{"ymdb_id":"YMDB00805","created_at":"2011-05-29T18:54:29.000Z","updated_at":"2016-09-08T18:35:55.000Z","name":"D-Tyrosine","cas":"556-02-5","state":"Solid","melting_point":"343 oC","description":"Tyrosine (abbreviated as Tyr or Y) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. D-isomers are used as carbon, nitrogen, and energy source. In plants and most microorganisms, tyrosine is produced via prephenate, an intermediate of the shikimate pathway.","experimental_water_solubility":"0.479 mg/mL at 25 oC [SEIDELL,A (1941)]","experimental_logp_hydrophobicity":"-2.26 [HANSCH,C ET AL. (1995)]","location":null,"synthesis_reference":null,"chebi_id":"28479","hmdb_id":"HMDB00158","kegg_id":"C06420","pubchem_id":"6057","cs_id":"64252","foodb_id":null,"wikipedia_link":"Tyrosine","biocyc_id":"TYR","iupac":"(2R)-2-amino-3-(4-hydroxyphenyl)propanoic acid","traditional_iupac":"(.+-.)-tyrosine","logp":"-1.4885940366836234","pka":"9.792157836784154","alogps_solubility":"7.67e+00 g/l","alogps_logp":"-2.39","alogps_logs":"-1.37","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"3","polar_surface_area":"83.55","refractivity":"47.09720000000001","polarizability":"18.05508871589717","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.185299922384795","pka_strongest_acidic":"1.9998472511533611","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(-)-a-Amino-p-hydroxyhydrocinnamate","(-)-a-Amino-p-hydroxyhydrocinnamic acid","(-)-alpha-Amino-p-hydroxyhydrocinnamate","(-)-alpha-Amino-p-hydroxyhydrocinnamic acid","(2R)-2-amino-3-(4-hydroxyphenyl)propanoic acid","(R)-2-Amino-3-(p-hydroxyphenyl)propionic acid","(R)-3-(p-Hydroxyphenyl)alanine","(S)-(-)-Tyrosine","(S)-2-Amino-3-(p-hydroxyphenyl)propionate","(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid","(S)-3-(p-Hydroxyphenyl)alanine","(S)-a-amino-4-hydroxy-Benzenepropanoate","(S)-a-amino-4-hydroxy-Benzenepropanoic acid","(S)-a-Amino-4-hydroxybenzenepropanoate","(S)-a-Amino-4-hydroxybenzenepropanoic acid","(S)-alpha-amino-4-hydroxy-Benzenepropanoate","(S)-alpha-amino-4-hydroxy-Benzenepropanoic acid","(S)-alpha-Amino-4-hydroxybenzenepropanoate","(S)-alpha-Amino-4-hydroxybenzenepropanoic acid","(S)-Tyrosine","3-(4-Hydroxyphenyl)-L-alanine","4-hydroxy-L-Phenylalanine","Benzenepropanoate","Benzenepropanoic acid","D-Tyrosin","D-Tyrosine","L-p-Tyrosine","L-tyrosine","p-Tyrosine","Tyr","Tyrosine"],"pathways":[{"name":"Tyrosine metabolism","kegg_map_id":"00350"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":5847960,"citation":"Zenk, M. H., Schmitt, J. H. (1965). \"[Purification and properties of acetyl-CoA: D-amino acid-alpha-N-acetyltransferase from yeast].\" Biochem Z 342:54-65."},{"pubmed_id":10935926,"citation":"Vaseghi, S., Baumeister, A., Rizzi, M., Reuss, M. (1999). \"In vivo dynamics of the pentose phosphate pathway in Saccharomyces cerevisiae.\" Metab Eng 1:128-140."}],"proteins":[{"created_at":"2011-05-26T23:37:41.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"N-acetyltransferase HPA3","uniprot_id":"P39979","uniprot_name":"HPA3_YEAST","enzyme":true,"transporter":false,"gene_name":"HPA3","num_residues":179,"molecular_weight":"20698.5","theoretical_pi":"7.84","general_function":"Involved in N-acetyltransferase activity","specific_function":"N-acetyltransferase whose physiological acetyl acceptor substrate is still unknown. In vitro, histone acetylation is very weak","reactions":[{"id":2617,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U18795","genbank_protein_id":"603252","gene_card_id":"HPA3","chromosome_location":"chromosome 5","locus":"YEL066W","synonyms":[],"enzyme_classes":["2.3.1.-","2.3.1.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" acetyltransferase activity"},{"category":"Function","description":" N-acetyltransferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Acetyltransf_1","identifier":"PF00583"}],"pathways":[],"gene_sequence":"ATGAAAAAGACCCCAGACCCATCTCCACCTTTTGCAAGCACGAAGAACGTAGGCATGTCAAACGAAGAACCGGAAAAAATGGTTAACGATCGAATTGTGGTGAAGGCCATCGAGCCAAAAGATGAGGAAGCCTGGAACAAACTGTGGAAGGAGTATCAGGGTTTCCAAAAAACGGTTATGCCTCCGGAAGTAGCCACCACTACCTTCGCAAGGTTTATAGACCCTACGGTCAAACTATGGGGTGCTCTAGCCTTTGACACCGAGACCGGCGATGCAATTGGCTTTGCACACTACCTGAACCATTTGACGTCGTGGCATGTCGAAGAAGTTGTCTACATGAATGACTTATATGTCACTGAACGCGCAAGAGTCAAAGGCGTAGGTAGAAAGCTCATAGAATTTGTATACAGCCGTGCCGATGAGCTCGGTACGCCTGCAGTGTACTGGGTTACAGACCATTACAATCACCGCGCACAGTTGCTGTACACCAAAGTGGCTTACAAGACAGATAAGGTTCTTTACAAGAGAAACGGATACTGA","protein_sequence":"MKKTPDPSPPFASTKNVGMSNEEPEKMVNDRIVVKAIEPKDEEAWNKLWKEYQGFQKTVMPPEVATTTFARFIDPTVKLWGALAFDTETGDAIGFAHYLNHLTSWHVEEVVYMNDLYVTERARVKGVGRKLIEFVYSRADELGTPAVYWVTDHYNHRAQLLYTKVAYKTDKVLYKRNGY"}]}