{"ymdb_id":"YMDB00761","created_at":"2011-05-29T18:50:48.000Z","updated_at":"2016-09-08T18:35:52.000Z","name":"O-Phospho-L-serine","cas":"407-41-0","state":"Solid","melting_point":"170-171 oC","description":"O-Phospho-L-serine is an intermediate in serine biosynthesis pathway. Serine is an important precursor used for the biosynthesis of glycine, cysteine, tryptophan, and phospholipids. [Biocyc SERSYN-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":"Barruel, Elena Mery.  Biosynthesis of phosphoserine in vitro.    Anales Fac. Quim. y Farm.  (1960),  12  228-33. ","chebi_id":"15811","hmdb_id":"HMDB00272","kegg_id":"C01005","pubchem_id":"68841","cs_id":"62074","foodb_id":null,"wikipedia_link":"Phosphoserine","biocyc_id":"3-P-SERINE","iupac":"(2S)-2-amino-3-(phosphonooxy)propanoic acid","traditional_iupac":"phosphoserine","logp":"-3.180275047030002","pka":"2.066741968210883","alogps_solubility":"1.99e+01 g/l","alogps_logp":"-2.32","alogps_logs":"-0.97","acceptor_count":"6","donor_count":"4","rotatable_bond_count":"4","polar_surface_area":"130.08","refractivity":"32.9139","polarizability":"13.968826440672615","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"9.39423622748354","pka_strongest_acidic":"1.1985006020847058","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(+)-L-serine dihydrogen phosphate (ester)","(2S)-2-amino-3-(phosphonooxy)propanoic acid","(S)-2-amino-3-hydroxypropanoic acid 3-phosphate","3-O-Phosphoserine","3-phosphoserine","Dexfosfoserine","Fosforina","L-3-Phosphoserine","L-O-Phosphoserine","L-O-Serine phosphate","L-Phosphoserine","L-Serine dihydrogen phosphate (ester)","L-Serine phosphate","L-Serinephosphorate","L-Serinephosphoric acid","L-Seryl phosphate","O-Phospho-L-serine","O-phosphoserine","phosphoserine"],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8017107,"citation":"Belhumeur, P., Fortin, N., Clark, M. W. (1994). \"A gene from Saccharomyces cerevisiae which codes for a protein with significant homology to the bacterial 3-phosphoserine aminotransferase.\" Yeast 10:385-389."},{"pubmed_id":1326413,"citation":"Melcher, K., Entian, K. D. (1992). \"Genetic analysis of serine biosynthesis and glucose repression in yeast.\" Curr Genet 21:295-300."}],"proteins":[{"created_at":"2011-05-26T17:20:37.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Phosphoserine aminotransferase","uniprot_id":"P33330","uniprot_name":"SERC_YEAST","enzyme":true,"transporter":false,"gene_name":"SER1","num_residues":395,"molecular_weight":"43415.19922","theoretical_pi":"6.52","general_function":"Involved in metabolic process","specific_function":"Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine","reactions":[{"id":1800,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1894,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2474,"direction":"\u003e","locations":null,"altext":"O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2475,"direction":"\u003e","locations":null,"altext":"4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3842,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006365","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"L20917","genbank_protein_id":"311153","gene_card_id":"SER1","chromosome_location":"chromosome 15","locus":"YOR184W","synonyms":["PSAT","Phosphohydroxythreonine aminotransferase"],"enzyme_classes":["2.6.1.52"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" L-serine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Aminotran_5","identifier":"PF00266"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTTTGGAAAGAGAGGAACCACAACATTTCGGAGCAGGGCCAGCTCAAATGCCTACACCAGTTTTGCAACAAGCTGCTAAAGACTTAATCAATTTCAATGACATAGGTTTGGGTATCGGTGAAATTTCTCACCGTTCGAAGGATGCCACCAAAGTGATTGAAGACTCTAAGAAGCACTTAATCGAACTGCTAAATATTCCTGACACTCATGAAGTGTTCTACTTGCAAGGTGGTGGCACTACTGGTTTTTCTTCCGTTGCTACTAATTTGGCAGCTGCATATGTGGGTAAGCATGGGAAGATTGCACCTGCCGGTTATTTAGTCACCGGTAGTTGGTCTCAGAAATCTTTTGAAGAGGCAAAGAGATTGCACGTTCCTGCTGAAGTTATCTTCAACGCTAAAGATTATAACAATGGCAAATTTGGTAAAATTCCGGATGAATCCCTTTGGGAAGATAAAATCAAAGGTAAGGCTTTCTCATACGTGTACCTATGTGAGAATGAAACTGTTCATGGTGTTGAATGGCCAGAATTACCAAAATGTTTAGTAAACGACCCCAACATCGAAATTGTTGCTGACTTATCCAGCGACATTTTGTCTCGTAAGATTGACGTTTCTCAATACGGTGTCATCATGGCAGGCGCCCAAAAAAACATTGGTTTAGCAGGCTTAACCCTATACATTATCAAGAAATCCATCCTTAAGAATATTTCTGGCGCTTCTGATGAAACATTACATGAATTGGGAGTACCAATCACCCCTATTGCATTCGACTATCCAACGGTGGTGAAGAACAACTCAGCCTATAATACAATTCCAATTTTCACTTTACATGTTATGGATCTCGTGTTCCAACATATTTTGAAGAAGGGTGGTGTTGAAGCGCAACAGGCTGAAAATGAAGAAAAGGCCAAGATATTATATGAGGCATTGGATGCAAATTCAGATTTTTACAACGTTCCAGTGGATCCAAAGTGTAGATCAAAAATGAATGTCGTTTTCACCCTTAAAAAGGACGGCCTTGATGACCAGTTTCTAAAAGAGGCAGCTGCTCGTCATTTAACCGGTTTGAAAGGACATCGTTCAGTTGGTGGGTTCAGAGCCTCCATCTATAACGCGCTTTCAGTGAAAGCTGTACAAAACTTGGTAGATTTTATCAAGGAATTTGCTGAGAAAAACGCTTAA","protein_sequence":"MSLEREEPQHFGAGPAQMPTPVLQQAAKDLINFNDIGLGIGEISHRSKDATKVIEDSKKHLIELLNIPDTHEVFYLQGGGTTGFSSVATNLAAAYVGKHGKIAPAGYLVTGSWSQKSFEEAKRLHVPAEVIFNAKDYNNGKFGKIPDESLWEDKIKGKAFSYVYLCENETVHGVEWPELPKCLVNDPNIEIVADLSSDILSRKIDVSQYGVIMAGAQKNIGLAGLTLYIIKKSILKNISGASDETLHELGVPITPIAFDYPTVVKNNSAYNTIPIFTLHVMDLVFQHILKKGGVEAQQAENEEKAKILYEALDANSDFYNVPVDPKCRSKMNVVFTLKKDGLDDQFLKEAAARHLTGLKGHRSVGGFRASIYNALSVKAVQNLVDFIKEFAEKNA"},{"created_at":"2011-05-27T01:59:56.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"Phosphoserine phosphatase","uniprot_id":"P42941","uniprot_name":"SERB_YEAST","enzyme":true,"transporter":false,"gene_name":"SER2","num_residues":309,"molecular_weight":"34207.0","theoretical_pi":"4.83","general_function":"Involved in catalytic activity","specific_function":"O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate","reactions":[{"id":1893,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2654,"direction":"\u003e","locations":"Cytoplasmic","altext":"O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3843,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006366","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"U36473","genbank_protein_id":"1015428","gene_card_id":"SER2","chromosome_location":"chromosome 7","locus":"YGR208W","synonyms":["PSP","PSPase","O-phosphoserine phosphohydrolase"],"enzyme_classes":["3.1.3.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" phosphoserine phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" L-serine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCAAAGTTTGTTATCACCTGCATAGCTCATGGAGAAAATCTCCCAAAAGAAACCATCGACCAGATTGCGAAAGAAATTACTGAAAGCTCGGCGAAAGATGTATCAATCAATGGTACCAAGAAACTATCGGCCAGAGCTACCGATATATTCATTGAAGTCGCAGGATCGATTGTTCAAAAAGACCTCAAGAATAAGCTGACGAACGTCATTGACAGTCATAATGATGTTGATGTTATTGTTTCTGTCGACAATGAATATCGTCAAGCCAAAAAGCTCTTTGTCTTTGACATGGATTCAACATTAATCTACCAAGAGGTCATCGAATTGATTGCCGCTTATGCTGGTGTTGAAGAACAAGTGCACGAGATCACAGAAAGAGCCATGAACAATGAACTTGATTTCAAAGAGTCTTTAAGAGAACGCGTTAAATTATTGCAAGGCCTCCAAGTCGATACACTATATGATGAAATAAAACAAAAGCTAGAGGTCACCAAGGGTGTGCCAGAACTATGCAAGTTCCTTCACAAAAAAAATTGCAAGCTCGCTGTTTTAAGCGGTGGTTTTATTCAGTTTGCCGGTTTTATCAAGGATCAGTTAGGTTTAGATTTTTGTAAGGCAAACTTGTTGGAAGTTGACACTGATGGAAAATTAACCGGTAAAACACTGGGTCCTATCGTAGACGGACAGTGCAAGAGTGAAACCCTTCTGCAACTATGTAATGACTACAATGTTCCAGTTGAAGCAAGTTGTATGGTGGGTGACGGTGGTAACGACCTGCCAGCCATGGCTACCGCCGGGTTTGGGATCGCATGGAACGCCAAGCCAAAGGTGCAGAAAGCTGCACCTTGTAAGTTGAATACCAAGAGCATGACTGACATTTTATACATTCTTGGTTACACCGATGATGAAATATACAATAGACAATGA","protein_sequence":"MSKFVITCIAHGENLPKETIDQIAKEITESSAKDVSINGTKKLSARATDIFIEVAGSIVQKDLKNKLTNVIDSHNDVDVIVSVDNEYRQAKKLFVFDMDSTLIYQEVIELIAAYAGVEEQVHEITERAMNNELDFKESLRERVKLLQGLQVDTLYDEIKQKLEVTKGVPELCKFLHKKNCKLAVLSGGFIQFAGFIKDQLGLDFCKANLLEVDTDGKLTGKTLGPIVDGQCKSETLLQLCNDYNVPVEASCMVGDGGNDLPAMATAGFGIAWNAKPKVQKAAPCKLNTKSMTDILYILGYTDDEIYNRQ"}]}