{"ymdb_id":"YMDB00849","created_at":"2011-05-29T18:58:07.000Z","updated_at":"2016-09-08T18:35:59.000Z","name":"D-Asparagine","cas":"2058-58-4","state":"Solid","melting_point":"234-235 oC","description":"Asparagine (abbreviated as Asn or N) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. D-isomers are used as carbon, nitrogen, and energy source.","experimental_water_solubility":"29.4 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-3.82 [CHMELIK,J ET AL. (1991)]","location":null,"synthesis_reference":null,"chebi_id":"28159","hmdb_id":"HMDB00168","kegg_id":"C01905","pubchem_id":"6267","cs_id":"388679","foodb_id":null,"wikipedia_link":"Asparagine","biocyc_id":"ASN","iupac":"(2R)-2-amino-3-carbamoylpropanoic acid","traditional_iupac":"D-asparagine","logp":"-4.287830841089268","pka":"16.09048069675879","alogps_solubility":"1.68e+02 g/l","alogps_logp":"-3.36","alogps_logs":"0.10","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"3","polar_surface_area":"106.41","refractivity":"28.354900000000004","polarizability":"11.774333776132538","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"8.433487205020551","pka_strongest_acidic":"1.998539099392778","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(-)-Asparagine","(2R)-2-amino-3-carbamoylpropanoic acid","(2R)-2,4-diamino-4-oxobutanoic acid","(R)-2-amino-3-carbamoylpropanoic acid","(S)-2,4-Diamino-4-oxobutanoate","(S)-2,4-Diamino-4-oxobutanoic acid","(S)-Asparagine","2-Aminosuccinamate","2-Aminosuccinamic acid","a-Aminosuccinamate","a-Aminosuccinamic acid","Agedoite","alpha Amminosuccinamate","alpha Amminosuccinamic acid","alpha-Aminosuccinamate","alpha-Aminosuccinamic acid","Altheine","Asn","Asparagine","Asparagine acid","Asparagine, L-","Asparamide","Aspartamate","Aspartamic acid","Aspartic acid amide","Aspartic acid b-amide","Aspartic acid beta amide","B2,4-(S)-diamino-4-oxo-utanoate","B2,4-(S)-diamino-4-oxo-utanoic acid","D-2-aminosuccinamic acid","D-Asparagin","D-Asparagine","D-aspartic acid beta-amide","L-2,4-Diamino-4-oxobutanoate","L-2,4-Diamino-4-oxobutanoic acid","l-Asparagine","L-Aspartamine","L-b-Asparagine","L-beta-Asparagine"],"pathways":[{"name":"Asparagine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":15375647,"citation":"Yow, G. Y., Uo, T., Yoshimura, T., Esaki, N. (2004). \"D-amino acid N-acetyltransferase of Saccharomyces cerevisiae: a close homologue of histone acetyltransferase Hpa2p acting exclusively on free D-amino acids.\" Arch Microbiol 182:396-403."}],"proteins":[{"created_at":"2011-05-26T23:37:41.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"N-acetyltransferase HPA3","uniprot_id":"P39979","uniprot_name":"HPA3_YEAST","enzyme":true,"transporter":false,"gene_name":"HPA3","num_residues":179,"molecular_weight":"20698.5","theoretical_pi":"7.84","general_function":"Involved in N-acetyltransferase activity","specific_function":"N-acetyltransferase whose physiological acetyl acceptor substrate is still unknown. In vitro, histone acetylation is very weak","reactions":[{"id":2617,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U18795","genbank_protein_id":"603252","gene_card_id":"HPA3","chromosome_location":"chromosome 5","locus":"YEL066W","synonyms":[],"enzyme_classes":["2.3.1.-","2.3.1.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" N-acetyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" acetyltransferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Acetyltransf_1","identifier":"PF00583"}],"pathways":[],"gene_sequence":"ATGAAAAAGACCCCAGACCCATCTCCACCTTTTGCAAGCACGAAGAACGTAGGCATGTCAAACGAAGAACCGGAAAAAATGGTTAACGATCGAATTGTGGTGAAGGCCATCGAGCCAAAAGATGAGGAAGCCTGGAACAAACTGTGGAAGGAGTATCAGGGTTTCCAAAAAACGGTTATGCCTCCGGAAGTAGCCACCACTACCTTCGCAAGGTTTATAGACCCTACGGTCAAACTATGGGGTGCTCTAGCCTTTGACACCGAGACCGGCGATGCAATTGGCTTTGCACACTACCTGAACCATTTGACGTCGTGGCATGTCGAAGAAGTTGTCTACATGAATGACTTATATGTCACTGAACGCGCAAGAGTCAAAGGCGTAGGTAGAAAGCTCATAGAATTTGTATACAGCCGTGCCGATGAGCTCGGTACGCCTGCAGTGTACTGGGTTACAGACCATTACAATCACCGCGCACAGTTGCTGTACACCAAAGTGGCTTACAAGACAGATAAGGTTCTTTACAAGAGAAACGGATACTGA","protein_sequence":"MKKTPDPSPPFASTKNVGMSNEEPEKMVNDRIVVKAIEPKDEEAWNKLWKEYQGFQKTVMPPEVATTTFARFIDPTVKLWGALAFDTETGDAIGFAHYLNHLTSWHVEEVVYMNDLYVTERARVKGVGRKLIEFVYSRADELGTPAVYWVTDHYNHRAQLLYTKVAYKTDKVLYKRNGY"}]}