water (YMDB00890)

General function:

Involved in glutathione peroxidase activity

Specific function:

May constitute a glutathione peroxidase-like protective system against oxidative stresses

Gene Name:

GPX2

Uniprot ID:

P38143

Molecular weight:

18406.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Non-essential protein which is required for efficient N- glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate

Gene Name:

CAX4

Uniprot ID:

P53223

Molecular weight:

27648.80078

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gene Name:

ADE6

Uniprot ID:

P38972

Molecular weight:

148904.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

TRP3

Uniprot ID:

P00937

Molecular weight:

53488.89844

Reactions

General function:

Involved in carboxyl- or carbamoyltransferase activity

Specific function:

This protein is a "fusion" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase)

Gene Name:

URA2

Uniprot ID:

P07259

Molecular weight:

245124.0

Reactions

General function:

Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor

Specific function:

Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln). Required for HMG2-induced ER-remodeling

Gene Name:

HER2

Uniprot ID:

Q03557

Molecular weight:

50918.0

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

CPA2

Uniprot ID:

P03965

Molecular weight:

123914.0

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

URA7

Uniprot ID:

P28274

Molecular weight:

64709.80078

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate

Gene Name:

GUA1

Uniprot ID:

P38625

Molecular weight:

58481.80078

Reactions

General function:

Involved in asparagine synthase (glutamine-hydrolyzing) activity

Specific function:

ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

Gene Name:

ASN1

Uniprot ID:

P49089

Molecular weight:

64469.60156

Reactions

General function:

Involved in asparagine synthase (glutamine-hydrolyzing) activity

Specific function:

ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

Gene Name:

ASN2

Uniprot ID:

P49090

Molecular weight:

64592.5

Reactions

General function:

Involved in amidophosphoribosyltransferase activity

Specific function:

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O

Gene Name:

ADE4

Uniprot ID:

P04046

Molecular weight:

56718.89844

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis

Gene Name:

URA8

Uniprot ID:

P38627

Molecular weight:

63055.69922

Reactions

General function:

Involved in NAD+ synthase (glutamine-hydrolyzing) activity

Specific function:

ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate

Gene Name:

QNS1

Uniprot ID:

P38795

Molecular weight:

80684.89844

Reactions

General function:

Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor

Specific function:

Hydrolysis of urea to ammonia and CO(2)

Gene Name:

DUR1

Uniprot ID:

P32528

Molecular weight:

201830.0

Reactions

General function:

Involved in allantoicase activity

Specific function:

Utilization of purines as secondary nitrogen sources, when primary sources are limiting

Gene Name:

DAL2

Uniprot ID:

P25335

Molecular weight:

38713.5

Reactions

General function:

Involved in arginase activity

Specific function:

L-arginine + H(2)O = L-ornithine + urea

Gene Name:

CAR1

Uniprot ID:

P00812

Molecular weight:

35661.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

Alpha,alpha-trehalose + H(2)O = 2 D-glucose

Gene Name:

NTH2

Uniprot ID:

P35172

Molecular weight:

89678.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

Alpha,alpha-trehalose + H(2)O = 2 D-glucose

Gene Name:

ATH1

Uniprot ID:

P48016

Molecular weight:

136919.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Alpha,alpha-trehalose + H(2)O = 2 D-glucose

Gene Name:

NTH1

Uniprot ID:

P32356

Molecular weight:

85878.5

Reactions

General function:

Involved in catalytic activity

Specific function:

Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process

Gene Name:

TPS2

Uniprot ID:

P31688

Molecular weight:

102976.0

Reactions

General function:

Involved in 1-aminocyclopropane-1-carboxylate synthase activity

Specific function:

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA)

Gene Name:

BNA3

Uniprot ID:

P47039

Molecular weight:

50081.89844

Reactions

General function:

Involved in catalytic activity

Specific function:

This is predominantly if not solely a fructose-2,6- bisphosphatase

Gene Name:

FBP26

Uniprot ID:

P32604

Molecular weight:

52594.5

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthesis and degradation of fructose 2,6-bisphosphate

Gene Name:

Not Available

Uniprot ID:

Q06137

Molecular weight:

58385.19922

Reactions

General function:

Involved in hydrolase activity

Specific function:

May eliminate potentially toxic dinucleoside polyphosphates during sporulation. Most active against diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A). Can also hydrolyze diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A), adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate)

Gene Name:

DDP1

Uniprot ID:

Q99321

Molecular weight:

21572.30078

Reactions

General function:

Involved in inositol trisphosphate 3-kinase activity

Specific function:

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance

Gene Name:

KCS1

Uniprot ID:

Q12494

Molecular weight:

119549.0

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP- InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2- InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Required for maintaining celllular integrity, normal growth and interactions with the ARP complex. Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability. Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth

Gene Name:

VIP1

Uniprot ID:

Q06685

Molecular weight:

129754.0

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol

Gene Name:

ERG11

Uniprot ID:

P10614

Molecular weight:

60719.80078

Reactions

General function:

Involved in catalytic activity

Specific function:

Interconversion of serine and glycine

Gene Name:

SHM2

Uniprot ID:

P37291

Molecular weight:

52218.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Interconversion of serine and glycine

Gene Name:

SHM1

Uniprot ID:

P37292

Molecular weight:

53686.0

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate

Gene Name:

LYS1

Uniprot ID:

P38998

Molecular weight:

41464.39844

Reactions

General function:

Involved in binding

Specific function:

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH

Gene Name:

LYS9

Uniprot ID:

P38999

Molecular weight:

48917.30078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

Gene Name:

ALD2

Uniprot ID:

P47771

Molecular weight:

55187.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(+) + H(2)O = an acid + NADH

Gene Name:

ALD4

Uniprot ID:

P46367

Molecular weight:

56723.19922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

Gene Name:

ALD3

Uniprot ID:

P54114

Molecular weight:

55384.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(+) + H(2)O = an acid + NADH

Gene Name:

ALD6

Uniprot ID:

P54115

Molecular weight:

54413.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose

Gene Name:

ALD5

Uniprot ID:

P40047

Molecular weight:

56620.39844

Reactions

General function:

Involved in catalytic activity

Specific function:

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)

Gene Name:

UTR4

Uniprot ID:

P32626

Molecular weight:

25187.19922

Reactions

General function:

Involved in metal ion binding

Specific function:

Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)

Gene Name:

MDE1

Uniprot ID:

P47095

Molecular weight:

27426.59961

Reactions

General function:

Involved in metabolic process

Specific function:

Required for growth on nonfermentable carbon sources and for biosynthesis of glutamate

Gene Name:

ACO1

Uniprot ID:

P19414

Molecular weight:

85367.5

Reactions

General function:

Involved in dihydroorotase activity

Specific function:

(S)-dihydroorotate + H(2)O = N-carbamoyl-L- aspartate

Gene Name:

URA4

Uniprot ID:

P20051

Molecular weight:

40313.0

Reactions

General function:

Involved in 3-dehydroquinate dehydratase activity

Specific function:

The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis

Gene Name:

ARO1

Uniprot ID:

P08566

Molecular weight:

174754.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)

Gene Name:

ARO4

Uniprot ID:

P32449

Molecular weight:

39748.80078

Reactions

General function:

Involved in catalytic activity

Specific function:

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)

Gene Name:

ARO3

Uniprot ID:

P14843

Molecular weight:

41069.5

Reactions

General function:

Involved in ureidoglycolate hydrolase activity

Specific function:

Utilization of purines as secondary nitrogen sources, when primary sources are limiting

Gene Name:

DAL3

Uniprot ID:

P32459

Molecular weight:

21726.59961

Reactions

General function:

Involved in catalytic activity

Specific function:

This isozyme is necessary for growth on acetate as sole C-source

Gene Name:

MLS1

Uniprot ID:

P30952

Molecular weight:

62790.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

This isozyme is involved in the degradation of allantoin (purine catabolism)

Gene Name:

DAL7

Uniprot ID:

P21826

Molecular weight:

62793.39844

Reactions

General function:

Involved in pyridoxamine-phosphate oxidase activity

Specific function:

Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

Gene Name:

PDX3

Uniprot ID:

P38075

Molecular weight:

26908.0

Reactions

General function:

Involved in peptidyl-lysine modification to hypusine

Specific function:

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue

Gene Name:

DYS1

Uniprot ID:

P38791

Molecular weight:

42891.80078

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance

Gene Name:

FMS1

Uniprot ID:

P50264

Molecular weight:

57805.10156

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2- hydroxybutane-1,2,4-tricarboxylate + CoA

Gene Name:

LYS21

Uniprot ID:

Q12122

Molecular weight:

48593.80078

Reactions

General function:

Involved in 2-isopropylmalate synthase activity

Specific function:

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Redundant to LEU4, responsible of about 20% of alpha-IPMS activity. Involved in leucine synthesis

Gene Name:

LEU9

Uniprot ID:

Q12166

Molecular weight:

67199.60156

Reactions

General function:

Involved in fatty acid elongase activity

Specific function:

Involved in synthesis of 1,3-beta-glucan. Could be a subunit of 1,3-beta-glucan synthase. Could be also a component of the membrane bound fatty acid elongation systems that produce the 26-carbon very long chain fatty acids that are precursors for ceramide and sphingolipids. Appears to be involved in the elongation of fatty acids up to 24 carbons. Appears to have the highest affinity for substrates with chain length less than 22 carbons

Gene Name:

FEN1

Uniprot ID:

P25358

Molecular weight:

40001.80078

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. Has an indirect role in endocytic membrane trafficking. May have a function in protein biosynthesis in mitochondrial small ribosomal subunit

Gene Name:

EHD3

Uniprot ID:

P28817

Molecular weight:

56287.89844

Reactions

General function:

Involved in catalytic activity

Specific function:

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. It may be involved in overall regulation of acetylation during melatonin synthesis

Gene Name:

ACH1

Uniprot ID:

P32316

Molecular weight:

58711.5

Reactions

General function:

Involved in acyl-CoA dehydrogenase activity

Specific function:

Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)

Gene Name:

POX1

Uniprot ID:

P13711

Molecular weight:

84041.39844

Reactions

General function:

Involved in hydroxymethylglutaryl-CoA synthase activity

Specific function:

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase

Gene Name:

ERG13

Uniprot ID:

P54839

Molecular weight:

55013.10156

Reactions

General function:

Involved in 2-isopropylmalate synthase activity

Specific function:

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)

Gene Name:

LEU4

Uniprot ID:

P06208

Molecular weight:

68408.29688

Reactions

General function:

Involved in fatty acid elongase activity

Specific function:

May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0)

Gene Name:

ELO1

Uniprot ID:

P39540

Molecular weight:

36233.60156

Reactions

General function:

Involved in acyl carrier activity

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Gene Name:

ACP1

Uniprot ID:

P32463

Molecular weight:

13942.5

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2- hydroxybutane-1,2,4-tricarboxylate + CoA

Gene Name:

LYS20

Uniprot ID:

P48570

Molecular weight:

47098.39844

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Acyltransferase which mediates the conversion of 1-acyl- sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a broad LPC fatty acyl chain substrate specificity utilizing LPC molecules ranging in length from C-10 to C-20. Does not utilize other lysolipids than LPC as acceptor. Also shows acyl-CoA-independent acyltransferase activity. Required for normal phospholipid content of mitochondrial membranes. Involved in the remodeling of the acyl groups of cardiolipin in the mitochondrial inner membrane, which affects the assembly and stability of respiratory chain complex IV and its supercomplex forms

Gene Name:

TAZ1

Uniprot ID:

Q06510

Molecular weight:

44187.19922

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

Gene Name:

POT1

Uniprot ID:

P27796

Molecular weight:

44729.89844

Reactions

General function:

Involved in transferase activity

Specific function:

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for:[acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase

Gene Name:

FAS1

Uniprot ID:

P07149

Molecular weight:

228689.0

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT3

Uniprot ID:

P43635

Molecular weight:

53810.69922

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of mitochondrial acyl-carrier-protein

Gene Name:

PPT2

Uniprot ID:

Q12036

Molecular weight:

19973.0

Reactions

General function:

Involved in acyl-CoA thioesterase activity

Specific function:

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH

Gene Name:

TES1

Uniprot ID:

P41903

Molecular weight:

40259.39844

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT2

Uniprot ID:

P08679

Molecular weight:

51412.89844

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT1

Uniprot ID:

P00890

Molecular weight:

53359.60156

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate

Gene Name:

Not Available

Uniprot ID:

Q04533

Molecular weight:

74312.70313

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate

Gene Name:

CYS3

Uniprot ID:

P31373

Molecular weight:

42541.69922

Reactions

General function:

Involved in catalytic activity

Specific function:

Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP2 and PHO5

Gene Name:

NPP1

Uniprot ID:

P25353

Molecular weight:

84733.20313

Reactions

General function:

Involved in hydrolase activity

Specific function:

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis

Gene Name:

YND1

Uniprot ID:

P40009

Molecular weight:

71851.20313

Reactions

General function:

Involved in catalytic activity

Specific function:

Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and PHO5

Gene Name:

NPP2

Uniprot ID:

P39997

Molecular weight:

57354.10156

Reactions

General function:

Involved in catalytic activity

Specific function:

Could be an enzyme that inactivates 6-azauracil by modifying it

Gene Name:

SDT1

Uniprot ID:

P53078

Molecular weight:

31968.40039

Reactions

General function:

Involved in zinc ion binding

Specific function:

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

Gene Name:

CDD1

Uniprot ID:

Q06549

Molecular weight:

15535.90039

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes the N-acetamido groups of N-acetyl-D- glucosamine residues in chitin

Gene Name:

CDA1

Uniprot ID:

Q06702

Molecular weight:

34642.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes the N-acetamido groups of N-acetyl-D- glucosamine residues in chitin

Gene Name:

CDA2

Uniprot ID:

Q06703

Molecular weight:

35692.80078

Reactions

General function:

Involved in N-acetylglucosaminylphosphatidylinositol de

Specific function:

Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol

Gene Name:

GPI12

Uniprot ID:

P23797

Molecular weight:

35445.60156

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

May constitute a glutathione peroxidase-like protective system against oxidative stresses

Gene Name:

GPX1

Uniprot ID:

P36014

Molecular weight:

19484.5

Reactions

General function:

Involved in deaminase activity

Specific function:

Adenosine + H(2)O = inosine + NH(3)

Gene Name:

AAH1

Uniprot ID:

P53909

Molecular weight:

39634.69922

Reactions

General function:

Involved in adenosylhomocysteinase activity

Specific function:

Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine

Gene Name:

SAH1

Uniprot ID:

P39954

Molecular weight:

49125.10156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR2 provides the diiron-tyrosyl radical center

Gene Name:

RNR2

Uniprot ID:

P09938

Molecular weight:

46147.0

Reactions

General function:

Involved in oxidation-reduction process

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Gene Name:

RNR1

Uniprot ID:

P21524

Molecular weight:

99560.20313

Reactions

General function:

Involved in phosphoribosylaminoimidazole carboxylase activity

Specific function:

5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)

Gene Name:

ADE2

Uniprot ID:

P21264

Molecular weight:

62338.69922

Reactions

General function:

Involved in imidazoleglycerol-phosphate dehydratase activity

Specific function:

D-erythro-1-(imidazol-4-yl)glycerol 3- phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O

Gene Name:

HIS3

Uniprot ID:

P06633

Molecular weight:

23833.0

Reactions

General function:

Involved in catalytic activity

Specific function:

L-serine = pyruvate + NH(3)

Gene Name:

CHA1

Uniprot ID:

P25379

Molecular weight:

39301.0

Reactions

General function:

Involved in protein binding

Specific function:

Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source

Gene Name:

GDE1

Uniprot ID:

Q02979

Molecular weight:

138013.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Glycerol 3-phosphate + H(2)O = glycerol + phosphate

Gene Name:

HOR2

Uniprot ID:

P40106

Molecular weight:

27813.5

Reactions

General function:

Involved in glycerophosphodiester phosphodiesterase activity

Specific function:

Probable glycerophosphocholine glycerophosphodiesterase which may be responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis

Gene Name:

Not Available

Uniprot ID:

Q08959

Molecular weight:

37069.39844

Reactions

General function:

Involved in catalytic activity

Specific function:

Glycerol 3-phosphate + H(2)O = glycerol + phosphate

Gene Name:

RHR2

Uniprot ID:

P41277

Molecular weight:

27946.59961

Reactions

General function:

Involved in oxygen-dependent protoporphyrinogen oxidase activity

Specific function:

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX

Gene Name:

HEM14

Uniprot ID:

P40012

Molecular weight:

59702.39844

Reactions

General function:

Involved in phosphoric ester hydrolase activity

Specific function:

D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate

Gene Name:

FBP1

Uniprot ID:

P09201

Molecular weight:

38262.19922

Reactions

General function:

Involved in formate-tetrahydrofolate ligase activity

Specific function:

5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH

Gene Name:

MIS1

Uniprot ID:

P09440

Molecular weight:

106216.0

Reactions

General function:

Involved in IMP cyclohydrolase activity

Specific function:

10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Gene Name:

ADE17

Uniprot ID:

P38009

Molecular weight:

65262.60156

Reactions

General function:

Involved in IMP cyclohydrolase activity

Specific function:

10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Gene Name:

ADE16

Uniprot ID:

P54113

Molecular weight:

65281.80078

Reactions

General function:

Involved in methionyl-tRNA formyltransferase activity

Specific function:

Formylates methionyl-tRNA in mitochondria

Gene Name:

FMT1

Uniprot ID:

P32785

Molecular weight:

44616.19922

Reactions

General function:

Involved in formate-tetrahydrofolate ligase activity

Specific function:

5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH

Gene Name:

ADE3

Uniprot ID:

P07245

Molecular weight:

102204.0

Reactions

General function:

Involved in porphobilinogen synthase activity

Specific function:

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen

Gene Name:

HEM2

Uniprot ID:

P05373

Molecular weight:

37739.69922

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

Gene Name:

HEM13

Uniprot ID:

P11353

Molecular weight:

37711.30078

Reactions

General function:

Involved in electron carrier activity

Specific function:

Could be a fumarate reductase

Gene Name:

OSM1

Uniprot ID:

P21375

Molecular weight:

55064.80078

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

A phosphate monoester + H(2)O = an alcohol + phosphate

Gene Name:

PHO11

Uniprot ID:

P35842

Molecular weight:

52757.39844

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Partially mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and NPP2

Gene Name:

PHO5

Uniprot ID:

P00635

Molecular weight:

52858.10156

Reactions

General function:

Involved in zinc ion binding

Specific function:

Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4

Gene Name:

FCY1

Uniprot ID:

Q12178

Molecular weight:

17506.90039

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate

Gene Name:

PNC1

Uniprot ID:

P53184

Molecular weight:

24993.19922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + NADH

Gene Name:

GDH2

Uniprot ID:

P33327

Molecular weight:

124331.0

Reactions

General function:

Involved in asparaginase activity

Specific function:

L-asparagine + H(2)O = L-aspartate + NH(3)

Gene Name:

ASP3-1

Uniprot ID:

P11163

Molecular weight:

38686.19922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

GDH3

Uniprot ID:

P39708

Molecular weight:

49626.80078

Reactions

General function:

Involved in hydroxymethylbilane synthase activity

Specific function:

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

Gene Name:

HEM3

Uniprot ID:

P28789

Molecular weight:

36674.19922

Reactions

General function:

Involved in aminomethyltransferase activity

Specific function:

The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine

Gene Name:

GCV1

Uniprot ID:

P48015

Molecular weight:

44468.69922

Reactions

General function:

Involved in asparaginase activity

Specific function:

L-asparagine + H(2)O = L-aspartate + NH(3)

Gene Name:

ASP1

Uniprot ID:

P38986

Molecular weight:

41394.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

GDH1

Uniprot ID:

P07262

Molecular weight:

49569.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

Exhibits dehydratase activity specific for L-threo-3- hydroxyaspartate

Gene Name:

SRY1

Uniprot ID:

P36007

Molecular weight:

34898.69922

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate

Gene Name:

STR3

Uniprot ID:

P53101

Molecular weight:

51828.0

Reactions

General function:

Involved in deaminase activity

Specific function:

AMP deaminase plays a critical role in energy metabolism

Gene Name:

AMD1

Uniprot ID:

P15274

Molecular weight:

93300.79688

Reactions

General function:

Involved in zinc ion binding

Specific function:

Involved in riboflavin biosynthesis. Converts 2,5- diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5- amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate

Gene Name:

RIB2

Uniprot ID:

Q12362

Molecular weight:

67035.29688

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate

Gene Name:

IRC7

Uniprot ID:

P43623

Molecular weight:

36971.10156

Reactions

General function:

Involved in zinc ion binding

Specific function:

Supplies the nucleotide substrate for thymidylate synthetase

Gene Name:

DCD1

Uniprot ID:

P06773

Molecular weight:

35645.69922

Reactions

General function:

Involved in hydrolase activity

Specific function:

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia

Gene Name:

GUD1

Uniprot ID:

Q07729

Molecular weight:

55203.19922

Reactions

General function:

Involved in 3-methyl-2-oxobutanoate hydroxymethyltransferase activity

Specific function:

5,10-methylenetetrahydrofolate + 3-methyl-2- oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate

Gene Name:

ECM31

Uniprot ID:

P38122

Molecular weight:

34464.69922

Reactions

General function:

Involved in 3'(2'),5'-bisphosphate nucleotidase activity

Specific function:

Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance. Confers resistance to lithium

Gene Name:

HAL2

Uniprot ID:

P32179

Molecular weight:

39148.89844

Reactions

General function:

Involved in hydrolase activity

Specific function:

NAD(+) + H(2)O = AMP + NMN

Gene Name:

NPY1

Uniprot ID:

P53164

Molecular weight:

43516.0

Reactions

General function:

Involved in 3',5'-cyclic-AMP phosphodiesterase activity

Specific function:

Controls the level of cAMP in yeast cells, together with the high-affinity cAMP phosphodiesterase (PDE2)

Gene Name:

PDE1

Uniprot ID:

P22434

Molecular weight:

42015.69922

Reactions

General function:

Involved in catalytic activity

Specific function:

Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock

Gene Name:

HNT2

Uniprot ID:

P49775

Molecular weight:

23541.59961

Reactions

General function:

Involved in hydrolase activity

Specific function:

ADP-ribose + H(2)O = AMP + D-ribose 5- phosphate

Gene Name:

YSA1

Uniprot ID:

Q01976

Molecular weight:

26086.80078

Reactions

General function:

Involved in ligase activity

Specific function:

Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha- aminoadipate by NADPH

Gene Name:

LYS2

Uniprot ID:

P07702

Molecular weight:

155344.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Controls the level of cAMP in yeast cells, together with the low-affinity cAMP phosphodiesterase (PDE1)

Gene Name:

PDE2

Uniprot ID:

P06776

Molecular weight:

60999.19922

Reactions

General function:

Involved in RNA binding

Specific function:

Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr)

Gene Name:

PUS1

Uniprot ID:

Q12211

Molecular weight:

62142.0

Reactions

General function:

Involved in RNA processing

Specific function:

Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs

Gene Name:

PUS4

Uniprot ID:

P48567

Molecular weight:

45273.10156

Reactions

General function:

Involved in RNA binding

Specific function:

Formation of pseudouridine in the anticodon stem and loop of transfer RNAs

Gene Name:

PUS2

Uniprot ID:

P53167

Molecular weight:

41874.80078

Reactions

General function:

Involved in RNA binding

Specific function:

Formation of pseudouridines at positions 38 and 39 in the anticodon stem and loop of transfer RNAs

Gene Name:

PUS3

Uniprot ID:

P31115

Molecular weight:

50888.30078

Reactions

General function:

Involved in fumarate hydratase activity

Specific function:

(S)-malate = fumarate + H(2)O

Gene Name:

FUM1

Uniprot ID:

P08417

Molecular weight:

53151.5

Reactions

General function:

Involved in monooxygenase activity

Specific function:

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid

Gene Name:

BNA4

Uniprot ID:

P38169

Molecular weight:

52428.89844

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively

Gene Name:

BNA5

Uniprot ID:

Q05979

Molecular weight:

51031.60156

Reactions

General function:

Involved in 3-isopropylmalate dehydratase activity

Specific function:

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate

Gene Name:

LEU1

Uniprot ID:

P07264

Molecular weight:

85793.70313

Reactions

General function:

Involved in methionine adenosyltransferase activity

Specific function:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP

Gene Name:

SAM1

Uniprot ID:

P10659

Molecular weight:

41818.0

Reactions

General function:

Involved in phosphomethylpyrimidine kinase activity

Specific function:

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probaby that of HMP to HMP- P

Gene Name:

THI20

Uniprot ID:

Q08224

Molecular weight:

61268.89844

Reactions

General function:

Involved in nucleotide binding

Specific function:

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses

Gene Name:

PMA1

Uniprot ID:

P05030

Molecular weight:

99618.39844

Reactions

General function:

Involved in catalytic activity

Specific function:

A phosphate monoester + H(2)O = an alcohol + phosphate

Gene Name:

PHO8

Uniprot ID:

P11491

Molecular weight:

63003.60156

Reactions

General function:

Involved in nucleotide binding

Specific function:

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses

Gene Name:

PMA2

Uniprot ID:

P19657

Molecular weight:

102171.0

Reactions

General function:

Involved in ATP binding

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits

Gene Name:

ATP2

Uniprot ID:

P00830

Molecular weight:

54793.30078

Reactions

General function:

Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Specific function:

D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

Gene Name:

TDH1

Uniprot ID:

P00360

Molecular weight:

35749.60156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals

Gene Name:

MCR1

Uniprot ID:

P36060

Molecular weight:

34137.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5- phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4-carboxamide

Gene Name:

HIS4

Uniprot ID:

P00815

Molecular weight:

87720.5

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase- epimerase activities. Converts trans-2-enoyl-CoA via D-3- hydroxyacyl-CoA to 3-ketoacyl-CoA

Gene Name:

FOX2

Uniprot ID:

Q02207

Molecular weight:

98702.39844

Reactions

General function:

Involved in catalytic activity

Specific function:

Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH

Gene Name:

IMD3

Uniprot ID:

P50095

Molecular weight:

56584.39844

Reactions

General function:

Involved in catalytic activity

Specific function:

Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH

Gene Name:

IMD2

Uniprot ID:

P38697

Molecular weight:

56529.5

Reactions

General function:

Involved in catalytic activity

Specific function:

Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH

Gene Name:

IMD1

Uniprot ID:

P39567

Molecular weight:

44385.80078

Reactions

General function:

Involved in catalytic activity

Specific function:

O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate

Gene Name:

SER2

Uniprot ID:

P42941

Molecular weight:

34207.0

Reactions

General function:

Involved in cysteine biosynthetic process from serine

Specific function:

L-serine + L-homocysteine = L-cystathionine + H(2)O

Gene Name:

CYS4

Uniprot ID:

P32582

Molecular weight:

56021.30078

Reactions

General function:

Involved in catalytic activity

Specific function:

L-serine + 1-C-(indol-3-yl)glycerol 3- phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O

Gene Name:

TRP5

Uniprot ID:

P00931

Molecular weight:

76625.5

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate

Gene Name:

ECM17

Uniprot ID:

P47169

Molecular weight:

161218.0

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate

Gene Name:

MET10

Uniprot ID:

P39692

Molecular weight:

114827.0

Reactions

General function:

Involved in histidinol-phosphatase activity

Specific function:

L-histidinol phosphate + H(2)O = L-histidinol + phosphate

Gene Name:

HIS2

Uniprot ID:

P38635

Molecular weight:

38581.5

Reactions

General function:

Involved in 6-phosphogluconolactonase activity

Specific function:

Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate

Gene Name:

SOL4

Uniprot ID:

P53315

Molecular weight:

28447.5

Reactions

General function:

Involved in 6-phosphogluconolactonase activity

Specific function:

May be involved in regulation of tRNA subcellular distribution

Gene Name:

SOL1

Uniprot ID:

P50278

Molecular weight:

35652.19922

Reactions

General function:

Involved in 6-phosphogluconolactonase activity

Specific function:

May be involved in regulation of tRNA subcellular distribution

Gene Name:

SOL2

Uniprot ID:

P37262

Molecular weight:

34500.89844

Reactions

General function:

Involved in protein complex assembly

Specific function:

Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase

Gene Name:

COX15

Uniprot ID:

P40086

Molecular weight:

54657.89844

General function:

Involved in oxidoreductase activity

Specific function:

(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H

Gene Name:

PUT2

Uniprot ID:

P07275

Molecular weight:

64434.60156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway

Gene Name:

ERG1

Uniprot ID:

P32476

Molecular weight:

55125.39844

Reactions

General function:

Involved in ubiquinone biosynthetic process

Specific function:

Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides

Gene Name:

COQ4

Uniprot ID:

O13525

Molecular weight:

38626.80078

General function:

Involved in metabolic process

Specific function:

Responsible for the dehydration of cis-homoaconitate to homoisocitric acid

Gene Name:

LYS4

Uniprot ID:

P49367

Molecular weight:

75150.10156

Reactions

General function:

Involved in uroporphyrinogen-III synthase activity

Specific function:

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III

Gene Name:

HEM4

Uniprot ID:

P06174

Molecular weight:

30911.30078

Reactions

General function:

Involved in GTP cyclohydrolase II activity

Specific function:

Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

Gene Name:

RIB1

Uniprot ID:

P38066

Molecular weight:

38331.60156

Reactions

General function:

Involved in gamma-glutamyltransferase activity

Specific function:

Plays a role in the turnover of the vacuolar glutathione and in the supply of growth requirements during nitrogen starvation

Gene Name:

ECM38

Uniprot ID:

Q05902

Molecular weight:

73179.79688

Reactions

General function:

Involved in hydrolase activity

Specific function:

Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid

Gene Name:

GLO2

Uniprot ID:

Q05584

Molecular weight:

31326.30078

Reactions

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Protects cells against oxidative damage due to reactive oxygen species

Gene Name:

GRX5

Uniprot ID:

Q02784

Molecular weight:

16931.30078

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYP1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYP1 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598') and a reduced Cys-36 in HYP1/GPX3

Gene Name:

HYR1

Uniprot ID:

P40581

Molecular weight:

18641.40039

Reactions

General function:

Involved in electron carrier activity

Specific function:

Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage

Gene Name:

GRX2

Uniprot ID:

P17695

Molecular weight:

15861.2998

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Serine hydrolase involved in the detoxification of formaldehyde

Gene Name:

Not Available

Uniprot ID:

P40363

Molecular weight:

33934.0

Reactions

General function:

Involved in hydrolase activity

Specific function:

Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid

Gene Name:

GLO4

Uniprot ID:

Q12320

Molecular weight:

32338.59961

Reactions

General function:

Involved in electron carrier activity

Specific function:

Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage

Gene Name:

GRX1

Uniprot ID:

P25373

Molecular weight:

12380.09961

Reactions

General function:

Involved in riboflavin biosynthetic process

Specific function:

Condensation of 5-amino-6-(1'-D)-ribityl-amino- 2,4(1H,3H)-pyrimidinedione with L-3,4-dihydroxy-2-butanone 4- phosphate to produce 6,7-dimethyl-8-(1-D-ribityl)lumazine

Gene Name:

RIB4

Uniprot ID:

P50861

Molecular weight:

18555.40039

Reactions

General function:

Involved in inositol or phosphatidylinositol phosphatase activity

Specific function:

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling

Gene Name:

INM2

Uniprot ID:

Q05533

Molecular weight:

32092.40039

Reactions

General function:

Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)

Gene Name:

PDA1

Uniprot ID:

P16387

Molecular weight:

46342.69922

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol

Gene Name:

ERG25

Uniprot ID:

P53045

Molecular weight:

36478.89844

Reactions

General function:

Involved in nicotinate phosphoribosyltransferase activity

Specific function:

Essential for growth under anaerobic conditions

Gene Name:

NPT1

Uniprot ID:

P39683

Molecular weight:

49018.19922

Reactions

General function:

Involved in ferroxidase activity

Specific function:

Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain

Gene Name:

YFH1

Uniprot ID:

Q07540

Molecular weight:

19490.0

Reactions

General function:

Involved in allantoinase activity

Specific function:

Utilization of purines as secondary nitrogen sources, when primary sources are limiting

Gene Name:

DAL1

Uniprot ID:

P32375

Molecular weight:

50125.89844

Reactions

General function:

Involved in hydrolase activity

Specific function:

This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

Gene Name:

DUT1

Uniprot ID:

P33317

Molecular weight:

15307.2002

Reactions

General function:

Involved in electron carrier activity

Specific function:

Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress

Gene Name:

TRX2

Uniprot ID:

P22803

Molecular weight:

11203.7998

Reactions

General function:

Involved in electron carrier activity

Specific function:

Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism

Gene Name:

TRX1

Uniprot ID:

P22217

Molecular weight:

11234.90039

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. Can function independently of the complex

Gene Name:

TPS1

Uniprot ID:

Q00764

Molecular weight:

56147.5

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine

Gene Name:

THR4

Uniprot ID:

P16120

Molecular weight:

57473.69922

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Involved in energy production. Its activity is stimulated by uncouplers of ATP synthesis

Gene Name:

PPA2

Uniprot ID:

P28239

Molecular weight:

35572.39844

Reactions

General function:

Involved in DNA binding

Specific function:

Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome

Gene Name:

TY2B-OR1

Uniprot ID:

Q12113

Molecular weight:

201982.0

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Diphosphate + H(2)O = 2 phosphate

Gene Name:

IPP1

Uniprot ID:

P00817

Molecular weight:

32299.30078

Reactions

General function:

Involved in protoheme IX farnesyltransferase activity

Specific function:

Converts protoheme IX and farnesyl diphosphate to heme O

Gene Name:

COX10

Uniprot ID:

P21592

Molecular weight:

52147.19922

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

A phosphate monoester + H(2)O = an alcohol + phosphate

Gene Name:

PHO3

Uniprot ID:

P24031

Molecular weight:

52776.10156

Reactions

General function:

Involved in protein binding

Specific function:

Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events. PLD activity is induced under sporulation conditions and seems to be necessary to complete the meiotic cycle, but not for vegetative cell growth

Gene Name:

SPO14

Uniprot ID:

P36126

Molecular weight:

195202.0

Reactions

General function:

Involved in hydrolase activity

Specific function:

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the conversion of tryptophan to nicotinic acid, NAD(H) and NADP(H)

Gene Name:

BNA7

Uniprot ID:

Q04066

Molecular weight:

29991.0

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H

Gene Name:

UGA2

Uniprot ID:

P38067

Molecular weight:

54188.80078

Reactions

General function:

Involved in metabolic process

Specific function:

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2- oxobutanoate + H(2)O

Gene Name:

ILV3

Uniprot ID:

P39522

Molecular weight:

62860.60156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR4 is required for proper folding of RNR2 and assembly with the large subunits

Gene Name:

RNR4

Uniprot ID:

P49723

Molecular weight:

40054.19922

Reactions

General function:

Involved in hydrolase activity

Specific function:

After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol

Gene Name:

GDA1

Uniprot ID:

P32621

Molecular weight:

56821.0

Reactions

General function:

Involved in binding

Specific function:

Hydrolyzes an epoxide moiety of LTA(4) to form LTB(4). The enzyme also has aminopeptidase activity

Gene Name:

Not Available

Uniprot ID:

Q10740

Molecular weight:

77352.10156

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolysis of terminal, non-reducing (1->4)- linked alpha-D-glucose residues with release of alpha-D-glucose

Gene Name:

MAL32

Uniprot ID:

P38158

Molecular weight:

68141.79688

Reactions

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose

Gene Name:

EXG2

Uniprot ID:

P52911

Molecular weight:

63507.60156

Reactions

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Probably involved in the processes of spore formation and contributes to ascospore thermoresistance by participating in the morphogenesis of ascospore walls. The enzyme may do this by modifying glucan linkages in the developing ascospore wall, thus strengthening it or lending it plasticity

Gene Name:

SPR1

Uniprot ID:

P32603

Molecular weight:

51809.10156

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins

Gene Name:

ROT2

Uniprot ID:

P38138

Molecular weight:

110265.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolysis of terminal, non-reducing (1->4)- linked alpha-D-glucose residues with release of alpha-D-glucose

Gene Name:

MAL12

Uniprot ID:

P53341

Molecular weight:

68093.70313

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Probable alpha-glucosidase involved in maltose metabolism

Gene Name:

Not Available

Uniprot ID:

P40439

Molecular weight:

68698.10156

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme hydrolyzes both 1,3-beta- and 1,6- beta-linkages and even has beta-glucosidase activity. It could also function biosynthetically as a transglycosylase

Gene Name:

EXG1

Uniprot ID:

P23776

Molecular weight:

51310.5

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolysis of terminal, non-reducing (1->4)- linked alpha-D-glucose residues with release of alpha-D-glucose

Gene Name:

MAL62

Uniprot ID:

P07265

Molecular weight:

68182.79688

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase

Gene Name:

BGL2

Uniprot ID:

P15703

Molecular weight:

34118.30078

Reactions

General function:

Involved in magnesium ion binding

Specific function:

2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O

Gene Name:

ERR1

Uniprot ID:

Q12007

Molecular weight:

47327.10156

Reactions

General function:

Involved in magnesium ion binding

Specific function:

2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O

Gene Name:

ERR3

Uniprot ID:

P42222

Molecular weight:

47312.10156

Reactions

General function:

Involved in magnesium ion binding

Specific function:

2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O

Gene Name:

ENO1

Uniprot ID:

P00924

Molecular weight:

46815.69922

Reactions

General function:

Involved in magnesium ion binding

Specific function:

2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O

Gene Name:

ENO2

Uniprot ID:

P00925

Molecular weight:

46913.69922

Reactions

General function:

Involved in catalytic activity

Specific function:

Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling

Gene Name:

LCB3

Uniprot ID:

P47013

Molecular weight:

47371.30078

Reactions

General function:

Involved in catalytic activity

Specific function:

Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling

Gene Name:

YSR3

Uniprot ID:

P23501

Molecular weight:

46487.69922

Reactions

General function:

Involved in iron ion binding

Specific function:

Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin

Gene Name:

SUR2

Uniprot ID:

P38992

Molecular weight:

40734.0

Reactions

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Hydrolysis of terminal non-reducing beta-D- fructofuranoside residues in beta-D-fructofuranosides

Gene Name:

SUC1

Uniprot ID:

P10594

Molecular weight:

60569.89844

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Hydrolysis of terminal non-reducing beta-D- fructofuranoside residues in beta-D-fructofuranosides

Gene Name:

SUC3

Uniprot ID:

P10595

Molecular weight:

8649.90039

General function:

Involved in catalytic activity

Specific function:

Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation

Gene Name:

GDB1

Uniprot ID:

Q06625

Molecular weight:

174970.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolysis of terminal (1->4)-linked alpha-D- glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose

Gene Name:

SGA1

Uniprot ID:

P08019

Molecular weight:

61462.39844

Reactions

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Hydrolysis of terminal non-reducing beta-D- fructofuranoside residues in beta-D-fructofuranosides

Gene Name:

SUC4

Uniprot ID:

P10596

Molecular weight:

60574.80078

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Hydrolysis of terminal non-reducing beta-D- fructofuranoside residues in beta-D-fructofuranosides

Gene Name:

SUC5

Uniprot ID:

P10597

Molecular weight:

8649.90039

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Hydrolysis of terminal non-reducing beta-D- fructofuranoside residues in beta-D-fructofuranosides

Gene Name:

SUC2

Uniprot ID:

P00724

Molecular weight:

60638.89844

Reactions

General function:

Involved in endo-1,3(4)-beta-glucanase activity

Specific function:

Involved in the dissoultion of the mother-daughter septum during cell separation

Gene Name:

DSE4

Uniprot ID:

P53753

Molecular weight:

121063.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Preferentially hydrolyzes isomaltose, with little activity towards isomaltotriose or longer oligosaccharides. Does not hydrolyze maltose

Gene Name:

FSP2

Uniprot ID:

P53051

Molecular weight:

68591.0

Reactions

General function:

Involved in protein binding

Specific function:

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for cell growth, osmoresistance and expression of GPD1

Gene Name:

PLC1

Uniprot ID:

P32383

Molecular weight:

100547.0

Reactions

General function:

Involved in inositol or phosphatidylinositol phosphatase activity

Specific function:

Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN

Gene Name:

INP53

Uniprot ID:

Q12271

Molecular weight:

124576.0

Reactions

General function:

Involved in inositol or phosphatidylinositol phosphatase activity

Specific function:

Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Specifically functions within the early endocytic pathway and actin organization

Gene Name:

INP52

Uniprot ID:

P50942

Molecular weight:

133330.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Active on 2-DOG-6P, also very active on fructose-1P

Gene Name:

DOG1

Uniprot ID:

P38774

Molecular weight:

27099.59961

Reactions

General function:

Involved in catalytic activity

Specific function:

Active on 2-DOG-6P, not very active on fructose-1p

Gene Name:

DOG2

Uniprot ID:

P38773

Molecular weight:

27164.80078

Reactions

General function:

Involved in catalytic activity

Specific function:

Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex

Gene Name:

TPS3

Uniprot ID:

P38426

Molecular weight:

118834.0

Reactions

General function:

Involved in glycogen (starch) synthase activity

Specific function:

Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. Is believed to regulate the synthesis of glycogen

Gene Name:

GSY2

Uniprot ID:

P27472

Molecular weight:

80078.20313

Reactions

General function:

Involved in glycogen (starch) synthase activity

Specific function:

Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. Is believed to regulate the synthesis of glycogen

Gene Name:

GSY1

Uniprot ID:

P23337

Molecular weight:

80509.60156

Reactions

General function:

Involved in metabolic process

Specific function:

Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol. Does not cleave phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid and phosphatidylinositol-bisphosphate

Gene Name:

PLB3

Uniprot ID:

Q08108

Molecular weight:

75076.20313

Reactions

General function:

Involved in metabolic process

Specific function:

Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol >> phosphatidylcholine > phosphatidylethanolamine

Gene Name:

PLB1

Uniprot ID:

P39105

Molecular weight:

71666.60156

Reactions

General function:

Involved in metabolic process

Specific function:

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium

Gene Name:

NTE1

Uniprot ID:

Q04958

Molecular weight:

187131.0

Reactions

General function:

Involved in metabolic process

Specific function:

Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol > phosphatidylcholine > phosphatidylethanolamine

Gene Name:

PLB2

Uniprot ID:

Q03674

Molecular weight:

75454.60156

Reactions

General function:

Involved in oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Specific function:

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product

Gene Name:

MXR1

Uniprot ID:

P40029

Molecular weight:

21140.69922

Reactions

General function:

Involved in aminopeptidase activity

Specific function:

Removes the amino-terminal methionine from nascent proteins

Gene Name:

MAP1

Uniprot ID:

Q01662

Molecular weight:

43373.0

General function:

Involved in aminopeptidase activity

Specific function:

Removes the amino-terminal methionine from nascent proteins

Gene Name:

MAP2

Uniprot ID:

P38174

Molecular weight:

47502.19922

General function:

Involved in catalytic activity

Specific function:

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

Gene Name:

Not Available

Uniprot ID:

Q12040

Molecular weight:

26176.5

Reactions

General function:

Involved in catalytic activity

Specific function:

Could be non-functional

Gene Name:

GPM2

Uniprot ID:

Q12008

Molecular weight:

36072.80078

Reactions

General function:

Involved in magnesium ion binding

Specific function:

IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation

Gene Name:

ISN1

Uniprot ID:

Q99312

Molecular weight:

51329.5

Reactions

General function:

Involved in GTP cyclohydrolase I activity

Specific function:

GTP + H(2)O = formate + 2-amino-4-hydroxy-6- (erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate

Gene Name:

FOL2

Uniprot ID:

P51601

Molecular weight:

27768.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5

Gene Name:

NCP1

Uniprot ID:

P16603

Molecular weight:

76771.10156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Acts on thioredoxins 1 and 2

Gene Name:

TRR1

Uniprot ID:

P29509

Molecular weight:

34237.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Acts on mitochondrial thioredoxin 3. Implicated in the defense against oxidative stress

Gene Name:

TRR2

Uniprot ID:

P38816

Molecular weight:

37087.0

Reactions

General function:

Involved in iron ion binding

Specific function:

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain

Gene Name:

CYC1

Uniprot ID:

P00044

Molecular weight:

12181.90039

Reactions

General function:

Involved in iron ion binding

Specific function:

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain

Gene Name:

CYC7

Uniprot ID:

P00045

Molecular weight:

12532.2998

Reactions

General function:

Involved in inositol or phosphatidylinositol phosphatase activity

Specific function:

Regulates the phosphatidylinositol (4,5)-diphosphate levels on the cytoplasmic surface of the endoplasmic reticulum and thereby regulates secretion

Gene Name:

INP54

Uniprot ID:

Q08227

Molecular weight:

43798.69922

Reactions

General function:

Involved in phosphoric ester hydrolase activity

Specific function:

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Major enzyme required for hyperosmotic shock- induced turnover of PtdIns(3,5)P2 and requires VAC14 for this function. In vivo, mediates turnover of PtdIns(3,5)P2 at the vacuole membrane necessary for vacuolar size control. In vitro, catalyzes the removal of phosphate from the fifth hydroxyl of the myo-inositol ring of phosphatidylinositol-3,5-bisphosphate

Gene Name:

FIG4

Uniprot ID:

P42837

Molecular weight:

101745.0

Reactions

General function:

Involved in cyclic-nucleotide phosphodiesterase activity

Specific function:

Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing

Gene Name:

CPD1

Uniprot ID:

P53314

Molecular weight:

26731.40039

Reactions

General function:

Involved in phosphoric ester hydrolase activity

Specific function:

Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton

Gene Name:

SAC1

Uniprot ID:

P32368

Molecular weight:

71124.10156

Reactions

General function:

Involved in phosphatase activity

Specific function:

Involved in the control of phosphotidylinositol 3- phosphate (PI(3)P)-dependent signaling and in the maintenance of endosomal system integrity

Gene Name:

YMR1

Uniprot ID:

P47147

Molecular weight:

80151.10156