{"ymdb_id":"YMDB00795","created_at":"2011-05-29T18:53:43.000Z","updated_at":"2016-09-12T20:56:47.000Z","name":"4,4-dimethyl-5alpha-cholest-7-en-3beta-ol","cas":"6384-28-7","state":"Solid","melting_point":null,"description":"4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol (14-demethyllanosterol) is an intermediate in sterol biosynthesis.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":"16455","hmdb_id":null,"kegg_id":"C04530","pubchem_id":"5460076","cs_id":"25994968","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(1R,2R,5S,7R,11R,14R,15R)-2,6,6,15-tetramethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-9-en-5-ol","traditional_iupac":"4,4-dimethylzymosterol","logp":"7.855862706999998","pka":null,"alogps_solubility":"2.88e-05 g/l","alogps_logp":"7.61","alogps_logs":"-7.16","acceptor_count":"1","donor_count":"1","rotatable_bond_count":"5","polar_surface_area":"20.23","refractivity":"129.48619999999997","polarizability":"54.27821686535964","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-0.8068021124545001","pka_strongest_acidic":"19.55417898387174","bioavailability":"1","number_of_rings":"4","rule_of_five":"0","ghose_filter":"0","veber_rule":"1","mddr_like_rule":"0","synonyms":["4,4-dimethyl-5alpha-cholest-7-en-3beta-ol"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."}],"proteins":[{"created_at":"2011-05-27T03:19:10.000Z","updated_at":"2011-07-22T17:54:21.000Z","name":"C-4 methylsterol oxidase","uniprot_id":"P53045","uniprot_name":"ERG25_YEAST","enzyme":true,"transporter":false,"gene_name":"ERG25","num_residues":309,"molecular_weight":"36478.89844","theoretical_pi":"8.22","general_function":"Involved in iron ion binding","specific_function":"Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol","reactions":[{"id":1356,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1357,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1358,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1359,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2715,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; 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