{"ymdb_id":"YMDB00757","created_at":"2011-05-29T18:50:22.000Z","updated_at":"2016-09-12T20:54:20.000Z","name":"Glycerylphosphorylethanolamine","cas":null,"state":"Solid","melting_point":null,"description":"Glycerylphosphorylethanolamine is a membrane breakdown product resulting from the cleavage of the lipid group from glycerophosphoethanlomine fatty acids (i.e. phosphatidylethanolamine).","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cell envelope","synthesis_reference":null,"chebi_id":"52330","hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":"110410","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2-aminoethoxy)(2,3-dihydroxypropoxy)phosphinic acid","traditional_iupac":"glycerophosphorylethanolamine","logp":"-3.3911924765119976","pka":"13.641343579378521","alogps_solubility":"3.65e+01 g/l","alogps_logp":"-2.31","alogps_logs":"-0.77","acceptor_count":"5","donor_count":"4","rotatable_bond_count":"7","polar_surface_area":"122.24000000000001","refractivity":"43.8211","polarizability":"19.073348670448354","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.999830157645516","pka_strongest_acidic":"1.8690882900003905","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-aminoethyl ester 1-Glycerophosphoric acid","a-Glycerophosphorylethanolamine","alpha-Glycerophosphorylethanolamine","Glycerol 3-phosphoethanolamine","Glycerol 3-phosphorylethanolamine","Glycerophosphoethanolamine","Glycerophosphorylethanolamine","Glyceryl-3-phosphorylethanolamine","Glycerylphosphorylethanolamine","GPEA","sn-glycero-3-Phosphoethanolamine","sn-Glycerol-3-phosphoethanolamine"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":166987,"citation":"Angus, W. W., Lester, R. L. (1975). \"The regulated catabolism of endogenous and exogenous phosphatidylinositol by Saccharomyces cerevisiae leading to extracellular glycerophosphorylinositol and inositol.\" J Biol Chem 250:22-30."},{"pubmed_id":8051052,"citation":"Lee, K. S., Patton, J. L., Fido, M., Hines, L. K., Kohlwein, S. D., Paltauf, F., Henry, S. A., Levin, D. E. (1994). \"The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity.\" J Biol Chem 269:19725-19730."}],"proteins":[{"created_at":"2011-05-27T06:41:25.000Z","updated_at":"2011-05-29T05:06:44.000Z","name":"Lysophospholipase 1","uniprot_id":"P39105","uniprot_name":"PLB1_YEAST","enzyme":true,"transporter":false,"gene_name":"PLB1","num_residues":664,"molecular_weight":"71666.60156","theoretical_pi":"4.3","general_function":"Involved in metabolic process","specific_function":"Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine \u003e phosphatidylinositol \u003e\u003e phosphatidylcholine \u003e phosphatidylethanolamine","reactions":[{"id":1870,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1871,"direction":"\u003c\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2793,"direction":"\u003e","locations":" Lipid-anchor, GPI-anchor (Potential); Lipid-anchor, GPI-anchor.;Endoplasmic reticulum membrane;Cell membrane; Multi-pass membrane protein;Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor (Probable)","altext":"2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-22","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Lipid-anchor, GPI-anchor (Probable)","genbank_gene_id":"AY692788","genbank_protein_id":"51013027","gene_card_id":"PLB1","chromosome_location":"chromosome 13","locus":"YMR008C","synonyms":["Phospholipase B 1"],"enzyme_classes":["3.1.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" lipase activity"},{"category":"Function","description":" phospholipase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" phospholipid catabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PLA2_B","identifier":"PF01735"}],"pathways":[{"name":"Glycerophospholipid metabolism","kegg_map_id":"00564"}],"gene_sequence":"ATGAAGTTGCAGAGTTTGTTGGTTTCTGCTGCAGTTTTGACTTCTCTAACAGAGAACGTTAACGCTTGGTCACCAAATAACAGTTACGTCCCTGCGAACGTAACCTGTGATGATGATATTAACTTAGTCAGAGAAGCATCTGGTTTGTCAGATAACGAAACAGAATGGCTGAAAAAAAGAGATGCATACACCAAGGAGGCTTTGCATTCTTTTTTGAATAGGGCCACTTCGAATTTCAGTGACACTTCCTTGCTATCCACTCTTTTTGGTAGCAACCCTTCCAATATGCCTAAGATTGCCGTCGCCTGTTCTGGTGGTGGTTACCGTGCCATGTTGTCTGGTGCTGGTATGCTTGCTGCTATGGACAATCGTACTGATGGCGCAAATGAGCATGGTCTTGGTGGGCTGCTGCAAGGTGCAACTTACTTGGCAGGTCTGTCGGGTGGTAACTGGTTAACAAGTACTTTGGCTTGGAACAACTGGACGTCTGTGCAAGCTATCGTGGATAATACAACAGAATCTAACTCAATTTGGGACATCTCTCATTCAATTCTTACCCCAGACGGCATTAACATCTTTAAGACTGGGAGTAGATGGGACGACATATCAGATGACGTTCAGGATAAAAAAGACGCCGGTTTCAACATCTCTTTGGCGGATGTTTGGGGCCGTGCTCTTGCGTACAATTTTTGGCCAAGCTTACACCGTGGTGGTGTAGGGTACACATGGTCAACTTTAAGGGAAGCTGATGTCTTCAAGAATGGAGAAATGCCCTTCCCTATCACTGTTGCAGACGGTAGATACCCAGGTACCACCGTGATAAACTTGAATGCCACTCTTTTCGAATTTAATCCCTTTGAAATGGGTTCATGGGACCCCACTTTGAACGCATTTACGGATGTGAAGTATTTAGGTACCAACGTTACAAACGGTAAACCAGTTAATAAAGGCCAATGCATTGCCGGGTTTGATAACACTGGTTTCATAACAGCCACTTCATCTACGTTGTTTAACCAATTTTTACTAAGATTGAATTCTACCGATTTACCTTCATTTATTGCTAACTTAGCCACCGATTTCCTGGAAGATTTATCCGACAATAGTGACGATATTGCAATTTACGCCCCAAATCCATTCAAGGAAGCTAATTTTCTTCAAAAGAACGCAACCTCCAGTATTATCGAATCAGAATATCTATTTTTGGTTGATGGTGGTGAAGATAACCAAAATATTCCTTTAGTTCCATTGTTGCAAAAGGAACGTGAACTAGATGTTATTTTTGCATTAGACAATTCTGCTGATACTGACGACTATTGGCCAGATGGTGCTTCATTAGTTAACACTTATCAGCGTCAATTTGGCAGCCAAGGTCTCAATTTGTCTTTCCCATATGTTCCAGATGTGAACACATTTGTCAACTTGGGGTTGAACAAAAAGCCAACCTTTTTTGGTTGTGATGCAAGAAATTTGACAGACTTGGAGTACATTCCACCATTAATTGTTTACATTCCAAATTCAAGACATTCATTTAATGGTAACCAAAGTACTTTTAAGATGTCATACTCCGATTCAGAACGTCTTGGTATGATTAAGAATGGGTTTGAAGCTGCCACAATGGGTAATTTTACTGATGATTCTGATTTCTTGGGCTGTGTTGGTTGCGCCATTATCAGACGTAAGCAACAAAACTTGAATGCTACATTGCCCTCTGAATGCAGCCAGTGTTTTACCAACTACTGCTGGAACGGTACTATTGACAGCAGGTCAGTCTCAGGTGTAGGAAATGATGATTATTCTTCTTCTGCTTCCTTGTCTGCCTCCGCCGCTGCTGCCTCTGCCTCTGCCTCTGCCTCTGCTTCCGCCTCTGCCTCTGCTTCTGGGTCTTCCACTCATAAGAAAAATGCGGGCAATGCTTTGGTGAATTATTCTAACTTAAACACTAACACTTTTATTGGTGTCTTAAGTGTCATTAGTGCCGTCTTCGGTCTAATTTAG","protein_sequence":"MKLQSLLVSAAVLTSLTENVNAWSPNNSYVPANVTCDDDINLVREASGLSDNETEWLKKRDAYTKEALHSFLNRATSNFSDTSLLSTLFGSNSSNMPKIAVACSGGGYRAMLSGAGMLAAMDNRTDGANEHGLGGLLQGATYLAGLSGGNWLTSTLAWNNWTSVQAIVDNTTESNSIWDISHSILTPDGINIFKTGSRWDDISDDVQDKKDAGFNISLADVWGRALAYNFWPSLHRGGVGYTWSTLREADVFKNGEMPFPITVADGRYPGTTVINLNATLFEFNPFEMGSWDPTLNAFTDVKYLGTNVTNGKPVNKGQCIAGFDNTGFITATSSTLFNQFLLRLNSTDLPSFIANLATDFLEDLSDNSDDIAIYAPNPFKEANFLQKNATSSIIESEYLFLVDGGEDNQNIPLVPLLQKERELDVIFALDNSADTDDYWPDGASLVNTYQRQFGSQGLNLSFPYVPDVNTFVNLGLNKKPTFFGCDARNLTDLEYIPPLIVYIPNSRHSFNGNQSTFKMSYSDSERLGMIKNGFEAATMGNFTDDSDFLGCVGCAIIRRKQQNLNATLPSECSQCFTNYCWNGTIDSRSVSGVGNDDYSSSASLSASAAAASASASASASASASASGSSTHKKNAGNALVNYSNLNTNTFIGVLSVISAVFGLI"}]}