{"ymdb_id":"YMDB00741","created_at":"2011-05-29T18:48:54.000Z","updated_at":"2016-09-08T18:35:50.000Z","name":"nicotinic acid D-ribonucleotide","cas":null,"state":null,"melting_point":null,"description":"Nicotinic acid D-ribonucleotide is involved in nicotinate and nicotinamide metabolism.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm, Mitochondrion","synthesis_reference":null,"chebi_id":"15763","hmdb_id":null,"kegg_id":"C01185","pubchem_id":"121992","cs_id":"24785392","foodb_id":null,"wikipedia_link":null,"biocyc_id":"NICOTINATE_NUCLEOTIDE","iupac":"3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1lambda5-pyridin-1-ylium","traditional_iupac":"3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1lambda5-pyridin-1-ylium","logp":"-5.437405301471745","pka":"2.769972865112575","alogps_solubility":"1.71e+00 g/l","alogps_logp":"-0.99","alogps_logs":"-2.34","acceptor_count":"8","donor_count":"5","rotatable_bond_count":"5","polar_surface_area":"157.63000000000002","refractivity":"69.8852","polarizability":"28.664880155700757","formal_charge":"1","physiological_charge":"-2","pka_strongest_basic":"-3.7319661030900226","pka_strongest_acidic":"1.200840941351724","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["beta-nicotinate d-ribonucleotide","Nicotinate D-ribonucleotide","nicotinate ribonucleotide","nicotinic acid ribonucleotide"],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":19416965,"citation":"Lu, S. P., Kato, M., Lin, S. J. (2009). \"Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.\" J Biol Chem 284:17110-17119."},{"pubmed_id":15078171,"citation":"Magni, G., Amici, A., Emanuelli, M., Orsomando, G., Raffaelli, N., Ruggieri, S. (2004). \"Structure and function of nicotinamide mononucleotide adenylyltransferase.\" Curr Med Chem 11:873-885."}],"proteins":[{"created_at":"2011-05-26T17:48:34.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Nicotinate-nucleotide pyrophosphorylase [carboxylating]","uniprot_id":"P43619","uniprot_name":"NADC_YEAST","enzyme":true,"transporter":false,"gene_name":"BNA6","num_residues":295,"molecular_weight":"32364.69922","theoretical_pi":"5.64","general_function":"Involved in catalytic activity","specific_function":"Involved in the catabolism of quinolinic acid (QA)","reactions":[{"id":1780,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2484,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4180,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006480","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"BNA6","chromosome_location":"chromosome 6","locus":"YFR047C","synonyms":["Quinolinate phosphoribosyltransferase [decarboxylating]","QAPRTase"],"enzyme_classes":["2.4.2.19"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nicotinate-nucleotide diphosphorylase (carboxylating) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Process","description":" NAD biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"}],"pfams":[{"name":"QRPTase_C","identifier":"PF01729"},{"name":"QRPTase_N","identifier":"PF02749"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCTGTTTATGAACACTTATTGCCCGTTAATGGAGCATGGAGACAAGACGTCACCAATTGGCTGAGCGAGGACGTTCCTTCTTTTGATTTTGGTGGATATGTTGTTGGTTCCGACCTAAAGGAGGCCAATTTGTACTGTAAGCAGGATGGTATGCTGTGTGGTGTCCCCTTTGCGCAAGAAGTCTTTAATCAGTGCGAATTGCAAGTTGAGTGGTTGTTTAAGGAAGGCTCCTTCTTGGAGCCTTCGAAGAATGACTCTGGTAAGATTGTTGTAGCTAAAATTACTGGGCCCGCTAAAAACATTCTATTAGCTGAAAGAACCGCCTTGAACATCCTTAGTAGAAGTAGTGGAATTGCCACCGCCTCACATAAGATAATCAGTTTGGCGCGTTCGACTGGTTACAAGGGGACCATTGCGGGGACAAGAAAGACTACACCAGGTTTACGTAGATTAGAAAAGTATTCCATGCTTGTAGGTGGCTGCGACACGCACAGATACGACCTTTCCTCTATGGTCATGCTCAAAGATAATCATATTTGGGCTACTGGTTCTATAACAAACGCAGTTAAGAACGCCAGGGCCGTGTGCGGGTTTGCTGTGAAGATCGAAGTGGAGTGTTTGAGTGAAGATGAAGCCACAGAGGCCATTGAAGCTGGTGCAGACGTTATCATGTTGGATAATTTCAAAGGTGACGGTTTGAAAATGTGCGCCCAAAGTCTTAAGAACAAATGGAATGGTAAAAAGCATTTCCTCTTGGAATGTAGTGGAGGCTTGAATTTGGACAACCTCGAGGAGTATTTGTGCGATGACATTGACATTTACAGCACTAGTAGCATTCATCAAGGCACACCAGTGATTGATTTCTCATTGAAACTGGCTCATTGA","protein_sequence":"MPVYEHLLPVNGAWRQDVTNWLSEDVPSFDFGGYVVGSDLKEANLYCKQDGMLCGVPFAQEVFNQCELQVEWLFKEGSFLEPSKNDSGKIVVAKITGPAKNILLAERTALNILSRSSGIATASHKIISLARSTGYKGTIAGTRKTTPGLRRLEKYSMLVGGCDTHRYDLSSMVMLKDNHIWATGSITNAVKNARAVCGFAVKIEVECLSEDEATEAIEAGADVIMLDNFKGDGLKMCAQSLKNKWNGKKHFLLECSGGLNLDNLEEYLCDDIDIYSTSSIHQGTPVIDFSLKLAH"},{"created_at":"2011-05-26T19:26:59.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Nicotinamide riboside kinase","uniprot_id":"P53915","uniprot_name":"NRK1_YEAST","enzyme":true,"transporter":false,"gene_name":"NRK1","num_residues":240,"molecular_weight":"27689.30078","theoretical_pi":"6.68","general_function":"Involved in ATP binding","specific_function":"Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)","reactions":[{"id":1954,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2567,"direction":"\u003e","locations":null,"altext":"ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide.","export":false,"pw_reaction_id":null,"source":null},{"id":2568,"direction":"\u003e","locations":null,"altext":"ATP + D-ribosylnicotinate = ADP + nicotinate D-ribonucleotide.","export":false,"pw_reaction_id":null,"source":null},{"id":4191,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006490","source":"Smpdb"},{"id":4192,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006496","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558011","genbank_protein_id":"45269912","gene_card_id":"NRK1","chromosome_location":"chromosome 14","locus":"YNL129W","synonyms":["NRK","NmR-K","Nicotinic acid riboside kinase","Ribosylnicotinamide kinase","RNK","Ribosylnicotinic acid kinase"],"enzyme_classes":["2.7.1.22"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PRK","identifier":"PF00485"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTTCGAAAAAAGTGATATTAGTTGCATTGAGTGGATGCTCCTCCAGTGGTAAGACGACAATTGCGAAACTTACAGCAAGTTTATTCACGAAGGCTACATTAATTCATGAAGATGACTTTTACAAACATGATAATGAAGTGCCAGTAGATGCTAAATATAACATTCAAAATTGGGATTCGCCAGAAGCTCTTGATTTTAAACTTTTCGGTAAAGAATTAGATGTGATCAAACAAACTGGTAAAATAGCCACCAAACTTATACACAATAACAACGTAGATGATCCCTTTACAAAGTTCCACATTGATAGACAAGTTTGGGACGAGTTAAAGGCTAAGTATGACTCTATTAATGACGACAAATATGAAGTTGTAATTGTAGATGGGTTTATGATTTTCAATAATACTGGAATATCAAAAAAATTTGATTTGAAGATATTAGTGCGTGCTCCCTATGAAGTACTAAAAAAAAGGAGGGCTTCCAGAAAAGGATACCAGACTTTGGATTCTTTCTGGGTGGATCCGCCGTATTATTTCGACGAATTTGTGTATGAATCTTATCGTGCAAATCATGCGCAGTTATTTGTTAATGGAGACGTAGAAGGTTTACTAGACCCAAGGAAGTCAAAGAATATAAAAGAGTTCATAAATGATGATGACACTCCAATTGCGAAACCTTTAAGCTGGGTGTGCCAAGAGATTCTAAAGCTTTGTAAGGATTAG","protein_sequence":"MTSKKVILVALSGCSSSGKTTIAKLTASLFTKATLIHEDDFYKHDNEVPVDAKYNIQNWDSPEALDFKLFGKELDVIKQTGKIATKLIHNNNVDDPFTKFHIDRQVWDELKAKYDSINDDKYEVVIVDGFMIFNNTGISKKFDLKILVRAPYEVLKKRRASRKGYQTLDSFWVDPPYYFDEFVYESYRANHAQLFVNGDVEGLLDPRKSKNIKEFINDDDTPIAKPLSWVCQEILKLCKD"},{"created_at":"2011-05-26T19:37:07.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Nicotinamide-nucleotide adenylyltransferase 2","uniprot_id":"P53204","uniprot_name":"NMA2_YEAST","enzyme":true,"transporter":false,"gene_name":"NMA2","num_residues":395,"molecular_weight":"44908.69922","theoretical_pi":"5.75","general_function":"Involved in nucleotidyltransferase activity","specific_function":"ATP + nicotinamide ribonucleotide = diphosphate + NAD(+);ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+","reactions":[{"id":1777,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1779,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2581,"direction":"\u003e","locations":"Nucleus","altext":"ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).","export":false,"pw_reaction_id":null,"source":null},{"id":2582,"direction":"\u003e","locations":"Nucleus","altext":"ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+","export":false,"pw_reaction_id":null,"source":null},{"id":4181,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006483","source":"Smpdb"},{"id":4182,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006491","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"Z72795","genbank_protein_id":"1322971","gene_card_id":"NMA2","chromosome_location":"chromosome 7","locus":"YGR010W","synonyms":["NAD(+) diphosphorylase 2","NAD(+) pyrophosphorylase 2","NMN adenylyltransferase 2"],"enzyme_classes":["2.7.7.1","2.7.7.18"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"},{"category":"Process","description":" NAD biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"}],"pfams":[{"name":"CTP_transf_2","identifier":"PF01467"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGGATCCCACCAAAGCACCCGATTTTAAACCGCCACAGCCAAATGAAGAACTACAACCACCGCCAGATCCAACACATACGATACCAAAATCTGGACCCATAGTTCCATATGTTTTAGCTGATTATAATTCTTCGATCGATGCTCCTTTCAATCTCGACATTTACAAAACCCTGTCGTCAAGGAAAAAAAACGCCAACTCAAGCAACCGAATGGACCATATTCCATTAAATACTAGTGACTTCCAGCCACTATCTCGGGATGTATCATCGGAGGAGGAAAGTGAAGGGCAATCGAATGGAATTGACGCTACTCTACAGGATGTTACGATGACTGGGAATTTGGGGGTACTGAAGAGCCAAATTGCTGATTTGGAAGAAGTTCCTCACACAATTGTAAGACAAGCCAGAACTATTGAAGATTACGAATTTCCTGTACACAGATTGACGAAAAAGTTACAAGATCCTGAAAAACTGCCTCTGATCATCGTTGCTTGTGGATCATTTTCTCCCATAACATACCTACATTTGAGAATGTTTGAAATGGCTTTAGATGATATCAATGAGCAAACGCGTTTTGAAGTGGTTGGTGGTTATTTTTCTCCAGTAAGTGATAACTATCAAAAGCGAGGGTTAGCCCCAGCTTATCATCGTGTCCGCATGTGCGAATTAGCATGCGAGCGGACATCATCTTGGTTAATGGTTGATGCCTGGGAATCTTTACAATCAAGTTATACAAGGACAGCAAAAGTCTTGGACCATTTCAATCATGAAATAAATATCAAGAGAGGTGGAATCATGACTGTAGATGGTGAAAAAATGGGCGTAAAAATCATGTTATTGGCAGGCGGTGATCTTATCGAATCCATGGGCGAGCCTCATGTGTGGGCTGATTCAGACCTGCACCATATTTTGGGTAATTATGGATGTTTGATCGTGGAAAGGACTGGTTCTGATGTTAGGTCCTTCTTGCTTTCCCATGATATCATGTATGAACACAGAAGAAATATCCTTATTATCAAACAACTTATTTACAATGATATTTCCTCTACGAAAGTGCGGCTTTTCATCAGACGTGGAATGTCAGTTCAATATCTTCTTCCAAACTCTGTCATCCGTTACATCCAAGAGTATAATCTATACATTAATCAAAGTGAACCGGTCAAGCAGGTCTTGGATAGCAAAGAGTGA","protein_sequence":"MDPTKAPDFKPPQPNEELQPPPDPTHTIPKSGPIVPYVLADYNSSIDAPFNLDIYKTLSSRKKNANSSNRMDHIPLNTSDFQPLSRDVSSEEESEGQSNGIDATLQDVTMTGNLGVLKSQIADLEEVPHTIVRQARTIEDYEFPVHRLTKKLQDPEKLPLIIVACGSFSPITYLHLRMFEMALDDINEQTRFEVVGGYFSPVSDNYQKRGLAPAYHRVRMCELACERTSSWLMVDAWESLQSSYTRTAKVLDHFNHEINIKRGGIMTVDGEKMGVKIMLLAGGDLIESMGEPHVWADSDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRGMSVQYLLPNSVIRYIQEYNLYINQSEPVKQVLDSKE"},{"created_at":"2011-05-26T20:11:17.000Z","updated_at":"2011-05-27T15:01:08.000Z","name":"Nicotinamide-nucleotide adenylyltransferase 1","uniprot_id":"Q06178","uniprot_name":"NMA1_YEAST","enzyme":true,"transporter":false,"gene_name":"NMA1","num_residues":401,"molecular_weight":"45858.60156","theoretical_pi":"6.89","general_function":"Involved in nucleotidyltransferase activity","specific_function":"ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)","reactions":[{"id":1778,"direction":"\u003c\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1779,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2581,"direction":"\u003e","locations":"Nucleus","altext":"ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).","export":false,"pw_reaction_id":null,"source":null},{"id":4181,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006483","source":"Smpdb"},{"id":4182,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006491","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U20618","genbank_protein_id":"662140","gene_card_id":"NMA1","chromosome_location":"chromosome 12","locus":"YLR328W","synonyms":["NAD(+) diphosphorylase 1","NAD(+) pyrophosphorylase 1","NMN adenylyltransferase 1"],"enzyme_classes":["2.7.7.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"},{"category":"Process","description":" NAD biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"}],"pfams":[{"name":"CTP_transf_2","identifier":"PF01467"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGGATCCCACAAGAGCTCCGGATTTCAAACCGCCATCTGCAGACGAGGAATTGATTCCTCCACCCGACCCGGAATCTAAAATTCCCAAATCTATTCCAATTATTCCATACGTCTTAGCCGATGCGAATTCCTCTATAGATGCACCTTTTAATATTAAGAGGAAGAAAAAGCATCCTAAGCATCATCATCACCATCATCACAGTCGTAAAGAAGGCAATGATAAAAAACATCAGCATATTCCATTGAACCAAGACGACTTTCAACCACTTTCCGCAGAAGTGTCTTCCGAAGATGATGACGCGGATTTTAGATCCAAGGAGAGATACGGTTCAGATTCAACCACAGAATCAGAAACTAGAGGTGTTCAGAAATATCAGATTGCTGATTTAGAAGAAGTTCCACATGGAATCGTTCGTCAAGCAAGAACCTTGGAAGACTACGAATTCCCCTCACACAGATTATCGAAAAAATTACTGGATCCAAATAAACTGCCGTTAGTAATAGTAGCATGTGGGTCTTTTTCACCAATCACCTACTTGCATCTAAGAATGTTTGAAATGGCTTTAGATGCAATCTCTGAACAAACAAGGTTTGAAGTCATAGGTGGATATTACTCCCCTGTTAGTGATAACTATCAAAAGCAAGGCTTGGCCCCATCCTACCATAGAGTACGTATGTGTGAATTGGCCTGCGAAAGAACCTCATCTTGGTTGATGGTGGATGCATGGGAGTCATTGCAACCTTCATACACAAGAACTGCCAAGGTCTTGGATCATTTCAATCACGAAATCAATATTAAGAGAGGTGGTGTAGCTACTGTTACTGGAGAAAAAATTGGTGTGAAAATAATGTTGCTGGCTGGTGGTGACCTAATAGAGTCAATGGGTGAACCAAACGTTTGGGCGGACGCCGATTTACATCACATTCTCGGTAATTACGGTTGTTTGATTGTCGAACGTACTGGTTCTGATGTAAGGTCTTTTTTGTTATCCCATGATATTATGTATGAACATAGAAGGAATATTCTTATCATCAAGCAACTCATCTATAATGATATTTCTTCCACGAAAGTTCGTCTATTTATCAGACGCGCCATGTCTGTACAATATTTGTTACCTAATTCGGTCATCAGGTATATCCAAGAACATAGACTATATGTGGACCAAACCGAACCTGTTAAGCAAGTTCTTGGAAACAAAGAATGA","protein_sequence":"MDPTRAPDFKPPSADEELIPPPDPESKIPKSIPIIPYVLADANSSIDAPFNIKRKKKHPKHHHHHHHSRKEGNDKKHQHIPLNQDDFQPLSAEVSSEDDDADFRSKERYGSDSTTESETRGVQKYQIADLEEVPHGIVRQARTLEDYEFPSHRLSKKLLDPNKLPLVIVACGSFSPITYLHLRMFEMALDAISEQTRFEVIGGYYSPVSDNYQKQGLAPSYHRVRMCELACERTSSWLMVDAWESLQPSYTRTAKVLDHFNHEINIKRGGVATVTGEKIGVKIMLLAGGDLIESMGEPNVWADADLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRAMSVQYLLPNSVIRYIQEHRLYVDQTEPVKQVLGNKE"},{"created_at":"2011-05-27T03:22:51.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Nicotinate phosphoribosyltransferase","uniprot_id":"P39683","uniprot_name":"NPT1_YEAST","enzyme":true,"transporter":false,"gene_name":"NPT1","num_residues":429,"molecular_weight":"49018.19922","theoretical_pi":"6.92","general_function":"Involved in nicotinate phosphoribosyltransferase activity","specific_function":"Essential for growth under anaerobic conditions","reactions":[{"id":1768,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2722,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4193,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006492","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1VLP","cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z75117","genbank_protein_id":"1420489","gene_card_id":"NPT1","chromosome_location":"chromosome 15","locus":"YOR209C","synonyms":["NAPRTase"],"enzyme_classes":["2.4.2.11"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" nicotinate phosphoribosyltransferase activity"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" NAD biosynthetic process"},{"category":"Process","description":" nucleotide biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nicotinate nucleotide biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"NAPRTase","identifier":"PF04095"}],"pathways":[{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCAGAACCAGTGATAAAGTCTCTTTTGGACACAGACATGTACAAGATTACGATGCATGCTGCTGTCTTCACTAATTTTCCAGATGTTACAGTTACTTATAAATATACCAACAGGTCGTCCCAATTGACCTTCAATAAGGAAGCCATTAATTGGTTGAAAGAGCAATTTTCGTATTTGGGAAATTTGAGGTTCACAGAAGAGGAAATTGAATACTTAAAACAGGAAATCCCATATTTGCCATCGGCATATATTAAGTATATTAGCAGTTCTAATTACAAACTACACCCTGAAGAGCAGATTTCCTTCACTTCAGAAGAAATCGAGGGCAAGCCCACCCACTACAAATTGAAAATTTTAGTCAGTGGTAGTTGGAAGGATACTATCCTTTATGAGATCCCCTTACTGTCCCTAATATCAGAAGCGTATTTTAAATTTGTTGACATCGACTGGGACTACGAAAACCAATTAGAACAAGCTGAGAAGAAGGCGGAAACTTTGTTTGATAATGGTATTAGATTCAGTGAATTTGGTACAAGACGTCGTAGATCTCTGAAGGCTCAAGATCTAATTATGCAAGGAATCATGAAAGCTGTGAACGGTAACCCAGACAGAAACAAATCGCTATTATTAGGCACATCAAATATTTTATTTGCCAAGAAATATGGAGTCAAGCCAATCGGTACTGTGGCTCACGAGTGGGTTATGGGAGTCGCTTCTATTAGTGAAGATTATTTGCATGCCAATAAAAATGCAATGGATTGTTGGATCAATACTTTTGGTGCAAAAAATGCTGGTTTAGCATTAACGGATACTTTTGGAACTGATGACTTTTTAAAATCATTCCGTCCACCATATTCTGATGCTTACGTCGGTGTTAGACAAGATTCTGGAGACCCAGTTGAGTATACCAAAAAGATTTCCCACCATTACCATGACGTGTTGAAATTGCCTAAATTCTCGAAGATTATCTGTTATTCCGATTCTTTGAACGTCGAAAAGGCAATAACTTACTCCCATGCAGCTAAAGAGAATGGAATGCTAGCCACATTCGGTATTGGCACAAACTTTACTAATGATTTTCGTAAGAAGTCAGAACCCCAGGTTAAAAGTGAGCCGTTAAACATCGTTATCAAACTATTAGAAGTAAATGGTAATCACGCTATCAAAATTTCTGATAACTTAGGTAAAAATATGGGAGATCCTGCCACTGTGAAGAGAGTGAAAGAGGAATTGGGATATACTGAACGAAGTTGGAGTGGTGATAACGAAGCGCACAGATGGACCTAA","protein_sequence":"MSEPVIKSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLTFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQEIPYLPSAYIKYISSSNYKLHPEEQISFTSEEIEGKPTHYKLKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQAEKKAETLFDNGIRFSEFGTRRRRSLKAQDLIMQGIMKAVNGNPDRNKSLLLGTSNILFAKKYGVKPIGTVAHEWVMGVASISEDYLHANKNAMDCWINTFGAKNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHDVLKLPKFSKIICYSDSLNVEKAITYSHAAKENGMLATFGIGTNFTNDFRKKSEPQVKSEPLNIVIKLLEVNGNHAIKISDNLGKNMGDPATVKRVKEELGYTERSWSGDNEAHRWT"}]}