{"ymdb_id":"YMDB00852","created_at":"2011-05-29T18:58:25.000Z","updated_at":"2016-09-08T18:35:59.000Z","name":"1D-myo-inositol 1,4-bisphosphate","cas":"47055-78-7","state":"Solid","melting_point":null,"description":"1D-Myo-inositol 1,4-bisphosphate is a product in D-myo-inositol (1,4,5)-trisphosphate degradation pathway and an intermediate in sphingolipid metabolism. [Biocyc PWY-6363 and SPHINGOLIPID-SYN-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":"Auchus, Richard J.; Kaiser, Susan L.; Majerus, Philip W.  Synthesis of inositol 1,2-(cyclic)-4,5-trisphosphate.    Proceedings of the National Academy of Sciences of the United States of America  (1987),  84(5),  1206-9.  ","chebi_id":"17816","hmdb_id":"HMDB00968","kegg_id":"C01220","pubchem_id":"805","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":"INOSITOL-1,4-BISPHOSPHATE","iupac":"{[(1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphonic acid","traditional_iupac":"[(1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxyphosphonic acid","logp":"-4.029141714666666","pka":"1.4635394895369545","alogps_solubility":"2.44e+01 g/l","alogps_logp":"-1.33","alogps_logs":"-1.14","acceptor_count":"10","donor_count":"8","rotatable_bond_count":"4","polar_surface_area":"214.43999999999997","refractivity":"57.520799999999994","polarizability":"25.09971267523206","formal_charge":"0","physiological_charge":"-4","pka_strongest_basic":"-3.667896845422092","pka_strongest_acidic":"0.8613145099702861","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1d-myo-inositol 1","1D-myo-Inositol 1,4-bisphosphate","1D-Myo-inositol 1,4-bisphosphic acid","4-bisphosphate","D-myo-inositol 1,4-bisphosphate","D-MYO-INOSITOL-1,4-BISPHOSPHATE","inositol 1","inositol 1,4-bisphosphate","myo-inositol 1","myo-inositol 1,4-bisphosphate"],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":10962003,"citation":"Whisstock, J. C., Romero, S., Gurung, R., Nandurkar, H., Ooms, L. M., Bottomley, S. P., Mitchell, C. A. (2000). \"The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis.\" J Biol Chem 275:37055-37061."},{"pubmed_id":15265867,"citation":"Morales-Johansson, H., Jenoe, P., Cooke, F. T., Hall, M. N. (2004). \"Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4.\" J Biol Chem 279:39604-39610."}],"proteins":[{"created_at":"2011-05-27T06:28:57.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Inositol-1,4,5-trisphosphate 5-phosphatase 3","uniprot_id":"Q12271","uniprot_name":"INP53_YEAST","enzyme":true,"transporter":false,"gene_name":"INP53","num_residues":1107,"molecular_weight":"124576.0","theoretical_pi":"7.2","general_function":"Involved in inositol or phosphatidylinositol phosphatase activity","specific_function":"Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN","reactions":[{"id":1845,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;vacuole;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1846,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1847,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1848,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1851,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell 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phosphate","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm.","genbank_gene_id":"X94335","genbank_protein_id":"1164954","gene_card_id":"INP53","chromosome_location":"chromosome 15","locus":"YOR109W","synonyms":["Suppressor of PMA1 protein 2","Synaptojanin-like protein 3"],"enzyme_classes":["3.1.3.36","3.1.3.56"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Exo_endo_phos","identifier":"PF03372"},{"name":"Syja_N","identifier":"PF02383"}],"pathways":[{"name":"Inositol phosphate 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5-phosphatase 2","uniprot_id":"P50942","uniprot_name":"INP52_YEAST","enzyme":true,"transporter":false,"gene_name":"INP52","num_residues":1183,"molecular_weight":"133330.0","theoretical_pi":"8.89","general_function":"Involved in inositol or phosphatidylinositol phosphatase activity","specific_function":"Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Specifically functions within the early endocytic pathway and actin organization","reactions":[{"id":1845,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;vacuole;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1846,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1847,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1848,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1851,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1904,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2788,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch; Cytoplasmic side;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2789,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch","altext":"D-myo-inositol 1,4,5-trisphosphate + H2O = D-myo-inositol 1,4-bisphosphate + phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":2790,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch","altext":"D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = D-myo-inositol 1,3,4-trisphosphate + phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm, cytoskeleton, actin patch","genbank_gene_id":"Z71382","genbank_protein_id":"1302022","gene_card_id":"INP52","chromosome_location":"chromosome 14","locus":"YNL106C","synonyms":["Synaptojanin-like protein 2"],"enzyme_classes":["3.1.3.36","3.1.3.56"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Exo_endo_phos","identifier":"PF03372"},{"name":"Syja_N","identifier":"PF02383"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAAATACTCCTATCGAAACAGCAAACTAGAAAGATAGCAATAGTTTCAGAAACACATGGACTGGTATTTAGGCCAATAAACAGTAAGAACTCTCGCAGATCTACATGTGCCGTGGAATTGGTTCCGAAAGCTGAATTAAATGGTAATGGTTTCAGAAGACTATCTAACCATGAAATATACGGTTTTATTGGTCTCATAGAAATTGAAGGCCTTATGTTCATAGCAACCATAACAGGTAAATCTAAGGTGGCCCAGCCGATCCCAAACAAAACGGTTAACAAAATATATGCTGTGGATTTTTTTTGCTTAAATAATTCTAAATGGGATTTCATGGACATCGATTCATCCGGTTATCCGATTGTTACTAATGATGGAGATTTTGCAATAAGCTCGCCTCCTAGTATTTCCACACATTCTTCTAGATCATCGCTACGTTCTTCTTCCTCTAGGAGTTTGAATGCTCAAGAACAAGCTCCCAAGCATCCATGTCATGAACTAAGAAAGCTATTATCAAATGGATCTTTTTATTACAGCACCGATTTTGATTTAACTTGTACATTGCAGAAACGTGGATTCACGGAACACTCTTTGAGTTTTGATGATTTTGACCGGGAGTTTATGTGGAACTCGTTTCTTATGGACGAAATCATCACATACAGAGACAGACTAGATGTAACGGCCAAAGAACTATTGGATCAACGAGGATTCCTCACGACCGTAATCCGAGGGTTTGCTGAAACAATTTTTAGCTATATTAATAGGTTGAAAGTAGGACTTACCATTATTTCCAGGCAAAGTTGGAAAAGAGCAGGCACAAGGTTTAATGCACGTGGTATAGATGATGATGGCCATGTCGCAAATTTTGTTGAAACAGAAATGATTATGTACTCTTCTCAGTATTGTTATGCTTTCACGCAGATAAGAGGAAGCCTTCCAATTTTTTGGGAGCAGGATACATCTTTGATTAGTCCAAAGATTCAAATTACCAGATCTGTTGAAGCAACACAGCCCACGTTTGATGAACATTTTATAAGACTATTTAAGAAGTATGGGCCAGTTCATATAATCAACCTGCTGTCTACTAAATCTTCAGAAATTCAATTATCGAGGCGATACAAGGAACAGTTGAAAAATTCTGAGAAAATGAAAATCGGTAGAGATGTGTTCCTAACAAGCTTTGATTTCCATAGAGAAACTTCGCAAGATGGGTTTGCAGCTGCAAGTAGGATTATCCCTAAAATAAGAAACACAATTTTGGACGCCGGTTACTTTTCATACGATGTAAAAGAAGGGCGATTAATATCCGAACAAGACGGTGTCTTTAGAACCAATTGCTTGGATTGTTTAGATAGAACAAATTTGATCCAACAGACGATTTCACTGGCCGTTTTCAAACTATTTTTGGAAGACTTCCGATTGGTAAAACCCAGTAGTTTCATCGACGATAATGAATTTGTGCAAAAGGTGAATGCTTTATGGGCCGACAACGGAGATCAGATATCACAAATTTACACTGGGACAAATGCTCTGAAATCGTCCTATTCAAGGAAAGGTAAAATGTCTTTTTCTGGCGCCCTTTCTGATGCGACGAAGTCCGTTAGTAGAATGTACATCAACAATTTTGTAGATAAAGGAAAACAGCAAAATATTGACACACTTTTGGGCAAACTACCGCACCAGCAAGTTGTTGAACTTTATGATCCAATCTGCGAATACGTCAATGAAAGGCTGTTAGAGTCAGAGGAAAAATTCACCACTCATTCTAACATAAATTTGTTTGTCGGTACATTCAATGTTAACGGAAACTCTCGAAGAGCAGATTTGTCAAAATGGTTATTTCCAATCGGCGATAAATTCAAACCTGATGTCGTTGTGTTAGGGTTGCAGGAAGTTATAGAGTTGACCGCAGGGTCTATCTTGAATGCAGATTATACGAAAAGTTCTTTTTGGGAAACTATGGTTACTGACTGTTTGAATCAATACGAAGAAAAATATCTTTTACTTAGAGTGGAACAGATGTCCTCTCTTTTGATACTATTTTTTGCAAGATCAGATAGAGCCTATAACATAAAAGAGGTAGGTGGGTCTACCAAAAAGACTGGGTTTGGTGGTATTACTGGAAACAAAGGTGCAGTAGCCATTAGATTCGATTATGGGGCAACTTCATTCTGTTTCGTTAATACACATTTATCAGCAGGTGCGAGTAACATTGACGAACGTCGCAATGACTACAACAATATCTACAGGAACATAACCTTTCCAAGATCAAAGACAATTCCACACCATGATTCGTTGTTTTGGTTGGGTGACCTTAACTACAGGATAACTTTGACAAATGATGAAGTTAGAAGAGAATTAAGGGCTCAAAAGGATGGCTATATTGATAGATTGCTTCAATATGATCAGTTGACTCAAGAAATAAATGAAGGAGTGGTATTTCAGGGCTTTAAAGAACCGACCCTCCAATTCCGTCCGACCTATAAATATGATTATGGCACAGATAATTATGATACTTCTGAAAAGGCGAGAACTCCGTCTTGGACTGATAGAATCATATATAAAGGTGAAAACCTGCATCCATTGGCATATTCGGACGCACCTTTAAAAATAAGCGATCATAAACCAGTTTATGCTGCATATAGGGCAAATGTGAAATTTGTTGACGAAAAAGAGAAGCTTAACCTAGTTGAGAAGCTGTATGCAGAATATAAGAATACGCATCCCGAAGCACTAACTACAGGTCCTGACGAACTTTCTCATGCAAGAATGGAAAAACAAAAGGAAAGTATACCCTTAGATGCAACCGTTCAATCAGCGGGCATAAAACTAATTGACCTAGATGATACTTCCTCGTGCGTTTCGCCTCTACTTTCTGGTCCCAGTCCCCAACCGTCTGTTGTTGGCCCTGGAGGACTCAGTAACGTATCACCCGATAAAAGTAAGCTCAATGTGCTTCCTCCGCCTCCTCCTACCTCGAGGCACAATAAGGAACCATCTTCTAAACTTCTTTCCCCTACCAAAGAGATTTCCATTGTCAGCGTATCGCCGCGTAAAGGTGAGAGCAATCTTCCTGCCTTAGAGAGACACAGTACACCCAAACCACTGCCGCCAGTGCCCGCTTTATCTTTATCTAAGCCAGTCTCTTTACAGAAAAGTTCTTCAGAATTACAGCATGCTAAAGAGACCATAGATAATGGGAAAATTGTTCCTCGACCTTGTCCTCCTATTAGAAGGAAGAGCAGTACTGCCCCGGACGAAATCTCTACATCTACCAAAAATTCAGGTGTGTCCACTACAGAAGATCCTGAGCCAGCAAAGGCCTCCACAAAACCTGAGAAGCCACCAGTTGTCAAAAAACCGCATTATTTAAGTGTTGCTGCTAACAAGCTTAACACCTCTCAAGAACACTCAATAAAAGTTTCCCCGTCGAATTCAAAATCTGAAGAGGAACTCCCTTGCAAGAAAAAGTCTAAACCAAAAGTTCCTGCGAAGAACCCTGAACTAGAGAAGCTAAGCGTTCATCCATTGAAGCCTTGCGACCCCAATTAA","protein_sequence":"MKILLSKQQTRKIAIVSETHGLVFRPINSKNSRRSTCAVELVPKAELNGNGFRRLSNHEIYGFIGLIEIEGLMFIATITGKSKVAQPIPNKTVNKIYAVDFFCLNNSKWDFMDIDSSGYPIVTNDGDFAISSPPSISTHSSRSSLRSSSSRSLNAQEQAPKHPCHELRKLLSNGSFYYSTDFDLTCTLQKRGFTEHSLSFDDFDREFMWNSFLMDEIITYRDRLDVTAKELLDQRGFLTTVIRGFAETIFSYINRLKVGLTIISRQSWKRAGTRFNARGIDDDGHVANFVETEMIMYSSQYCYAFTQIRGSLPIFWEQDTSLISPKIQITRSVEATQPTFDEHFIRLFKKYGPVHIINLLSTKSSEIQLSRRYKEQLKNSEKMKIGRDVFLTSFDFHRETSQDGFAAASRIIPKIRNTILDAGYFSYDVKEGRLISEQDGVFRTNCLDCLDRTNLIQQTISLAVFKLFLEDFRLVKPSSFIDDNEFVQKVNALWADNGDQISQIYTGTNALKSSYSRKGKMSFSGALSDATKSVSRMYINNFVDKGKQQNIDTLLGKLPHQQVVELYDPICEYVNERLLESEEKFTTHSNINLFVGTFNVNGNSRRADLSKWLFPIGDKFKPDVVVLGLQEVIELTAGSILNADYTKSSFWETMVTDCLNQYEEKYLLLRVEQMSSLLILFFARSDRAYNIKEVGGSTKKTGFGGITGNKGAVAIRFDYGATSFCFVNTHLSAGASNIDERRNDYNNIYRNITFPRSKTIPHHDSLFWLGDLNYRITLTNDEVRRELRAQKDGYIDRLLQYDQLTQEINEGVVFQGFKEPTLQFRPTYKYDYGTDNYDTSEKARTPSWTDRIIYKGENLHPLAYSDAPLKISDHKPVYAAYRANVKFVDEKEKLNLVEKLYAEYKNTHPEALTTGPDELSHARMEKQKESIPLDATVQSAGIKLIDLDDTSSCVSPLLSGPSPQPSVVGPGGLSNVSPDKSKLNVLPPPPPTSRHNKEPSSKLLSPTKEISIVSVSPRKGESNLPALERHSTPKPLPPVPALSLSKPVSLQKSSSELQHAKETIDNGKIVPRPCPPIRRKSSTAPDEISTSTKNSGVSTTEDPEPAKASTKPEKPPVVKKPHYLSVAANKLNTSQEHSIKVSPSNSKSEEELPCKKKSKPKVPAKNPELEKLSVHPLKPCDPN"},{"created_at":"2011-05-27T08:00:14.000Z","updated_at":"2011-05-27T15:01:29.000Z","name":"Inositol-1,4,5-trisphosphate 5-phosphatase 1","uniprot_id":"P40559","uniprot_name":"INP51_YEAST","enzyme":true,"transporter":false,"gene_name":"INP51","num_residues":946,"molecular_weight":"108429.0","theoretical_pi":"6.7","general_function":"Involved in inositol or phosphatidylinositol phosphatase activity","specific_function":"Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth","reactions":[{"id":1847,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1848,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2788,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch; Cytoplasmic side;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14838,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007015","source":"Smpdb"},{"id":14839,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007021","source":"Smpdb"},{"id":14840,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007039","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm, cytoskeleton, actin patch","genbank_gene_id":"Z38062","genbank_protein_id":"557848","gene_card_id":"INP51","chromosome_location":"chromosome 9","locus":"YIL002C","synonyms":["Synaptojanin-like protein 1"],"enzyme_classes":["3.1.3.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Exo_endo_phos","identifier":"PF03372"},{"name":"Syja_N","identifier":"PF02383"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAGACTCTTCATCGGTAGAAGATCACGGTCGATTGTAATATCTTCCAACAACTACTGTTTATCCTTCCAGCGTTTGCGCAGCATACCAGGTGCCAGTTCTCAGCAGCGTCAATTAAGTAAAACTCCTAGCGTAACAATCAAGTCCTACCCTGACACAGATCTTTCAAGTGATAGTAACTATCTCGAAGTCAAAAGTTGCATATTTAATGGATTATTAGGGCTCGTTTGTCTTAATGGTGATATATATGTTGCCGTCATATCTGGTGTTCAGAATGTTGGGTTTCCTCGATGGAAACTGATAGATCATCAAGTTAGGCCTTCGGAGAGCATTTATAAAGTATTGGATGTTGACTTTTACAGCTTAGAAAATGATGTTTTCGACTACCTCCTCTGCGAGAGATCAGAGCAAAACTATGATAAATTGATTCATGAGCATCCTTGCGGCCCCCTGAAAAAACTGTTTAGTGATGGAACATTCTACTATTCTAGAGATTTCGACATCTCTAATATCGTGAAAAACCATGGTTTATCACATAACTTAGAATATACCGTAGATAATCAAGATTTATCATTTATTTGGAATGCTAACTTAGCAAGTGAGGTAATCAACTGGAGAAGCAAGATTTCAAATGAGGAGAAACAACTTTTTGCCAACGCAGGGTTCTTAACATTTGTAATTCGGGGTTATTGCAAGACAGCATTAATAGAAGACGGCCCAAATACAGCCTCTATAACCATTATTTCCAGAATTTCGACTGAGAGCAAGCAGGATACGCTAGAATTGGAGGGTATTAGTGAAGATGGGAGAGTGTCGCTATTTGTTGAGACAGAAATTGTAGTAACCACAGAAAAGTTTATTTTTTCTTATACTCAAGTGAACGGAAGCATTCCTCTTTTTTGGGAATCTGTAGAAAGTCAACTGTTGTATGGAAAAAAAATTAAGGTAACAAAAGATTCTATTGAAGCTCAGGGAGCTTTTGACAGGCATTTTGATAATTTAACCTCAAAGTATGGTGTTGTGAGTATCGTTAATATCATAAAACCTAAAAGCGAATCACAAGAAAAGTTAGCACTGACGTACAAGGATTGTGCTGAATCAAAGGGAATAAAAATAACAAATATAGAATACAGCTCAAGCGTTCTGACAAAGTCTCCCCACAAATTACTTTATTTATTAAAACAGGATATTTACGAGTTTGGAGCGTTTGCCTATGATATCTCTAGGGGCATCTACTTTGCAAAACAAACGGGGGTATTAAGAATAAGCGCATTTGATTCAATTGAAAAACCTAACACAGTTGAAAGGTTAGTGAGCAAGGAGGTACTTGAATTAACCACAAATGAAATTGATGTATTTGAATTGACTTCCCCATTCTTGGACGCACATGATAAGCTATGGTCAGAAAACTATTACTGGCTTGATCGAACGTATACTAAGCACACGAAGAATTCTGGTAAATATACAAAGGTTTATTCGAAGTTATTTGGTTCCCGAGTTAGATTATACGACCCGCTCCATATCTACATCTCTCAGTATTTAAAGCAATTAAGGTCAAAATATACGTTTGAGAAAGACATCTCAATTTTTGCAGGTACATTTAATATAAGTGGTAAAATTCCAAAAGATGATATAAAAGATTGGATATTTCCAAAATCAATGTCCAAGGAGGATGAAATGGCTGATCTTTATGTTATCGGATTAGAAGAAGTGGTAGAACTTACCCCAGGTCATATGCTTGCTACCGATCCATATGTCCGACAATTTTGGGAGAAGAAGATATTAACACTATTAAATGGGCCCGGACGCAAAAAAAAATATATCCGTTTATGGAGTACACAGTTGGGTGGTATTTTACTATTATTATTCATGAATGAAACGGAATATTCCAAGGTAAAGCATATTGAGGGGGATGTTAAAAAAACCGGGTTTGGAGGAATGGCTTCTAATAAAGGAGCTGTCGCGGTTAGTTTTAAATACTCAGCTACAAGATTTTGCGTACTAGTATCTCATTTAGCGGCAGGCTTAGAAAATGTTGAACAAAGGCATAATGATTATAAGACGATTGCGAAAAGCATACGATTTTCTAAAGGATTACGAATAAAGGATCACGATGCAATTATTTGGATGGGCGATTTCAATTACAGAATATTGATGTCAAACGAAGATGTTAGACGAAAAATTGTTTCTAAAGAATATGCCAGCCTATTTGAAAAGGATCAACTTAATCAACAAATGATCGCAGGTGAGTCTTTTCCATATTTCCATGAAATGGCGATTGATTTCCCACCTACCTATAAATTCGACCCAGGAACTAAAAACTACGACACGAGCGAAAAAATGAGAATACCAGCATGGACTGATAGGATTTTAAGTAGGGGAGAAGTACTAGAACAGTTAGAATATAAATGCTGTGAAGATATACTATTTTCCGATCATCGGCCCGTATATGCCATATTTAGGGCTAGAGTGACTGTAGTGGATGAACAAAAAAAGACTACTTTGGGTACGCAAATCTACGAGAAGATTATGGAAAGGCTAGAGGGATTGGATGATGATGAGAAAATTGCAGTTTTGAGTGATGATGCATTTGTTATCGAAAGTTTTGAGGGCAGTGATTCGATAGCTGGCCCTACGCATTCTCCGACACCAATTCCCGAGCCCAAAAGAGGTAGAAAGTTACCACCACCTAGTTCGGATTTAAAAAAATGGTGGATTGGAAGTGGGAAGCAAGTTAAAGTAGTTCTTGACGTAGACCCGGCCGTTTACATGATTAATCCTAAAAGAGATCCCAATCCATTCGTTGAGAACGAAGATGAGCCACTTTTTATAGAAAGGTAA","protein_sequence":"MRLFIGRRSRSIVISSNNYCLSFQRLRSIPGASSQQRQLSKTPSVTIKSYPDTDLSSDSNYLEVKSCIFNGLLGLVCLNGDIYVAVISGVQNVGFPRWKLIDHQVRPSESIYKVLDVDFYSLENDVFDYLLCERSEQNYDKLIHEHPCGPLKKLFSDGTFYYSRDFDISNIVKNHGLSHNLEYTVDNQDLSFIWNANLASEVINWRSKISNEEKQLFANAGFLTFVIRGYCKTALIEDGPNTASITIISRISTESKQDTLELEGISEDGRVSLFVETEIVVTTEKFIFSYTQVNGSIPLFWESVESQLLYGKKIKVTKDSIEAQGAFDRHFDNLTSKYGVVSIVNIIKPKSESQEKLALTYKDCAESKGIKITNIEYSSSVLTKSPHKLLYLLKQDIYEFGAFAYDISRGIYFAKQTGVLRISAFDSIEKPNTVERLVSKEVLELTTNEIDVFELTSPFLDAHDKLWSENYYWLDRTYTKHTKNSGKYTKVYSKLFGSRVRLYDPLHIYISQYLKQLRSKYTFEKDISIFAGTFNISGKIPKDDIKDWIFPKSMSKEDEMADLYVIGLEEVVELTPGHMLATDPYVRQFWEKKILTLLNGPGRKKKYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDVKKTGFGGMASNKGAVAVSFKYSATRFCVLVSHLAAGLENVEQRHNDYKTIAKSIRFSKGLRIKDHDAIIWMGDFNYRILMSNEDVRRKIVSKEYASLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYKFDPGTKNYDTSEKMRIPAWTDRILSRGEVLEQLEYKCCEDILFSDHRPVYAIFRARVTVVDEQKKTTLGTQIYEKIMERLEGLDDDEKIAVLSDDAFVIESFEGSDSIAGPTHSPTPIPEPKRGRKLPPPSSDLKKWWIGSGKQVKVVLDVDPAVYMINPKRDPNPFVENEDEPLFIER"}]}