{"ymdb_id":"YMDB00729","created_at":"2011-05-29T18:47:14.000Z","updated_at":"2016-09-08T18:35:50.000Z","name":"Delta(6)-trans,Delta(8)-cis-leukotriene B4","cas":null,"state":null,"melting_point":null,"description":"Delta(6)-trans,Delta(8)-cis-leukotriene B4 is an isomer of leukotriene B4. Leukotrienes are fatty signaling molecules. Leukotrienes are fatty signaling molecules. Leukotrienes are synthesized in the cell from arachidonic acid. The catalytic mechanism involves the insertion of an oxygen moiety at a specific position in the arachidonic acid backbone. [Wikipedia]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"nucleus;cytoplasm","synthesis_reference":null,"chebi_id":"53027","hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":"24608111","foodb_id":null,"wikipedia_link":"Leukotriene_B4","biocyc_id":null,"iupac":"(5S,6E,8Z,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid","traditional_iupac":"(5S,6E,8Z,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid","logp":"4.125548676999999","pka":"17.720820347637158","alogps_solubility":"1.52e-02 g/l","alogps_logp":"5.46","alogps_logs":"-4.34","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"14","polar_surface_area":"77.76","refractivity":"102.98500000000001","polarizability":"39.82602535753441","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-1.2749373349576958","pka_strongest_acidic":"4.6463449725928205","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["(5S,12R,6E,8Z,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid","(5S,6E,8Z,10E,12R,14Z)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoic acid","(6E,8Z)-LTB4","5,12-DiHETE","5,12-dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate","5,12-dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid","5(S),12(R)-dihydroxy-6(E),8(Z),10(E),14(Z)-eicosatetraenoic acid","5(S),12(R)-dihydroxy-6(E),8(Z),10(E),14(Z)-icosatetraenoic acid","Acetic acid, iodo-","Delta(6)-trans,Delta(8)-cis-LTB4","Iodoacetic acid","leukotriene b4","leukotriene B4 ethanol solution","LTB4"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":11601994,"citation":"Kull, F., Ohlson, E., Lind, B., Haeggstrom, J. Z. (2001). \"Saccharomyces cerevisiae leukotriene A4 hydrolase: formation of leukotriene B4 and identification of catalytic residues.\" Biochemistry 40:12695-12703."},{"pubmed_id":18407956,"citation":"Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). \"A multidimensional chromatography technology for in-depth phosphoproteome analysis.\" Mol Cell Proteomics 7:1389-1396."},{"pubmed_id":14562095,"citation":"Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). \"Global analysis of protein localization in budding yeast.\" Nature 425:686-691."}],"proteins":[{"created_at":"2011-05-27T05:42:17.000Z","updated_at":"2011-05-27T05:42:17.000Z","name":"Leukotriene A-4 hydrolase","uniprot_id":"Q10740","uniprot_name":"LKHA4_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":671,"molecular_weight":"77352.10156","theoretical_pi":"6.55","general_function":"Involved in binding","specific_function":"Hydrolyzes an epoxide moiety of LTA(4) to form LTB(4). The enzyme also has aminopeptidase activity","reactions":[{"id":1714,"direction":"\u003c\u003e","locations":"cytoplasm;nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1715,"direction":"\u003c\u003e","locations":"cytoplasm;nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1716,"direction":"\u003c\u003e","locations":"cytoplasm;nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2780,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"X94547","genbank_protein_id":"1149543","gene_card_id":null,"chromosome_location":null,"locus":"YNL045W","synonyms":["LTA-4 hydrolase","Leukotriene A(4) hydrolase"],"enzyme_classes":["3.3.2.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" leukotriene-A4 hydrolase activity"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity, acting on ether bonds"},{"category":"Function","description":" peptidase activity"},{"category":"Function","description":" peptidase activity, acting on L-amino acid peptides"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" metallopeptidase activity"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" ether hydrolase activity"},{"category":"Process","description":" unsaturated fatty acid metabolic process"},{"category":"Process","description":" icosanoid metabolic process"},{"category":"Process","description":" leukotriene metabolic process"},{"category":"Process","description":" leukotriene biosynthetic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" protein metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" proteolysis"}],"pfams":[{"name":"Leuk-A4-hydro_C","identifier":"PF09127"},{"name":"Peptidase_M1","identifier":"PF01433"}],"pathways":[{"name":"Arachidonic acid metabolism","kegg_map_id":"00590"}],"gene_sequence":"ATGTTCTTGCTTCCATTTGTCATTCGTCATTCCAGCTCTATTTACCTGCCCACGCTTCGATTTCGAGGTTTACTTACTGTAATCTCAAGAAACATACACATTTCCACCCCTCATAAAATGTTGCCTCTTTCAATTGAGCAGAGAAGACCTTCCCGCTCCCCCGAATACGATCAGTCTACTTTATCAAATTATAAGGACTTCGCAGTTCTTCACACCGATTTAAACCTGTCTGTTTCCTTCGAAAAGTCAGCCATTTCAGGGAGCGTTACATTCCAATTGAAAAAACTGCACGAAGGTAAAAATAAATCGGATGAATTACATCTGGATACATCCTATTTGGATGTCCAGGAGGTTCATATTGATGGTTCCAAGGCAGATTTTCAAATTGAGCAAAGAAAGGAGCCATTGGGCTCCAGGTTAGTCATCAATAACGCTTCTTGCAACGATAACTTTACCTTGAATATTCAATTTCGTACGACTGACAAGTGCACCGCTTTGCAATGGTTGAACAGCAAGCAAACCAAGGGCGGTAAACCGTACGTGTTTTCACAGTTGGAAGCTATTCATGCGAGGTCTTTGTTCCCCTGCTTTGATACTCCCTCTGTGAAGTCTACTTTCACTGCATCTATCGAGTCCCCACTACCAGTGGTTTTTTCAGGCATCAGGATTGAAGATACAAGCAAGGATACTAATATTTACAGATTTGAACAGAAAGTCCCTATCCCAGCCTACCTGATCGGTATTGCTTCCGGTGATTTGTCAAGCGCTCCAATTGGACCTCGTTCCACAGTTTACACTGAACCATTTCGTTTGAAAGATTGTCAATGGGAATTTGAAAACGATGTAGAGAAATTCATTCAAACTGCAGAGAAAATTATCTTTGAATACGAGTGGGGCACTTATGATATCTTAGTTAACGTCGATTCGTACCCTTACGGCGGTATGGAGTCTCCGAATATGACTTTTGCTACGCCCACCTTGATTGCACATGACAGATCCAACATTGATGTCATCGCCCATGAACTTGCTCACTCATGGTCTGGTAACTTAGTGACCAATTGTTCGTGGAATCATTTTTGGTTGAATGAAGGTTGGACCGTTTACTTAGAAAGAAGAATTATTGGTGCCATTCATGGCGAACCAACTAGACATTTCAGTGCTCTGATTGGTTGGAGCGATTTGCAGAATTCTATTGATTCTATGAAAGATCCTGAAAGATTTTCCACTTTGGTACAAAACTTGAACGATAACACTGACCCTGACGATGCCTTTTCCACTGTTCCGTACGAAAAGGGGTTCAACTTACTATTTCACTTGGAAACTATTTTGGGTGGTAAGGCTGAATTTGATCCATTTATTAGACACTATTTCAAGAAGTTTGCCAAAAAATCATTGGATACTTTCCAGTTTTTGGATACTTTGTATGAGTTCTATCCCGAAAAGAAAGAAATTTTGGATTCCGTTGACTGGGAAACTTGGCTGTATAAACCAGGTATGCCACCAAGGCCTCATTTTATTACGGCTTTGGCTGATAATGTTTATCAATTGGCTGACAAGTGGGTCGAAATGGCTCAACATTTGAAAACCACAGAGGATTTCCGGTCTGAATTTAACGCTATTGACATTAAGGATTTTAATTCAAATCAATTGGTTTTGTTCTTGGAAACTTTGACACAAAATGGCCATTCCAACAAGAAACCAAAAGATTTTGACTGGGCCAAGTTTCCCGTGGCATCTAGGGCACTGTTAGATATCTATCAAGATAACATTGTTAAATCACAGAACGCGGAAGTTGTTTTCAAGATGTTCAAATTTCAGATCTTTGCCAAGCTGCAAGAAGAATATAAGCATTTGGCCGATTGGTTGGGAACTGTAGGTAGAATGAAGTTTGTCCGTCCCGGTTACAGACTATTAAACTCTGTAGACCGTCGATTGGCACTTGCAACTTTCGACAAATTCAAGGACACGTATCATCCAATCTGTAAAGCTCTTGTGAAACAAGATTTAGGTCTTTGA","protein_sequence":"MFLLPFVIRHSSSIYLPTLRFRGLLTVISRNIHISTPHKMLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRTTDKCTALQWLNSKQTKGGKPYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESPLPVVFSGIRIEDTSKDTNIYRFEQKVPIPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPTLIAHDRSNIDVIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDSMKDPERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWETWLYKPGMPPRPHFITALADNVYQLADKWVEMAQHLKTTEDFRSEFNAIDIKDFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDRRLALATFDKFKDTYHPICKALVKQDLGL"}]}