{"ymdb_id":"YMDB00879","created_at":"2011-05-29T19:00:46.000Z","updated_at":"2016-09-08T18:36:01.000Z","name":"5,10-Methenyltetrahydrofolate","cas":"7444-29-3","state":"Solid","melting_point":null,"description":"5,10-Methenyltetrahydrofolate is a substrate in the tetrahydrofolate salvage pathway. Tetrahydrofolate (vitamin B9) and its derivatives, commonly termed folates, are essential cofactors that facilitate the transfer of one-carbon units from donor molecules into important biosynthetic pathways leading to methionine, purine, and pyrimidine biosynthesis. Folates also mediate the interconversion of serine and glycine, and play a role in histidine catabolism. [Biocyc PWY-6613]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":"HMDB01354","kegg_id":"C00445","pubchem_id":"644350","cs_id":null,"foodb_id":null,"wikipedia_link":"5,10-methenyltetrahydrofolate","biocyc_id":"5,10-methenyl-thf","iupac":"3-amino-8-(4-{[(1S)-1,3-dicarboxypropyl]carbamoyl}phenyl)-1-oxo-1H,4H,5H,6H,6aH,7H,8H-10λ⁵-imidazo[1,5-f]pteridin-10-ylium","traditional_iupac":"3-amino-8-(4-{[(1S)-1,3-dicarboxypropyl]carbamoyl}phenyl)-1-oxo-4H,5H,6H,6aH,7H-10λ⁵-imidazo[1,5-f]pteridin-10-ylium","logp":"-4.915939549471744","pka":"4.050927208428313","alogps_solubility":"1.19e-01 g/l","alogps_logp":"-0.65","alogps_logs":"-3.62","acceptor_count":"11","donor_count":"6","rotatable_bond_count":"7","polar_surface_area":"189.46000000000004","refractivity":"134.1721","polarizability":"44.17702617780863","formal_charge":"1","physiological_charge":"-2","pka_strongest_basic":"1.2667928727760485","pka_strongest_acidic":"3.218475459914346","bioavailability":"0","number_of_rings":"4","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["(6R)-5,10-CH2-H4folate","(6r)-5,10-methenyltetrahydrofolate","(6R)-5,10-methylenetetrahydrofolate","5,10-methenyl-THF","5,10-Methenyltetrahydrofolate","anhydro-leucovorin","anhydro-leucovorin a","anhydroleucovorin","anhydroleucovorin a","ch-thf","methenyl-tetrahydrofolate","methenyl-thf","methenyltetrahydrofolate","methenyltetrahydrofolic acid","N-(5,10-methylene-5,6,7,8-tetrahydropteroyl)-L-glutamate","n5-n10-ch-thf","n5-n10-methenyltetrahydrofolate","n5,n10-methenyl-5,6,7,8-tetrahydrofolate","n5,n10-methenyl-tetrahydrofolate"],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":8218174,"citation":"Yang, X. M., MacKenzie, R. E. (1993). \"NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene.\" Biochemistry 32:11118-11123."},{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."}],"proteins":[{"created_at":"2011-05-26T17:51:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"C-1-tetrahydrofolate synthase, mitochondrial","uniprot_id":"P09440","uniprot_name":"C1TM_YEAST","enzyme":true,"transporter":false,"gene_name":"MIS1","num_residues":975,"molecular_weight":"106216.0","theoretical_pi":"9.02","general_function":"Involved in formate-tetrahydrofolate ligase activity","specific_function":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH","reactions":[{"id":1548,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1727,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1733,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2488,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2489,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":2490,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":3849,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006370","source":"Smpdb"},{"id":3850,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006371","source":"Smpdb"},{"id":3851,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006372","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"J03724","genbank_protein_id":"171953","gene_card_id":"MIS1","chromosome_location":"chromosome 2","locus":"YBR084W","synonyms":["C1-THF synthase","Methylenetetrahydrofolate dehydrogenase","Methenyltetrahydrofolate cyclohydrolase","Formyltetrahydrofolate synthetase"],"enzyme_classes":["1.5.1.5","3.5.4.9","6.3.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" formate-tetrahydrofolate ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"FTHFS","identifier":"PF01268"},{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTTGTCGAGACTATCTTTATTGAGTAACTCGAGGGCGTTCCAACAGGCCAGATGGCGCATTTACCGCTTAAAAGTTTCGCCAACTGTGCATGCTTCTCAATACCATATTCTTTCTGGTAGGAAACTTGCTCAATCTATTCGAGAAAAAGCCAATGATGAGATACAAGCCATTAAGCTTAAGCATCCTAATTTCAAGCCTACCTTGAAAATCATTCAAGTCGGGGCCAGACCAGACTCATCTACGTACGTGAGGATGAAATTGAAAGCTTCAAAGGACAGCAATGTAGACTGTATCATAGAGAAGTTACCAGCAGAAATCACTGAAGTTGAGCTTTTGAAGAAAATTAGTGACATCAATGATGATGACTCTATCCATGGGTTGCTAATTCAACTACCTCTACCGCGTCACTTGGATGAAACCACGATTACAAACGCTGTGGACTTTAAAAAGGACGTTGATGGGTTCCACAGATATAATGCTGGTGAATTGGCTAAAAAAGGAGGGAAACCATACTTCATACCATGTACTCCTTATGGTTGCATGAAATTACTTGAAGAAGCTCATGTTAAGTTAGATGGTAAGAACGCCGTCGTGTTAGGCAGATCAAGTATCGTCGGAAATCCAATTGCTTCGTTGTTGAAAAATGCGAATGCCACTGTTACTGTCTGTCATAGTCATACAAGGAACATTGCAGAAGTGGTCTCCCAAGCTGATATAGTTATCGCAGCTTGCGGTATTCCTCAATACGTTAAATCAGACTGGATTAAAGAAGGCGCCGTGGTTATTGATGTAGGTATCAACTACGTACCTGATATCAGTAAGAAAAGTGGGCAAAAATTAGTTGGTGATGTTGATTTTGATTCTGTAAAGGAAAAGACATCTTATATTACCCCTGTTCCTGGTGGAGTGGGTCCAATGACTGTCGCTATGCTTGTTTCCAATGTACTATTAGCTGCTAAAAGGCAATTCGTGGAATCTGAAAAGCTTCCAGTTATCAAACCTCTTCCATTACACTTAGAAAGTCCAGTGCCTTCAGATATTGATATATCAAGAGCTCAGAGTCCTAAGCATATCAAGCAAGTTGCCGAGGAGTTGGGAATCCACTCTCACGAATTAGAATTATACGGCCACTATAAGGCAAAAATTTCTCCAAATATTTTTAAAAGATTAGAATCTAGAGAAAACGGTAAGTACGTCCTTGTTGCAGGTATTACTCCGACTCCATTGGGTGAAGGTAAATCCACTACGACTATGGGGTTGGTGCAGGCTTTATCCGCTCATTTAGGGAAACCATCCATCGCGAACGTTAGACAACCATCTCTTGGCCCAACCCTGGGTGTCAAAGGTGGTGCTGCTGGTGGTGGTTATGCCCAAGTTATTCCTATGGACGAGTTCAATTTACATTTGACCGGGGATATTCATGCTATCAGCGCTGCGAACAATCTTCTTGCAGCAGCTATCGACACTAGAATGTTCCATGAAGCCACTCAGAAGAATGATAGTACATTTTACAAGAGACTAGTTCCAAGAAAAAAAGGCATCAGAAAGTTTACCCCATCCATGCAGAGAAGGCTTAAAAGATTGGATATTGAAAAAGAAGACCCTGATGCTTTAACACCTGAAGAAGTCAAAAGATTTGCTAGATTGAACATAAATCCCGATACTATCACTATCAGAAGAGTTGTCGACATCAATGACAGGATGTTAAGACAAATTACCATTGGCGAAGCCGCTACGGAGAAGGGTTTTACAAGGACCACTGGATTCGATATCACTGTTGCCTCTGAATTAATGGCCATTTTAGCTCTATCTAAAAGCTTACACGAGATGAAGGAACGTATTGGACGCATGGTTATTGGTGCTGATTATGATAACAAACCAGTAACAGTAGAAGATATTGGCTGTACCGGTGCTCTGACTGCATTATTACGTGACGCTATAAAGCCTAACTTAATGCAAACTTTGGAAGGGACCCCCGTAATGGTTCACGCTGGTCCTTTCGCCAACATCTCCATCGGCGCATCATCAGTAATTGCAGACTTAATGGCATTGAAGCTTGTTGGTTCAGAAAAGAACCCGTTAAATGACAAGAACATCCATGAACCTGGTTATGTAGTTACTGAAGCAGGATTCGATTTTGCCATGGGTGGTGAAAGATTCTTTGATATCAAATGTCGTTCCTCTGGATTGGTGCCAGATGCAGTTGTCTTAGTCGCAACCGTAAGAGCTTTGAAATCTCATGGAGGTGCTCCAAATGTTAAGCCCGGACAATCATTACCAAAAGAATACACAGAGGAAAACATCGATTTTGTTGCCAAGGGTGTTAGTAATTTGGTTAAGCAGATTGAAAACATCAAAACGTTTGGAATACCAGTCGTTGTAGCAATCAACAGATTTGAAACAGACTCACAGGCAGAGATTGAGGTAATCAAGAAAGCAGCCTTGAATGCTGGCGCATCTCATGCCGTTACTTCTAATCACTGGATGGAAGGTGGTAAAGGTGCAGTAGAATTAGCACATGCTGTGGTAGATGCAACGAAAGAACCAAAGAACTTTAACTTTTTGTACGACGTCAATAGCTCCATCGAGGACAAGCTTACCAGCATCGTCCAAAAAATGTATGGTGGGGCAAAAATCGAAGTATCACCAGAAGCCCAAAAAAAGATAGACACCTACAAAAAACAAGGCTTCGGTAATCTTCCCATCTGTATTGCTAAGACACAATATTCATTATCCCATGATCCATCATTAAAGGGTGTTCCTAGAGGTTTTACGTTCCCCATCAGGGATGTGAGAGCTTCAATAGGTGCAGGTTATTTATACGCTTTGGCTGCAGAAATTCAAACCATACCGGGTCTATCGACATATGCTGGTTACATGGCAGTAGAAGTCGACGACGACGGTGAAATTGAAGGTCTATTTTAA","protein_sequence":"MLSRLSLLSNSRAFQQARWRIYRLKVSPTVHASQYHILSGRKLAQSIREKANDEIQAIKLKHPNFKPTLKIIQVGARPDSSTYVRMKLKASKDSNVDCIIEKLPAEITEVELLKKISDINDDDSIHGLLIQLPLPRHLDETTITNAVDFKKDVDGFHRYNAGELAKKGGKPYFIPCTPYGCMKLLEEAHVKLDGKNAVVLGRSSIVGNPIASLLKNANATVTVCHSHTRNIAEVVSQADIVIAACGIPQYVKSDWIKEGAVVIDVGINYVPDISKKSGQKLVGDVDFDSVKEKTSYITPVPGGVGPMTVAMLVSNVLLAAKRQFVESEKLPVIKPLPLHLESPVPSDIDISRAQSPKHIKQVAEELGIHSHELELYGHYKAKISPNIFKRLESRENGKYVLVAGITPTPLGEGKSTTTMGLVQALSAHLGKPSIANVRQPSLGPTLGVKGGAAGGGYAQVIPMDEFNLHLTGDIHAISAANNLLAAAIDTRMFHEATQKNDSTFYKRLVPRKKGIRKFTPSMQRRLKRLDIEKEDPDALTPEEVKRFARLNINPDTITIRRVVDINDRMLRQITIGEAATEKGFTRTTGFDITVASELMAILALSKSLHEMKERIGRMVIGADYDNKPVTVEDIGCTGALTALLRDAIKPNLMQTLEGTPVMVHAGPFANISIGASSVIADLMALKLVGSEKNPLNDKNIHEPGYVVTEAGFDFAMGGERFFDIKCRSSGLVPDAVVLVATVRALKSHGGAPNVKPGQSLPKEYTEENIDFVAKGVSNLVKQIENIKTFGIPVVVAINRFETDSQAEIEVIKKAALNAGASHAVTSNHWMEGGKGAVELAHAVVDATKEPKNFNFLYDVNSSIEDKLTSIVQKMYGGAKIEVSPEAQKKIDTYKKQGFGNLPICIAKTQYSLSHDPSLKGVPRGFTFPIRDVRASIGAGYLYALAAEIQTIPGLSTYAGYMAVEVDDDGEIEGLF"},{"created_at":"2011-05-26T17:53:55.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"C-1-tetrahydrofolate synthase, cytoplasmic","uniprot_id":"P07245","uniprot_name":"C1TC_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE3","num_residues":946,"molecular_weight":"102204.0","theoretical_pi":"6.83","general_function":"Involved in formate-tetrahydrofolate ligase activity","specific_function":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH","reactions":[{"id":1548,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1727,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1733,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2488,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2489,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":2490,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY692966","genbank_protein_id":"51013383","gene_card_id":"ADE3","chromosome_location":"chromosome 7","locus":"YGR204W","synonyms":["C1-THF synthase","Methylenetetrahydrofolate dehydrogenase","Methenyltetrahydrofolate cyclohydrolase","Formyltetrahydrofolate synthetase"],"enzyme_classes":["1.5.1.5","3.5.4.9","6.3.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" formate-tetrahydrofolate ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"FTHFS","identifier":"PF01268"},{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGGCTGGTCAAGTGTTGGACGGCAAAGCATGCGCTCAGCAGTTTAGAAGCAATATTGCTAATGAAATCAAAAGCATTCAAGGTCACGTGCCTGGGTTTGCACCTAACCTTGCCATCATTCAAGTAGGCAACAGACCAGACTCAGCCACATATGTACGCATGAAGCGTAAGGCAGCTGAAGAGGCCGGCATTGTTGCTAATTTCATTCATTTAGATGAATCCGCTACTGAATTTGAAGTTCTGCGTTACGTGGACCAGCTGAATGAGGACCCACATACACACGGTATTATCGTGCAACTACCATTACCCGCTCATTTGGACGAGGATAGAATCACCTCGAGAGTGTTGGCAGAAAAGGACGTGGACGGGTTCGGGCCCACCAACATTGGCGAATTGAATAAGAAGAACGGACACCCATTCTTTTTGCCCTGCACGCCCAAGGGGATCATTGAGCTGCTTCACAAGGCCAACGTCACGATTGAAGGTTCCCGGTCCGTTGTGATCGGAAGATCTGACATTGTTGGCTCTCCTGTTGCAGAATTGTTAAAATCTCTAAACTCCACCGTCACCATCACTCATTCTAAAACCCGTGATATCGCATCATACTTACACGACGCGGACATCGTAGTCGTTGCCATCGGCCAACCAGAATTTGTGAAGGGTGAATGGTTCAAACCAAGAGACGGCACTTCCAGTGATAAGAAAACCGTGGTAATTGATGTTGGCACCAACTACGTTGCTGATCCTTCCAAAAAGTCCGGTTTCAAATGTGTTGGTGACGTTGAGTTCAATGAAGCAATCAAATACGTCCATCTAATCACTCCAGTGCCCGGTGGTGTGGGCCCCATGACGGTGGCTATGTTAATGCAAAATACCTTGATTGCTGCCAAACGCCAAATGGAAGAATCCTCGAAGCCTTTGCAGATTCCTCCCTTGCCATTGAAGTTGCTAACACCTGTTCCTTCCGATATAGACATCTCCAGAGCACAACAGCCAAAGCTTATCAACCAGCTTGCTCAAGAATTGGGTATTTACTCTCATGAGTTGGAGCTGTACGGACATTACAAGGCCAAAATTTCTCCTAAAGTCATCGAAAGGCTGCAGACGCGCCAAAATGGTAAGTACATCTTGGTGTCTGGTATCACACCAACACCACTGGGAGAGGGTAAATCCACTACAACAATGGGTCTTGTCCAGGCACTAACGGCTCACTTGGGCAAGCCAGCCATTGCGAACGTCAGACAACCCTCCCTAGGACCCACTTTAGGTGTCAAAGGTGGTGCTGCGGGTGGTGGTTATTCCCAAGTCATCCCAATGGACGAATTCAACTTACATTTGACTGGTGACATTCACGCCATTGGTGCGGCTAACAACCTACTTGCTGCCGCTATTGACACTAGAATGTTCCATGAGACCACTCAAAAGAACGACGCTACCTTCTACAACAGACTAGTGCCTAGAAAGAACGGAAAGAGAAAGTTTACTCCCTCCATGCAAAGAAGATTGAACAGACTGGGTATTCAAAAGACCAACCCCGATGATCTAACACCCGAAGAGATCAACAAATTCGCCAGATTGAACATTGACCCGGACACTATTACTATCAAGAGGGTGGTCGATATCAACGACAGAATGTTAAGACAAATCACCATTGGTCAAGCCCCTACCGAGAAGAACCACACAAGAGTTACTGGATTCGATATCACCGTTGCTTCTGAATTGATGGCTATTCTTGCTCTTTCAAAGGACTTGAGGGACATGAAGGAACGTATTGGAAGAGTCGTTGTTGCTGCTGACGTAAACAGGTCTCCAGTCACTGTTGAAGATGTGGGTTGTACCGGTGCCTTAACCGCTTTATTAAGAGACGCTATCAAGCCCAACTTGATGCAAACTTTAGAAGGTACTCCTGTCTTGGTCCATGCCGGCCCATTTGCCAACATCTCTATCGGTGCCTCTTCTGTTATTGCTGATCGCGTGGCTTTGAAATTGGTTGGTACCGAGCCAGAGGCAAAAACAGAAGCTGGTTATGTGGTTACTGAAGCAGGGTTCGATTTCACTATGGGTGGTGAAAGATTCTTCAACATCAAGTGCCGTTCCTCTGGATTGACACCTAATGCTGTGGTCTTGGTTGCTACTGTTAGGGCATTGAAGTCACACGGTGGTGCTCCAGATGTCAAACCTGGCCAACCTTTACCTTCCGCATACACTGAAGAGAATATCGAGTTTGTCGAAAAAGGTGCCGCTAACATGTGTAAACAAATTGCCAACATTAAGCAATTTGGCGTCCCCGTCGTTGTCGCAATTAACAAGTTTGAAACTGACACTGAAGGTGAAATAGCCGCCATTAGAAAAGCCGCTTTGGAAGCTGGTGCATTTGAAGCCGTAACCTCTAACCATTGGGCCGAAGGTGGTAAAGGTGCTATCGACTTGGCCAAGGCCGTCATCGAAGCTTCCAACCAACCAGTGGACTTCCATTTCCTATATGACGTTAACTCCTCCGTTGAAGACAAATTAACTACTATCGTTCAAAAGATGTACGGTGGTGCCGCAATCGATATCTTGCCTGAAGCACAACGCAAGATTGACATGTACAAGGAACAAGGTTTCGGTAACTTGCCAATTTGTATCGCCAAGACACAATACTCTTTATCCCACGATGCAACTTTGAAAGGTGTTCCAACCGGGTTCACTTTCCCCATCAGAGACGTCAGATTGTCTAATGGTGCTGGATACTTATACGCTCTTGCCGCCGAAATACAAACCATTCCTGGTTTGGCTACCTATGCTGGTTACATGGCCGTGGAAGTCGATGATGACGGTGAGATCGATGGCCTGTTCTAA","protein_sequence":"MAGQVLDGKACAQQFRSNIANEIKSIQGHVPGFAPNLAIIQVGNRPDSATYVRMKRKAAEEAGIVANFIHLDESATEFEVLRYVDQLNEDPHTHGIIVQLPLPAHLDEDRITSRVLAEKDVDGFGPTNIGELNKKNGHPFFLPCTPKGIIELLHKANVTIEGSRSVVIGRSDIVGSPVAELLKSLNSTVTITHSKTRDIASYLHDADIVVVAIGQPEFVKGEWFKPRDGTSSDKKTVVIDVGTNYVADPSKKSGFKCVGDVEFNEAIKYVHLITPVPGGVGPMTVAMLMQNTLIAAKRQMEESSKPLQIPPLPLKLLTPVPSDIDISRAQQPKLINQLAQELGIYSHELELYGHYKAKISPKVIERLQTRQNGKYILVSGITPTPLGEGKSTTTMGLVQALTAHLGKPAIANVRQPSLGPTLGVKGGAAGGGYSQVIPMDEFNLHLTGDIHAIGAANNLLAAAIDTRMFHETTQKNDATFYNRLVPRKNGKRKFTPSMQRRLNRLGIQKTNPDDLTPEEINKFARLNIDPDTITIKRVVDINDRMLRQITIGQAPTEKNHTRVTGFDITVASELMAILALSKDLRDMKERIGRVVVAADVNRSPVTVEDVGCTGALTALLRDAIKPNLMQTLEGTPVLVHAGPFANISIGASSVIADRVALKLVGTEPEAKTEAGYVVTEAGFDFTMGGERFFNIKCRSSGLTPNAVVLVATVRALKSHGGAPDVKPGQPLPSAYTEENIEFVEKGAANMCKQIANIKQFGVPVVVAINKFETDTEGEIAAIRKAALEAGAFEAVTSNHWAEGGKGAIDLAKAVIEASNQPVDFHFLYDVNSSVEDKLTTIVQKMYGGAAIDILPEAQRKIDMYKEQGFGNLPICIAKTQYSLSHDATLKGVPTGFTFPIRDVRLSNGAGYLYALAAEIQTIPGLATYAGYMAVEVDDDGEIDGLF"},{"created_at":"2011-05-27T01:31:06.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"5-formyltetrahydrofolate cyclo-ligase","uniprot_id":"P40099","uniprot_name":"FTHC_YEAST","enzyme":true,"transporter":false,"gene_name":"FAU1","num_residues":211,"molecular_weight":"24058.5","theoretical_pi":"7.14","general_function":"Involved in ATP binding","specific_function":"Utilizes 5-formyltetrahydrofolate (folinic acid) as substrate in an alternative way of folate biosynthesis","reactions":[{"id":1216,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2627,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"U18922","genbank_protein_id":"603424","gene_card_id":"FAU1","chromosome_location":"chromosome 5","locus":"YER183C","synonyms":["5,10-methenyl-tetrahydrofolate synthetase","MTHFS","Methenyl-THF synthetase"],"enzyme_classes":["6.3.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" cyclo-ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" 5-formyltetrahydrofolate cyclo-ligase activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"5-FTHF_cyc-lig","identifier":"PF01812"}],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGGCCACTAAGCAATTACTGAGACGTCAAATCAAAAGGGTAATAAATGCTCTTGACTACGATATTATCGCTGCAGAGTCGCATACTATTTCTCAAGCAGTACGCTCATTGATCGCTTCCGCCAATTCTAGGCGTGTAGCGTGTTATATGAGCATGGATAAAGGAGAAGTAACGACTGGAGAAATCATTAAGAATTTATTTCAAGATGGCCAGGAGGTCTTTCTGCCAAGATGTACTCATACTTCTGAATCGAAACACTTCAAATTACGGGAAGATCATCATCCACATTTAATATTCCATCGAATGAGTAGTTTGAAAATGGTTCGTGATTTGAAGCCTCAAGGTCCATATCAACTAAAAGAGCCTGAACCGCATATTGAGGAATCAGATATTCTAGATGTCGTATTGGTGCCTGGAGTGGCGTTTGATATTAAAACTGGTGCAAGGATGGGTCACGGTGCTGGGTATTATGACGATTTTTTCCAACGGTATAAGATACTGCATGAAGGCCAAAAGCCCCTCCTAGTTGGACTATGTCTTATGGAACAGGTGGCCTCTCCAATTCCTTTAGAAAAACATGATTATTCCATGGATTGTATAGTATGCGGAGATGGATCCATACATTGGTTTCAATAA","protein_sequence":"MATKQLLRRQIKRVINALDYDIIAAESHTISQAVRSLIASANSRRVACYMSMDKGEVTTGEIIKNLFQDGQEVFLPRCTHTSESKHFKLREDHHPHLIFHRMSSLKMVRDLKPQGPYQLKEPEPHIEESDILDVVLVPGVAFDIKTGARMGHGAGYYDDFFQRYKILHEGQKPLLVGLCLMEQVASPIPLEKHDYSMDCIVCGDGSIHWFQ"},{"created_at":"2011-05-27T01:39:09.000Z","updated_at":"2011-05-27T15:01:15.000Z","name":"Methylenetetrahydrofolate dehydrogenase [NAD+]","uniprot_id":"Q02046","uniprot_name":"MTD1_YEAST","enzyme":true,"transporter":false,"gene_name":"MTD1","num_residues":320,"molecular_weight":"36239.30078","theoretical_pi":"7.01","general_function":"Involved in binding","specific_function":"Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis","reactions":[{"id":1732,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2634,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1EE9","cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"L02934","genbank_protein_id":"172016","gene_card_id":"MTD1","chromosome_location":"chromosome 11","locus":"YKR080W","synonyms":[],"enzyme_classes":["1.5.1.15"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"}],"pfams":[{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGTCGAAGCCTGGTCGTACTATTTTAGCAAGCAAGGTCGCCGAAACTTTCAATACCGAAATAATTAACAACGTAGAGGAATACAAGAAGACACATAATGGTCAAGGTCCCCTTCTTGTGGGATTCCTAGCTAATAATGATCCTGCTGCAAAGATGTATGCTACATGGACTCAAAAGACTAGCGAGTCAATGGGGTTCCGCTATGACTTAAGGGTCATTGAAGATAAGGATTTTTTGGAAGAAGCGATAATACAAGCTAACGGCGATGACTCTGTGAACGGTATCATGGTATACTTTCCTGTTTTCGGTAATGCTCAAGATCAGTATTTGCAACAGGTTGTGTGCAAGGAAAAGGATGTAGAAGGGTTAAATCATGTTTACTACCAAAACCTGTACCATAATGTCAGATACCTGGACAAAGAAAACCGTTTGAAATCCATTCTACCTTGCACACCACTAGCTATCGTTAAGATATTGGAATTCTTGAAAATTTACAACAATTTGTTACCAGAAGGAAACAGACTGTATGGGAAGAAATGCATAGTAATTAACAGGTCAGAAATCGTCGGTAGACCACTGGCGGCGCTATTAGCCAATGATGGTGCCACAGTATACTCTGTGGACGTTAACAACATTCAAAAATTCACCCGTGGTGAAAGTTTGAAATTAAACAAGCATCATGTGGAAGACCTTGGGGAGTACTCTGAAGATCTGTTGAAAAAGTGTTCTCTTGATTCAGATGTGGTCATCACTGGTGTCCCTAGTGAAAATTACAAATTCCCCACCGAATACATCAAAGAAGGTGCCGTCTGCATCAATTTTGCATGCACCAAAAATTTTAGCGATGATGTCAAGGAAAAAGCTTCTCTTTACGTTCCAATGACTGGTAAAGTTACCATTGCAATGTTGTTGAGAAACATGTTACGTTTAGTAAGGAACGTAGAACTGTCTAAAGAAAAATAG","protein_sequence":"MSKPGRTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESMGFRYDLRVIEDKDFLEEAIIQANGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVEGLNHVYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCIVINRSEIVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLNKHHVEDLGEYSEDLLKKCSLDSDVVITGVPSENYKFPTEYIKEGAVCINFACTKNFSDDVKEKASLYVPMTGKVTIAMLLRNMLRLVRNVELSKEK"}]}