{"ymdb_id":"YMDB00884","created_at":"2011-05-29T19:01:14.000Z","updated_at":"2016-09-08T18:36:01.000Z","name":"Linoleic acid","cas":"60-33-3","state":"Liquid","melting_point":"-8.5 oC","description":"Linoleic acid is a doubly unsaturated fatty acid, also known as an omega-6 fatty acid. It is used in the biosynthesis of cell membranes and prostaglandins via arachidonic acid. It is an essential fatty acid in human nutrition. ","experimental_water_solubility":null,"experimental_logp_hydrophobicity":"7.05 [SANGSTER (1993)]","location":"cell envelope;mitochondrion;extracellular;endoplasmic reticulum;lipid particle;cytoplasm","synthesis_reference":"Walborsky, Harry M.; Davis, Robert H.; Howton, David R. A total synthesis of linoleic acid. Journal of the American Chemical Society (1951), 73 2590-4.","chebi_id":"17351","hmdb_id":"HMDB00673","kegg_id":"C01595","pubchem_id":"3931","cs_id":"24841863","foodb_id":null,"wikipedia_link":"Linoleic_acid","biocyc_id":"LINOLEIC_ACID","iupac":"(9E,12E)-octadeca-9,12-dienoic acid","traditional_iupac":"linoelaidic acid","logp":"6.421876794333333","pka":null,"alogps_solubility":"1.54e-04 g/l","alogps_logp":"7.06","alogps_logs":"-6.26","acceptor_count":"2","donor_count":"1","rotatable_bond_count":"14","polar_surface_area":"37.3","refractivity":"88.5188","polarizability":"35.44594461144679","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":null,"pka_strongest_acidic":"4.988167283903808","bioavailability":"0","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(9Z,12Z)-9,12-Octadecadienoate","(9Z,12Z)-9,12-Octadecadienoic acid","(Z,Z)-9,12-Octadecadienoate","(Z,Z)-9,12-Octadecadienoic acid","9-cis,12-cis-Linoleate","9-cis,12-cis-Linoleic acid","9Z,12Z-Linoleate","9Z,12Z-Linoleic acid","9Z,12Z-Octadecadienoate","9Z,12Z-Octadecadienoic acid","all-cis-9,12-Octadecadienoate","all-cis-9,12-Octadecadienoic acid","cis-9,cis-12-Octadecadienoate","cis-9,cis-12-Octadecadienoic acid","cis-D9,12-Octadecadienoate","cis-D9,12-Octadecadienoic acid","cis,cis-Linoleate","cis,cis-Linoleic acid","Linolate","Linoleate","Linoleic acid","Linolic acid"],"pathways":[{"name":"Linoleic acid metabolism","kegg_map_id":"00591"},{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-24T21:20:10.000Z","updated_at":"2011-07-22T17:54:57.000Z","name":"Long-chain-fatty-acid--CoA ligase 4","uniprot_id":"P47912","uniprot_name":"LCF4_YEAST","enzyme":true,"transporter":false,"gene_name":"FAA4","num_residues":694,"molecular_weight":"77266.5","theoretical_pi":"6.52","general_function":"Involved in catalytic activity","specific_function":"Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Contributes, with FAA1, to the activation of imported myristate","reactions":[{"id":1512,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1513,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1516,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1517,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1518,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1520,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1521,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2380,"direction":"\u003e","locations":"Cytoplasm. Mitochondrion.","altext":"ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3871,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006387","source":"Smpdb"},{"id":14185,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006609","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z48744","genbank_protein_id":"732946","gene_card_id":"FAA4","chromosome_location":"chromosome 13","locus":"YMR246W","synonyms":["Fatty acid activator 4","Long-chain acyl-CoA synthetase 4"],"enzyme_classes":["6.2.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"AMP-binding","identifier":"PF00501"}],"pathways":[{"name":"Fatty acid metabolism","kegg_map_id":"00071"},{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"}],"gene_sequence":"ATGACCGAACAATATTCCGTTGCAGTTGGCGAAGCCGCCAATGAGCATGAAACCGCTCCAAGAAGAAATATCAGGGTTAAAGACCAGCCTTTGATTAGACCCATAAACTCCTCAGCATCTACACTGTACGAATTCGCCCTGGAATGTTTTACCAAGGGTGGTAAGAGAGACGGTATGGCATGGAGAGATATTATAGATATACATGAGACGAAAAAAACCATAGTCAAGAGGGTGGATGGTAAGGATAAGCCCATCGAAAAAACATGGTTGTACTACGAACTGACTCCCTACATAACCATGACATACGAGGAGATGATCTGCGTAATGCACGACATTGGACGTGGGCTGATAAAGATTGGTGTTAAACCTAACGGTGAGAACAAGTTCCACATCTTTGCCTCTACTTCTCACAAGTGGATGAAAACTTTTCTTGGTTGCATGTCACAAGGTATTCCTGTGGTCACCGCGTACGACACTTTGGGTGAGAGCGGTTTGATTCACTCCATGGTGGAAACAGATTCCGTCGCCATTTTCACGGACAACCAGCTGTTGTCCAAATTAGCAGTTCCTTTGAAAACCGCCAAGAACGTAAAATTCGTCATTCACAACGAACCCATCGATCCAAGTGACAAAAGACAAAATGGTAAGCTTTACAAGGCTGCCAAGGATGCTGTTGACAAAATCAAGGAAGTTAGACCGGACATAAAAATCTACAGTTTCGATGAAATTATTGAGATAGGTAAAAAGGCCAAGGACGAGGTTGAATTGCATTTCCCCAAGCCTGAAGATCCAGCTTGTATCATGTACACTTCTGGTTCCACTGGTACACCAAAGGGTGTGGTATTGACACATTACAACATTGTAGCTGGCATTGGTGGTGTGGGCCATAACGTTATCGGATGGATTGGCCCAACAGACCGTATTATCGCATTCTTGCCATTGGCTCATATTTTTGAATTAACCTTTGAATTCGAAGCGTTCTACTGGAATGGTATCCTAGGGTACGCCAATGTCAAGACTTTAACCCCAACTTCTACACGTAATTGCCAAGGTGACCTGATGGAGTTTAAACCTACCGTAATGGTGGGTGTCGCCGCAGTTTGGGAAACAGTGAGAAAAGGTATCCTGGCCAAGATCAACGAATTGCCCGGTTGGTCTCAAACGCTTTTCTGGACTGTCTATGCTTTGAAAGAGAGAAATATACCATGTAGCGGCTTGCTGAGTGGGTTGATCTTCAAGAGAATCAGAGAAGCAACCGGTGGAAACTTAAGGTTTATTCTGAACGGTGGGTCTGCAATCAGCATAGACGCCCAAAAATTCCTCTCCAACCTTCTATGTCCTATGCTCATTGGATATGGGCTAACTGAGGGTGTGGCTAATGCCTGTGTCCTGGAGCCTGAACATTTTGATTACGGTATTGCTGGTGACCTTGTCGGAACTATTACAGCTAAATTGGTGGATGTCGAAGATTTGGGCTATTTTGCCAAGAATAATCAAGGTGAATTGCTGTTTAAGGGTGCACCCATCTGTTCTGAATACTATAAGAATCCTGAAGAAACTGCTGCGGCCTTTACCGATGATGGCTGGTTCCGTACCGGTGATATCGCTGAATGGACCCCCAAGGGACAAGTTAAGATCATTGATAGAAAGAAAGGTTTGGTTAAGACCTTAAATGGTGAGTACATTGCATTGGAAAAATTAGAATCCATTTACAGATCAAATCCTTACGTCCAAAACATCTGTGTCTACGCTGATGAAAACAAAGTTAAGCCTGTCGGTATTGTGGTCCCTAACTTAGGACACTTGTCTAAGCTGGCTATCGAATTAGGTATAATGGTACCAGGTGAAGATGTCGAAAGCTATATCCATGAAAAGAAGCTACAGGATGCCGGTTGCAAAGATATGCTGTCAACTGCCAAATCTCAAGGCTTGAATGGTATTGAATTATTATGTGGCATTGTTTTCTTTGAAGAAGAATGGACTCCAGAAAATGGCCTTGTTACATCCGCCCAAAAATTAAAGAGAAGAGATATTCTAGCGGCTGTCAAGCCAGATGTGGAAAGAGTTTATAAAGAAAACACTTAA","protein_sequence":"MTEQYSVAVGEAANEHETAPRRNIRVKDQPLIRPINSSASTLYEFALECFTKGGKRDGMAWRDIIDIHETKKTIVKRVDGKDKPIEKTWLYYELTPYITMTYEEMICVMHDIGRGLIKIGVKPNGENKFHIFASTSHKWMKTFLGCMSQGIPVVTAYDTLGESGLIHSMVETDSVAIFTDNQLLSKLAVPLKTAKNVKFVIHNEPIDPSDKRQNGKLYKAAKDAVDKIKEVRPDIKIYSFDEIIEIGKKAKDEVELHFPKPEDPACIMYTSGSTGTPKGVVLTHYNIVAGIGGVGHNVIGWIGPTDRIIAFLPLAHIFELTFEFEAFYWNGILGYANVKTLTPTSTRNCQGDLMEFKPTVMVGVAAVWETVRKGILAKINELPGWSQTLFWTVYALKERNIPCSGLLSGLIFKRIREATGGNLRFILNGGSAISIDAQKFLSNLLCPMLIGYGLTEGVANACVLEPEHFDYGIAGDLVGTITAKLVDVEDLGYFAKNNQGELLFKGAPICSEYYKNPEETAAAFTDDGWFRTGDIAEWTPKGQVKIIDRKKNLVKTLNGEYIALEKLESIYRSNPYVQNICVYADENKVKPVGIVVPNLGHLSKLAIELGIMVPGEDVESYIHEKKLQDAVCKDMLSTAKSQGLNGIELLCGIVFFEEEWTPENGLVTSAQKLKRRDILAAVKPDVERVYKENT"},{"created_at":"2011-05-24T21:43:31.000Z","updated_at":"2011-07-22T17:54:57.000Z","name":"Long-chain-fatty-acid--CoA ligase 1","uniprot_id":"P30624","uniprot_name":"LCF1_YEAST","enzyme":true,"transporter":false,"gene_name":"FAA1","num_residues":700,"molecular_weight":"77865.79688","theoretical_pi":"7.69","general_function":"Involved in catalytic activity","specific_function":"Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities","reactions":[{"id":1512,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1513,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1516,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1517,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1518,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1520,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1521,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2380,"direction":"\u003e","locations":"Cytoplasm. Mitochondrion.","altext":"ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3871,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006387","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X66194","genbank_protein_id":"3692","gene_card_id":"FAA1","chromosome_location":"chromosome 15","locus":"YOR317W","synonyms":["Fatty acid activator 1","Long-chain acyl-CoA synthetase 1"],"enzyme_classes":["6.2.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"AMP-binding","identifier":"PF00501"}],"pathways":[{"name":"Fatty acid metabolism","kegg_map_id":"00071"},{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"}],"gene_sequence":"ATGGTTGCTCAATATACCGTTCCAGTTGGGAAAGCCGCCAATGAGCATGAAACTGCTCCAAGAAGAAATTATCAATGCCGCGAGAAGCCGCTCGTCAGACCGCCTAACACAAAGTGTTCCACTGTTTATGAGTTTGTTCTAGAGTGCTTTCAGAAGAACAAAAATTCAAATGCTATGGGTTGGAGGGATGTTAAGGAAATTCATGAAGAATCCAAATCGGTTATGAAAAAAGTTGATGGCAAGGAGACTTCAGTGGAAAAGAAATGGATGTATTATGAACTATCGCATTATCATTATAATTCATTTGACCAATTGACCGATATCATGCATGAAATTGGTCGTGGGTTGGTGAAAATAGGATTAAAGCCTAATGATGATGACAAATTACATCTTTACGCAGCCACTTCTCACAAGTGGATGAAGATGTTCTTAGGAGCGCAGTCTCAAGGTATTCCTGTCGTCACTGCCTACGATACTTTGGGAGAGAAAGGGCTAATTCATTCTTTGGTGCAAACGGGGTCTAAGGCCATTTTTACCGATAACTCTTTATTACCATCCTTGATCAAACCAGTGCAAGCCGCTCAAGACGTAAAATACATAATTCATTTCGATTCCATCAGTTCTGAGGACAGGAGGCAAAGTGGTAAGATCTATCAATCTGCTCATGATGCCATCAACAGAATTAAAGAAGTTAGACCTGATATCAAGACCTTTAGCTTTGACGACATCTTGAAGCTAGGTAAAGAATCCTGTAACGAAATCGATGTTCATCCACCTGGCAAGGATGATCTTTGTTGCATCATGTATACGTCTGGTTCTACAGGTGAGCCAAAGGGTGTTGTCTTGAAACATTCAAATGTTGTCGCAGGTGTTGGTGGTGCAAGTTTGAATGTTTTGAAGTTTGTGGGCAATACCGACCGTGTTATCTGTTTTTTGCCACTAGCTCATATTTTTGAATTGGTTTTCGAACTATTGTCCTTTTATTGGGGGGCCTGCATTGGTTATGCCACCGTAAAAACTTTAACTAGCAGCTCTGTGAGAAATTGTCAAGGTGATTTGCAAGAATTCAAGCCCACAATCATGGTTGGTGTCGCCGCTGTTTGGGAAACAGTGAGAAAAGGGATCTTAAACCAAATTGATAATTTGCCCTTCCTCACCAAGAAAATCTTCTGGACCGCGTATAATACCAAGTTGAACATGCAACGTCTCCACATCCCTGGTGGCGGCGCCTTAGGAAACTTGGTTTTCAAAAAAATCAGAACTGCCACAGGTGGCCAATTAAGATATTTGTTAAACGGTGGTTCTCCAATCAGTCGGGATGCTCAGGAATTCATCACAAATTTAATCTGCCCTATGCTTATTGGTTACGGTTTAACCGAGACATGCGCTAGTACCACCATCTTGGATCCTGCTAATTTTGAACTCGGCGTCGCTGGTGACCTAACAGGTTGTGTTACCGTCAAACTAGTTGATGTTGAAGAATTAGGTTATTTTGCTAAAAACAACCAAGGTGAAGTTTGGATCACAGGTGCCAATGTCACGCCTGAATATTATAAGAATGAGGAAGAAACTTCTCAAGCTTTAACAAGCGATGGTTGGTTCAAGACCGGTGACATCGGTGAATGGGAAGCAAATGGCCATTTGAAAATAATTGACAGGAAGAAAAACTTGGTCAAAACAATGAACGGTGAATATATCGCACTCGAGAAATTAGAGTCCGTTTACAGATCTAACGAATATGTTGCTAACATTTGTGTTTATGCCGACCAATCTAAGACTAAGCCAGTTGGTATTATTGTACCAAATCATGCTCCATTAACGAAGCTTGCTAAAAAGTTGGGAATTATGGAACAAAAAGACAGTTCAATTAATATCGAAAATTATTTGGAGGATGCAAAATTGATTAAAGCTGTTTATTCTGATCTTTTGAAGACAGGTAAAGACCAAGGTTTGGTTGGCATTGAATTACTAGCAGGCATAGTGTTCTTTGACGGCGAATGGACTCCACAAAACGGTTTTGTTACGTCCGCTCAGAAATTGAAAAGAAAAGACATTTTGAATGCTGTCAAAGATAAAGTTGACGCCGTTTATAGTTCGTCTTAA","protein_sequence":"MVAQYTVPVGKAANEHETAPRRNYQCREKPLVRPPNTKCSTVYEFVLECFQKNKNSNAMGWRDVKEIHEESKSVMKKVDGKETSVEKKWMYYELSHYHYNSFDQLTDIMHEIGRGLVKIGLKPNDDDKLHLYAATSHKWMKMFLGAQSQGIPVVTAYDTLGEKGLIHSLVQTGSKAIFTDNSLLPSLIKPVQAAQDVKYIIHFDSISSEDRRQSGKIYQSAHDAINRIKEVRPDIKTFSFDDILKLGKESCNEIDVHPPGKDDLCCIMYTSGSTGEPKGVVLKHSNVVAGVGGASLNVLKFVGNTDRVICFLPLAHIFELVFELLSFYWGACIGYATVKTLTSSSVRNCQGDLQEFKPTIMVGVAAVWETVRKGILNQIDNLPFLTKKIFWTAYNTKLNMQRLHIPGGGALGNLVFKKIRTATGGQLRYLLNGGSPISRDAQEFITNLICPMLIGYGLTETCASTTILDPANFELGVAGDLTGCVTVKLVDVEELGYFAKNNQGEVWITGANVTPEYYKNEEETSQALTSDGWFKTGDIGEWEANGHLKIIDRKKNLVKTMNGEYIALEKLESVYRSNEYVANICVYADQSKTKPVGIIVPNHAPLTKLAKKLGIMEQKDSSINIENYLEDAKLIKAVYSDLLKTGKDQGLVGIELLAGIVFFDGEWTPQNGFVTSAQKLKRKDILNAVKDKVDAVYSSS"},{"created_at":"2011-05-24T21:45:48.000Z","updated_at":"2011-07-22T17:54:57.000Z","name":"Long-chain-fatty-acid--CoA ligase 3","uniprot_id":"P39002","uniprot_name":"LCF3_YEAST","enzyme":true,"transporter":false,"gene_name":"FAA3","num_residues":694,"molecular_weight":"77946.0","theoretical_pi":"9.41","general_function":"Involved in catalytic activity","specific_function":"Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. This enzyme acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10","reactions":[{"id":1512,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1513,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1516,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1517,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1518,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1520,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1521,"direction":"\u003c\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2380,"direction":"\u003e","locations":"Cytoplasm. Mitochondrion.","altext":"ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3871,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006387","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558110","genbank_protein_id":"45270110","gene_card_id":"FAA3","chromosome_location":"chromosome 9","locus":"YIL009W","synonyms":["Fatty acid activator 3","Long-chain acyl-CoA synthetase 3"],"enzyme_classes":["6.2.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"AMP-binding","identifier":"PF00501"}],"pathways":[{"name":"Fatty acid metabolism","kegg_map_id":"00071"},{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"},{"name":"Biosynthesis of unsaturated fatty acids (docosanoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (tetracosanoyl-CoA)","kegg_map_id":null}],"gene_sequence":"ATGTCCGAACAACACTCTGTCGCAGTCGGTAAAGCTGCTAATGAGCACGAGACTGCCCCTAGGAGAAATGTTAGAGTCAAGAAGCGGCCCTTAATTAGACCATTGAACTCGTCAGCATCTACGCTGTATGAATTTGCCCTAGAGTGTTTCAACAAGGGTGGAAAACGAGATGGTATGGCTTGGAGAGATGTCATCGAGATTCATGAGACAAAGAAAACCATTGTGAGAAAGGTAGACGGCAAGGATAAATCTATAGAAAAGACATGGCTGTATTATGAAATGTCACCATATAAAATGATGACCTACCAGGAACTGATCTGGGTGATGCACGATATGGGCCGTGGGCTGGCAAAAATAGGCATCAAGCCCAATGGAGAACACAAATTCCACATCTTCGCATCTACTTCCCATAAATGGATGAAGATTTTCCTTGGTTGCATATCCCAGGGTATCCCCGTAGTAACCGCGTATGATACTTTGGGTGAGAGCGGTTTGATTCACTCCATGGTTGAAACCGAGTCTGCTGCTATTTTCACTGATAATCAATTATTGGCTAAAATGATAGTGCCTTTGCAATCTGCTAAAGATATCAAATTTCTTATCCATAACGAACCTATCGACCCCAATGACAGAAGACAAAACGGCAAACTTTACAAGGCTGCTAAGGATGCCATTAATAAGATCAGAGAAGTTAGGCCAGACATAAAAATTTATAGTTTTGAAGAAGTTGTCAAGATAGGTAAAAAAAGTAAAGATGAGGTCAAACTTCATCCACCTGAGCCAAAAGATTTGGCTTGTATCATGTACACCTCGGGCTCGATCAGTGCACCAAAAGGTGTAGTATTGACTCATTATAATATTGTTTCGGGTATCGCTGGTGTAGGTCACAACGTCTTTGGATGGATCGGCTCTACAGACCGTGTTTTGTCGTTCTTGCCATTGGCTCATATTTTTGAACTGGTCTTTGAATTCGAAGCCTTTTACTGGAACGGTATTCTTGGGTACGGTAGTGTTAAGACTTTGACTAATACTTCGACTCGTAATTGTAAGGGTGACCTGGTTGAGTTTAAGCCTACTATTATGATCGGTGTGGCTGCCGTTTGGGAAACTGTGAGAAAAGCTATTTTGGAAAAGATCAGCGATTTAACTCCCGTACTCCAAAAGATTTTTTGGTCTGCCTATAGTATGAAAGAAAAGAGTGTACCATGCACCGGGTTTTTAAGTCGTATGGTCTTCAAGAAAGTCAGACAAGCCACCGGTGGTCATCTTAAGTATATTATGAACGGTGGGTCTGCGATCAGTATTGATGCTCAGAAATTCTTTTCTATCGTCCTGTGTCCTATGATTATCGGTTACGGCCTTACTGAAACAGTTGCGAATGCTTGTGTTTTGGAGCCTGATCATTTCGAATATGGTATAGTTGGTGATCTTGTTGGATCGGTCACTGCCAAATTGGTGGATGTTAAGGACCTAGGTTATTATGCAAAAAACAATCAAGGTGAATTGCTTCTAAAGGGTGCGCCGGTCTGTTCTGAATATTATAAGAATCCAATAGAAACGGCGGTCTCTTTCACTTACGATGGATGGTTTCGTACTGGTGATATTGTTGAATGGACTCCCAAGGGACAACTTAAAATTATTGATAGAAGAAAGAATTTGGTTAAAACCCTAAATGGTGAATATATTGCATTAGAAAAGTTAGAATCTGTTTACAGGTCAAACTCCTATGTGAAAAATATCTGTGTTTATGCCGATGAAAGTAGGGTTAAACCGGTGGGTATTGTGGTACCCAACCCAGGACCCCTATCTAAATTTGCTGTCAAATTGCGTATTATGAAAAAGGGTGAAGACATCGAAAACTATATCCATGACAAAGCATTACGAAATGCTGTTTTCAAAGAGATGATCGCAACAGCCAAATCTCAAGGTTTGGTTGGTATTGAACTATTATGTGGTATTGTTTTCTTTGATGAAGAATGGACACCTGAAAATGGCTTTGTCACATCTGCTCAAAAATTAAAGAGAAGAGAAATCTTAGCCGCTGTTAAATCAGAAGTCGAAAGGGTTTACAAAGAAAATTCTTAG","protein_sequence":"MSEQHSVAVGKAANEHETAPRRNVRVKKRPLIRPLNSSASTLYEFALECFNKGGKRDGMAWRDVIEIHETKKTIVRKVDGKDKSIEKTWLYYEMSPYKMMTYQELIWVMHDMGRGLAKIGIKPNGEHKFHIFASTSHKWMKIFLGCISQGIPVVTAYDTLGESGLIHSMVETESAAIFTDNQLLAKMIVPLQSAKDIKFLIHNEPIDPNDRRQNGKLYKAAKDAINKIREVRPDIKIYSFEEVVKIGKKSKDEVKLHPPEPKDLACIMYTSGSISAPKGVVLTHYNIVSGIAGVGHNVFGWIGSTDRVLSFLPLAHIFELVFEFEAFYWNGILGYGSVKTLTNTSTRNCKGDLVEFKPTIMIGVAAVWETVRKAILEKISDLTPVLQKIFWSAYSMKEKSVPCTGFLSRMVFKKVRQATGGHLKYIMNGGSAISIDAQKFFSIVLCPMIIGYGLTETVANACVLEPDHFEYGIVGDLVGSVTAKLVDVKDLGYYAKNNQGELLLKGAPVCSEYYKNPIETAVSFTYDGWFRTGDIVEWTPKGQLKIIDRRKNLVKTLNGEYIALEKLESVYRSNSYVKNICVYADESRVKPVGIVVPNPGPLSKFAVKLRIMKKGEDIENYIHDKALRNAVFKEMIATAKSQGLVGIELLCGIVFFDEEWTPENGFVTSAQKLKRREILAAVKSEVERVYKENS"},{"created_at":"2011-05-26T16:04:15.000Z","updated_at":"2011-05-27T15:00:59.000Z","name":"Fatty acid synthase subunit beta","uniprot_id":"P07149","uniprot_name":"FAS1_YEAST","enzyme":true,"transporter":false,"gene_name":"FAS1","num_residues":2051,"molecular_weight":"228689.0","theoretical_pi":"5.73","general_function":"Involved in transferase activity","specific_function":"Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for:[acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase","reactions":[{"id":2400,"direction":"\u003e","locations":"","altext":"Acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NAD(+) + 2n NADP(+).","export":false,"pw_reaction_id":null,"source":null},{"id":2401,"direction":"\u003e","locations":null,"altext":"Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null},{"id":2402,"direction":"\u003e","locations":"Mitochondrion","altext":"Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null},{"id":2403,"direction":"\u003e","locations":null,"altext":"(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] = hexadec-2-enoyl-[acyl-carrier-protein] + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2404,"direction":"\u003e","locations":null,"altext":"Acyl-[acyl-carrier-protein] + NAD(+) = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":2405,"direction":"\u003e","locations":null,"altext":"Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M30162","genbank_protein_id":"171500","gene_card_id":"FAS1","chromosome_location":"chromosome 11","locus":"YKL182W","synonyms":["3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase","Enoyl-[acyl-carrier-protein] reductase [NADH]","[Acyl-carrier-protein] acetyltransferase","[Acyl-carrier-protein] malonyltransferase","S-acyl fatty acid synthase thioesterase"],"enzyme_classes":["2.3.1.86","4.2.1.61","1.3.1.9","2.3.1.38","2.3.1.39","3.1.2.14"],"go_classes":[{"category":"Component","description":" fatty acid synthase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" fatty acid synthase activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"}],"pfams":[{"name":"Acyl_transf_1","identifier":"PF00698"},{"name":"DUF1729","identifier":"PF08354"},{"name":"MaoC_dehydratas","identifier":"PF01575"}],"pathways":[{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"}],"gene_sequence":"ATGGACGCTTACTCCACAAGACCATTAACCCTATCTCACGGTTCTTTAGAGCACGTGCTTCTGGTACCAACCGCTTCATTTTTCATTGCTTCGCAATTACAAGAACAATTTAATAAAATTTTGCCCGAACCCACTGAAGGGTTTGCTGCAGATGACGAGCCTACCACACCTGCTGAACTAGTGGGGAAATTCCTTGGCTACGTATCTTCTCTAGTCGAACCTTCCAAGGTCGGTCAATTCGATCAGGTCTTGAACCTTTGCTTAACAGAATTTGAAAACTGTTATTTAGAAGGCAATGACATTCACGCCTTGGCTGCTAAACTATTACAGGAAAACGACACAACTTTAGTGAAGACTAAAGAACTAATTAAAAATTATATTACCGCCAGAATAATGGCTAAGAGACCATTTGACAAAAAATCCAACTCTGCTCTTTTTAGGGCCGTCGGCGAGGGTAACGCACAATTGGTAGCCATTTTCGGTGGTCAAGGTAACACCGACGACTACTTTGAAGAATTGCGTGATCTATATCAAACTTATCATGTCTTAGTGGGAGATTTAATCAAGTTCTTCGCTGAAACTTTAAGTGAACTGATTAGAACTACTTTAGATGCTGAAAAAGTCTTTACTCAAGGTTTAAACATATTGGAATGGTTGGAGAACCCTTCAAATACCCCAGACAAGGACTATTTACTTTCCATTCCAATTTCATGCCCCTTAATTGGTGTCATTCAATTGGCTCACTACGTAGTTACTGCCAAGCTTTTGGGTTTCACTCCAGGTGAGTTAAGATCTTACTTAAAAGGTGCTACAGGTCACTCTCAAGGTTTGGTTACTGCTGTCGCCATAGCTGAGACGGATTCCTGGGAATCCTTCTTCGTCTCCGTAAGAAAAGCAATTACTGTATTATTCTTCATCGGTGTTCGTTGTTACGAAGCATACCCAAACACTTCCCTACCACCATCCATCTTGGAAGATTCCTTGGAAAACAATGAAGGTGTTCCATCTCCAATGTTGTCCATTTCCAATCTAACTCAAGAACAAGTTCAAGACTATGTAAATAAGACTAACTCTCATTTGCCAGCTGGTAAACAAGTTGAAATTTCTCTAGTCAATGGTGCGAAGAATCTAGTCGTATCGGGCCCACCACAATCATTATATGGTTTAAACTTGACTTTAAGAAAGGCCAAGGCCCCATCTGGACTGGATCAATCAAGAATCCCATTCAGCGAAAGAAAATTGAAGTTCTCCAATAGGTTCTTACCTGTTGCATCACCATTCCATTCCCATCTATTGGTTCCAGCTTCAGATTTGATTAACAAAGACTTAGTCAAAAACAATGTCAGCTTTAACGCTAAAGATATTCAAATCCCCGTTTACGACACTTTTGATGGTTCAGATCTAAGAGTCCTTTCAGGTTCCATTTCCGAGAGAATCGTCGACTGCATCATTAGATTACCTGTCAAATGGGAAACTACTACACAATTCAAAGCCACCCACATATTAGACTTTGGTCCAGGTGGAGCTTCCGGTTTAGGTGTTTTAACCCATCGTAATAAAGATGGTACTGGTGTTCGTGTTATCGTTGCCGGTACTCTCGACATTAACCCAGATGATGATTACGGATTCAAGCAAGAAATCTTTGATGTTACTAGTAATGGTTTGAAGAAAAATCCAAACTGGTTGGAAGAATACCATCCAAAATTAATTAAGAACAAATCAGGCAAAATTTTTGTCGAAACAAAATTTTCTAAATTAATCGGTAGACCACCTTTATTGGTTCCTGGTATGACACCATGTACTGTTTCTCCAGATTTCGTAGCTGCTACCACAAATGCTGGTTATACCATTGAGTTGGCCGGTGGTGGTTACTTTTCCGCAGCAGGTATGACCGCCGCTATTGATTCTGTGGTTTCTCAGATAGAAAAGGGTAGTACCTTCGGTATCAACTTGATCTACGTCAATCCATTTATGTTACAATGGGGTATTCCATTAATCAAGGAACTAAGAAGCAAAGGTTATCCAATTCAATTCTTGACCATTGGTGCTGGTGTCCCATCATTGGAAGTTGCTAGTGAATACATAGAGACATTAGGTTTGAAGTACTTGGGTTTGAAACCAGGTTCCATTGATGCTATTTCGCAAGTTATAAACATTGCTAAAGCACATCCAAACTTCCCAATAGCTTTACAATGGACCGGTGGTAGAGGTGGTGGTCATCATTCTTTCGAAGATGCCCACACTCCAATGTTACAAATGTACTCCAAGATTAGAAGACATCCAAACATTATGTTGATATTCGGTTCTGGTTTCGGTTCTGCTGATGACACTTACCCATACTTAACCGGTGAATGGTCCACAAAATTCGATTATCCACCAATGCCATTCGATGGTTTCCTATTTGGTTCGAGGGTCATGATTGCTAAGGAAGTTAAAACTTCTCCTGATGCTAAGAAGTGTATTGCTGCTTGTACTGGTGTTCCTGATGATAAATGGGAACAAACCTACAAGAAGCCAACTGGTGGTATTGTCACTGTTCGCTCTGAAATGGGTGAACCAATTCACAAAATTGCCACTCGTGGTGTTATGCTATGGAAGGAATTCGACGAAACCATCTTCAACTTACCAAAGAATAAGTTGGTACCAACTTTGGAAGCAAAGAGAGATTACATTATCTCAAGATTGAACGCCGATTTCCAAAAACCATGGTTTGCTACCGTCAACGGTCAAGCCCGTGACCTAGCCACAATGACATACGAAGAAGTTGCAAAGAGATTGGTGGAATTAATGTTCATCAGATCTACCAACTCTTGGTTTGATGTCACATGGAGAACCTTTACTGGTGATTTCCTACGTCGTGTCGAAGAACGTTTCACTAAAAGTAAGACATTGTCTTTAATCCAATCCTATTCTCTACTAGACAAGCCTGATGAAGCTATTGAAAAAGTATTTAATGCTTATCCTGCCGCTAGGGAACAGTTCTTGAATGCGCAAGATATTGATCACTTTTTGAGCATGTGTCAAAATCCAATGCAAAAACCAGTGCCTTTTGTTCCAGTTTTGGATCGTAGATTCGAGATTTTTTTCAAAAAAGATTCGTTATGGCAATCTGAGCAATTGGAAGCCGTCGTCGACCAAGACGTTCAAAGAACATGTATCCTACATGGACCTGTTGCAGCACAATTCACTAAAGTCATCGATGAACCAATTAAGAGCATTATGGATGGTATTCACGATGGTCACATCAAAAAGTTACTACATCAATATTACGGTGACGATGAGTCAAAGATTCCAGCAGTTGAGTACTTTGGTGGTGAAAGCCCTGTAGACGTACAAAGTCAAGTTGATTCTTCCTCTGTATCTGAAGACTCAGCTGTTTTTAAGGCAACATCCTCTACTGATGAAGAAAGCTGGTTTAAGGCTTTGGCGGGATCCGAAATTAACTGGAGACATGCAAGTTTCTTATGTTCCTTTATCACTCAAGATAAAATGTTTGTTTCTAACCCAATTAGAAAAGTTTTCAAGCCAAGCCAAGGAATGGTTGTTGAGTTTTCCAACGGCAATACTTCTTCAAAGACTGTTGTCACTCTTTCAGAACCTGTTCAAGGTGAATTGAAACCAACTGTTATTTTGAAGTTGTTGAAGGAGAACATAATCCAAATGGAAATGATTGAGAACAGAACTATGGATGGTAAGCCCGTCAGCTTGCCATTGTTGTACAACTTCAACCCAGATAATGGTTTTGCTCCAATCTCTGAAGTTATGGAGGACAGAAACCAAAGAATTAAGGAAATGTACTGGAAATTATGGATTGATGAGCCTTTCAATTTGGACTTTGACCCAAGAGATGTCATTAAGGGCAAAGATTTCGAGATCACCGCTAAAGAAGTTTATGACTTTACACACGCTGTTGGAAACAATTGTGAAGACTTCGTTTCTAGACCTGATAGAACGATGTTGGCCCCAATGGACTTTGCTATTGTTGTCGGATTGAGAGGCATCATCAAGGCCATTTTCCCTAATACGGTCGATGGTGACTTATTGAAGTTGGTTCATTTGTCTAACGGCTACAAGATGATTCCTGGCGCTAAGCCACTGCAAGTTGGTGATGTTGTTTCAACTACTGCTGTTATTGAATCTGTCGTCAACCAACCTACAGGAAAGATTGTCGATGTGGTAGGTACATTATCGAGAAATGGCAAGCCTGTCATGGAAGTCACCTCCTCATTCTTCTACAGAGGCAACTATACTGACTTTGAAAACACTTTCCAAAAGACTGTTGAACCTGTTTATCAAATGCACATCAAAACTTCTAAAGATATAGCTGTCTTGCGCTCTAAGGAGTGGTTCCAATTGGACGATGAAGACTTCGATCTGTTAAACAAAACTTTGACTTTCGAAACTGAAACTGAAGTTACTTTCAAGAATGCTAACATCTTCTCTTCAGTGAAATGTTTTGGCCCAATTAAAGTTGAATTGCCAACCAAAGAAACCGTGGAGATCGGTATTGTCGATTACGAAGCCGGTGCCTCTCACGGTAACCCTGTTGTTGATTTCTTGAAGAGAAACGGTTCCACATTGGAACAAAAGGTCAATCTAGAAAATCCTATTCCAATTGCAGTACTTGATTCGTACACTCCAAGTACCAACGAACCATACGCTAGAGTTTCTGGTCATTTGAATCCAATTCACGTTTCACGTCATTTTGCCTCTTACGCAAACTTGCCAGGTACTATCACGCACGGTATGTTTTCTTCTGCTTCCGTCCGTGCTTTGATTGAAAACTGGGCTGCTGACAGTGTTTCATCCAGGGTACGTGGCTACACTTGTCAATTTGTTGACATGGTTTTGCCTAACACTGCTTTGAAAACATCGATTCAACATGTTGGTATGATCAATGGTAGAAAATTGATAAAGTTTGAAACTAGAAATGAAGATGACGTTGTAGTTTTGACTGGTGAAGCCGAAATTGAACAACCTGGTACTACCTTCGTTTTCACTGGTCAAGGTTCACAAGAACAAGGTATGGGTATGGACTTATACAAAACTTCTAAAGCTGCTCAAGATGTTTGGAATAGAGCTGACAACCATTTCAAGGACACTTATGGTTTCTCTATCTTAGACATTGTCATTAACAACCCAGTTAACTTAACAATTCACTTCGGTGGTGAAAAGGGTAAGAGGATCAGAGAAAACTATTCTGCTATGATCTTTGAGACTATCGTGGATGGAAAATTGAAGACTGAAAAAATTTTCAAGGAAATTAATGAGCACAGTACTTCTTACACATTTAGATCTGAAAAAGGTTTATTGTCTGCTACTCAATTTACACAACCAGCTTTAACTTTGATGGAAAAAGCTGCTTTCGAAGACTTGAAATCTAAAGGTTTGATCCCAGCCGATGCTACTTTTGCTGGTCACTCTTTAGGTGAGTATGCTGCTTTGGCCTCTTTGGCTGATGTTATGTCTATCGAATCTTTAGTTGAAGTTGTGTTCTACAGAGGTATGACTATGCAAGTTGCTGTTCCAAGAGATGAGTTGGGCAGATCCAACTATGGTATGATTGCCATTAACCCAGGTAGAGTCGCTGCATCATTCTCTCAAGAAGCTTTGCAATATGTTGTTGAGAGAGTTGGTAAGAGAACCGGCTGGTTGGTTGAAATCGTCAACTACAACGTTGAAAACCAACAATATGTTGCAGCTGGTGATCTAAGAGCTTTAGACACCGTTACCAATGTTCTAAACTTCATCAAATTACAAAAAATTGATATTATTGAACTACAAAAGTCCTTATCTTTGGAAGAAGTTGAAGGTCATTTGTTTGAGATCATTGACGAAGCTTCCAAGAAATCTGCTGTCAAGCCTCGCCCACTTAAATTGGAGAGAGGTTTTGCTTGTATCCCATTAGTTGGTATTTCTGTTCCTTTCCATTCCACCTACTTGATGAATGGTGTTAAACCATTCAAGAGTTTCTTGAAGAAGAATATCATAAAAGAAAATGTGAAGGTTGCTAGATTGGCCGGAAAGTACATTCCAAACTTGACTGCAAAACCATTCCAGGTTACTAAGGAATATTTCCAGGACGTTTATGATTTGACTGGCTCCGAACCTATCAAGGAAATCATCGACAACTGGGAAAAGTATGAACAATCCTAA","protein_sequence":"MDAYSTRPLTLSHGSLEHVLLVPTASFFIASQLQEQFNKILPEPTEGFAADDEPTTPAELVGKFLGYVSSLVEPSKVGQFDQVLNLCLTEFENCYLEGNDIHALAAKLLQENDTTLVKTKELIKNYITARIMAKRPFDKKSNSALFRAVGEGNAQLVAIFGGQGNTDDYFEELRDLYQTYHVLVGDLIKFSAETLSELIRTTLDAEKVFTQGLNILEWLENPSNTPDKDYLLSIPISCPLIGVIQLAHYVVTAKLLGFTPGELRSYLKGATGHSQGLVTAVAIAETDSWESFFVSVRKAITVLFFIGVRCYEAYPNTSLPPSILEDSLENNEGVPSPMLSISNLTQEQVQDYVNKTNSHLPAGKQVEISLVNGAKNLVVSGPPQSLYGLNLTLRKAKAPSGLDQSRIPFSERKLKFSNRFLPVASPFHSHLLVPASDLINKDLVKNNVSFNAKDIQIPVYDTFDGSDLRVLSGSISERIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGVLTHRNKDGTGVRVIVAGTLDINPDDDYGFKQEIFDVTSNGLKKNPNWLEEYHPKLIKNKSGKIFVETKFSKLIGRPPLLVPGMTPCTVSPDFVAATTNAGYTIELAGGGYFSAAGMTAAIDSVVSQIEKGSTFGINLIYVNPFMLQWGIPLIKELRSKGYPIQFLTIGAGVPSLEVASEYIETLGLKYLGLKPGSIDAISQVINIAKAHPNFPIALQWTGGRGGGHHSFEDAHTPMLQMYSKIRRHPNIMLIFGSGFGSADDTYPYLTGEWSTKFDYPPMPFDGFLFGSRVMIAKEVKTSPDAKKCIAACTGVPDDKWEQTYKKPTGGIVTVRSEMGEPIHKIATRGVMLWKEFDETIFNLPKNKLVPTLEAKRDYIISRLNADFQKPWFATVNGQARDLATMTYEEVAKRLVELMFIRSTNSWFDVTWRTFTGDFLRRVEERFTKSKTLSLIQSYSLLDKPDEAIEKVFNAYPAAREQFLNAQDIDHFLSMCQNPMQKPVPFVPVLDRRFEIFFKKDSLWQSEHLEAVVDQDVQRTCILHGPVAAQFTKVIDEPIKSIMDGIHDGHIKKLLHQYYGDDESKIPAVEYFGGESPVDVQSQVDSSSVSEDSAVFKATSSTDEESWFKALAGSEINWRHASFLCSFITQDKMFVSNPIRKVFKPSQGMVVEISNGNTSSKTVVTLSEPVQGELKPTVILKLLKENIIQMEMIENRTMDGKPVSLPLLYNFNPDNGFAPISEVMEDRNQRIKEMYWKLWIDEPFNLDFDPRDVIKGKDFEITAKEVYDFTHAVGNNCEDFVSRPDRTMLAPMDFAIVVGWRAIIKAIFPNTVDGDLLKLVHLSNGYKMIPGAKPLQVGDVVSTTAVIESVVNQPTGKIVDVVGTLSRNGKPVMEVTSSFFYRGNYTDFENTFQKTVEPVYQMHIKTSKDIAVLRSKEWFQLDDEDFDLLNKTLTFETETEVTFKNANIFSSVKCFGPIKVELPTKETVEIGIVDYEAGASHGNPVVDFLKRNGSTLEQKVNLENPIPIAVLDSYTPSTNEPYARVSGDLNPIHVSRHFASYANLPGTITHGMFSSASVRALIENWAADSVSSRVRGYTCQFVDMVLPNTALKTSIQHVGMINGRKLIKFETRNEDDVVVLTGEAEIEQPVTTFVFTGQGSQEQGMGMDLYKTSKAAQDVWNRADNHFKDTYGFSILDIVINNPVNLTIHFGGEKGKRIRENYSAMIFETIVDGKLKTEKIFKEINEHSTSYTFRSEKGLLSATQFTQPALTLMEKAAFEDLKSKGLIPADATFAGHSLGEYAALASLADVMSIESLVEVVFYRGMTMQVAVPRDELGRSNYGMIAINPGRVAASFSQEALQYVVERVGKRTGWLVEIVNYNVENQQYVAAGDLRALDTVTNVLNFIKLQKIDIIELQKSLSLEEVEGHLFEIIDEASKKSAVKPRPLKLERGFACIPLVGISVPFHSTYLMNGVKPFKSFLKKNIIKENVKVARLAGKYIPNLTAKPFQVTKEYFQDVYDLTGSEPIKEIIDNWEKYEQS"}]}