{"ymdb_id":"YMDB00724","created_at":"2011-05-29T18:46:48.000Z","updated_at":"2016-09-08T18:35:49.000Z","name":"L-glucitol","cas":"6706-59-8","state":null,"melting_point":null,"description":"Sorbitol (glucitol) is a six-carbon sugar alcohol found in apples, pears, peaches, and prunes. It is synthesized by sorbitol-6-phosphate dehydrogenase, and converted to fructose by succinate dehydrogenase and sorbitol dehydrogenase. Succinate dehydrogenase is an enzyme complex that participates in the citric acid cycle.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"extracellular;cytoplasm","synthesis_reference":null,"chebi_id":"28789","hmdb_id":null,"kegg_id":"C01722","pubchem_id":"82170","cs_id":"24533858","foodb_id":null,"wikipedia_link":"Sorbitol","biocyc_id":null,"iupac":"(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol","traditional_iupac":"D-sorbitol","logp":"-3.7300188486666666","pka":"13.37874915684328","alogps_solubility":"2.29e+02 g/l","alogps_logp":"-2.68","alogps_logs":"0.10","acceptor_count":"6","donor_count":"6","rotatable_bond_count":"5","polar_surface_area":"121.38000000000001","refractivity":"38.4036","polarizability":"17.12411136029489","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-2.974211614825128","pka_strongest_acidic":"12.585200956788803","bioavailability":"1","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2R,3S,4S,5S)-hexane-1,2,3,4,5,6-hexol","D-Gulitol","L-glucitol","L-Sorbitol"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":11102521,"citation":"Gasch, A. P., Spellman, P. T., Kao, C. M., Carmel-Harel, O., Eisen, M. B., Storz, G., Botstein, D., Brown, P. O. (2000). \"Genomic expression programs in the response of yeast cells to environmental changes.\" Mol Biol Cell 11:4241-4257."},{"pubmed_id":17270724,"citation":"Hirasawa, T., Ashitani, K., Yoshikawa, K., Nagahisa, K., Furusawa, C., Katakura, Y., Shimizu, H., Shioya, S. (2006). \"Comparison of transcriptional responses to osmotic stresses induced by NaCl and sorbitol additions in Saccharomyces cerevisiae using DNA microarray.\" J Biosci Bioeng 102:568-571."}],"proteins":[{"created_at":"2011-05-26T18:00:48.000Z","updated_at":"2011-07-22T17:54:34.000Z","name":"Sorbitol dehydrogenase 1","uniprot_id":"P35497","uniprot_name":"DHSO1_YEAST","enzyme":true,"transporter":false,"gene_name":"SOR1","num_residues":357,"molecular_weight":"38165.39844","theoretical_pi":"6.94","general_function":"Involved in zinc ion binding","specific_function":"L-iditol + NAD(+) = L-sorbose + NADH","reactions":[{"id":1435,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1705,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2503,"direction":"\u003e","locations":"","altext":"L-iditol + NAD(+) = L-sorbose + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":3819,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006333","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY693012","genbank_protein_id":"51013475","gene_card_id":"SOR1","chromosome_location":"chromosome 10","locus":"YJR159W","synonyms":["L-iditol 2-dehydrogenase 1"],"enzyme_classes":["1.1.1.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"ADH_N","identifier":"PF08240"},{"name":"ADH_zinc_N","identifier":"PF00107"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Fructose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTCAAAATAGTAACCCTGCAGTAGTTCTAGAGAAAGTCGGCGATATTGCCATCGAGCAAAGACCAATCCCTACCATTAAGGACCCCCATTATGTCAAGTTAGCTATTAAAGCCACTGGTATCTGCGGCTCTGATATTCATTATTATAGAAGCGGTGGTATTGGTAAGTACATATTGAAGGCGCCAATGGTTTTAGGTCATGAATCAAGCGGACAGGTTGTGGAAGTTGGTGATGCCGTCACAAGGGTCAAAGTTGGTGACCGTGTTGCTATTGAACCTGGTGTTCCTAGCCGTTACTCTGATGAGACCAAAGAAGGGAGGTATAACCTTTGCCCACATATGGCATTTGCTGCAACTCCTCCAATTGATGGTACTCTTGTGAAGTACTATTTATCTCCAGAAGATTTCCTTGTGAAATTGCCAGAAGGCGTCAGTTATGAAGAGGGCGCTTGTGTCGAACCCTTATCAGTCGGTGTACACTCTAATAAATTGGCTGGGGTCCGCTTTGGTACCAAAGTTGTTGTATTTGGTGCAGGTCCTGTGGGGCTTTTAACTGGCGCAGTCGCCCGCGCTTTTGGTGCCACCGACGTCATTTTCGTCGATGTATTCGACAACAAGCTACAGAGAGCAAAAGATTTCGGAGCCACAAACACTTTCAATTCTTCCCAGTTTTCCACCGATAAAGCCCAAGACTTGGCCGATGGGGTCCAAAAGCTTTTGGGCGGAAATCACGCAGATGTGGTGTTTGAGTGTTCAGGTGCTGATGTTTGCATTGATGCCGCTGTCAAAACAACTAAGGTTGGAGGTACCATGGTGCAAGTCGGTATGGGTAAAAACTACACTAATTTTCCAATTGCTGAAGTTAGTGGAAAGGAAATGAAATTGATTGGATGTTTCCGTTATTCATTCGGTGATTATCGTGACGCTGTGAACTTGGTTGCCACAGGAAAAGTCAATGTCAAGCCATTGATAACCCACAAATTTAAATTTGAAGATGCAGCCAAGGCTTACGACTACAACATTGCCCATGGTGGAGAGGTAGTCAAGACTATTATCTTTGGTCCTGAATGA","protein_sequence":"MSQNSNPAVVLEKVGDIAIEQRPIPTIKDPHYVKLAIKATGICGSDIHYYRSGGIGKYILKAPMVLGHESSGQVVEVGDAVTRVKVGDRVAIEPGVPSRYSDETKEGRYNLCPHMAFAATPPIDGTLVKYYLSPEDFLVKLPEGVSYEEGACVEPLSVGVHSNKLAGVRFGTKVVVFGAGPVGLLTGAVARAFGATDVIFVDVFDNKLQRAKDFGATNTFNSSQFSTDKAQDLADGVQKLLGGNHADVVFECSGADVCIDAAVKTTKVGGTMVQVGMGKNYTNFPIAEVSGKEMKLIGCFRYSFGDYRDAVNLVATGKVNVKPLITHKFKFEDAAKAYDYNIAHGGEVVKTIIFGPE"}]}