{"ymdb_id":"YMDB00858","created_at":"2011-05-29T18:58:51.000Z","updated_at":"2016-09-08T18:35:59.000Z","name":"Phosphoglycolic acid","cas":"13147-57-4","state":"Solid","melting_point":"","description":"Phosphoglycolic acid is a substrate for triose-phosphate isomerase.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":null,"synthesis_reference":"Courtois, Jean.  Action of periodic acid on hexosediphosphoric acid.    Compt. rend.  (1941),  212  1172-4.  CAN 38:22678  AN 1944:22678 ","chebi_id":"17150","hmdb_id":"HMDB00816","kegg_id":"C00988","pubchem_id":"529","cs_id":"514","foodb_id":null,"wikipedia_link":null,"biocyc_id":"CPD-67","iupac":"2-(phosphonooxy)acetic acid","traditional_iupac":"phosphoglycolate","logp":"-1.1641597916666666","pka":"3.599355522037208","alogps_solubility":"1.84e+01 g/l","alogps_logp":"-2.26","alogps_logs":"-0.93","acceptor_count":"5","donor_count":"3","rotatable_bond_count":"3","polar_surface_area":"104.06","refractivity":"25.218799999999998","polarizability":"10.672348907073108","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":null,"pka_strongest_acidic":"1.143159703328946","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(phosphonooxy)-acetate","(phosphonooxy)-acetic acid","(Phosphonooxy)acetate","(Phosphonooxy)acetic acid","2-Phosphoglycolate","2-Phosphoglycolic acid","Glycolic acid di-H phosphate","Glycolic acid dihydrogen phosphate","Glycolic acid phosphate","Glycophosphorate","Glycophosphoric acid","Phosphoglycolate","Phosphoglycolic acid"],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":2204418,"citation":"Lolis, E., Petsko, G. A. (1990). \"Crystallographic analysis of the complex between triosephosphate isomerase and 2-phosphoglycolate at 2.5-A resolution: implications for catalysis.\" Biochemistry 29:6619-6625."}],"proteins":[{"created_at":"2011-05-24T20:34:21.000Z","updated_at":"2011-05-29T14:01:21.000Z","name":"Enolase-phosphatase E1","uniprot_id":"P32626","uniprot_name":"ENOPH_YEAST","enzyme":true,"transporter":false,"gene_name":"UTR4","num_residues":227,"molecular_weight":"25187.19922","theoretical_pi":"5.3","general_function":"Involved in catalytic activity","specific_function":"Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)","reactions":[{"id":2327,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2328,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm. Nucleus","altext":"2-Phosphoglycolate + H2O = glycolate + phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":3792,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006311","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U18779","genbank_protein_id":"603641","gene_card_id":"UTR4","chromosome_location":"chromosome 5","locus":"YEL038W","synonyms":["2,3-diketo-5-methylthio-1-phosphopentane phosphatase","Unknown transcript 4 protein"],"enzyme_classes":["3.1.3.77","3.1.3.18"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" phosphoglycolate phosphatase activity"},{"category":"Function","description":" acireductone synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" amino acid salvage"},{"category":"Process","description":" L-methionine salvage from methylthioadenosine"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGGTCATTGGGCAAAAGGTCCTGCTAGCTCGTATACCAAAAATGGGAGACAATTACTCGACTTACTTGCTTGATATTGAAGGGACAGTGTGCCCGATCTCGTTCGTGAAGGAGACTTTATTCCCTTATTTCACGAATAAAGTGCCGCAATTGGTTCAACAGGATACAAGGGACTCCCCGGTTTCCAACATTCTGTCGCAGTTTCACATCGACAATAAGGAGCAGTTGCAGGCGCATATTTTGGAGTTGGTGGCCAAGGATGTGAAGGATCCAATCTTGAAACAGTTGCAAGGCTACGTCTGGGCTCACGGATACGAATCTGGGCAGATTAAGGCGCCCGTTTATGCAGATGCTATTGACTTTATCAAGAGGAAGAAGCGTGTGTTTATCTACTCTAGTGGATCTGTAAAGGCACAGAAATTGCTGTTCGGGTATGTTCAGGATCCCAACGCGCCTGCGCATGATTCGTTGGATTTGAATTCTTATATAGATGGTTATTTCGACATCAACACTTCTGGAAAGAAAACCGAAACACAGTCTTACGCCAACATCTTGCGGGATATCGGTGCGAAGGCTAGCGAGGTACTGTTCTTGAGCGATAATCCATTGGAATTGGACGCAGCGGCCGGCGTTGGAATAGCTACTGGGTTAGCTTCCCGACCTGGTAATGCACCTGTCCCCGATGGGCAAAAGTACCAGGTATACAAGAATTTTGAAACTCTTTAA","protein_sequence":"MGDNYSTYLLDIEGTVCPISFVKETLFPYFTNKVPQLVQQDTRDSPVSNILSQFHIDNKEQLQAHILELVAKDVKDPILKQLQGYVWAHGYESGQIKAPVYADAIDFIKRKKRVFIYSSGSVKAQKLLFGYVQDPNAPAHDSLDLNSYIDGYFDINTSGKKTETQSYANILRDIGAKASEVLFLSDNPLELDAAAGVGIATGLASRPGNAPVPDGQKYQVYKNFETL"},{"created_at":"2011-05-27T18:43:37.000Z","updated_at":"2011-05-29T14:01:21.000Z","name":"Putative uncharacterized hydrolase YOR131C","uniprot_id":"Q12486","uniprot_name":"YOR31_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":218,"molecular_weight":"24839.80078","theoretical_pi":"6.63","general_function":"Involved in catalytic activity","specific_function":null,"reactions":[{"id":2328,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm. Nucleus","altext":"2-Phosphoglycolate + H2O = glycolate + phosphate","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"X90518","genbank_protein_id":"1050822","gene_card_id":null,"chromosome_location":null,"locus":"YOR131C","synonyms":[],"enzyme_classes":["3.-.-.-","3.1.3.18"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" phosphoglycolate phosphatase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGACAAAGCTACAAGGACTACAGGGATTAAAACACATCAAAGCGGTTGTATTTGATATGGATGGCACATTATGCCTACCCCAGCCTTGGATGTTTCCAGCAATGAGAAACGCCATAGGATTGGAGGACAAATCGATTGATATCCTTCATTTCATTGATACATTGCCCACAGAAAAAGAAAAAAAAGAAGCGCATGATAGAATAGAATTAGTTGAGGCAAAAGCCATGAAGGAGATGCAACCGCAGCCTGGTCTGGTTGACATAATGAGGTATTTGACGAAAAATGGTATTAGCAAGAACATATGTACTAGAAATGTCGGAGCCCCGGTAGAGACTTTTGTTAAAAGATTTATTCCATCCGAGCTTTCGAGGTTTGACTATATTGTGACAAGGGAGTTTAGGCCTACAAAACCGCAACCAGACCCATTATTACACATCGCCTCGAAGCTAAATATAAGGCCCTTGGAAATGATCATGGTAGGAGATTCATTTGACGACATGAAATCCGGTAGATCTGCTGGATGTTTCACGGTATTACTCAAGAATCATGTGAATGGACATTTACTGCTCGAACATAAAGAACTAGTAGACGTTTCAGTAGAGGATCTTTCCGAAATAATTGAATTGATTCAAAATATGAATAAAGAAAGTTTCTAA","protein_sequence":"MTKLQGLQGLKHIKAVVFDMDGTLCLPQPWMFPAMRNAIGLEDKSIDILHFIDTLPTEKEKKEAHDRIELVEAKAMKEMQPQPGLVDIMRYLTKNGISKNICTRNVGAPVETFVKRFIPSELSRFDYIVTREFRPTKPQPDPLLHIASKLNIRPLEMIMVGDSFDDMKSGRSAGCFTVLLKNHVNGHLLLEHKELVDVSVEDLSEIIELIQNMNKESF"},{"created_at":"2011-05-27T18:44:06.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Uncharacterized protein YMR130W","uniprot_id":"Q04223","uniprot_name":"YM14_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":302,"molecular_weight":"35278.10156","theoretical_pi":"6.18","general_function":"Involved in catalytic activity","specific_function":null,"reactions":[{"id":2328,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm. Nucleus","altext":"2-Phosphoglycolate + H2O = glycolate + phosphate","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"AY557987","genbank_protein_id":"45269864","gene_card_id":null,"chromosome_location":null,"locus":"YMR130W","synonyms":[],"enzyme_classes":["3.1.3.18"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" phosphoglycolate phosphatase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[],"gene_sequence":"ATGACCTATCCGAAAAGAATACCTATAAATGCGTGGTCTGAAGTTCATAGGGTGGCAAGGCCACTAATTATTACTTTCGACGCATATAATACACTATACGCCACAAAACTTCCCGTCATGGAACAATACTGCATTGTTGGGCGTAAATATGGTATCAAGGCGAATCCTTCGACTTTAACAAACAATTTTCCACACGTTTTTAAAAAACTGAAGGAAGACTATCCCCAATACGGAAAATATTCTGGTATCAAGCCCGAACAATGGTGGTCCATCTTGATTAGGAACGTCTTCGCACCAAACGAAATTCCCGATGAGATGATAAATGAAATATTAATGCGGTTTGAGGGCTTCGATTCGTATTTTGTTTATCCAGATTTGATCAAATTTTTAAAGGATTTGAAGTCAAGACATCCTGATGTTATCTTAGGAATAGTAAGCAATACTGATCCAATTTTTTACAAATTATTAAAGAATATCGGATTATTTGAGACATTTTCCGGTCACATTTATTTATCATATGAGCTTAATCTCGCCAAACCTGATAGAGCAATATTTCAATATGCGCTTGACGATATTATATCTAAACAACCTCATTTACTCGAAAAGTACACCAGGGAGGAAATTCTACAGCATTGCTTTCACATCGGAGATGAATTAAAGAACGATCTCGAAGGGGCAGAAGCTGCCGGTTGGACTGGTATACTGTTAGATAGAAATGATAAATACGGGTTTCTTTCAAACTCGATTAGTAAACCAATGCGGGACGAATACAAGCTGTCAATTGATAAAATAGATAATAATTCAATAAACACTTGGGAAGCCAATACTAAGCAAACTGACACGTTACAGTTGAGTGAAAGAAAGTACGTTGTTTCGAATCTTGAGGTTTTAGAGGAACTCTTTCCCTGA","protein_sequence":"MTYPKRIPINAWSEVHRVARPLIITFDAYNTLYATKLPVMEQYCIVGRKYGIKANPSTLTNNFPHVFKKLKEDYPQYGKYSGIKPEQWWSILIRNVFAPNEIPDEMINEILMRFEGFDSYFVYPDLIKFLKDLKSRHPDVILGIVSNTDPIFYKLLKNIGLFETFSGHIYLSYELNLAKPDRAIFQYALDDIISKQPHLLEKYTREEILQHCFHIGDELKNDLEGAEAAGWTGILLDRNDKYGFLSNSISKPMRDEYKLSIDKIDNNSINTWEANTKQTDTLQLSERKYVVSNLEVLEELFP"}]}