAAGTCGCTGACCATTATGTCTTAGACGACTTGTACGCTAAAGTTCTGCCCGCTTCGTTGGCAGCTAATATTCCTGTCAAGTGGCAGAAATTGCTAGGGTTGAACAGTGGGTTCAGCAATTCTACGATTTTGCAGGAGACTTTGAACTCCAAGAATGCCGTCAAAGAATGTAGAAGGTTCTACGGGCAGGTGCCATTCCTGTTTGATATGTCGACGACGTCTTTTGCATCGCTATTGCCTCGTTCCAGCATCTTGAGAGAATTCCTCTCACTATGGGTTATTGTTACGATCTTTGGTTTACTACTTTACTTATTCACGGCTAGTCTCAGCTACGTGTTTGTGTTTGACAAGTCGATTTTCAACCATCCTCGTTACTTGAAAAACCAAATGGCAATGGAAATCAAGTTGGCAGTCAGTGCTATCCCATGGATGTCGATGTTGACCGTTCCATGGTTTGTTATGGAATTGAACGGCCATTCTAAACTATACATGAAGATTGATTATGAAAACCACGGTGTAAGGAAGCTCATTATCGAGTACTTCACTTTCATCTTTTTCACTGATTGCGGTGTGTATTTAGCGCACAGATGGTTGCATTGGCCAAGGGTCTACCGTGCTCTGCACAAGCCTCATCACAAGTGGCTGGTCTGCACACCTTTCGCATCTCATTCTTTCCATCCTGTAGACGGGTTTTTGCAATCCATCTCGTACCACATCTACCCATTGATTCTGCCATTACACAAGGTTTCTTATTTGATTCTGTTCACTTTTGTTAACTTTTGGACTGTTATGATTCATGACGGTCAATACCTATCAAACAATCCTGCCGTCAACGGTACTGCCTGCCACACGGTTCACCATCTATATTTCAACTACAACTACGGTCAATTCACCACTCTGTGGGACAGACTAGGGGGTTCTTACCGTAGACCAGATGACTCATTGTTTGATCCTAAGTTAAGAGATGCTAAGGAGACCTGGGACGCTCAAGTTAAGGAAGTTGAACATTTCATCAAGGAGGTCGAAGGTGATGATAATGATAGAATCTATGAAAACGACCCAAATACCAAGAAGAACAACTGA","protein_sequence":"MDLVLEVADHYVLDDLYAKVLPASLAANIPVKWQKLLGLNSGFSNSTILQETLNSKNAVKECRRFYGQVPFLFDMSTTSFASLLPRSSILREFLSLWVIVTIFGLLLYLFTASLSYVFVFDKSIFNHPRYLKNQMAMEIKLAVSAIPWMSMLTVPWFVMELNGHSKLYMKIDYENHGVRKLIIEYFTFIFFTDCGVYLAHRWLHWPRVYRALHKPHHKWLVCTPFASHSFHPVDGFLQSISYHIYPLILPLHKVSYLILFTFVNFWTVMIHDGQYLSNNPAVNGTACHTVHHLYFNYNYGQFTTLWDRLGGSYRRPDDSLFDPKLRDAKETWDAQVKEVEHFIKEVEGDDNDRIYENDPNTKKNN"},{"created_at":"2011-05-27T08:44:03.000Z","updated_at":"2011-07-22T17:54:23.000Z","name":"Catalase T","uniprot_id":"P06115","uniprot_name":"CATT_YEAST","enzyme":true,"transporter":false,"gene_name":"CTT1","num_residues":562,"molecular_weight":"64583.0","theoretical_pi":"6.51","general_function":"Involved in catalase activity","specific_function":"Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide","reactions":[{"id":1368,"direction":"\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2820,"direction":"\u003e","locations":"Peroxisome;Cytoplasm","altext":"2 H(2)O(2) = O(2) + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X04625","genbank_protein_id":"3608","gene_card_id":"CTT1","chromosome_location":"chromosome 7","locus":"YGR088W","synonyms":[],"enzyme_classes":["1.11.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" peroxidase activity"},{"category":"Function","description":" catalase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" response to stimulus"},{"category":"Process","description":" response to stress"},{"category":"Process","description":" response to oxidative stress"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Catalase","identifier":"PF00199"},{"name":"Catalase-rel","identifier":"PF06628"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Stress-activated signalling pathways: high osmolarity test 1","kegg_map_id":null}],"gene_sequence":"ATGAACGTGTTCGGTAAAAAAGAAGAAAAGCAAGAAAAAGTTTACTCTCTACAAAACGGTTTTCCGTACTCTCATCACCCATACGCTTCTCAATACTCAAGACCAGACGGCCCTATCTTACTGCAAGACTTCCATCTGCTGGAAAATATCGCAAGTTTCGATAGAGAAAGAGTTCCGGAGCGTGTAGTCCATGCCAAAGGTGGTGGTTGTAGACTGGAGTTCGAACTAACAGATTCTTTGAGTGATATTACATACGCCGCTCCATACCAGAATGTGGGTTACAAATGTCCTGGTCTTGTTCGTTTTTCCACCGTTGGTGGTGAAAGTGGTACACCAGACACTGCAAGAGACCCAAGAGGTGTTTCTTTTAAATTCTATACCGAGTGGGGGAACCATGACTGGGTCTTCAACAATACTCCCGTCTTCTTCCTCAGAGACGCTATTAAGTTTCCCGTATTTATTCATTCGCAAAAGAGAGACCCTCAGTCTCATCTGAATCAGTTTCAGGACACTACCATATACTGGGATTATCTAACATTGAATCCGGAATCAATCCATCAAATAACTTACATGTTTGGTGATAGAGGTACTCCTGCTTCGTGGGCTAGTATGAACGCGTACTCTGGTCATTCCTTCATCATGGTCAACAAAGAAGGTAAGGACACATATGTGCAATTCCACGTCTTGTCGGATACTGGTTTTGAAACCTTGACTGGAGATAAGGCTGCTGAACTGTCAGGCTCCCACCCTGATTATAATCAGGCAAAGCTGTTCACTCAATTGCAAAATGGCGAAAAGCCAAAATTTAACTGTTATGTGCAAACAATGACACCCGAACAAGCAACTAAGTTCAGGTATTCGGTAAATGACCTAACGAAAATATGGCCACACAAGGAATTCCCTTTGAGAAAATTTGGTACCATCACCCTAACGGAGAATGTTGACAATTATTTCCAAGAAATTGAACAAGTTGCATTCAGTCCAACGAACACTTGTATCCCAGGTATTAAGCCTTCTAATGATTCCGTTCTACAAGCCAGACTTTTCTCCTATCCAGACACTCAACGTCATAGATTGGGAGCCAACTATCAGCAATTGCCCGTCAACAGACCAAGAAACTTGGGATGTCCATACTCCAAAGGTGATTCCCAATACACTGCCGAACAGTGTCCATTTAAAGCAGTGAACTTCCAAAGGGACGGCCCAATGAGTTACTACAATTTCGGTCCTGAGCCAAATTATATTTCCAGTTTACCAAATCAAACTCTGAAATTCAAAAATGAAGTCAACGACGAAGTATCTGATAAGTTCAAAGGGATAGTTCTTGACGAAGTAACAGAAGTTTCTGTGAGAAAACAGGAACAAGACCAAATCAGAAACGAGCATATTGTTGATGCCAAAATTAATCAATATTACTACGTTTATGGTATTAGTCCACTAGACTTCGAACAGCCAAGAGCTCTATATGAAAAGGTATACAACGATGAACAGAAGAAATTATTCGTTCATAACGTTGTTTGCCACGCTTGTAAGATCAAAGATCCTAAAGTCAAAAAGAGAGTTACGCAATACTTTGGTTTGCTAAACGAAGATTTGGGTAAAGTCATTGCAGAAGGCTTGGGAGTTCCTTGGGAACCTGTTGACCTTGAAGGTTATGCCAAGACTTGGTCCATTGCAAGTGCCAATTAA","protein_sequence":"MNVFGKKEEKQEKVYSLQNGFPYSHHPYASQYSRPDGPILLQDFHLLENIASFDRERVPERVVHAKGGGCRLEFELTDSLSDITYAAPYQNVGYKCPGLVRFSTVGGESGTPDTARDPRGVSFKFYTEWGNHDWVFNNTPVFFLRDAIKFPVFIHSQKRDPQSHLNQFQDTTIYWDYLTLNPESIHQITYMFGDRGTPASWASMNAYSGHSFIMVNKEGKDTYVQFHVLSDTGFETLTGDKAAELSGSHPDYNQAKLFTQLQNGEKPKFNCYVQTMTPEQATKFRYSVNDLTKIWPHKEFPLRKFGTITLTENVDNYFQEIEQVAFSPTNTCIPGIKPSNDSVLQARLFSYPDTQRHRLGANYQQLPVNRPRNLGCPYSKGDSQYTAEQCPFKAVNFQRDGPMSYYNFGPEPNYISSLPNQTLKFKNEDNDEVSDKFKGIVLDEVTEVSVRKQEQDQIRNEHIVDAKINQYYYVYGISPLDFEQPRALYEKVYNDEQKKLFVHNVVCHACKIKDPKVKKRVTQYFGLLNEDLGKVIAECLGVPWEPVDLEGYAKTWSIASAN"},{"created_at":"2011-05-27T08:44:57.000Z","updated_at":"2011-07-22T17:54:23.000Z","name":"Peroxisomal catalase A","uniprot_id":"P15202","uniprot_name":"CATA_YEAST","enzyme":true,"transporter":false,"gene_name":"CTA1","num_residues":515,"molecular_weight":"58555.19922","theoretical_pi":"7.49","general_function":"Involved in catalase activity","specific_function":"Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide","reactions":[{"id":1368,"direction":"\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2820,"direction":"\u003e","locations":"Peroxisome;Cytoplasm","altext":"2 H(2)O(2) = O(2) + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1A4E","cellular_location":"Peroxisome","genbank_gene_id":"X13028","genbank_protein_id":"3605","gene_card_id":"CTA1","chromosome_location":"chromosome 4","locus":"YDR256C","synonyms":[],"enzyme_classes":["1.11.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" peroxidase activity"},{"category":"Function","description":" catalase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" response to stimulus"},{"category":"Process","description":" response to stress"},{"category":"Process","description":" response to oxidative stress"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Catalase","identifier":"PF00199"},{"name":"Catalase-rel","identifier":"PF06628"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGTCGAAATTGGGACAAGAAAAAAATGAAGTAAATTACTCTGATGTAAGAGAGGATAGAGTTGTGACAAACTCCACTGGTAATCCAATCAATGAACCATTTGTCACCCAACGTATTGGGGAACATGGCCCTTTGCTTTTGCAAGATTATAACTTAATTGATTCTTTGGCTCATTTCAACAGGGAAAATATTCCTCAAAGGAATCCACATGCTCATGGTTCTGGTGCCTTCGGCTATTTTGAAGTAACCGATGACATTACTGATATCTGCGGGTCTGCTATGTTTAGTAAAATTGGGAAAAGAACGAAATGTCTAACAAGATTTTCGACTGTGGGTGGTGATAAAGGTAGTGCCGACACGGTTCGTGATCCAAGGGGGTTTGCCACCAAATTCTACACTGAAGAAGGTAATTTAGATTGGGTCTACAATAATACACCGGTATTCTTTATCAGAGACCCTTCCAAGTTCCCTCACTTTATCCACACACAGAAGAGAAACCCACAAACCAACCTAAGGGATGCTGACATGTTTTGGGATTTCCTCACCACTCCTGAAAATCAGGTGGCCATTCATCAAGTAATGATCCTTTTTTCAGACCGTGGTACCCCTGCCAACTACCGTAGTATGCATGGTTATTCTGGTCATACCTATAAATGGTCCAATAAAAACGGAGATTGGCATTATGTGCAAGTTCATATCAAAACCGATCAAGGAATAAAGAATTTGACCATAGAAGAGGCTACCAAAATTGCGGGATCCAATCCAGATTACTGCCAGCAGGATTTATTTGAGGCTATTCAGAATGGAAACTATCCTTCCTGGACAGTTTATATTCAAACAATGACCGAACGCGATGCCAAAAAATTACCATTTTCAGTCTTTGATTTGACTAAAGTATGGCCTCAGGGGCAATTCCCTTTACGGCGTGTGGGTAAGATTGTTTTGAACGAGAATCCACTGAACTTCTTCGCACAGGTGGAACAAGCTGCCTTCGCCCCCAGTACCACGGTTCCTTACCAAGAAGCAAGCGCTGATCCAGTATTACAGGCCCGTTTGTTTTCATATGCGGATGCTCATAGATACAGGCTAGGTCCTAACTTCCATCAAATACCCGTAAACTGTCCATATGCATCTAAATTTTTCAATCCCGCTATCAGAGATGGACCGATGAATGTTAACGGCAACTTCGGCTCAGAACCTACATATTTGGCCAACGATAAATCGTACACGTATATCCAACAGGACAGACCCATTCAACAACACCAAGAGGTATGGAATGGGCCAGCTATCCCTTATCATTGGGCAACATCCCCAGGTGATGTAGATTTCGTGCAAGCAAGAAATCTCTACCGCGTTTTGGGTAAACAACCTGGACAGCAAAAGAACTTGGCATATAACATCGGCATTCATGTAGAAGGCGCCTGTCCTCAAATACAGCAGCGCGTTTATGATATGTTTGCTCGTGTTGATAAGGGACTATCTGAGGCAATTAAAAAAGTAGCTGAGGCAAAACATGCTTCTGAGCTTTCGAGTAACTCCAAATTTTGA","protein_sequence":"MSKLGQEKNEVNYSDVREDRVVTNSTGNPINEPFVTQRIGEHGPLLLQDYNLIDSLAHFNRENIPQRNPHAHGSGAFGYFEVTDDITDICGSAMFSKIGKRTKCLTRFSTVGGDKGSADTVRDPRGFATKFYTEEGNLDWVYNNTPVFFIRDPSKFPHFIHTQKRNPQTNLRDADMFWDFLTTPENQVAIHQVMILFSDRGTPANYRSMHGYSGHTYKWSNKNGDWHYVQVHIKTDQGIKNLTIEEATKIAGSNPDYCQQDLFEAIQNGNYPSWTVYIQTMTERDAKKLPFSVFDLTKVWPQGQFPLRRVGKIVLNENPLNFFAQVEQAAFAPSTTVPYQEASADPVLQARLFSYADAHRYRLGPNFHQIPVNCPYASKFFNPAIRDGPMNVNGNFGSEPTYLANDKSYTYIQQDRPIQQHQEVWNGPAIPYHWATSPGDVDFVQARNLYRVLGKQPGQQKNLAYNIGIHVEGACPQIQQRVYDMFARVDKGLSEAIKKVAEAKHASELSSNSKF"},{"created_at":"2011-05-27T09:49:08.000Z","updated_at":"2011-05-27T15:01:31.000Z","name":"FAD-linked sulfhydryl oxidase ERV2","uniprot_id":"Q12284","uniprot_name":"ERV2_YEAST","enzyme":true,"transporter":false,"gene_name":"ERV2","num_residues":196,"molecular_weight":"22141.30078","theoretical_pi":"7.5","general_function":"Involved in thiol oxidase activity","specific_function":"FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1","reactions":[{"id":2824,"direction":"\u003e","locations":"Mitochondrion intermembrane space; Lumenal side; Single-pass type III membrane protein;Endoplasmic reticulum membrane","altext":"4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"13-35","pdb_id":"1JRA","cellular_location":"Endoplasmic reticulum membrane; Single-pass type III membrane protein; Lumenal side","genbank_gene_id":"Z68111","genbank_protein_id":"1072405","gene_card_id":"ERV2","chromosome_location":"chromosome 16","locus":"YPR037C","synonyms":[],"enzyme_classes":["1.8.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"},{"category":"Function","description":" thiol oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Evr1_Alr","identifier":"PF04777"}],"pathways":[],"gene_sequence":"ATGAAACAGATAGTCAAAAGAAGCCATGCCATCAGAATAGTTGCAGCATTAGGAATCATAGGCCTGTGGATGTTTTTCTCGTCTAATGAACTATCCATCGCTACGCCGGGCCTAATCAAGGCGAAGTCTGGTATAGATGAAGTGCAAGGGGCGGCTGCTGAGAAGAACGACGCTCGGTTGAAAGAGATCGAGAAGCAAACCATTATGCCATTGATGGGCGATGACAAGGTGAAGAAGGAAGTGGGCAGGGCGTCGTGGAAGTACTTCCATACCCTGCTGGCCCGTTTTCCGGACGAGCCTACTCCTGAAGAAAGAGAGAAACTGCACACGTTTATTGGGTTGTATGCAGAACTCTATCCATGCGGGGAATGTTCATATCACTTTGTAAAGTTGATTGAGAAGTATCCCGTACAGACATCTAGCAGGACGGCTGCCGCAATGTGGGGATGCCACATTCACAACAAGGTGAACGAATACCTAAAGAAAGACATATATGACTGTGCTACCATCCTGGAGGACTACGATTGTGGATGTAGTGACAGCGACGGTAAACGCGTGTCTCTCGAGAAGGAGGCTAAACAGCACGGTTGA","protein_sequence":"MKQIVKRSHAIRIVAALGIIGLWMFFSSNELSIATPGLIKAKSGIDEVQGAAAEKNDARLKEIEKQTIMPLMGDDKVKKEVGRASWKYFHTLLARFPDEPTPEEREKLHTFIGLYAELYPCGECSYHFVKLIEKYPVQTSSRTAAAMWGCHIHNKVNEYLKKDIYDCATILEDYDCGCSDSDGKRVSLEKEAKQHG"},{"created_at":"2011-05-27T09:49:50.000Z","updated_at":"2011-05-29T05:06:49.000Z","name":"Mitochondrial FAD-linked sulfhydryl oxidase ERV1","uniprot_id":"P27882","uniprot_name":"ERV1_YEAST","enzyme":true,"transporter":false,"gene_name":"ERV1","num_residues":189,"molecular_weight":"21639.30078","theoretical_pi":"8.36","general_function":"Involved in thiol oxidase activity","specific_function":"FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS). Forms a redox cycle with MIA40 that involves a disulfide relay system. Important for maintaining the cysteine residues in MIA40 in an oxidized state. Reduced ERV1 is reoxidized by cytochrome c. Required for the maturation of cytoplasmic, but not of mitochondrial Fe/S proteins","reactions":[{"id":2824,"direction":"\u003e","locations":"Mitochondrion intermembrane space; Lumenal side; Single-pass type III membrane protein;Endoplasmic reticulum membrane","altext":"4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"Z72814","genbank_protein_id":"1945314","gene_card_id":"ERV1","chromosome_location":"chromosome 7","locus":"YGR029W","synonyms":["14 kDa regulatory protein","Essential for respiration and vegetative growth protein 1"],"enzyme_classes":["1.8.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"},{"category":"Function","description":" thiol oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Evr1_Alr","identifier":"PF04777"}],"pathways":[],"gene_sequence":"ATGAAAGCAATAGATAAAATGACGGATAATCCACCACAAGAAGGCTTAAGTGGGAGGAAAATAATATATGACGAAGATGGCAAACCTTGCCGATCATGTAACACCCTACTTGACTTTCAGTACGTGACCGGGAAGATATCTAATGGCCTGAAGAACCTCTCATCTAACGGTAAACTAGCAGGTACGGGGGCTCTCACTGGCGAAGCTTCAGAGTTGATGCCTGGCTCAAGAACATACAGGAAGGTTGACCCTCCTGACGTAGAGCAACTAGGTAGATCTTCATGGACGCTGTTACACTCTGTAGCTGCCAGCTATCCTGCTCAACCTACAGACCAACAGAAGGGTGAAATGAAACAGTTCTTGAATATCTTCTCACATATTTATCCTTGCAACTGGTGTGCTAAAGACTTTGAAAAATATATCAGAGAAAATGCACCACAAGTTGAGTCAAGAGAAGAACTTGGGAGGTGGATGTGTGAAGCCCACAATAAAGTCAATAAGAAATTGAGGAAGCCCAAATTTGACTGTAATTTCTGGGAAAAAAGATGGAAGGACGGCTGGGACGAATAA","protein_sequence":"MKAIDKMTDNPPQEGLSGRKIIYDEDGKPCRSCNTLLDFQYVTGKISNGLKNLSSNGKLAGTGALTGEASELMPGSRTYRKVDPPDVEQLGRSSWTLLHSVAASYPAQPTDQQKGEMKQFLNIFSHIYPCNWCAKDFEKYIRENAPQVESREELGRWMCEAHNKVNKKLRKPKFDCNFWEKRWKDGWDE"},{"created_at":"2011-05-29T04:39:32.000Z","updated_at":"2011-05-29T04:39:32.000Z","name":"NADH-cytochrome b5 reductase 1","uniprot_id":"P38626","uniprot_name":"NCB5R_YEAST","enzyme":true,"transporter":false,"gene_name":"CBR1","num_residues":284,"molecular_weight":"31493.59961","theoretical_pi":"9.19","general_function":"Involved in oxidoreductase activity","specific_function":"Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes. Plays a role in bud morphology","reactions":[{"id":2635,"direction":"\u003e","locations":" Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein;Endoplasmic reticulum membrane;NADH-cytochrome b5 reductase p34 form:Mitochondrion outer membrane; Single-pass membrane protein (Potential)","altext":"NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"7-27","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein (Potential)","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"CBR1","chromosome_location":null,"locus":null,"synonyms":["Microsomal cytochrome b reductase","P35"],"enzyme_classes":["1.6.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"FAD_binding_6","identifier":"PF00970"},{"name":"NAD_binding_1","identifier":"PF00175"}],"pathways":[{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGGCTATTGATGCTCAAAAGCTTGTGGTGGTCATCGTGATCGTGGTCGTGCCTTTGCTCTTCAAGTTCATTATCGGACCGAAGACCAAGCCTGTGCTGGATCCCAAAAGGAATGACTTCCAATCATTTCCGCTGGTTGAAAAAACCATCTTAACGCATAATACTTCGATGTACAAGTTCGGGCTACCTCATGCTGACGACGTACTCGGTTTACCAATTGGTCAGCATATCGTAATTAAGGCCAATATCAATGGTAAGGATATTACCAGATCGTATACGCCCACATCGTTGGATGGAGATACAAAGGGAAACTTTGAATTACTAGTGAAGTCTTACCCCACAGGTAACGTTTCTAAGATGATTGGAGAGTTGAAGATAGGTGACTCGATCCAGATCAAGGGCCCTCGTGGGAACTATCATTATGAGAGAAACTGCCGTTCCCATCTAGGGATGATTGCTGGTGGTACTGGTATTGCGCCCATGTATCAGATCATGAAAGCTATTGCCATGGACCCTCACGACACTACCAAGGTCTCTCTAGTCTTTGGGAACGTCCATGAGGAGGATATTCTGTTGAAGAAGGAACTGGAAGCGTTGGTGGCCATGAAGCCTTCCCAATTTAAGATAGTTTACTACTTAGACTCTCCTGACCGTGAAGACTGGACTGGTGGTGTAGGATACATTACCAAGGATGTCATCAAGGAACACTTGCCCGCTGCTACAATGGACAACGTTCAAATTTTGATCTGTGGTCCTCCAGCCATGGTTGCCTCAGTTAGAAGAAGTACCGTGGACTTGGGGTTCAGACGTTCCAAACCGCTTTCCAAGATGGAAGACCAGGTGTTTGTGTTTTAA","protein_sequence":"MAIDAQKLVVVIVIVVVPLLFKFIIGPKTKPVLDPKRNDFQSFPLVEKTILTHNTSMYKFGLPHADDVLGLPIGQHIVIKANINGKDITRSYTPTSLDGDTKGNFELLVKSYPTGNVSKMIGELKIGDSIQIKGPRGNYHYERNCRSHLGMIAGGTGIAPMYQIMKAIAMDPHDTTKVSLVFGNVHEEDILLKKELEALVAMKPSQFKIVYYLDSPDREDWTGGVGYITKDVIKEHLPAATMDNVQILICGPPAMVASVRRSTVDLGFRRSKPLSKMEDQVFVF"},{"created_at":"2011-07-22T04:56:51.000Z","updated_at":"2011-07-22T04:56:51.000Z","name":"1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase","uniprot_id":"Q03677","uniprot_name":"MTND_YEAST","enzyme":false,"transporter":false,"gene_name":"ADI1","num_residues":179,"molecular_weight":"20879.19922","theoretical_pi":"4.98","general_function":"Involved in metal ion binding","specific_function":"Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)","reactions":[{"id":2860,"direction":"\u003e","locations":"Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus","altext":"1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + formate + CO.","export":false,"pw_reaction_id":null,"source":null},{"id":3791,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006310","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus","genbank_gene_id":"AY558584","genbank_protein_id":"45271058","gene_card_id":"ADI1","chromosome_location":null,"locus":null,"synonyms":["Acireductone dioxygenase","ARD"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"oxidoreductase activity"},{"category":"Function","description":"dioxygenase activity"},{"category":"Function","description":"binding"},{"category":"Function","description":"ion binding"},{"category":"Function","description":"cation binding"},{"category":"Function","description":"metal ion binding"},{"category":"Function","description":"catalytic activity"},{"category":"Process","description":"oxidation reduction"},{"category":"Process","description":"cellular metabolic process"},{"category":"Process","description":"cellular amino acid and derivative metabolic process"},{"category":"Process","description":"cellular amino acid metabolic process"},{"category":"Process","description":"cellular amino acid biosynthetic process"},{"category":"Process","description":"amino acid salvage"},{"category":"Process","description":"L-methionine salvage from methylthioadenosine"},{"category":"Process","description":"metabolic process"}],"pfams":[{"name":"ARD","identifier":"PF03079"}],"pathways":[{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGGTTAAGGTATATATTCATGACAACAAGGTTGACTCCGATTATCGCGCACCCCACAATTCTGGAACAGAACTTTCCCTGGATGAATTAGCCAAGTTAGGAGTGATTTATAAATACTGTGCAAATGAGGAAGAAGTGAATGAAATTGCTAGGCAAAGAGAATATAAAAATAGAGATGTGGTCAACATCTGCGAAGGTTCCTTCAAAAGTGAAGCAGAGTTTAATGAAAAACTAGCAACATTCTACCAAGAGCATTTACATGAAGACGAAGAAATAAGATACTGTCTCGAGGGTGCTGGATACTTTGACGTCAGGGATGCTTCCACACCAGAGAACTGGATTAGGTGTTTGGTAGAGTCAGGTGATTTACTGATTCTTCCACCAGGCATCTATCATCGTTTCACCTTGACAACTAGCAACCACATCAAGGCCTTGAGACTGTTTAAGGACGAGCCCAAATGGCAAGCTATCAACAGGTCAAATCAGGCTGATTCATTGCCTGTACGCAAGGACTACATTGCCCTGATCAATCAGTACTAA","protein_sequence":"MVKVYIHDNKVDSDYRAPHNSGTELSLDELAKLGVIYKYCANEEEVNEIARQREYKNRDVVNICEGSFKSEAEFNEKLATFYQEHLHEDEEIRYCLEGAGYFDVRDASTPENWIRCLVESGDLLILPPGIYHRFTLTTSNHIKALRLFKDEPKWQAINRSNQADSLPVRKDYIALINQY"},{"created_at":"2011-07-22T06:23:02.000Z","updated_at":"2011-07-22T06:23:02.000Z","name":"Cytochrome P450 61","uniprot_id":"P54781","uniprot_name":"ERG5_YEAST","enzyme":false,"transporter":false,"gene_name":"ERG5","num_residues":538,"molecular_weight":"61333.80078","theoretical_pi":"8.01","general_function":"Secondary metabolites biosynthesis, transport and catabolism","specific_function":"Required to form the C-22(23) double bond in the sterol side chain","reactions":[{"id":14414,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006927","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U34636","genbank_protein_id":"1235991","gene_card_id":"ERG5","chromosome_location":null,"locus":null,"synonyms":["C-22 sterol desaturase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"oxidoreductase activity"},{"category":"Function","description":"heme binding"},{"category":"Function","description":"electron carrier activity"},{"category":"Function","description":"iron ion binding"},{"category":"Function","description":"monooxygenase activity"},{"category":"Function","description":"binding"},{"category":"Function","description":"ion binding"},{"category":"Function","description":"cation binding"},{"category":"Function","description":"metal ion binding"},{"category":"Function","description":"transition metal ion binding"},{"category":"Function","description":"catalytic activity"}],"pfams":[{"name":"p450","identifier":"PF00067"}],"pathways":[{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null},{"name":"Steroid biosynthesis","kegg_map_id":"00100"}],"gene_sequence":"ATGAGTTCTGTCGCAGAAAATATAATACAACATGCCACTCATAATTCTACGCTACACCAATTGGCTAAAGACCAGCCCTCTGTAGGCGTCACTACTGCCTTCAGTATCCTGGATACACTTAAGTCTATGTCATATTTGAAAATATTTGCTACTTTAATCTGTATTCTTTTGGTTTGGGACCAAGTTGCATATCAAATCAAGAAAGGTTCCATCGCAGGTCCAAAGTTTAAGTTCTGGCCCATCATCGGTCCATTTTTGGAATCCTTAGATCCAAAGTTTGAAGAATATAAGGCTAAGTGGGCATCCGGTCCACTTTCATGTGTTTCTATTTTCCATAAATTTGTTGTTATCGCATCTACTAGAGACTTGGCAAGAAAGATCTTGCAATCTTCCAAATTCGTCAAACCTTGCGTTGTCGATGTTGCTGTGAAGATCTTAAGACCTTGCAATTGGGTTTTTTTGGACGGTAAAGCTCATACTGATTACAGAAAATCATTAAACGGTCTTTTCACTAAACAAGCTTTGGCTCAATACTTACCTTCATTGGAACAAATCATGGATAAGTACATGGATAAGTTTGTTCGTTTATCTAAGGAGAATAACTACGAGCCCCAGGTCTTTTTCCATGAAATGAGAGAAATTCTTTGCGCCTTATCATTGAACTCTTTCTGTGGTAACTATATTACCGAAGATCAAGTCAGAAAGATTGCTGATGATTACTATTTGGTTACAGCAGCATTGGAATTAGTCAACTTCCCAATTATTATCCCTTACACTAAAACATGGTATGGTAAGAAAACTGCAGACATGGCCATGAAGATTTTCGAAAACTGTGCTCAAATGGCTAAGGATCATATTGCTGCAGGTGGTAAGCCAGTTTGTGTTATGGATGCTTGGTGTAAGTTGATGCACGATGCAAAGAATAGTAACGATGATGATTCTAGAATCTACCACAGAGAGTTTACTAACAAGGAAATCTCCGAAGCTGTTTTCACTTTCTTATTTGCTTCTCAAGATGCCTCTTCTTCTTTAGCTTGTTGGTTGTTCCAAATTGTTGCTGACCGTCCAGATGTCTTAGCTAAGATCAGAGAAGAACAATTGGCTGTTCGTAACAATGACATGTCTACCGAATTGAACTTGGATTTGATTGAGAAAATGAAGTACACCAATATGGTCATAAAAGAAACTTTGCGTTACAGACCTCCTGTCTTGATGGTTCCATATGTTGTTAAGAAGAATTTCCCAGTTTCCCCTAACTATACCGCACCAAAGGGCGCTATGTTAATTCCAACCTTATACCCAGCTTTACATGATCCTGAAGTTTACGAAAATCCTGATGAGTTCATCCCTGAAAGATGGGTAGAAGGCTCTAAGGCTAGTGAAGCAAAGAAGAATTGGTTGGTTTTTGGTTGTGGTCCACACGTTTGCTTAGGTCAAACATATGTCATGATTACCTTCGCCGCTTTGTTGGGTAAATTTGCACTATATACTGATTTCCATCATACAGTGACTCCATTAAGTGAAAAAATCAAGGTTTTCGCTACAATTTTCCCAAAAGATGATTTGTTACTGACTTTCAAAAAGAGAGACCCAATTACTGGAGAAGTCTTCGAATAA","protein_sequence":"MSSVAENIIQHATHNSTLHQLAKDQPSVGVTTAFSILDTLKSMSYLKIFATLICILLVWDQVAYQIKKGSIAGPKFKFWPIIGPFLESLDPKFEEYKAKWASGPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHTDYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCALSLNSFCGNYITEDQVRKIADDYYLVTAALELVNFPIIIPYTKTWYGKKTADMAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYRPPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGKFALYTDFHHTVTPLSEKIKVFATIFPKDDLLLTFKKRDPITGEVFE"}]}