{"ymdb_id":"YMDB00846","created_at":"2011-05-29T18:57:51.000Z","updated_at":"2016-09-08T18:35:58.000Z","name":"Alpha-D-Mannose","cas":"3458-28-4","state":"Solid","melting_point":"132 oC","description":"Mannose is a six-carbon sugar (aldohexose), C-2 epimer of glucose. Only the D-isomers are known to occur naturally. D-Mannose can be formed by the oxidation of D-mannitol. Alpha-D-Mannose is the alpha anomer of D-mannose.","experimental_water_solubility":"713 mg/mL at 17 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":" Sowden, John C.; Fischer, Hermann O. L. Condensation of nitromethane with D- and L-arabinose: preparation of L-glucose and L-mannose. Journal of the American Chemical Society (1947), 69 1963-5.","chebi_id":"28729","hmdb_id":"HMDB00169","kegg_id":"C00936","pubchem_id":"18950","cs_id":"23184483","foodb_id":null,"wikipedia_link":"Mannose","biocyc_id":"MANNOSE","iupac":"(2S,3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol","traditional_iupac":"α-D-mannose","logp":"-2.932539218","pka":"12.687538461190869","alogps_solubility":"7.82e+02 g/l","alogps_logp":"-2.57","alogps_logs":"0.64","acceptor_count":"6","donor_count":"5","rotatable_bond_count":"1","polar_surface_area":"110.38000000000001","refractivity":"35.9234","polarizability":"16.13167794027091","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-2.9810792051782764","pka_strongest_acidic":"11.298101552080594","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(+-)-mannose","(+)-mannose","alpha-D-Man","alpha-D-Mannose","Carubinose","Carubinose (van)","D-Mannopyranose","D-mannose","D(+)-mannose","DL-mannose","Hexose","Mannose","Mannose, d-","Seminose"],"pathways":[{"name":"Mannose Metabolism","kegg_map_id":null},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":338603,"citation":"Kaya, T., Aikawa, M., Matsumoto, T. (1977). \"Purification and properties of alpha-mannosidase from bakers' yeast.\" J Biochem 82:1443-1449."},{"pubmed_id":4570370,"citation":"Kaya, T., Shibano, M., Kutsumi, T. (1973). \"Isolation and characterization of -D-mannosidase from baker's yeast.\" J Biochem 73:181-182."}],"proteins":[{"created_at":"2011-05-27T09:41:16.000Z","updated_at":"2011-05-27T15:01:30.000Z","name":"Alpha-mannosidase","uniprot_id":"P22855","uniprot_name":"MAN1_YEAST","enzyme":true,"transporter":false,"gene_name":"AMS1","num_residues":1083,"molecular_weight":"124498.0","theoretical_pi":"7.26","general_function":"Involved in catalytic activity","specific_function":"Degrades free oligosaccharides in the vacuole","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Vacuole.","genbank_gene_id":"M29146","genbank_protein_id":"171058","gene_card_id":"AMS1","chromosome_location":"chromosome 7","locus":"YGL156W","synonyms":["Alpha-D-mannoside mannohydrolase"],"enzyme_classes":["3.2.1.24"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity, hydrolyzing O-glycosyl compounds"},{"category":"Function","description":" binding"},{"category":"Function","description":" alpha-mannosidase activity"},{"category":"Function","description":" mannosidase activity"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity, acting on glycosyl bonds"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" mannose metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"Alpha-mann_mid","identifier":"PF09261"},{"name":"Glyco_hydro_38","identifier":"PF01074"},{"name":"Glyco_hydro_38C","identifier":"PF07748"}],"pathways":[{"name":"Other glycan degradation","kegg_map_id":"00511"}],"gene_sequence":"ATGTCATCTGAGGATATCATTTATGATCCTCAGTTCAAACCTGTTCAGGGAATCTACGAGAATAGATTAAGACAATTTATTGATACTGGTGGGGATTACCATGACTTAAATTTACCCAAGTTTTATGATAAGAAGCGCATTTCATTAGATCATGATCACGTTAAGGTTTGGTGGTACCAGGTTTCTTTTGAACGTGGATCTTCCCCTGTTTCCCCTGATAAGAGGCCATCTTGGAAATCTATTATTGAACGTGACAAGAAGGGTGAATTGGAGTTTAGAGAAGCGAACATAAATCAGCCCTTTGGACCCAGTTGGTCTACCACTTGGTTCAAGGTGAAAATCTCTTTGCCTGAAGATTGGGTTAAATCAAACGAGCAACTACTTTTCCAATGGGATTGTTCTAACGAAGGAATTGTCATAGACCCAAAGACTCTAATCCCTGTGACTGCTTTTTCAGGTGGTGAAAGGACTGAATATGTTTTACCGAAAACATCGGATGGGAAACATTTCTTTTACATCGAAGCTGGTAATAATGGTATGTTTGGCTGCGGTGCAGGATCCACTATAAATCCACCAGATGATAATAGATTTTTTCATTTGAGAAAAGCTGATATCGTTTGGCCCGATCTAGATGCTCGTGCATTGTATATCGATTTTTGGATGCTAGGGGATGCTGCAAGAGAGCTACCTGGAGACTCCTGGCAAAAACACCAGGCAAGACAACTAGGCAATGCAGTTATGAATCTTTTTGACCCGAATGATCGTTCAAGTGTTCGTAAATGTCGTGAATTACTACAAAGGGAATACTTTGACTCCTTTTTAGAAAGCAGTAAGGTTTACGAACAAGGTGAATCTCAAGTTTTAACAAATGTTTATGGTATCGGCAACTGTCATATAGATACAGCTTGGCTATGGCCATTCGCAGAAACAAGAAGGAAAATTGTGAGATCTTGGTCTTCCCAATGTACTTTAATGGATCGCTTCCCAGAGTATAAATTTGTTGCTTCACAAGCCCAACAATTTAAATGGTTATTAGAAGATCATCCCGAATTTTTCAATAAAGTGTTAATTCCAAAAATTCAGCAATCTCAGTTTTTTGCTGTTGGTGGTACATGGGTTGAGAATGATACCAATATTCCCTCAGGGGAATCGCTGGCAAGGCAATTCTTTTTTGGTCAAAGGTTTTTCTTGAAGCATTTTGGTCTCAAGTCAAAGATATTTTGGTTACCTGACACCTTTGGTTATTCTTCGCAAATGCCACAACTTTGCCGCTTATCTGGTATTGATAAATTTTTGACTCAAAAGCTTTCCTGGAATAACATCAACAGTTTTCCGCATAGCACGTTTAACTGGGCAGGGATTGACGGTTCTCAATTATTGACTCACATGCCTCCTGGTAATACGTATACAGCAGATTCACACTTCGGTGATGTTTTGCGTACTGCCAAGCAGAATAAGACACCAGAATATTACGGCTCCGGTTTAATGTTGTACGGAAAGGGTGATGGTGGTGGAGGACCAACTGAGGAAATGCTGCAAAAAATGAGGCGTATTAGATCCATGAATAACAGAAATGGTAATGTTATTCCAAAGTTACAAGTTGGTATAACGGTTGATGAATTTTATGATGACATTTTGAAAAGGACTAACCAAGGCCATGATTTACCCACATGGAGTGGTGAATTGTATTTCGAATTTCATAGGGGGACATACACCAGTCAAGCTCAGACCAAAAAATTAATGAGGTTGTCCGAAATTAAACTACATGATTTGGAATGGATAGCTGCCAAAACATCAGTTTTATATCCCGATTCGTATAAATACCCTTCCAAACAGATTAACGAACTTTGGGAGAATGTTTTGTTATGTCAATTTCACGATGTTCTACCAGGATCATGTATTGAAATGGTATATAAGTATGAGGCTGTCCCTATGTTGCACAACGTTGTGAAAGAATGTACTTCCTTAATAGACAAAACCGTTCAATTTCTTCAGAGTCAGAGTAAGGCAGATTTGGTTGAGATGAGAACATTAACTTGGTCAAAACCAGAAAAGGTTTCTGAGGAGTGCTCGTTGAACGGTAGTTACACGTCCTCTGTAACCGGGTACGATGACTATATAGTCCTTGCCAATGGGAAGTTGAAAGTTATCATTTGCAAAAAGACTGGGGTGATCACAAGCATTACGGATGAAACTTTGGGGGTAGAATACCTGGACACGGAACATGGCAGAAACAAATTGGGCGCCAACCAGTTTGTTATTTATGATGATAAACCTTTGGGCTGGCAGGCTTGGGATACTGAACTTTATTCCGTCAACCAATACAAGTATGTAACAAAGCCGAAGAAAGTTCAACTTTCCTGCAACACAAAAGAGAAATGTGCTGTTGAGGCTATTTTTCAAATTTCCGAAAAATGCAAAATCAAATCAGTGATATCACTCAATGCAACTGCGGTCACTGATGCTAAATTAAGTAAAGTAGACATTTCTACGACGGTAGAAAACTGGGATGCTAGAAACAAATTTTTAAAAGTTGAATTTCCCGTTAATATTCGGAACGATTTTGCTTCGTATGAAACTCAATTCGGGATTACCAAAAGACCAACACATTATAATACCTCATGGGACGTCGCTAAATTTGAGGTTTGCCATCACAAATTTGCTGATTATTCTGAATACAGCAAGGGTGTTTCAATTTTGAACGATTGCAAATATGGGTTTTCCACACACGGTAACTTGATGAGATTATCATTATTAAGGTCACCAAAGGCTCCGGATGCGCATGCTGATATGGGTACTCATGAGATAAAATATGCTATCTATCCACATAGAGGAGCACTATCAAGCGACACTGTTAAGCTCGCTCACGAATTCAATTATTGCTTCAAATACAAACTCCCCAAAGATATTGGCATGAATTTTGATGACATCATAAGCATTTCCGGAGATGAGAATGTCATTTTGTCTAACATAAAAAGAGGCGAAGATGATAGTGCTGTCAAGTCCAACTATTCATTAAATCCAAGGGATGAACAAAGTATTGTGGTAAGGGTTTACGAATCTCTTGGCGGGGAATCTTTTGCTTCACTAAATACCACACTAAATTTGAAGCGTATTGAGAAGGTCGATAACTTGGAGATGAAAGTTTATAAGAGTTTGACAGCAACGCGAGACGAATCAAATCATGCAATAAACAGAATTCCCATTAAATTGAGACCTTTTGAGATTGCCTCATTCAGGTTGTATTTCTGA","protein_sequence":"MSSEDIIYDPQFKPVQGIYENRLRQFIDTGGDYHDLNLPKFYDKKRISLDHDHVKVWWYQVSFERGSSPVSPDKRPSWKSIIERDKKGELEFREANINQPFGPSWSTTWFKVKISLPEDWVKSNEQLLFQWDCSNEGIVIDPKTLIPVTAFSGGERTEYVLPKTSDGKHFFYIEAGNNGMFGCGAGSTINPPDDNRFFHLRKADIVWPDLDARALYIDFWMLGDAARELPGDSWQKHQARQLGNAVMNLFDPNDRSSVRKCRELLQREYFDSFLESSKVYEQGESQVLTNVYGIGNCHIDTAWLWPFAETRRKIVRSWSSQCTLMDRFPEYKFVASQAQQFKWLLEDHPEFFNKVLIPKIQQSQFFAVGGTWVENDTNIPSGESLARQFFFGQRFFLKHFGLKSKIFWLPDTFGYSSQMPQLCRLSGIDKFLTQKLSWNNINSFPHSTFNWAGIDGSQLLTHMPPGNTYTADSHFGDVLRTAKQNKTPEYYGSGLMLYGKGDGGGGPTEEMLQKMRRIRSMNNRNGNVIPKLQVGITVDEFYDDILKRTNQGHDLPTWSGELYFEFHRGTYTSQAQTKKLMRLSEIKLHDLEWIAAKTSVLYPDSYKYPSKQINELWENVLLCQFHDVLPGSCIEMVYKYEAVPMLHNVVKECTSLIDKTVQFLQSQSKADLVEMRTLTWSKPEKVSEECSLNGSYTSSVTGYDDYIVLANGKLKVIICKKTGVITSITDETLGVEYLDTEHGRNKLGANQFVIYDDKPLGWQAWDTELYSVNQYKYVTKPKKVQVSCNTKEKCAVEVIFQISEKCKIKSVISLNATAVTDAKLSKVDISTTVENWDARNKFLKVEFPVNIRNDFASYETQFGITKRPTHYNTSWDVAKFEVCHHKFADYSEYSKGVSILNDCKYGFSTHGNLMRLSLLRSPKAPDAHADMGTHEIKYAIYPHRGALSSDTVKLAHEFNYCFKYKLPKDIGMNFDDIISISGDENVILSNIKRGEDDSAVKSNYSLNPRDEQSIVVRVYESLGGESFASLNTTLNLKRIEKVDNLEMKVYKSLTATRDESNHAINRIPIKLRPFEIASFRLYF"}]}