{"ymdb_id":"YMDB00737","created_at":"2011-05-29T18:48:30.000Z","updated_at":"2016-09-08T18:35:50.000Z","name":"N-acetyl-D-glucosamine 6-phosphate","cas":"102029-88-9","state":"Solid","melting_point":"","description":"N-Acetyl-D-glucosamine 6-phosphate is an intermediate in the aminosugars metabolism. It is a substrate for glucosamine 6-phosphate N-acetyltransferase.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":null,"chebi_id":"15784","hmdb_id":"HMDB01062","kegg_id":"C00357","pubchem_id":"440996","cs_id":"389821","foodb_id":null,"wikipedia_link":null,"biocyc_id":"N-ACETYL-D-GLUCOSAMINE-6-P","iupac":"{[(2R,3S,4R,5R)-5-acetamido-3,4,6-trihydroxyoxan-2-yl]methoxy}phosphonic acid","traditional_iupac":"[(2R,3S,4R,5R)-5-acetamido-3,4,6-trihydroxyoxan-2-yl]methoxyphosphonic acid","logp":"-3.3441404429999997","pka":"6.248988545780625","alogps_solubility":"1.76e+01 g/l","alogps_logp":"-2.02","alogps_logs":"-1.23","acceptor_count":"8","donor_count":"6","rotatable_bond_count":"4","polar_surface_area":"165.78","refractivity":"57.8976","polarizability":"25.79907399050358","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-0.7858520307052878","pka_strongest_acidic":"1.2274470828963118","bioavailability":"1","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["N-Acetyl-D-Glucosamine 6-Phosphate","N-Acetyl-D-Glucosamine 6-Phosphic acid","n-acetyl-d-glucosamine-6-p","N-acetyl-D-glucosamine-6-phosphate","n-acetyl-glucosamine-6-p","n-acetyl-glucosamine-6-phosphate","n-acetylglucosamine-6-p"],"pathways":[{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":9867860,"citation":"Mio, T., Yamada-Okabe, T., Arisawa, M., Yamada-Okabe, H. (1999). \"Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis.\" J Biol Chem 274:424-429."}],"proteins":[{"created_at":"2011-05-24T21:14:00.000Z","updated_at":"2011-05-29T05:06:15.000Z","name":"Phosphoacetylglucosamine mutase","uniprot_id":"P38628","uniprot_name":"AGM1_YEAST","enzyme":true,"transporter":false,"gene_name":"PCM1","num_residues":557,"molecular_weight":"62066.10156","theoretical_pi":"5.75","general_function":"Involved in intramolecular transferase activity, phosphotransferases","specific_function":"Interconverts GlcNAc-6-P and GlcNAc-1-P","reactions":[{"id":1857,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1865,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2374,"direction":"\u003e","locations":null,"altext":"N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4135,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006430","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U18795","genbank_protein_id":"603260","gene_card_id":"PCM1","chromosome_location":"chromosome 5","locus":"YEL058W","synonyms":["PAGM","Acetylglucosamine phosphomutase","N-acetylglucosamine-phosphate mutase"],"enzyme_classes":["5.4.2.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" intramolecular transferase activity, phosphotransferases"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" phosphoacetylglucosamine mutase activity"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"PGM_PMM_I","identifier":"PF02878"},{"name":"PGM_PMM_II","identifier":"PF02879"},{"name":"PGM_PMM_IV","identifier":"PF00408"}],"pathways":[{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGAAGGTTGATTACGAGCAATTGTGCAAACTCTACGATGACACGTGCCGCACAAAGAATGTGCAGTTCAGTTACGGTACGGCCGGATTCAGAACGCTGGCCAAGAATTTGGATACGGTGATGTTCAGTACTGGTATACTGGCGGTTCTCAGGTCGCTGAAGCTTCAGGGTCAGTATGTGGGGGTGATGATCACGGCGTCGCACAACCCATACCAGGACAACGGGGTCAAGATCGTGGAACCAGACGGATCGATGCTTTTGGCCACATGGGAGCCATATGCCATGCAGTTGGCCAATGCGGCCTCTTTTGCCACTAATTTTGAAGAATTTCGTGTTGAGTTGGCCAAGCTGATTGAACACGAAAAGATTGATTTGAATACAACCGTCGTGCCTCACATCGTGGTTGGGAGAGACTCTAGGGAAAGTAGTCCATACTTGCTGCGCTGCTTGACTTCCTCCATGGCCAGCGTCTTCCACGCGCAAGTTTTGGACCTAGGCTGTGTCACTACGCCTCAATTGCATTACATTACTGATTTGTCCAACAGGCGGAAACTGGAAGGAGACACAGCGCCAGTTGCCACAGAACAGGACTACTATTCGTTCTTTATAGGAGCCTTCAACGAGCTCTTCGCCACGTATCAGCTGGAGAAGAGGCTGTCTGTCCCAAAATTGTTCATAGACACAGCCAATGGTATCGGTGGTCCACAGTTGAAAAAACTACTGGCCTCCGAAGATTGGGACGTGCCAGCGGAGCAAGTTGAGGTAATCAACGACAGGTCCGATGTTCCAGAACTGTTGAATTTTGAATGCGGTGCGGATTATGTGAAGACTAACCAGAGATTACCCAAGGGTCTTTCTCCATCCTCGTTTGATTCGCTATATTGCTCCTTTGATGGTGACGCAGACAGGGTTGTGTTCTACTATGTCGACTCAGGATCAAAATTTCATTTGTTGGATGGTGACAAAATTTCCACTTTGTTTGCAAAGTTCTTGTCTAAACAACTAGAATTGGCACACCTAGAACATTCTTTGAAGATTGGTGTTGTGCAAACTGCCTATGCAAACGGCAGTTCCACCGCTTACATAAAAAATACGTTGCACTGTCCCGTGTCTTGCACTAAGACAGGTGTTAAACACTTGCATCATGAAGCTGCCACTCAGTACGATATTGGCATTTATTTCGAAGCAAATGGACATGGTACGATTATATTCAGCGAAAAATTTCATCGAACTATCAAATCTGAATTATCCAAGTCCAAGTTAAATGGTGATACGTTAGCTTTGAGAACTTTGAAGTGTTTCTCTGAATTGATTAATCAGACCGTGGGAGATGCTATTTCAGACATGCTTGCTGTCCTTGCTACTTTGGCGATTTTGAAAATGTCGCCAATGGATTGGGATGAAGAGTATACTGATTTGCCCAACAAGCTGGTTAAGTGCATCGTTCCTGATAGGTCAATTTTCCAAACCACGGACCAGGAAAGAAAATTGCTCAATCCAGTGGGGTTGCAAGACAAGATAGATCTTGTGGTAGCCAAGTATCCCATGGGAAGAAGCTTTGTCAGAGCCAGTGGTACGGAGGATGCGGTGAGGGTTTATGCGGAATGTAAGGACTCCTCTAAGTTAGGTCAATTTTGTGACGAAGTGGTGGAGCACGTTAAGGCATCTGCTTGA","protein_sequence":"MKVDYEQLCKLYDDTCRTKNVQFSYGTAGFRTLAKNLDTVMFSTGILAVLRSLKLQGQYVGVMITASHNPYQDNGVKIVEPDGSMLLATWEPYAMQLANAASFATNFEEFRVELAKLIEHEKIDLNTTVVPHIVVGRDSRESSPYLLRCLTSSMASVFHAQVLDLGCVTTPQLHYITDLSNRRKLEGDTAPVATEQDYYSFFIGAFNELFATYQLEKRLSVPKLFIDTANGIGGPQLKKLLASEDWDVPAEQVEVINDRSDVPELLNFECGADYVKTNQRLPKGLSPSSFDSLYCSFDGDADRVVFYYVDSGSKFHLLDGDKISTLFAKFLSKQLELAHLEHSLKIGVVQTAYANGSSTAYIKNTLHCPVSCTKTGVKHLHHEAATQYDIGIYFEANGHGTIIFSEKFHRTIKSELSKSKLNGDTLALRTLKCFSELINQTVGDAISDMLAVLATLAILKMSPMDWDEEYTDLPNKLVKCIVPDRSIFQTTDQERKLLNPVGLQDKIDLVVAKYPMGRSFVRASGTEDAVRVYAECKDSSKLGQFCDEVVEHVKASA"},{"created_at":"2011-05-24T21:14:37.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Glucosamine 6-phosphate N-acetyltransferase","uniprot_id":"P43577","uniprot_name":"GNA1_YEAST","enzyme":true,"transporter":false,"gene_name":"GNA1","num_residues":159,"molecular_weight":"18134.80078","theoretical_pi":"4.87","general_function":"Involved in N-acetyltransferase activity","specific_function":"Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate","reactions":[{"id":1753,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2375,"direction":"\u003e","locations":null,"altext":"Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4134,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006429","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1I1D","cellular_location":null,"genbank_gene_id":"AB017626","genbank_protein_id":"4115733","gene_card_id":"GNA1","chromosome_location":"chromosome 6","locus":"YFL017C","synonyms":["Phosphoglucosamine acetylase","Phosphoglucosamine transacetylase"],"enzyme_classes":["2.3.1.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" acetyltransferase activity"},{"category":"Function","description":" N-acetyltransferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Acetyltransf_1","identifier":"PF00583"}],"pathways":[{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGAGCTTACCCGATGGATTTTATATAAGGCGAATGGAAGAGGGGGATTTGGAACAGGTCACTGAGACGCTAAAGGTTTTGACCACCGTGGGCACTATTACCCCCGAATCCTTCAGCAAACTCATAAAATACTGGAATGAAGCCACAGTATGGAATGATAACGAAGATAAAAAAATAATGCAATATAACCCCATGGTGATTGTGGACAAGCGCACCGAGACGGTTGCCGCTACGGGGAATATCATCATCGAAAGAAAGATCATTCATGAACTGGGGCTATGTGGCCACATCGAGGACATTGCAGTAAACTCCAAGTATCAGGGCCAAGGTTTGGGCAAGCTCTTGATTGATCAATTGGTAACTATCGGCTTTGACTACGGTTGTTATAAGATTATTTTAGATTGCGATGAGAAAAATGTCAAATTCTATGAAAAATGTGGGTTTAGCAACGCAGGCGTGGAAATGCAAATTAGAAAATAG","protein_sequence":"MSLPDGFYIRRMEEGDLEQVTETLKVLTTVGTITPESFSKLIKYWNEATVWNDNEDKKIMQYNPMVIVDKRTETVAATGNIIIERKIIHELGLCGHIEDIAVNSKYQGQGLGKLLIDQLVTIGFDYGCYKIILDCDEKNVKFYEKCGFSNAGVEMQIRK"}]}